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Flexible bronchoscopy for foreign body aspiration in children:A single-centre experience

World Journal of Clinical Pediatrics 2024年第2期13卷 127-134页

作者： Aleh Sautin Kirjl Marakhouski Aleh Pataleta Kirill Sanfirau Diagnostic Division Republican Scientific and Practical Centre of Paediatric SurgeryMinsk 220013Belarus

BACKGROUND The technological evolution of bronchoscopy has led to the widespread adoption of flexible techniques and their use for both diagnostic and therapeutic ***,there is an active debate regarding the comparative efficacy and safety of rigid vs flexible bronchoscopy in the treatment of foreign body *** To evaluate our experience with tracheobronchial foreign body extraction using flexible bronchoscopy and provide a literature *** This was a single-centre retrospective ***-four patients were enrolled between January 2017 and January *** records of patients aged below 18 years who were admitted to authors’affiliated institution with a suspected diagnosis of foreign body aspiration were collected from hospital’s database to Microsoft Excel *** were analysed using MedCalc Statistical *** Patient ages varied from 9 months to 11 *** median age was 23.5 months,95%confidence interval(CI)*** observed age clustering in children with foreign body aspiration at our institution with three age subgroups:(1)0-25 months;(2)40-60 months;and(3)120-140 *** expectancy of an organic tracheobronchial foreign body was significantly higher in 0-25 months subgroup than that in older ones when subgroups 40-60 and 120-140 months were combined together(odds ratio=10.0,95%CI:1.44-29.26,P=0.0197).Successful foreign body extraction was performed in all *** to a rigid bronchoscope was not required in any of the *** major complications(massive bleeding,tracheobronchial tree perforation,or asphyxia)were *** Flexible bronchoscopy is an effective and safe method for tracheobronchial foreign body extraction in children.

关键词： Foreign body aspiration Tracheobronchial foreign body Paediatric bronchoscopy Flexible bronchoscopy Rigid bronchoscopy

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Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis

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World Journal of Hepatology 2024年第5期16卷 822-831页

作者： Irina Efremova Roman Maslennikov Elena Poluektova Oleg Medvedev Anna Kudryavtseva George Krasnov Maria Fedorova Filipp Romanikhin Maria Zharkova Oxana Zolnikova Gyunay Bagieva Vladimir Ivashkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Department of scientific Scientific Community for the Promotion of the Clinical Study of the Human MicrobiomeMoscow 119435Russia Department of Pharmacology Lomonosov Moscow State UniversityMoscow 119192Russia Department of Post-Genomic research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

BACKGROUND The gut–liver axis and bacterial translocation are important in cirrhosis,but there is no available universal biomarker of cellular bacterial translocation,for which presepsin may be a *** To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious *** This study included 48 patients with Child–Pugh cirrhosis classes B and C and 15 healthy *** fecal microbiome was assessed using 16S rRNA gene *** levels of presepsin were measured.A total of 22 patients received a probiotic(Saccharomyces boulardii)for 3 *** Presepsin levels were higher in patients with cirrhosis than in healthy individuals[342(91-2875)vs 120(102-141)pg/mL;P=0.048].Patients with elevated presepsin levels accounted for 56.3%of all included *** had lower levels of serum albumin and higher levels of serum total bilirubin and overall severity of cirrhosis as assessed using the Child–Pugh *** with elevated presepsin levels had an increased abundance of the main taxa responsible for bacterial translocation,namely Bacilli and Proteobacteria(including the main class Gammaproteobacteria and the minor taxa Xanthobacteraceae and Stenotrophomonas),and a low abundance of bacteria from the family Lachnospiraceae(including the minor genus Fusicatenibacter),which produce short-chain fatty acids that have a positive effect on intestinal barrier *** presepsin level directly correlated with the relative abundance of Bacilli,Proteobacteria,and inversely correlated with the abundance of Lachnospiraceae and *** 3 months of taking the probiotic,the severity of cirrhosis on the Child–Pugh scale decreased significantly only in the group with elevated presepsin levels[from 9(8-11)to 7(6-9);P=0.004],while there were no significant changes in the group with normal presepsin levels[from 8(7-8)to 7(6-8);P=0.123].A high level of presepsin

关键词： Dysbiosis Gut Intestinal permeability Leaky gut Gut-liver axis Liver Microbiota

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An intelligent DNA nanodevice for precision thrombus therapy

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Science China Chemistry 2024年第10期67卷 3195-3197页

作者： Yihao Zhou Qiangbin Wang CAS Key Laboratory of Nano-bio Interface Division of Nanobiomedicine and i-LabSuzhou Instiute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

Obstruction of blood vessels(thrombosis)due to blood clots is one of the main causes of death worldwide and is associated with many cardiovascular diseases,such as myocardial infarction,ischemic stroke,and pulmonary embolism[1].Thrombolytic therapy is currently the preferred treatment for acute thrombosis and is administered intravenously with thrombolytic drugs,such as tissue plasminogen activator(tPA)[2].

关键词： drugs cardiovascular acute

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Synthesis of Core-shell ZSM-5@ Ordered Mesoporous Silica by Tetradecylamine Surfactant

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 332-336页

作者：马扩彦 ZHAO Pengxian YI Hongyu 俞海军 ZHOU Moxi ZHANG Lingling LIU Yupu Chongqing Key laboratory of scientific Utilization of Tobacco Resource Chongqing 400060China Department of Chemistry Laboratory of Advanced MaterialsFudan UniversityShanghai 200433China

A core-shell composite consisting of ZSM-5 zeolite as the core and ordered mesoporous silica as the shell was prepared by a surfactant-controlled sol-gel process and using tetradecylamine(TDA) as the template and Tetraethylorthosilicate(TEOS) as the silica *** pores of the silica shell were found to be ordered and perpendicular to the crystal faces of the zeolite *** thickness of the shell in the coreshell structured composite can be adjusted in the range of 20-90 nm,while the surface morphology and the pore size distribution were modified by changing the mass ratio of TEOS to *** composite molecular sieves have higher surface area for capturing molecules than ZSM-5,and with the increase of mesoporous shell layer,the ZSM-5@SiO_(2)-x composites show stronger adsorption capacity of ***,when the shell thickness exceeds 90 nm,the adsorption capacity of butyraldehyde decreases *** composites have a huge potential for environmental applications.

关键词： core-shell composite tetradecylamine surfactant adsorption

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Investigation of anisotropic strength criteria for layered rock mass

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1289-1304页

作者： Shuling Huang Jinxin Zhang Xiuli Ding Chuanqing Zhang Gang Han Guoqi Yu Lulu Qu Key Laboratory of Geotechnical Mechanics and Engineering of the Ministry of Water Resources Changjiang River Scientific Research InstituteWuhan430071China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430000China University of Chinese Academy of Sciences Beijing100049China

Layered rock mass is a type of engineering rock mass with sound mechanical anisotropy,which is generally unfavorable to the stability of underground *** investigate the strength anisotropy of layered rock,the Mohr-Coulomb and Hoek-Brown criteria are introduced to establish the two transverse isotropic strength criteria based on Jaeger's single weak plane theory and maximum axial strain theory,and parameter determination ***,the sensitivity of strength parameters(K 1,K 2,and K 3)that are used to characterize the anisotropy strength of non-sliding failure involved in the strength criteria and confining pressure are *** results demonstrate that strength parameters K 1 and K 2 affect the strength of layered rock samples at all bedding angles except for the bedding angle of 90°and the angle range that can cause the shear sliding failure along the bedding *** strength of samples at any bedding angle decreases with increasing K 1,whereas the opposite is for K *** for bedding angles of 0°and 90°and the bedding angle range that can cause the shear sliding along the bedding plane,K 3 has an impact on the strength of rock samples with other bedding angles that the specimens'strength increases with increase of K *** addition,the strength of the rock sample increases as confining pressure ***,the uniaxial and triaxial tests of chlorite schist samples were carried out to verify and evaluate the strength criteria proposed in the *** shows that the predicted strength is in good agreement with the experimental *** test the applicability of the strength criterion,the strength data of several types of rock in the literature are ***,a comparison is made between the fitting effects of the two strength criteria and other available criteria for layered rocks.

关键词： Layered rock Strength anisotropy Strength criterion Experimental verification

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Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation

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National Science Review 2024年第6期11卷 119-128页

作者： Chunyu Zhao Jia Tu Chuchu Wang Wenbin Liu Jinge Gu Yandong Yin Shengnan Zhang Dan Li Jiajie Diao Zheng-Jiang Zhu Cong Liu Interdisciplinary research Center on biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education Shanghai Jiao Tong University Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University Department of Cancer biology University of Cincinnati College of Medicine

Accumulation of aggregated α-synuclein(α-syn) in Lewy bodies is the pathological hallmark of Parkinson's disease(PD). Genetic mutations in lipid metabolism are causative for a subset of patients with Parkinsonism. The role of α-syn's lipid interactions in its function and aggregation is recognized, yet the specific lipids involved and how lipid metabolism issues trigger α-syn aggregation and neurodegeneration remain unclear. Here, we found that α-syn shows a preference for binding to lysophospholipids(LPLs),particularly targeting lysophosphatidylcholine(LPC) without relying on electrostatic interactions. LPC is capable of maintaining α-syn in a compact conformation, significantly reducing its propensity to aggregate both in vitro and within cellular environments. Conversely, a reduction in the production of cellular LPLs is associated with an increase in α-syn accumulation. Our work underscores the critical role of LPLs in preserving the natural conformation of α-syn to inhibit improper aggregation, and establishes a potential connection between lipid metabolic dysfunction and α-syn aggregation in PD.

关键词： α-synuclein Parkinson's disease lysophosphatidylcholine, aggregation

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Black gill disease in Litopenaeus vannamei made by various agents

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Aquaculture and Fisheries 2024年第4期9卷 626-634页

作者： Mohammad Khalil Pazir Sajjad Pourmozaffar Ivone Giffard Mena Ren Shengjie Amirhossein Ahmadi Issa Sharifpour Iran Shrimp research Center Iranian Fisheries Science Research InstituteAgricultural ResearchEducation and Extension Organization(AREEO)Bushehr75169-89177Iran Persian Gulf Mollusks research Station Persian Gulf and Oman Sea Ecology Research CenterIranian Fisheries Sciences Research InstituteAgricultural Research Education and Extension Organization(AREEO)Bandar-e-Lengeh75145Iran AEO Team UMR 5119 EcolagUniversite Montpellier IIMontpellier Cedex 0534095France Faculty of Science Queensland University of TechnologyQLD4001Australia Department of biological Science and Technology Faculty of Nano and Bio Science and TechnologyPersian Gulf UniversityBushehr75169Iran Iranian Fisheries Science research Institute Agricultural ResearchEducation and Extension Organization(AREEO)Tehran14968-13151Iran

Melanization of shrimp gills is a general symptom in shrimp black bill diseases(sBG);therefore,the cause is not immediately *** study aimed to determine the primary and secondary agents associated with a black gill outbreak in the Delvar complex in the Bushehr Province of *** July and August of 2020,450 healthy and affected shrimps were collected based on brown to black gill color from three farms of the Bushehr Province in *** of pathogens was performed by gross signs,wet mounts,microbiological tests,histopathology methods,and sequencing of molecular *** mean weight and length of infected shrimps was significantly(Pbiotic factors,including bacterial(Vibrio owensii and ***)probably are secondary agents associated with sBG disease.

关键词： Black gill disease Litopenaeus vannamei Aspergillus Vibrio sp. Protozoan

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Lean methane combustion over zeolite-supported Pd catalysts:Structure-performance relationship and deactivation mechanism

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Journal of Environmental Sciences 2024年第11期145卷 128-138页

作者： Xingyu Liu Jingkun Chen Bowen Han Renna Li Le Shi Zhongbiao Wu Xiaole Weng Key Laboratory of Environment Remediation and Ecological Health Ministry of EducationCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China ZJU-Hangzhou Global scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200China Zhejiang Provincial Engineering research Centre of Industrial Boiler&Furnace Flue Gas Pollution Control Hangzhou 310058China

Zeolites are a promising support for Pd catalysts in leanmethane(CH_(4))***,three types of zeolites(H-MOR,H-ZSM-5 and H-Y)were selected to estimate their structural effects and deactivation mechanisms in CH_(4)*** show that variations in zeolite structure and surface acidity led to distinct changes in Pd ***/H-MOR with external high-dispersing Pd nanoparticles exhibited the best apparent activity,with activation energy(Ea)at 73 kJ/mol,while Pd/H-ZSM-5 displayed the highest turnover frequency(TOF)at 19.6×10^(−3)sec^(−1),presumably owing to its large particles with more step sites providing active sites in one particle for CH_(4)***/H-Y with dispersed PdO within pore channels and/or Pd2+ions on ion-exchange sites yielded the lowest apparent activity and ***,Pd/H-MOR and Pd/H-ZSM-5 were both stable under a dry condition,but introducing 3 vol.%H_(2)O caused the CH_(4)conversion rate on Pd/H-MOR drop from 100%to 63%and that on Pd/H-ZSM-5 decreased remarkably from 82%to 36%.The former was shown to originate fromzeolite structural dealumination,and the latter principally owed to Pd aggregation and the loss of active PdO.

关键词： Methane combustion Pd catalysts Zeolite Structure-performance relationship Deactivation mechanism

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METTL5 promotes cell proliferation,invasion,and migration by up-regulating Toll-like receptor 8 expression in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2006-2017页

作者： Ling-Shang Kong Ran Tao Yi-Fan Li Wen-Bin Wang Xue Zhao Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Vascular Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230002Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230012Anhui ProvinceChina Department of scientific research Anhui Public Health Clinical CenterHefei 230012Anhui ProvinceChina Department of scientific research The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND N6-methyladenosine(m6A)modification represents the predominant alteration found in eukaryotic messenger RNA and plays a crucial role in the progression of various ***,despite its significance,the comprehensive investigation of METTL5,a key m6A methyltransferase,in colorectal cancer(CRC)remains *** To investigate the role of METTL5 in *** We assessed METTL5 expression levels in clinical samples obtained from CRC patients as well as in CRC cell *** elucidate the downstream targets of METTL5,we performed RNA-sequencing analysis coupled with correlation analysis,leading us to identify Toll-like receptor 8(TLR8)as a potential downstream *** vitro functional assessments of METTL5 and TLR8 were conducted using CCK-8 assays,scratch assays,as well as assays measuring cell migration and *** Our findings reveal a pronounced upregulation of METTL5 expression in both CRC cells and tissues,which correlated significantly with an unfavorable *** vitro experiments unequivocally demonstrated the oncogenic role of METTL5,as evidenced by its promotion of CRC cell proliferation,invasion,and ***,we identified TLR8 as a downstream target of METTL5,and subsequent down-regulation of TLR8 led to a significant inhibition of CRC cell proliferation,invasion,and tumor *** The heightened expression of METTL5 in CRC is strongly associated with clinicopathological features and a poor prognosis,thereby underscoring its potential utility as a critical marker for facilitating early diagnosis and prognostication in CRC.

关键词： METTL5 Toll-like receptor 8 Colorectal cancer

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Roles of NAC transcription factors in cotton

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Journal of Cotton research 2024年第3期7卷 289-301页

作者： XU Yuewei ZHAO Yunlei CHEN Wei SANG Xiaohui ZHAO Pei WANG Hongmei Zhengzhou research Base National Key Laboratory of Cotton Bio‑breeding and Integrated UtilizationZhengzhou UniversityZhengzhouHenan 450001China National Key Laboratory of Cotton bio‑breeding and Integrated Utilization Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China

Climate deterioration,water shortages,and abiotic stress are the main threats worldwide that seriously affect cotton growth,yield,and fiber ***,research on improving cotton yield and tolerance to biotic and abiotic stresses is of great *** NAC proteins are crucial and plant-specific transcription factors(TFs)that are involved in cotton growth,development,and stress *** comprehensive utilization of cotton NAC TFs in the improvement of cotton varieties through novel biotechnological methods is *** on cotton genomic data,genome-wide identification and analyses have revealed potential functions of cotton NAC ***,we comprehensively summarize the recent progress in understanding cotton NAC TFs roles in regulating responses to drought,salt,and Verticillium wilt-related stresses,as well as leaf senescence and the development of fibers,xylem,and *** detailed regulatory network of NAC proteins in cotton is also *** NAC TFs directly bind to the promoters of genes associated with ABA biosynthesis and secondary cell-wall formation,participate in several biological processes by interacting with related proteins,and regulate the expression of downstream *** have shown that the overexpression of NAC TF genes in cotton and other model plants improve their drought or salt *** review elucidates the latest findings on the functions and regulation of cotton NAC proteins,broadens our understanding of cotton NAC TFs,and lays a fundamental foundation for further molecular breeding research in cotton.

关键词： Cotton NAC transcription factor Stress Regulatory network

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