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Transfer matrix method for free and forced vibrations of multi-level functionally graded material stepped beams with different boundary conditions

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 983-1000页

作者： Xiaoyang SU Tong HU Wei ZHANG Houjun KANG Yunyue CONG Quan YUAN School of Civil Engineering and Architecture Guangxi UniversityNanning 530004China scientific research Center of Engineering Mechanics Guangxi UniversityNanning 530004China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Guangxi UniversityNanning 530004China

Functionally graded materials(FGMs)are a novel class of composite materials that have attracted significant attention in the field of engineering due to their unique mechanical *** study aims to explore the dynamic behaviors of an FGM stepped beam with different boundary conditions based on an efficient solving *** the assumptions of the Euler-Bernoulli beam theory,the governing differential equations of an individual FGM beam are derived with Hamilton’s principle and decoupled via the separation-of-variable ***,the free and forced vibrations of the FGM stepped beam are solved with the transfer matrix method(TMM).Two models,i.e.,a three-level FGM stepped beam and a five-level FGM stepped beam,are considered,and their natural frequencies and mode shapes are *** demonstrate the validity of the method in this paper,the simulation results by ABAQUS are also *** this basis,the detailed parametric analyses on the frequencies and dynamic responses of the three-level FGM stepped beam are carried *** results show the accuracy and efficiency of the TMM.

关键词： transfer matrix method(TMM) free vibration forced vibration functionally graded material(FGM) stepped beam

The interplay of drug therapeutics and immune responses to SARS-CoV-2

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Cellular & Molecular Immunology 2024年第2期21卷 197-200页

作者： Valeria Fumagalli Matteo Iannacone Division of Immunology Transplantationand Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly Experimental Imaging Centre IRCCS San Raffaele Scientific InstituteMilanItaly

The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative *** vaccines form the frontline of defense,antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures,particularly for those unable or unwilling to be *** review delves into the potential influence of nirmatrelvir on enduring *** parallel,the potential of drug repurposing is explored,with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory *** importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.

关键词： SARS-CoV-2 Nirmatrelvir Bisphosphonates Adaptive immunity Drug repurposing

Inhibition of M2 tumor-associated macrophages polarization by modulating the Wnt/β-catenin pathway as a possible liver cancer therapy method

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World Journal of Gastroenterology 2024年第40期30卷 4399-4403页

作者： Vladislav V Tsukanov Julia L Tonkikh Edward V Kasparov Alexander V Vasyutin Clinical Department of the Digestive System Pathology of Adults and Children Federal Research Center“Krasnoyarsk Science Center”of the Siberian Branch of the Russian Academy of SciencesScientific Research Institute of Medical Problems of the NorthKrasnoyarsk 660022Russia

The problem of liver cancer is becoming increasingly important due to the epi-demic of metabolic diseases and persistent high alcohol *** deter-mines great attention to the development and improvement of methods for early diagnosis and treatment of liver *** et al presented a study in the World Journal of Gastroenterology,in which they showed that the use of the traditional Chinese medicine Calculus bovis(CB)can suppress tumor growth in mice by inhibiting M2 tumor-associated macrophages(TAM)through modulating the activity of the Wnt/β-catenin *** interaction of CB components with the Wnt/β-catenin pathway,M2 TAM polarization,and tumor dynamics were studied using network pharmacology,transcriptomics,and molecular *** is now generally accepted that the polarization of TAM and the differentiation of the functions of M1 and M2 phagocytes are of great importance for the progression of *** is assumed that M2 TAM promote proliferation and migration of tumor *** to medicinally influence the Wnt/β-catenin pathway in order to modulate phagocyte polarization now belong to one of the most promising areas of immunotherapy of oncological ***,the work of the Chinese authors deserves attention and further development.

关键词： Liver cancer Treatment Calculus bovis Tumor-associated macrophages M2 tumor Macrophage polarization Wnt/β-catenin pathway

Reactivation of hepatitis B virus infection – an important aspect of multifaceted problem

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World Journal of Gastroenterology 2024年第26期30卷 3193-3197页

作者： Sergey Morozov Sergey Batskikh Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of Hepatology Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia

In this editorial we comment on the article published in the recent issue of the W orld Journal of *** focus specifically on the problem of occult hepatitis B virus(HBV)infection,that is a result of previous hepatitis B(PHB)and a source for reactivation of *** prevalence of PHB is underestimated due to the lack of population testing ***,this condition not only com-plicate anticancer treatment,but may be responsible for the development of other diseases,like cancer or autoimmune *** we unveil possible mecha-nisms responsible for realization of these processes and suggest practical approa-ches for diagnosis and treatment.

关键词： Occult hepatitis B virus infection Hepatitis B virus reactivation Previous hepatitis B Cancer Autoimmune disorders

Engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy

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Science China Chemistry 2024年第7期67卷 2412-2422页

作者： Yu Chen Yu Guo Jiaoli Wang Ruiting Liu Xiaohai Yang Kemin Wang Ying Pu Hui Shi Jin Huang Key Laboratory of Chemo/biosensing and Chemometrics College of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan UniversityChangsha 410082China National Clinical research Center for Geriatric Disorders Department of GeriatricsXiangya HospitalCentral South UniversityChangsha 410008China

DNAzyme-based gene therapy faces some challenges including cell penetration,activity limitation,and co-delivery ***-assembled DNA nanomedicine has attracted widespread attention due to its many *** is urgent to develop a universal DNA degradation strategy for precise programmable drug ***,we reported a self-catabolic DNAzyme nanospheres(SCNS),which could simultaneously achieve cell penetration,activity enhancement,and co-delivery *** SCNS were assembled through Y-DNA stepwise hybridization with each other,which were then loaded with aptamer(Apt),doxorubicin(Dox),and zinc oxide nanoparticles(ZnO NPs).The acid-triggered dissociation of ZnO NPs leads to the generation of Zn^(2+)ions cofactors for immediately self-catabolic DNAzyme *** the disassembly of the SCNS,three types of anticancer treatments would be activated,which include Zn^(2+)involved reactive oxygen species(ROS),Dox-induced chemotherapy,and DNAzyme-based gene *** experimental results show that the nanoplatform(Apt-SCNS-Dox-ZnO)has a good tumor-killing effect and minimal side *** a smart self-driven drug delivery nanoplatform,it is anticipated to displace extraordinary potential in biomedicine and bioengineering.

关键词： DNAzyme nanosphere ZnO NPs ROS Dox anticancer therapy

Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata(Desv.)Spring against inflammatory bowel disease

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Journal of Pharmaceutical Analysis 2024年第2期14卷 177-195页

作者： Haochen Hui Zhuoya Wang Xuerong Zhao Lina Xu Lianhong Yin Feifei Wang Liping Qu Jinyong Peng Department of Pharmaceutical Analysis College of PharmacyDalian Medical UniversityDalianLiaoning116044China Innovation Materials research and Development Center Botanee Research InstituteYunnan Botanee Bio-technology Group Co.Ltd.Kunming650106China Department of Traditional Chinese Medicine Pharmacology School of PharmacyAnhui University of Chinese MedicineHefei230012China

Inflammatory bowel disease(IBD)is a serious disorder,and exploration of active compounds to treat it is *** acidic polysaccharide named SUSP-4 was purified from Selaginella uncinata(Desv.)Spring,which contained galacturonic acid,galactose,xylose,arabinose,and rhamnose with the main chain structure of→4)-α-d-GalAp-(1→and→6)-β-d-Galp-(1→and the branched structure of→5)-α-l-Araf-(1→.Animal experiments showed that compared with Model group,SUSP-4 significantly improved body weight status,disease activity index(DAI),colonic shortening,and histopathological damage,and elevated occludin and zonula occludens protein 1(ZO-1)expression in mice induced by dextran sulfate sodium salt(DSS).16S ribosomal RNA(rRNA)sequencing indicated that SUSP-4 markedly downregulated the level of Akkermansia and *** results confirmed that SUSP-4 obviously elevated thiamine levels compared with Model mice by adjusting thiamine metabolism,which was further confirmed by a targeted metabolism *** transplantation experiments showed that SUSP-4 exerted an anti-IBD effect by altering the intestinal flora in mice.A mechanistic study showed that SUSP-4 markedly inhibited macrophage activation by decreasing the levels of phospho-nuclear factor kappa-B(p-NF-κB)and cyclooxygenase-2(COX-2)and elevating NF-E2-related factor 2(Nrf2)levels compared with Model *** conclusion,SUSP-4 affected thiamine metabolism by regulating Akkermania and inhibited macrophage activation to adjust NF-κB/Nrf2/COX-2-mediated inflammation and oxidative stress against *** is the first time that plant polysaccharides have been shown to affect thiamine metabolism against IBD,showing great potential for in-depth research and development applications.

关键词： Gut microbiota Inflammatory bowel disease Polysaccharide Selaginella uncinata(Desv.)Spring Thiamine metabolism

Exocrine pancreatic insufficiency: more compromise than precision

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 523-526页

作者： Matteo Tacelli Paolo Giorgio Arcidiacono Gabriele Capurso Pancreato-Biliary Endoscopy and Endosonography Division Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSMilanItaly Vita-Salute San Raffaele University MilanItaly

Exocrine pancreatic insufficiency(EPI)can be defined as a reduction in the secretion or intraluminal activity of pancreatic enzymes at a level that does not allow the normal digestion of nutrients contained in *** condition is difficult to diagnose and treat and has long been misunderstood,underestimated,and overlooked to some extent.

关键词： Exocrine pancreatic insufficiency(EPI) fecal elastase-1(FE-1) chronic pancreatitis pancreaticoduodenectomy(PD) pancreatic enzyme replacement therapy(PERT)

Upper-Bound Limit Analysis of the Multi-Layer Slope Stability and Failure Mode Based on Generalized Horizontal Slice Method

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Journal of Earth Science 2024年第3期35卷 929-940页

作者： Huawei Zhang Changdong Li Wenqiang Chen Ni Xie Guihua Wang Wenmin Yao Xihui Jiang Jingjing Long Key Laboratory of Geotechnical Mechanics and Engineering of Ministry of Water Resources Changjiang River Scientific Research InstituteWuhan 430010China Faculty of Engineering China University of GeosciencesWuhan 430074China Badong National Observation and research Station of Geohazards China University of GeosciencesWuhan 430074China School of Civil Engineering Zhengzhou UniversityZhengzhou 450001China

Multi-layer slopes are widely found in clay residue receiving fields.A generalized horizontal slice method(GHSM)for assessing the stability of multi-layer slopes that considers the energy dissipation between adjacent horizontal slices is *** view of the upper-bound limit analysis theory,the energy equation is derived and the ultimate failure mode is generated by comparing the sliding surface passing through the slope toe(mode A)with that below(mode B).In addition,the influence of the number of slices on the stability coefficients in the GHSM is studied and the stable value is *** to the original method(Chen’s method),the GHSM can acquire more precise results,which takes into account the energy dissipation in the inner sliding soil ***,the GHSM,limit equilibrium method(LEM)and numerical simulation method(NSM)are applied to analyze the stability of a multi-layer slope with different slope angles and the results of the safety factor and failure mode are very close in each *** ultimate failure modes are shown to be mode B when the slope angle is not more than 28°.It illustrates that the determination of the ultimate sliding surface requires comparison of multiple failure modes,not only mode A.

关键词： stability and failure mode slope stability generalized horizontal slice method upperbound limit analysis energy dissipation geotechnical engineering.

An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo

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Virologica Sinica 2024年第3期39卷 447-458页

作者： Yingjian Li Xue Tan Jikai Deng Xuemei Liu Qianyun Liu Zhen Zhang Xiaoya Huang Chao Shen Ke Xu Li Zhou Yu Chen State Key Laboratory of Virology RNA InstituteCollege of Life Sciences and Frontier Science Center for Immunology and MetabolismWuhan UniversityWuhan430072China Institute for Vaccine research at Animal bio-safety Level III Laboratory Wuhan University School of MedicineWuhan430071China

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still epidemic around the *** manipulation of SARS-CoV-2 is restricted to biosafety level 3 laboratories(BSL-3).In this study,we developed a SARS-CoV-2ΔN-GFP-HiBiT replicon delivery particles(RDPs)encoding a dual reporter gene,GFP-HiBiT,capable of producing both GFP signal and luciferase *** optimal selection of the reporter gene,GFP-HiBiT demonstrated superior stability and convenience for antiviral ***,we established a RDP infection mouse model by delivering the N gene into K18-hACE2 KI mouse through *** mouse model supports RDP replication and can be utilized for in vivo antiviral *** summary,the RDP system serves as a valuable tool for efficient antiviral screening and studying the gene function of ***,this system can be manipulated in BSL-2 laboratories,decreasing the threshold of experimental requirements.

关键词： SARS-CoV-2 RDP Antiviral evaluation Mouse model BSL-2