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Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants

Virologica Sinica 2022年第5期37卷 724-730页

作者： Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang Hebei center for disease control and prevention Shijiazhuang050021China National Engineering Technology Research center for Combined Vaccines Wuhan Institute of Biological Product Co.Ltd.Wuhan430207China National Institutes for Food and Drug control Beijing100050China Zhejiang center for disease control and prevention Hangzhou310051China Guangxi Zhuang Autonomous Region center for disease control and prevention Nanning530028China Hunan center for disease control and prevention Changsha410005China Zhengding county center for disease control and prevention Shijiazhuang050800China Daming county center for disease control and prevention Handan056900China Liucheng county center for disease control and prevention Liuzhou545200China Xiangtan county center for disease control and prevention Xiangtan411228China Yuhuan county center for disease control and prevention Taizhou317600China Yongnian county center for disease control and prevention Handan056000China Rongshui Miao Autonomous county center for disease control and prevention Liuzhou545300China You county center for disease control and prevention Zhuzhou412315China Longyou county center for disease control and prevention Quzhou324400China Laishui county center for disease control and prevention Baoding 074100China Jiangshan county center for disease control and prevention Quzhou324100China China National Biotec Group Company Limited National Engineering Technology Research Center for Combined VaccinesWuhan430207China

A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)*** the subjects received three oral doses of vaccine four weeks *** vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus *** against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also *** adverse events(AEs)were collected for 30 days after each *** AEs(SAEs)and intussusception cases were collected during the entire *** data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)*** against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were *** was no significant difference in incidences of SAEs in HRV and placebo *** study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants.

关键词： Rotavirus gastroenteritis(RVGE) Infants Vaccine Efficacy Safety

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Prevalence of antifolate drug resistance markers in Plasmodium vivax in China

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Frontiers of Medicine 2022年第1期16卷 83-92页

作者： Fang Huang Yanwen Cui He Yan Hui Liu Xiangrui Guo Guangze Wang Shuisen Zhou Zhigui Xia National Institute of Parasitic diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Center for Tropical DiseasesNational Centre for International Research on Tropical DiseasesNHC Key Laboratory of Parasite and Vector Biology(National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention)Shanghai 200025China Yunnan Institute of Parasitic diseases Puer 665000China yingjiang county for disease control and prevention Yingjiang 679300China Hainan center for disease control&prevention Haikou 570203China

The dihydrofolate reductase(dhfr)and dihydropteroate synthetase(dhps)genes of Plasmodium vivax,as antifolate resistance-associated genes were used for drug resistance surveillance.A total of 375 *** isolates collected from different geographical locations in China in 2009–2019 were used to sequence Pvdhfr and *** majority of the isolates harbored a mutant type allele for Pvdhfr(94.5%)and Pvdhps(68.2%).The most predominant point mutations were S117T/N(77.7%)in Pvdhfr and A383G(66.8%)in *** acid changes were identified at nine residues in Pvdhfr.A quadruple-mutant haplotype at 57,58,61,and 117 was the most frequent(57.4%)among 16 distinct Pvdhfr *** in Pvdhps were detected at six codons,and the double-mutant A383G/A553G was the most prevalent(39.3%).Pvdhfr exhibited a higher mutation prevalence and greater diversity than Pvdhps in *** isolates from Yunnan carried multiple mutant haplotypes,while the majority of samples from temperate regions and Hainan Island harbored the wild type or single mutant *** study indicated that the antifolate resistance levels of *** parasites were different across China and molecular markers could be used to rapidly monitor drug *** provided evidence for updating national drug policy and treatment guidelines.

关键词： drug resistance antifolates molecular markers Plasmodium vivax China

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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第01期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital center for disease control and prevention of Sheyang county Department of Cancer prevention and control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan center for disease control and prevention Office for Cancer control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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Identification of Novel Bartonella washoensis Sequence Type 22 in Marmota himalayana-Jiuquan City,Gansu Province,China,2021–2022

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China CDC weekly 2023年第20期5卷 442-445,I0001页

作者： Ran Duan Xiaojin Zheng Qun Duan Asaiti Bukai Peng Zhang Shuai Qin Xinmin Lu Dongyue Lyu Haonan Han Dan Zhang Zhaokai He Junrong Liang Deming Tang Jinxiao Xi Huaiqi Jing Xin Wang State Key Laboratory of Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Akesai Kazak Autonomous county center for disease control and prevention JiuquanChina Gansu Provincial center for disease control and prevention LanzhouChina

Summary What is already known about this topic?The prevalence of rodent-adapted Bartonella species has been increasing ***,the specific Bartonella species carried by Marmota himalayana(***),a large rodent species,and the potential risk it poses to human populations remain *** is added by this report?Bartonella washoensis(***),associated with human endocarditis,was initially identified in ***,exhibiting a detection rate of approximately one-third and demonstrating a predilection for the heart and *** discovery of the novel Sequence Type 22 has expanded both the isolation source and genetic lineage of *** are the implications for public health practice?Individuals residing within the *** plague focus are at an elevated risk for *** ***,there is a pressing need for public health warnings and efficient clinical case identification in this population.

关键词： Barton expanded initially

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Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-Xizang Plateau,China,2000–2022

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China CDC weekly 2024年第4期6卷 69-74,I0006页

作者： Qun Duan Xiaojin Zheng Zhiqiang Gan Dongyue Lyu Hanyu Sha Xinmin Lu Xiaoling Zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao Xi Di Wu Peng Zhang Deming Tang Zhaokai He Huaiqi Jing Biao Kan Xin Wang National Institute for Communicable disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina Akesai Kazak Autonomous county center for disease control and prevention Jiuquan CityGansu ProvinceChina Jiuquan center for disease control and prevention Jiuquan CityGansu ProvinceChina Gansu Provincial center for disease control and prevention Lanzhou CityGansu ProvinceChina

Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic *** change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in ***:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang *** data spanned from 2000 to *** describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s ***:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(***)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),***,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in *** regards to climate,there was little variation,and a decreasing trend in blowing-sand days was *** temperature in the previous year showed a negative correlation with the *** isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current *** average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of *** from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of ***,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics.

关键词： Plague epidemiology Plateau

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Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality,China,August 2021

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China CDC weekly 2022年第1期4卷 4-7页

作者： Changying Lin Xiangfeng Dou Daitao Zhang Yinqi Sun Huiqiang Han Chunzhi Chen Xiaojun Zhang Shuang Li Yanwei Chen Hongbin Zhang Bin Wang Zhichao Liang Xin Zhang Feng Wei Jiangli Wang Feng Liu Quanyi Wang Jian Shi Peng Yang Beijing center for disease control and prevention BeijingChina Hebei Provincial center for disease control and prevention ShijiazhuangHebeiChina Chengde center for disease control and prevention ChengdeHebeiChina Haidian District center of disease control and prevention HaidianBeijingChina Weichang county center for disease control and prevention ChengdeHebeiChina.

Summary What is already known about this topic?Inhalational anthrax,also known as pulmonary anthrax,is an infectious disease caused by Bacillus *** patients are usually infected by inhaling aerosolized *** spores from dead animals or animal *** to cutaneous anthrax,inhalational anthrax is rare and deadly and few cases in China were *** is added by this report?This report covers all information of clinical features,laboratory testing,and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August *** laboratory techniques,including second-generation sequencing,polymerase chain reaction,and rapid test for serum antibody,played an important role in the *** are the implications for public health practice?The information provided in this report,including the correct sample type,epidemiological investigation details,and application of the new diagnostic criteria of anthrax,could assist public health professionals in dealing with anthrax epidemics.

关键词： clinical details dealing

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Emergency Response for a Laboratory Biosafety Incident

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Biomedical and Environmental Sciences 2019年第3期32卷 231-233页

作者： ZHANG En Min WANG Jia Qi GAO Li Dong ZHAN Zhi Fei ZHANG Heng HU Yan Hong WEI Jian Chun LIANG Xu Dong WAN Kang Lin WEI Qiang National Institute for Communicable disease control and prevention Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control Chinese center for disease control and prevention Hunan Provincial center for disease control and prevention Changsha center for disease control and prevention Yuelu District center for disease control and prevention

On December 14, 2017, a faculty member of a university in Hunan Province reported that an anthrax vaccine strain might have recovered virulence during an undergraduate experiment and potential exposure could not be ruled out for the students involved. Upon receiving the case report, the CDC, health bureaus, and local governments at the county, prefectural, and provincial levels promptly organized experts in different fields (including epidemiologists, biosafety experts, and laboratory testing experts) for case investigation, evaluation, and response. As the investigation results showed, no virulence recovery was identified in the involved anthrax vaccine strain;and no contamination of Bacillus anthracis was detected at the involved areas. Thus, the university returned to normal functioning.

关键词： Emergency Response Laboratory Biosafety Incident

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Anaplasma bovis Infection in Fever and Thrombocytopenia Patients——Anhui Province,China,2021

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China CDC weekly 2022年第12期4卷 249-253,I0005,I0006页

作者： Miao Lu Qingqing Chen Xincheng Qin Yong Lyu Zhongqiu Teng Kun Li Liang Yu Xiaojing Jin Hongwei Chang Wen Wang Dayin Hong Yong Sun Biao Kan Lei Gong Tian Qin State Key Laboratory of Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Anhui Provincial center for disease control and prevention Hefei CityAnhui ProvinceChina Lu’an Municipal center for disease control and prevention Lu’an CityAnhui ProvinceChina Jinzhai county center for disease control and prevention Lu’an CityAnhui ProvinceChina Jinzhai county People’s Hospital Lu’an CityAnhui ProvinceChina

Summary What is already known about this topic?The genus Anaplasma contains seven recognized bacterial species,mainly transmitted by tick *** two species,*** and ***,are known commonly to cause diseases in *** is added by this report?Anaplasma bovis was initially thought to be only an animal agent until the first patient case was reported in *** study investigated another two patients who became sick within one month in the same township and were infected with *** in Anhui Province.

关键词： Anhui Province. initially

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Re-isolation of Wuxiang Virus from Wild Sandflies Collected from Yangquan county, China

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Virologica Sinica 2021年第5期36卷 1177-1186页

作者： Qinyan Wang Shihong Fu Jingxia Cheng Xiuyan Xu Jing Wang Bin Wu Xiaodong Tian Yan Li Ying He Fan Li Kai Nie Songtao Xu Bin Wang Huanyu Wang Xiaoqing Lu Guodong Liang Qingdao University Qingdao 266071China State Key Laboratory of Infectious disease prevention and control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Shanxi Province center for disease control and prevention Taiyuan 030001China Yangquan center for disease control and prevention Yangquan 045000China

We previously isolated a new species of the genus Phlebovirus from wild sandflies collected from Wuxiang county in central China,which named the Wuxiang virus(WUXV).In this study,we re-isolated the WUXV from wild sandflies collected from two villages in Yangquan county,China in *** virus isolates that caused cytopathic effects in BHK-21 cells were successfully isolated from sandfly specimens collected from chicken pens and sheep *** analyses of the L,M and S gene segments of the viruses revealed that the four virus strains represented the previously isolated *** minimum infection rate(MIR)of the virus isolated from the sheep pen was 3.21,and the MIR of the virus isolated from the chicken pen was *** positive rates of Wuxiang virus neutralizing antibodies in serum samples of local healthy people and domestic chickens were 8.7%(4/46)and 100%(4/4),respectively,suggesting that Wuxiang virus can infect human and *** view of the fact that Wuxiang virus is infectious to humans and animals and has a relatively wide geographical distribution in China,it is of great public health significance to strengthen the investigation and study on the infection status of Wuxiang virus in humans and animals.

关键词： Sandfly Phlebovirus Wuxiang virus(WUXV)

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Folate and Vitamin B_(12)Status and Related Dietary Factors among the Elderly Northern and Southern Rural Chinese Population

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Biomedical and Environmental Sciences 2021年第7期34卷 552-556页

作者： LIU Zhen MAN Qing Qing JIA Shan Shan SONG Peng Kun WANG Jing Zhong WANG Xi Le KANG Bing Xian YANG Li Gui ZHANG Jian National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Wuyuan county center for disease control and prevention Wuyuan CountyBayannaoer 015100Inner Mongoli Autonomous RegionChina Luxi county center for disease control and prevention Luxi CountyHonghe Hani and Yi Autonomous Region 661100YunnanChina

Folate and vitamin B_(12)are involved in the carbon metabolism pathway supplying essential methyl groups for DNA and protein synthesis and play a vital role in individual *** have also been shown to be associated with cardiovascular disease,especially stroke.A recent study showed that stroke was the leading cause of death and disabilityadjusted life years(DALYs)at the national level in ***,the nutritional status of folate and vitamin B_(12)in the Chinese population is a *** elderly are more prone to develop folate and vitamin B_(12)deficiencies due to poor appetite,dental defects,and issues with digestion.

关键词： synthesis vitamin

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