Re-isolation of Wuxiang Virus from Wild Sandflies Collected from Yangquan County, China

作     者：Qinyan Wang Shihong Fu Jingxia Cheng Xiuyan Xu Jing Wang Bin Wu Xiaodong Tian Yan Li Ying He Fan Li Kai Nie Songtao Xu Bin Wang Huanyu Wang Xiaoqing Lu Guodong Liang Qinyan Wang;Shihong Fu;Jingxia Cheng;Xiuyan Xu;Jing Wang;Bin Wu;Xiaodong Tian;Yan Li;Ying He;Fan Li;Kai Nie;Songtao Xu;Bin Wang;Huanyu Wang;Xiaoqing Lu;Guodong Liang

作者机构：Qingdao UniversityQingdao 266071China State Key Laboratory of Infectious Disease Prevention and ControlNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Shanxi Province Center for Disease Control and PreventionTaiyuan 030001China Yangquan Center for Disease Control and PreventionYangquan 045000China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2021年第36卷第5期

页      面：1177-1186页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by the Ministry of Science and Technology of the People’s Republic of China(2018ZX10711001,2018ZX10734-404-003) National Key Research and Development Program(No.2018YFA0900800) National Science and Technology Major Project(2018ZX10102001) National Natural Science Foundation of China(31900156) Key Research and Development(R&D)Projects of Shanxi Province,China(201803D31205) the United States National Institutes of Health U01 AI151810 Development Grant of the State Key Laboratory of Infectious Disease Prevention and Control(2014SKLID103,2015SKLID505) 

主　　题：Sandfly Phlebovirus Wuxiang virus(WUXV) 

摘      要：We previously isolated a new species of the genus Phlebovirus from wild sandflies collected from Wuxiang County in central China,which named the Wuxiang virus(WUXV).In this study,we re-isolated the WUXV from wild sandflies collected from two villages in Yangquan County,China in *** virus isolates that caused cytopathic effects in BHK-21 cells were successfully isolated from sandfly specimens collected from chicken pens and sheep *** analyses of the L,M and S gene segments of the viruses revealed that the four virus strains represented the previously isolated *** minimum infection rate(MIR)of the virus isolated from the sheep pen was 3.21,and the MIR of the virus isolated from the chicken pen was *** positive rates of Wuxiang virus neutralizing antibodies in serum samples of local healthy people and domestic chickens were 8.7%(4/46)and 100%(4/4),respectively,suggesting that Wuxiang virus can infect human and *** view of the fact that Wuxiang virus is infectious to humans and animals and has a relatively wide geographical distribution in China,it is of great public health significance to strengthen the investigation and study on the infection status of Wuxiang virus in humans and animals.