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A COMPARATIVE STUDY ON CHARACTERISTICS AND THERMODYNAMIC DEVELOPMENT MECHANISMS OF TWO TYPES OF WARMSECTOR HEAVY RAINFALL ALONG THE SOUTH CHINA COAST

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Journal of Tropical Meteorology 2018年第4期24卷 494-507页

作者： MIAO Chun-sheng YANG Yi-ya WANG Jian-hong LI Ping Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education Nanjing University of Information Science & Technology (NUIST) Center for Monsoon System Research Institute of Atmospheric Physics Chinese Academy of Sciences School of Marine Sciences NUIST Liaoning Meteorological Observatory

Warm-sector heavy rainfalls along the south China coast from April to June during 2009-2014 can be divided into two main types based on their low-level circulations. Type I is the southerly pattern with meridional convergence line at the west of the Pearl River estuary, which is formed by the convergence of southeasterly, southerly, and southwesterly flows. Type II is the southwesterly pattern with a latitudinal convergence line at the east of the Pearl River estuary, which is formed by the convergence of westerly and southwesterly flows. Statistics on 6-hourly heavy rainfall events indicates that, during the afore-mentioned 6 years, there were on average 73.2 occurrences of the southerly pattern and 50.3 occurrences of the southwesterly pattern per year. After the onset of summer monsoon in the South China Sea, the occurrence frequencies of both patterns increase remarkably. The synthetic diagnosis of pattern circulation shows that, at 500 h Pa, for the southerly pattern, there is a broad warm high ridge, and a temperature ridge is behind the high ridge, which causes an obvious warm advection at the high ridge area. There is no frontal region. For the southwesterly pattern, the circulation is a weak trough with a temperature trough behind it. The position of the frontal region is near yangzi River, and the south China coast is in the warm-sector of the frontal region. At the vertical cross-section of each of the two categories of heavy rainfall, there is a strong vertical motion center stretching to 400 hPa, where the convergence layer in the rainfall region is deep and with several vertical convergence centers overlapping one another. Both types of heavy rainfalls are with abundant water vapor, accompanied with deep convective instability energy layers, and with strong release of latent heat caused by condensation of water vapor. The release of latent heat leads to the warming-up and stretching of the air column, thus strengthens deep convergence and vertical velo

关键词： warm-sector heavy rainfall the convergence line at low level thermodynamic developing mechanism numerical simulation latent heat

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机械敏感蛋白PC1调控破骨细胞及骨吸收的作用机制

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Science Bulletin 2024年第12期69卷 1964-1979页

作者：黄梅周静璇李潇骁刘冉姜洋子陈开璇焦玉睿尹欣刘玲孙宇晨王维山肖业苏甜郭奇黄燕杨觅魏婕 L.Darryl Quarles 肖洲生曾超罗湘杭雷光华李长俊 Department of Endocrinology Endocrinology Research CenterXiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Joint Degeneration and Injury Changsha 410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangsha 410008China School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Center for Neuromusculoskeletal Restorative Medicine(CNRM) The Chinese University of Hong KongHong Kong 999077China Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShihezi 832061China Department of Orthopaedics Xiangya HospitalCentral South UniversityChangsha 410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410008China Department of Medicine University of Tennessee Health Science CenterMemphis 38163USA National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Laboratory Animal Center Xiangya HospitalCentral South UniversityChangsha 410008China

Mechanical loading is required for bone homeostasis,but the underlying mechanism is still *** previous studies revealed that the mechanical protein polycystin-1(PC1,encoded by Pkd1)is critical for bone ***,the role of PC1 in bone resorption is ***,we found that PC1directly regulates osteoclastogenesis and bone *** conditional deletion of Pkd1 in the osteoclast lineage resulted in a reduced number of osteoclasts,decreased bone resorption,and increased bone mass.A cohort study of 32,500 patients further revealed that autosomal dominant polycystic kidney disease,which is mainly caused by loss-of-function mutation of the PKD1 gene,is associated with a lower risk of hip fracture than those with other chronic kidney ***,mice with osteoclastspecific knockout of Pkd1 showed complete resistance to unloading-induced bone loss.A mechanistic study revealed that PC1 facilitated TAZ nuclear translocation via the C-terminal tail-TAZ complex and that conditional deletion of Taz in the osteoclast lineage resulted in reduced osteoclastogenesis and increased bone *** regulation of the PC1-TAZ axis alleviated unloading-and estrogen deficiency-induced bone ***,the PC1-TAZ axis may be a potential therapeutic target for osteoclast-related osteoporosis.

关键词： Polycystin1 Osteoclastogenesis Bone resorption Mechanical stress

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Types,characteristics,and time-space distribution of molybdenum deposits in China

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Types,characteristics,and time-space distribution of molybde...

The Influence of Housing Prices on Urban Competitiveness:Review and Prospects

中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： Qingdong Zeng Jianming Liu Kezhang Qin Hongrui Fan Shaoxiong Chu Yongbin Wang Lingli Zhou Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences

Molybdenum exploration activity in China has accelerated tremendously during the past decade owing to the continuous. increasing demand for Earth *** possesses the largest Mo reserves in the world(exceeding 19.6 Mt).The major ore deposits are of porphyry,porphyry-skarn,skarn,vein,and sedimentary *** molybdenum deposits contain 77.5%of the Chinese Mo reserves,with lesser amounts in porphyry-skarns(13%),skarns(5.1%).and veins(4.4%). Exploitation of sedimentary-type molybdenum deposits thus far has been *** six Mo provinces are in the Northeast China,***-Dabie,middle-lower Yangtze River Valley,South China,and Sanjiang *** rec- ognize six ore-forming periods:(1)Precambrian(>541 Ma).(2)Palaeozoic(541-250 Ma),(3)Triassic(250-200 Ma), (4)Jurassic Early Cretaceous(190-135 Ma),(5)Cretaceous(135-90 Ma),and(6)Cenozoic(55-12 Ma).The abun- dance of Mo ore deposits in China reflects the occurrence of multiple periods of *** interactions between the Siberian,North China,Yangtze,India,and Palaeo-Pacific *** molybdenum deposits are related to Mesoproterozoic volcanism in an extensional *** Cu-Mo deposits are related to calc-alkaline granitic plutons in an island arc or a continental margin *** Mo deposits formed in the syn-collision postcollision tectonic set- ting between the Siberian and North China plates and between the North China and yangzi *** Early Cretaceous molybdenum deposits formed along the eastern margin of Asia and are associated with the palaeo-Pacific plate-subduction tectonic *** Mo deposits are related to high-K calc-alkaline granitic rocks and formed in a lithospheric thin- ping *** molybdenum deposits formed in a collision setting between the Indian and Eurasian continents and the subsequent extensional setting.

关键词： molybdenum deposit six Mo ore-forming stages major metallogenic belt China

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Chinese Journal of Urban and Environmental Studies 2019年第3期7卷 40-52页

作者： NI Pengfei ZHANG yangzi CAO Qingfeng National Academy of Economic Strategy Chinese Academy of Social Sciences China Everbright Group Post-Doctoral Scientific Research Workstation China Everbright Center Tsinghua University Applied Economics Postdoctoral Mobile Station Modern Economic and Management institute Tianjin University of Finance and Economics

To examine the impact of housing prices on urban competitiveness, we first sort out the relevant literature on the compositions and performances of urban competitiveness. The internal compositions of urban competitiveness include factor endowments and industrial development. The external manifestations include market size, economic growth and productivity. Additionally,from the perspectives of urban economics and new economic geography, the theoretical basis of housing price’s impact on urban competitiveness is analyzed. On this basis, we analyze the mechanism and direction of housing price’s impact on urban competitiveness. The results show that most of the existing researches pay attention to the impact of housing prices on urban competitiveness through economic growth, industrial structure or production factors. However,there are differences in the specific direction of influence, and there is no research that considers the relationship of multiple influences.

关键词： Housing price new economic geography urban competitiveness urban economics

Understanding convergent signaling regulation in metastatic breast cancer cells using a bioengineered stem cell microenvironment

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Journal of Cancer Metastasis and Treatment 2019年第3期4卷 42-58页

作者： Bridget Mooney yangzi Isabel Tian Erin Rousseau Yubing Xie Colleges of Nanoscale Science and Engineering SUNY Polytechnic InstituteAlbanyNY 12203USA

Aim:The convergence of tumorigenic and embryonic signaling pathways drives us to exploit the embryonic stem cell(ESC)microenvironment to restrict metastatic potential of cancer *** have previously demonstrated that bioengineered ESC microenvironments could restrict growth and metastatic potential of highly aggressive breast cancer cell(BCC).This study aims to further understand the regulation of convergent EGFR and canonical Wnt/β-catenin signaling pathway function in triple negative metastatic BCCs using the 3D in vitro ESC microenvironment created by encapsulating ESCs in alginate hydrogel ***:Co-culture with ESC-microstrands increased sensitivity to two chemotherapeutic drugs in metastatic *** test whether these changes were due to restored signaling pathway regulation in BCCs,we probed for changes in gene expression of key molecules related to the EGFR and canonical Wnt/β-catenin signaling pathways using quantitative reverse transcription polymerase chain reaction and Western blot ***:ESC-microstrands are able to alter the gene expression of highly aggressive BCCs at both mRNA and protein *** changes are indicative of a reversal of EGFR and canonical Wnt/β-catenin signaling pathway hyperactivation following *** NKD2 mRNA and protein expression coinciding with dual signaling pathway inhibition within co-cultured BCCs suggests that this reversal may be attributable to restored regulation of NKD2 within these ***:ESC-microstrands are able to reverse oncogenic signaling pathway hyperactivation and restore signaling pathway regulation in metastatic *** studies could provide insight into what role NKD2 up-regulation plays ;in BCC inhibition,leading to the development of a new targeted therapy for metastatic breast cancer.

关键词： Metastasis cancer cell signaling 3D culture stem cells EGFR Wnt/β-catenin NKD2

T-Cell Immunoglobulin and ITIM Domain(TIGIT) Contributes to CD8+T cell Immunosenescence

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T-Cell Immunoglobulin and ITIM Domain(TIGIT) Contributes to ...

Bibliometric Analysis of Status Quo and Trend of the Research on Duck Based on the Web of Science Database

第十二届全国免疫学学术大会

作者： kong yaxian Song yangzi Wang Beibei Song Rui Hao Yu Wang Di Li Yuxin Jiang Yu Xu Ling Zeng Hui institute of Infectious Diseases Beijing Ditan HospitalCapital Medical University The National Clinical Key Department of Infectious Disease Beijing Ditan HospitalCapital Medical University

Background:Aging is associated with immune dysfunction,especially T cell defects,which result in increased susceptibility to various *** studies showed that T cells from aged mice express multiple inhibitory re-

关键词： TIGIT Aging T cell immunosenescence CD8+T cells Coinhibitory receptors

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Agricultural Biotechnology 2021年第1期10卷 44-48,52页

作者： Piao ZHANG Xia YANG Maoqin ZENG Yanhan LIU yangzi ZHANG Ying YANG Guilan WEN Zhentao CHENG Ming WEN College of Animal Science Guizhou UniversityGuiyang 550025China Guizhou institute of Animal Husbandry and Veterinary Medicince Guiyang 550005China Research Center of Engineering Technology for Animal Biological Products of Guizhou Guiyang 550025China

[Objectives] This study was conducted to understand the current status of duck related research. [Methods] CiteSpace knowledge graph analysis tool, VOSviewer visual analysis software and HistCite citation graph analysis tool were used to analyze the number of publications and subject distribution of duck-related research fields in the Web of Science core collection database. The main countries(regions) and institutions, the main academic journals, the main research scholars, the main research hotspots and their changing trends were used for quantitative analysis. [Results](1) Duck-related research is receiving more and more attention, which further supports ducks’ important significance in the livestock and poultry industry.(2) Countries such as China, the United States, Canada, and France had published more articles in this field, and there was close cooperation between countries.(3) The top two journals with local citations in the duck-related research fields were PLOS ONE and JOURNAL OF VIROLOGY, and the journal with the highest impact factor in 2019 was JOURNAL OF VIROLOGY.(4) High-yield scholars in duck related research fields included Cheng Anchun, Wang Mingshu, Jia Renyong, etc.(5) Infection was a research hotspot in duck-related research. Typical pathogenic microorganisms included Newcastle disease, Avian influenza, and campylobacter.(6) The future trend of duck-related research mainly focuses on breeds, living environment, diseases, and molecular mechanisms. [Conclusions] Based on data from the Web of Science core collection database, this paper provides a complete bibliometric analysis of the current research status of ducks.

关键词： Duck Bibliometric analysis Infection CiteSpace VOSviewer HistCite

Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity

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Science China(Life Sciences) 2022年第1期65卷 223-226页

作者： Junyan Han Ning Zhang Danying Chen Yuhuan Gong Guoli Li Yaxian Kong Lin Pu Chen Chen Jingyuan Liu Qi Wang Ju Zhang Xuesen Zhao Juan Du Kai Han Chuan Song Linghang Wang Mingxi Hua Yu Hao Rui Song yangzi Song Fengting Yu Siyuan Yang Haofeng Xiong Wei Zhang George F.Gao Fujie Zhang Ang Li Hui Zeng Yuhai Bi Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research andEarly-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Intensive Care Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Laboratory of Infectious Diseases Center of Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China The Infectious Disease Diagnostic Therapeutic and Research CentersBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Clinical Center for HIV/AIDS Clinical and Research Center of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,The coronavirus disease 2019(COVID-19)pandemic is generating a demand for simultaneous vaccine development,which is expected to prevent future outbreaks by eliciting sufficient and protective immunity.

关键词： protective vaccine severity

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“Slow walk”mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel

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Bioactive Materials 2023年第7期25卷 256-272页

作者： Jing Sun Yau Tsz Chan Ki Wai Kevin Ho Li Zhang Liming Bian Rocky S.Tuan yangzi Jiang institute for Tissue Engineering and Regenerative Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongAnd Prince of Wales HospitalShatinHong Kong Special Administrative Region of China Department of Mechanical and Automation Engineering Faculty of EngineeringThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Center for Neuromusculoskeletal Restorative Medicine Hong Kong Special Administrative Region of China

Meniscus,the cushion in knee joint,is a load-bearing tissue that transfers mechanical forces to extracellular matrix(ECM)and tissue resident *** mechanoresponse of human tissue resident stem/progenitor cells in meniscus(hMeSPCs)is significant to tissue homeostasis and regeneration but is not well *** study reports that a mild cyclic tensile loading regimen of~1800 loads/day on hMeSPCs seeded in 3-dimensional(3D)photocrosslinked gelatin methacryloyl(GelMA)hydrogel is critical in maintaining cellular ***,a“slow walk”biomimetic cyclic loading regimen(10%tensile strain,0.5 Hz,1 h/day,up to 15 days)is applied to hMeSPCs encapsulated in GelMA hydrogel with a magnetic force-controlled loading *** loading significantly increases cell differentiation and fibrocartilage-like ECM deposition without affecting cell *** analysis reveals 332 mechanoresponsive genes,clustered into cell senescence,mechanical sensitivity,and ECM dynamics,associated with interleukins,integrins,and collagens/matrix metalloproteinase *** cell-GelMA constructs show active ECM remodeling,traced using a green fluorescence tagged(GFT)-GelMA *** enhances nascent pericellular matrix production by the encapsulated hMeSPCs,which gradually compensates for the hydrogel loss in the *** findings demonstrate the strong tissue-forming ability of hMeSPCs,and the importance of mechanical factors in maintaining meniscus homeostasis.

关键词： Human meniscus progenitor cells 3D cell-based constructs Biomimetic cyclic loading GelMA hydrogel Extracellular matrix