Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak

作     者：Ju Zhang Nan Ding Yangzi Song Rui Song Yang Pan Linghang Wang Shuo Yan Qi Wang Shanfang Ma Lirong Wei Fengting Yu Lianhe Lu Fujie Zhang Chen Chen Hui Zeng 

作者机构：Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Emerging Infectious DiseasesBeijing 100015China Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and ControlBeijing 100013China These authors contributed equally 

出 版 物：《The Innovation》 (创新（英文）)

年 卷 期：2021年第2卷第2期

页      面：150-156页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Project of China(2020YFC0840800) the National Natural Science Foundation of China(no.31801093) 

主　　题：SARS-CoV-2 COVID-19 asymptomatic transmission outbreak phylogenomic 

摘      要：SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the *** transmission of SARS-CoV-2 is the Achilles’heel of COVID-19 public health control *** data on SARS-CoV-2 could provide more direct information about asymptomatic *** this study,using a novel MINERVA sequencing technology,we traced asymptomatic transmission of COVID-19 patients in Beijing,*** hundred and seventy-eight close contacts were quarantined,and 14 COVID-19 patients were laboratory confirmed by *** provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the *** data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.