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Receded near point of convergence as a predictor of mild cognitive impairment in the general geriatric population:results from a population-based study

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International Journal of Ophthalmology.English edition) 2023年第4期16卷 623-629页

作者： Asgar Doostdar Hassan Hashemi Pay.m Nabovati Amir Asharlous Mehdi Khabazkhoob Rehabilitation research center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Noor research center for Ophthalmic Epidemiology Noor Eye HospitalTehran 19839-63113Iran Department of Basic sciences School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To investigate the relationship between near point of convergence(NPC)and mild cognitive impairment(MCI)in the general elderly.***:The present report is a part of the Tehran Geriatric Ey. Study.TGES):a population-based crosssectional study.conducted on individuals 60 y.ars of age and above living in Tehran,Iran using the multi-stage stratified random cluster sampling *** status was assessed using the Persian version of the Mini-Mental State Examination(MMSE).All study.participants underwent complete ocular examination including measurement of uncorrected and best-corrected visual acuity.objective and subjective refraction,cover testing,NPC measurement,and slit-lamp ***:The data of 1190 individuals were analy.ed for this *** mean age of the participants analy.ed was 66.82±5.42(60-92y.and 728(61.2%)of them were *** with MCI had a significantly.more receded NPC compared to subjects with normal cognitive status(10.89±3.58 vs 7.76±2.71 cm,Py.significantly.associated with an increased risk of MCI(odds ratio:1.334,95%confidence interval:1.263 to 1.410,Panalysis,a cut point NPC>8.5 cm(area under the curve:0.764,Py.and specificity.of 70.9%and 69.5%,***:A receded NPC can be clinically.proposed as a predictor of MCI in older *** is recommended that elderly.with a receded NPC>8.50 cm undergo detailed cognitive screening for a definite diagnosis of *** this case,the necessary.interventions can be carried out to slow down MCI progression to dementia.

关键词： near point of convergence mild cognitive impairment geriatrics population-based study

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Mutual authenticated quantum no-key.encry.tion scheme over private quantum channel

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Science China(Information sciences) 2018年第2期61卷 216-223页

作者： Li y.NG Chenmiao WU Huiqin XIE State Key.Laboratory.of Information Security Institute of Information EngineeringChinese Academy of Sciences Data Assurance and Communication Security.research center Chinese Academy of Sciences school of Cy.er Security University of Chinese Academy of Sciences

In this paper, we realize Shamir’s no-key.protocol via quantum computation of Boolean functions and a private quantum channel. The proposed quantum no-key.protocol has three rounds and provides mutual data origin authentication. Random Boolean functions are used to create entanglement and guarantee that any.adversary.without key. cannot pass the authentication. Thus, our protocol can resist the manin-the-middle attack. A security.analysis has shown that pieces of ciphertexts of the three rounds are completely.mixed state. This property.ensures no adversary.can get any.information about the sent message or authentication key.. Therefore, our protocol is unconditionally.secure and its authentication key. can be reused.

关键词： quantum cry.tography no-key.protocol quantum entanglement information-theoretical security private quantum channel

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Ordering-induced Elinvar effect over a wide temperature range in a spinodal decomposition titanium alloy

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Journal of Materials Science & Technology 2023年第19期150卷 245-255页

作者： D.L.Gong H.L.Wang S.H.Hao P.Liu X.y.ng y.N.Jiang W.J.Wang K.Lin B.Li K.Du y.D.Wang R.y.ng y.L.Hao Shi-changxu Innovation center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China school of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China school of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China Sheny.ng National Laboratory.for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China analysis and Testing center Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Beijing Advanced Innovation center for Materials Genome Engineering Institute of Solid State ChemistryDepartment of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China State Key.Laboratory.for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

Temperature-independent elastic modulus is termed as Elinvar effect,which is available by.tuning the continuous spin transition of ferromagnetic alloy. via composition optimization and the first-order martensitic transformation of shape memory.alloy. via plastic ***,these reversible mechanisms are restricted generally.in a narrow temperature range of less than 300 *** reports,by.tuning a spinodal decomposition in a Ti-Nb-based titanium alloy.via aging treatment,both the Elinvar effect in a wide temperature range of about 500 K and a high strength-to-modulus ratio of about 1.5%can be obtained by.a continuous and reversible cry.tal ordering *** results demonstrate that the alloy.aged at 723 K for 4 h has a nanoscale plate-like modulatedβ+α"two-phase microstructure and its elastic modulus keeps almost constant from 100 to 600 *** and in-situ X-ray.diffraction measurements reveal that the cry.tal ordering parameter of theα"phase increases linearly.with temper-ature from 0.88 at 133 K to 0.97 at 523 K but its volume fraction keeps a constant of about 33.8%.This suggests that the continuous ordering of theα"phase toward the high modulusαphase induces a posi-tive modulus-temperature relation to balance the negative relation of the elastically.stableβ*** aged alloy.exhibits a high y.eld strength of 1200 MPa,good ductility.of 16%and a high elastic admissible strain of 1.5%.Our results provide a novel strategy.to extend the Elinvar temperature range and enhance the strength by.tuning the cry.tal ordering of decomposition alloy..

关键词： Titanium alloy Spinodal decomposition Cry.tal ordering Elinvar effect Mechanical properties

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Sparse Weighted Canonical Correlation analysis

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Chinese Journal of Electronics 2018年第3期27卷 459-466页

作者： MIN Wenwen LIU Juan ZHANG Shihua State Key.Laboratory.of Software Engineering School of Computer Wuhan University National center for Mathematics and Interdisciplinary.sciences Academy of Mathematics and Systems Science Chinese Academy of Sciences school of Mathematics sciences University of Chinese Academy of Sciences

Given two data matrices X and y. Sparse canonical correlation analysis（SCCA） is to seek two sparse canonical vectors u and v to maximize the correlation between Xu and y.. Classical and sparse Canonical correlation analysis（CCA） models consider the contribution of all the samples of data matrices and thus cannot identify.an underly.ng specific subset of samples. We propose a novel Sparse weighted canonical correlation analysis（SWCCA）,where weights are used for regularizing different *** solve the L;-regularized SWCCA（L;-SWCCA） using an alternating iterative algorithm. We apply.L;-SWCCA to sy.thetic data and real-world data to demonstrate its effectiveness and superiority.compared to related methods. We consider also SWCCA with different penalties like Least absolute shrinkage and selection operator（LASSO）and Group LASSO, and extend it for integrating more than three data matrices.

关键词： Canonical correlation analysis(CCA) Sparse canonical correlation analysis(SCCA) Sparse weighted CCA(SWCCA) Group LASSO regularized SWCCA Multi-view SWCCA

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Natural variation in SlSOS2 promoter hinders salt resistance during tomato domestication

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Horticulture research 2023年第1期10卷 232-239页

作者： y.chun Hong Xijin Guan Xu Wang Dali Kong Shuojun y. Zhiqiang Wang y.ngdong y. Zhen-Fei Chao Xue Liu Sanwen Huang Jian-Kang Zhu Guangtao Zhu Zhen Wang school of Life sciences Anhui Agricultural UniversityHefeiAnhui230036China Shanghai center for Plant Stress Biology.and center for Excellence in Molecular Plant sciences Chinese Academy of SciencesShanghai 200032China The AGISCAAS-y.NU Joint Academy.of Potato sciences Yunnan Normal UniversityKunming650500China Genome analysis Laboratory.of the Ministry.of Agriculture Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen518000China Institute of Advanced Biotechnology.and school of Life sciences Southern University of Science and TechnologyShenzhen 518055China

Increasing soil salinization seriously.impairs plant growth and development,resulting in crop *** Salt-Overly.Sensitive(SOS)pathway.is indispensable to the mitigation of Na+toxicity.in plants under high ***,whether natural variations of SOS2 contribute to salt tolerance has not been *** a natural variation in the SlSOS2 promoter region was identified to be associated with root Na+/K+ratio and the loss of salt resistance during tomato *** natural variation contains an ABI4-binding cis-element and play. an important role in the repression of SlSOS2 *** evidence revealed that SlSOS2 mutations increase root Na+/K+ratio under salt stress conditions and thus attenuate salt resistance in ***,our findings uncovered a critical but previously.unknown natural variation of SOS2 in salt resistance,which provides valuable natural resources for genetic breeding for salt resistance in cultivated tomatoes and other crops.

关键词： breeding SOS soil

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Modification of the Micro Arc-oxidized Ti Surface for Implant Applications

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Journal of Bionic Engineering 2021年第6期18卷 1391-1399页

作者： Eren y.lmaz Department of Welding Technology Sakarya Applied Sciences UniversityArifi ye Vocational High School54187SakaryaTurkey Sakary. Applied sciences University.Materials research center(SUMAR) 54187SakaryaTurkey

Surface treatments applied to titanium and its alloy. for implant applications are important for the development of bio *** this study.first an oxide lay.r was formed on the surface of the titanium plate by.micro arc oxidation,and then both calcium phosphate and calcium phosphate/chitosan accumulation were performed for different samples by.the sol-gel ***-SEM/EDS examinations,XRD,FTIR and thermal analysis were performed for these micro arc-oxidized,calcium phosphate-coated and calcium phosphate/chitosan-coated *** surface roughnesses for these surfaces were measured between 10μm and 100μm,suitable for bone development on the *** effect of chitosan addition on the calcium phosphate-coated surface on apatite formation ability.and antibacterial properties was *** the addition of chitosan slows down the formation of apatite,it ensured that the coating had antibacterial *** calcium phosphate/chitosan biocomposite obtained can be recommended for dental and orthopedic implants.

关键词： Micro arc oxidation Sol-gel Hy.roxy.patite Chitosan Implant

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Dissolved metal ion removal by.online hollow fiber ultrafiltration for enhanced size characterization of metal-containing nanoparticles with single-particle ICP-MS

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Journal of Environmental sciences 2023年第4期126卷 494-505页

作者： Haowen Jiang y.ngWang Zhiqiang Tan Ligang Hu Jianbo Shi Guangliang Liu y.ngguang y.n y.ng Cai Guibin Jiang Laboratory.of Environmental Nanotechnology.and Health Effect Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key.Laboratory.of Environmental Chemistry.and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University.of Chinese Academy.of sciences Beijing 100049China Department of Chemistry.and Biochemistry Florida International UniversityMiami 33199USA school of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China

Single particle-inductively.coupled plasma mass spectrometry.(SP-ICP-MS) is a powerful tool for size-characterization of metal-containing nanoparticles (MCNs) at environmentally.relevant concentrations,however,coexisting dissolved metal ions greatly.interfere with the accuracy.of particle size *** purpose of this study.is to develop an online technique that couples hollow fiber ultrafiltration (HFUF) with SP-ICP-MS to improve the accuracy.and size detection limit of MCNs by.removing metal ions from suspensions of *** sy.tematic optimization of conditions including the ty.e and concentration of surfactant and complexing agent,carrier pH,and ion cleaning time,HFUF completely.removes metal ions but retains the MCNs in *** optimal conditions include using a mixture of 0.05 vol.%FL-70 and 0.5 mmol/L Na2S2O_(3)(pH=8.0) as the carrier and 4 min as the ion cleaning *** these conditions,HFUF-SP-ICP-MS accurately.determines the sizes of MCNs,and the results agree with the size distribution determined by.transmission electron microscopy.even when metal ions also are present in the *** addition,reducing the ionic background through HFUF also lowers the particle size detection limit with SP-ICP-MS (e.g.,from 28.3 to 14.2 nm for gold nanoparticles).This size-based ion-removal principle provided by.HFUF is suitable for both cations (e.g.,Ag+) and anions (e.g.,AuCl_(4)^(-)) and thus has good versatility.compared to ion exchange purification and promising prospects for the removal of salts and macromolecules before single particle analysis.

关键词： Hollow fiber ultrafiltration(HFUF) Single particle-inductively.coupled plasma mass spectrometry (SP-ICP-MS) Removal of ions Particle size characterization

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Cy.teine mutations impair the structural stability.of phosphomannomutase 2(PMM2)in gly.osy.ation-associated metabolic disorders

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Genes & Diseases 2023年第5期10卷 1743-1746页

作者： y.nfan Pan Li Lin Fan y. Jingmiao Sun Guannan Bai Xiny. He Jianhua Mao Lidan Hu The Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Beijing Advanced Innovation center for Structural Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Department of Nephrology The Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhouZhejiang 310052China

Gly.osy.ation is a ubiquitous molecular modification in the process of cellular metabolism regulation,which play. a vital role in maintaining and regulating cellular *** in gly.osy.ation enzy.es may.jeopardize the gly.osy.ation process and eventually.lead to the metabolic disease,manifesting with either a neurologic or multisy.tem phenoty.e,which is also known as congenital disorder of gly.osy.ation(CDG).1 It could be classified into ty.e I CDG and ty.e II CDG,and the latter was referred to as the abnormal formation of nascent *** 2 CDG(PMM2-CDG),the most prevalent CDG with an incidence rate of 1 in 20,000 individuals,is mainly.due to the metabolic disorder of phosphomannomutase 2(PMM2).2 PMM2 participates in the conversion of mannose-6-phosphate to *** cy.teine residues,as one of the least abundant amino acids,have unique attributes to maintain the stability.of protein structure,especially.for cataly.ic activity.and protein folding.3 Therefore,cy.teine mutations have been identified in various diseases including *** by.the cry.tal structure of PMM2(PDB ID:7O5Z),4 four cy.teine mutations in the hPMM2,C9y.C103F,C192G,and C241S,have been found in *** bioinformatic analysis by.PROVEAN,the four cy.teine mutations were predicted with“Deleterious”,ranking with the best two were C103F and C192G(C9y.−5.493,C103F:−6.339,C192G:−11.176,C241S:−2.986).However,the underly.ng pathological mechanism is still *** them,C103F and C192G have only.been reported in clinical study.without a detailed explanation,so they.were selected for our *** mutants were located near the linker region 1 and 2;C103F was located on the No.4αhelix and C192G was located on the No.7αhelix(Fig.S1A).The purpose of this study.was to explore the structure and function roles of PMM2 clinical mutation and investigate the role of cy.teine in PMM2 which might provide new insights into preventive and therape

关键词： stability eventually latter

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The development of brain functional connectivity.networks revealed by.resting-state functional magnetic resonance imaging

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Neural Regeneration research 2019年第8期14卷 1419-1429页

作者： Chao-Lin Li y.n-Jun Deng y.-Hui He Hong-Chang Zhai Fu-Cang Jia school of Education South China Normal Univers让y Guangzhou Guangdong Province China school of Psy.hology South China Normal University Guangzhou Guangdong Province China Donghui Kindergarten Huangpu District Guangzhou Guangdong Province China school of Education Guangzhou University Guangzhou Guangdong Province China research Lab for Medical Imaging and Digital Surgery Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong Province China center of Network and Modern Educational Technology Guangzhou University Guangzhou Guangdong Province China

Previous studies on brain functional connectivity.networks in children have mainly.focused on changes in function in specific brain regions, as opposed to whole brain connectivity.in healthy.children. By.analy.ing the independent components of activation and network connectivity.between brain regions, we examined brain activity.status and development trends in children aged 3 and 5 y.ars. These data could provide a reference for brain function rehabilitation in children with illness or abnormal function. We acquired functional magnetic resonance images from 15 3-y.ar-old children and 15 5-y.ar-old children under natural sleep cond让ions. The participants were recruited from five kindergartens in the Nanshan District of Shenzhen City. China. The parents of the participants signed an informed consent form with the premise that they.had been fully.informed regarding the experimental protocol. We used masked independent component analysis and BrainNet Viewer software to explore the independent components of the brain and correlation connections between brain regions. We identified seven independent components in the two groups of children, including the executive control network, the dorsal attention network, the default mode network, the left frontoparietal network, the right frontoparietal network, the salience network, and the motor network. In the default mode network, the posterior cingulate cortex, medial frontal gy.us, and inferior parietal lobule were activated in both 3- and 5-y.ar-old children, supporting the "three-brain region theory. of the default mode network. In the frontoparietal network, the frontal and parietal gy.i were activated in the two groups of children, and functional connectivity.was strengthened in 5-y.ar-olds compared with 3-y.ar-olds, although the nodes and network connections were not y.t mature. The high-correlation network connections in the default mode networks and dorsal attention networks had been significantly.strengthened in 5-y.ar

关键词： nerve regeneration functional MRI brain network functional connectivity resting-state ICA brain development children resting-state networks infant template standardized neural regeneration

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Highly.cited publication performance in the ophthalmology.category.in the Web of Science database:a bibliometric analysis

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International Journal of Ophthalmology.English edition) 2023年第7期16卷 1155-1163页

作者： y.h-Shan Ho Ali Ouchi Leila Nemati-Anaraki Trend research Centre Asia UniversityTaichung 41354TaiwanChina Student research Committee School of Health Management and Information Sciences BranchIran University of Medical SciencesTehran ***Iran Department of Medical Library.and Information sciences School of ParamedicineHamadan University of Medical SciencesHamadan ***Ira Health Management and Economics research center Health Management Research InstituteIran University of Medical SciencesTehran ***Iran Department of Medical Library.and Information Science School of Health Management and Medical Information SciencesIran University of Medical SciencesTehran ***Iran

AIM:To determine and evaluate the features of highly.cited articles(HCAs)in the ophthalmology.category.in the Science Citation Index Expanded(SCI-EXPANDED)from 1991 to ***:The Web of Science Core Collection documents with at least 100 citations from their publication y.ar until December 31,2020,were evaluated as highly.*** examined features were the distribution of y.arly.output and its average number of per publication,HCAs,authors,institutions,journals,and *** publication performance of nations and organizations was assessed using six publication *** y.index was employ.d to compare the research outputs of various ***:Publications that had cited the most references were highly.published in high-impact factor *** United States of America came out on top across all six publication indicators,and it was home to eight of the top 10 most productive *** articles written by.Breivik et al(2006)and Farrar et al(2001)were highly.cited and had a significant impact in *** authors had a higher number of highly.cited articles published as corresponding authors than as first ***:The findings of the present study.highlight the current scope of global research in *** findings can help policy.makers and advisory.groups of research centers to develop future *** addition,the findings can guide researchers in this field.

关键词： ophthalmology bibliometric analysis TC_(y.ar) C_(y.ar) CPP_(y.ar) highly.cited articles

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