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Oleanolic acid inhibits colon cancer cell stemness and reverses chemoresistance by suppressing JAK2/STAT3 signaling pathway

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BIOCELL 2024年第7期48卷 1037-1046页

作者： RUOYU CHEN YIMAN WU FENG WANG JUNTAO ZHOU HUAZHANG ZHUANG WEI LI Department of Anus and Intestine Surgery Shenzhen Longhua District Central HospitalShenzhenChina Department of Urology Shenzhen Longhua District Central HospitalShenzhenChina

Background:Oleanolic acid(OA),a pentacyclic triterpenoid exhibiting speciﬁc anti-cancer properties and highly effective antioxidant activity,was isolated from traditional Chinese medicinal ***,the OA that impacts colon cancer(CC)cells and its underlying mechanisms remain poorly ***:The cytotoxic effect of OA alone or OA-5-Fluorouracil(5-FU)combination on normal and CC cells was analyzed by methyl thiazolyl diphenyl-tetrazolium bromide(MTT).Then,the impact of OA on CC cell lines(LoVo and HT-29)proliferation and stemness were measured using colon formation and tumorsphere formation ***-binding transcription factor 4(Oct4),Prominin-1(CD133),Nanog,and transcription factor SOX-2(SOX2)are cell stemness-related indicators whose expression was assessed usingﬂuorescence qPCR assay,Western blotting,and *** effect of OA on the proliferative potency of CC cells was evaluated using an in vivo ***:The stem-like characteristics and clone production of colon cancer cells were markedly reduced by OA alone or in combination with ***,OA increases the susceptibility of CC cells to 5-FU by blocking the cell stemness-related markers(CD133,Nanog,SOX2,and Oct4)expression levels both in vitro and in vivo,as well as by inactivating the activator of transcription 3(STAT3 signaling)and Janus kinase 2/signal transducer(JAK2).Conclusion:Theseﬁndings imply that oleanolic acid,both in vitro and in vivo,suppresses the JAK2/STAT3 pathway,which in turn reverses chemoresistance and decreases colon cancer cell ***,by reducing the recommended amount of 5-FU,this strategy may improve chemotherapeutic effectiveness and minimize undesired side effects.

关键词： Colon cancer,Oleanolic acid,Stemness,5-FU JAK2/STAT3 signaling pathway

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Cardiac infiltration of diffuse large B-cell lymphoma manifesting as sustained ventricular tachycardia:a case report

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Journal of Geriatric Cardiology 2024年第2期21卷 242-245页

作者： Wei CHEN Kun HUANG Wei-Wei GUO Fan ZHOU De-Ning LIAO Department of Cardiology Shanghai Jingan District Zhabei Central HospitalShanghaiChina Department of Cardiology Shanghai Changzheng HospitalShanghaiChina Department of Hematology Shanghai Jingan District Zhabei Central HospitalShanghaiChina

Cardiac tumors are ***,cardiac metastases can occur in up to 10%of patients with *** cardiac neoplasms,metastases are much more common than primary cardiac tumors.[1]Metastatic cardiac neoplasms most frequently metast... 详细信息

关键词： neoplasms sustained cardiac

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Status,outcome,and related factors of postpartum hypertension in the Shanghai community

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World Journal of Clinical Cases 2024年第21期12卷 4632-4641页

作者： Ling-Xia Wu Man Jin Jian Yang Department of Women's Health Xuhui District Maternal and Child Health HospitalShanghai 200235China

BACKGROUND Postpartum hypertension poses a considerable health *** research on gestational hypertension,comprehensive studies focusing on postpartum hypertension in communities are *** its prevalence and associated risk factors is crucial for effective prevention and *** To provide insights for postpartum hypertension’s prevention and *** In total,3297 women who gave birth between June 2021 and December 2022 in xuhui district,Shanghai were *** pressure was measured thrice within one month post-delivery during home ***-six women with hypertension were followed up for four months to analyze hypertension persistence and its related risk factors.A predictive model for persistent postpartum hypertension was established and verified using the Nomo diagram *** Hypertension prevalence 1 month post-delivery was 2.61%(86/3297).Among the 86 pregnant women,32(37.21%)had persistent hypertension at four months *** logistic regression analysis revealed that older age[odds ratio(OR)=1.212;95%confidence interval(CI):1.065–1.380]and higher pre-pregnancy body mass index(BMI)(OR=1.188;95%CI:1.006–1.404)were associated with hypertension(OR=10.781;95%CI:1.006–1.404)during pregnancy.A 95%CI of 1.243–93.480 is a risk factor for persistent postpartum *** Nomograph model accurately predicted the risk of persistent postpartum hypertension,demonstrating high *** In xuhui,older age,higher pre-pregnancy BMI,and gestational hypertension are risk factors for persistent postpartum *** prediction model can identify high-risk individuals,thereby improving patient quality of life.

关键词： Postpartum High blood pressure Shanghai community Hypertensive diseases during pregnancy Risk factors Nomo diagram model

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Anemarsaponin B mitigates acute pancreatitis damage in mice through apoptosis reduction and MAPK pathway modulation

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BIOCELL 2024年第5期48卷 745-758页

作者： YI HU ZHONGYANG REN ZHENGZHONG ZHAO YONGJIA HUANG WANTING HUANG JIE LIU LING DING Gastroenterology Department Chongqing University Jiangjin HospitalJiangjin Central Hosptial of ChongqingChongqingChina Surgical Department Chongqing Jiangjin District Hospital of Chinese MedicineChongqingChina Pharmacy Department Chongqing University Jiangjin HospitalJiangjin Central Hosptial of ChongqingChongqingChina

Background:Acute pancreatitis(AP),known for its rapid onset and significant incidence and mortality rates,presents a clinical challenge due to the limited availability of effective treatments and preventive *** B(ASB)has emerged as a potential therapeutic agent,demonstrating capabilities in reducing immune inflammation,positioning it as a promising candidate for AP ***:We investigated the effects of ASB on AP in mice,induced by caerulein and lipopolysaccharide(LPS).Peripheral blood samples were collected 24 h post-induction with caerulein to assess of key biomarkers including lipase,amylase,TNF-α,IL-1β,IL-6,SOD,and GSH-Px.A range of techniques such as immunohistochemistry staining,immunofluorescence staining,Western blotting,and quantitative Polymerase Chain Reaction(q-PCR),were employed to measure the expression of critical ***,pancreas samples from the mice were harvested for microbiome and metabolome sequencing,with the data analyzed to understand the impact of ASB on ***:Our study revealed that,compared to the sham group,the AP group exhibited significantly higher serum levels of lipase,amylase,and cytokines,while levels of SOD and GSH Px were notably *** with ASB led to a substantial decrease in the levels of lipase,amylase,and cytokines,and an increase in SOD and GSH-Px levels.q-PCR analysis of pancreatic histiocytes corroborated these serum *** and Eosin(H&E)staining indicated significant alterations in the pathological changes in the pancreas,lungs,and small intestine of the AP model due to *** assays demonstrated that ASB alleviated the apoptosis of pancreatic histiocytes in the AP *** Blot and histological analyses showed that ASB reduced the phosphorylation of TAK,p38,JNK,and ERK proteins,as well as the levels of TRAF6 protein in the AP ***,metabolomic and gut microbiota analysis identified 27 differential metabolites and 34 diffe

关键词： Anemarsaponin B Acute pancreatitis Cytokines MAPK TRAF6 Gut flora

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The application of renal sympathetic denervation in cardiovascular and other diseases

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South China Journal of Cardiology 2024年第1期25卷 57-66,F0003页

作者：邢海珊王大英刘宗军张颖袁航 Putuo district central hospital Putuo District 200062ShanghaiChina

Background The role of renal artery sympathetic nerve ablation,widely known as renal sympathetic denervation(RDN)in the treatment of resistant hypertension(RH)has been clarified,and there is more and more evidence to support its effect in the treatment of heart failure,ventricular hypertrophy and *** studies also reported its role in treatment related to respiratory system(pulmonary hypertension,sleep apnea syndrome),endocrine system(metabolic syndrome,blood lipid metabolism,polycystic ovary syndrome),kidney disease(acute renal injury,renal failure)and other inflammation,remodeling,pain and so *** most of them were subgroup analysis and small-sample studies,even case reports,they had shed some light on possible use of RDN in the treatment of multi-system diseases.[S Chin J Cardiol 2024;25(1):57-66].

关键词： Renal artery sympathetic nerve ablation Respiratory disease Endocrine Kidney

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Clinical effect of spleen aminopeptide on improving liver function damage and immune function in children with infant hepatitis syndrome

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1742-1748页

作者： Xiao-Qing Fang Tian Gan Lie-Min Wang Department of Pediatrics General Hospital of Central Theater Command of PLAWuhan 430061Hubei ProvinceChina Department of Pharmacy The First People’s Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina Department of Neonatal Central Hospital of EnshiEnshi 445000Hubei ProvinceChina

BACKGROUND Infant hepatitis syndrome(IHS)is a clinical syndrome in infants less than one year of age with generalized skin jaundice,abnormal liver function,and hepato-megaly due to various etiologies such as *** To investigate the effect of IHS patients,after treatment with arsphenamine-based peptides,on patients'liver function damage and immune *** Of 110 patients with IHS treated in our hospital from January 2019 to January 2021 were grouped according to the randomized residual grouping method,with 5 cases in each group shed due to transfer,***,50 cases remained in each *** control group was treated with reduced glutathione,and the treat-ment group was treated with sesquiterpene peptide based on the control *** and compare the differences in indicators after *** The comparison of serum total bilirubin,direct bilirubin,and serum alanine transferase after treatment was significantly different and lower in the treatment group than in the control group(P<0.05).The comparison of CD4+,CD3+,CD4+/CD8+after treatment was significantly different and higher in the treatment group than in the control group,and the comparison was statist-ically significant(P<0.05).The complication of the two groups showed that the rash,cough and sputum,elevated platelets,and gastrointestinal reactions in the treatment group were significantly lower than those in the control group,and the differences were statistically significant by test(P<0.05).CONCLUSION The comparative study of IHS treated with arsphenamine combined with reduced glutathione is more effective.

关键词： Infant hepatitis syndrome Splenamin Reduced glutathione Liver function Immune function Complication

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Gastric cancer immunotherapy:A scientometric and clinical trial review

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World Journal of Gastroenterology 2024年第2期30卷 196-198页

作者： Qian-Cheng Du Xin-Yu Wang Hua Yu Thoracic Surgery Shanghai Xuhui Central HospitalShanghai 200031China Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of General Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

This letter is intended to arouse your interest in a recent review of comprehensive scientometrics and clinical trials on immunotherapy for gastric cancer(GC).Our study reviews recent advances in immunotherapy in the field of GC and highlights its new prospects as a treatment for *** research reveals China’s leadership in this field,as well as new therapeutic strategies such as immune checkpoint inhibitors,cellular immunotherapy,and *** combined findings highlight the potential of immunotherapy to improve survival and quality of life in patients with stomach *** believe that this study will provide important guidance for the future direction of the GC treatment field.

关键词： Gastric cancer Immunotherapy Bibliometrics Comment Therapeutic strategies

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Identification prognostic features related to sphingolipid metabolism and experimental validation of TRIM47 in hepatocellular carcinoma

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BIOCELL 2024年第4期48卷 639-651页

作者： JIAN TANG CHENQIANG ZHU YUN CHEN YUNLONG WU MING HE YI ZHOU MINGHUA XIE Department of Intensive Care Unit The First People’s Hospital of Linping DistrictHangzhouChina Department of Pharmacy The First People’s Hospital of Linping DistrictHangzhouChina

Background:The speciﬁc impact of sphingolipid metabolism on developing hepatocellular Carcinoma(HCC)remains *** study aims to explore the relationship between sphingolipid metabolism and HCC prognosis,immune response,and drug ***:Data were obtained from The Cancer Genome Atlas(TCGA)-Hepatocellular Carcinoma(LIHC)and Gene Expression Omnibus(GEO,GSE14520 datasets).47 sphingolipid metabolism genes were obtained from the Kyoto Encyclopedia of Genes and Genomes(KEGG)*** classifying HCC samples using the Non-negative Matrix Factorization(NMF)clustering method,differentially expressed genes were ***,8 risk genes were obtained by univariate analysis,survival random forest reduction and lasso *** expression of 8 risk genes was veriﬁed in ***:8 risk genes were used to construct the Sphingolipid score ***-Sphingolipid score predicted poor prognosis of HCC *** score was associated with immune checkpoints(IL-1B,TLR4,TGFB1,and IL-10),immune cells(Th2,Treg,MDSC,Neutrophil,Fibroblasts and macrophage),and MAPK *** the High-Sphingolipid score group,a signiﬁcantly higher proportion of patients with TP53(p53)mutations was signiﬁcantly higher(56%).Furthermore,patients with a high-Sphingolipid score were predicted to have a higher sensitivity to chemotherapy *** vitro validation showed that compared with normal liver cells LX-2,TRIM47,and S100A9 signiﬁcantly increased in liver cancer cells Hep G2,MHCC-97H,and Hep3B2.1-7,while SLC1A7,LPCAT1,and CFHR4 signiﬁcantly *** TRIM47 reduced the proliferation and promoted *** levels of ceramide synthesis-related indexes(CERS1,CERS6,CERS5,and SPTLC2)increased,and the ACER3 related to catalytic hydrolysis ***:We constructed a sphingolipid metabolism-related prognostic signature(Sphingolipid score)based on 8 risk ***47 may affect the development of liver cancer by regulating the relevant indicators of

关键词： Hepatocellular carcinoma Sphingolipid metabolism TRIM47 Prognosis

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Self‑Healing Dynamic Hydrogel Microparticles with Structural Color for Wound Management

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Nano-Micro Letters 2024年第11期16卷 177-190页

作者： Li Wang Xiaoya Ding Lu Fan Anne M.Filppula Qinyu Li Hongbo Zhang Yuanjin Zhao Luoran Shang Department of General Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025People’s Republic of China Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096People’s Republic of China Pharmaceutical Sciences Laboratory Åbo Akademi University20520 TurkuFinland Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001People’s Republic of China Shanghai xuhui central hospital Zhongshan‑Xuhui Hospitaland the Shanghai Key Laboratory of Medical Epigeneticsthe International Co‑laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032People’s Republic of China

Chronic diabetic wounds confront a significant medical challenge because of increasing prevalence and difficult-healing *** is vital to develop multifunctional hydrogel dressings,with well-designed morphology and structure to enhance flexibility and effectiveness in wound *** achieve these,we propose a self-healing hydrogel dressing based on structural color microspheres for wound *** microsphere comprised a photothermal-responsive inverse opal framework,which was constructed by hyaluronic acid methacryloyl,silk fibroin methacryloyl and black phosphorus quantum dots(BPQDs),and was further re-filled with a dynamic *** dynamic hydrogel filler was formed by Knoevenagel condensation reaction between cyanoacetate and benzaldehyde-functionalized dextran(DEX-CA and DEX-BA).Notably,the composite microspheres can be applied arbitrarily,and they can adhere together upon near-infrared irradiation by leveraging the BPQDs-mediated photothermal effect and the thermoreversible stiffness change of dynamic ***,eumenitin and vascular endothelial growth factor were co-loaded in the microspheres and their release behavior can be regulated by the same ***,effective monitoring of the drug release process can be achieved through visual color *** microsphere system has demonstrated desired capabilities of controllable drug release and efficient wound *** characteristics suggest broad prospects for the proposed composite microspheres in clinical applications.

关键词： Black phosphorus Structural color Dynamic hydrogel Inverse opal Wound management

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Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio:Markers predicting immune-checkpoint inhibitor efficacy and immune-related adverse events

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 577-582页

作者： Qiu-Yu Jiang Ru-Yi Xue Department of Gastroenterology and Hepatology Zhongshan HospitalShanghai Institute of Liver DiseaseFudan UniversityShanghai 200032China Department of Gastroenterology and Hepatology Shanghai Baoshan District Wusong Central Hospital(Zhongshan Hospital Wusong BranchFudan University)Shanghai 200940China

We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor(ICI)and the occurrence of immune-related adverse events(irAEs).The predictive potential of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in determining ICI effectiveness has been extensively investigated,while limited research has been conducted on predicting ***,the combined model incor-porating NLR and PLR,either with each other or in conjunction with additional markers such as carcinoembryonic antigen,exhibits superior predictive capabilities compared to individual markers *** and PLR are promising markers for clinical *** models ought to incorporate established efficacious models and newly identified ones,thereby constituting a multifactor composite ***,efforts should be made to explore effective clinical application approaches that enhance the predictive accuracy and efficiency.

关键词： Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Immunecheckpoint inhibitor Immune-related adverse event

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