Clinical effect of spleen aminopeptide on improving liver function damage and immune function in children with infant hepatitis syndrome
作者机构：Department of PediatricsGeneral Hospital of Central Theater Command of PLAWuhan 430061Hubei ProvinceChina Department of PharmacyThe First People’s Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina Department of NeonatalCentral Hospital of EnshiEnshi 445000Hubei ProvinceChina
出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)
年 卷 期：2024年第16卷第6期
页 面：1742-1748页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：Infant hepatitis syndrome Splenamin Reduced glutathione Liver function Immune function Complication
摘 要：BACKGROUND Infant hepatitis syndrome(IHS)is a clinical syndrome in infants less than one year of age with generalized skin jaundice,abnormal liver function,and hepato-megaly due to various etiologies such as *** To investigate the effect of IHS patients,after treatment with arsphenamine-based peptides,on patients liver function damage and immune *** Of 110 patients with IHS treated in our hospital from January 2019 to January 2021 were grouped according to the randomized residual grouping method,with 5 cases in each group shed due to transfer,***,50 cases remained in each *** control group was treated with reduced glutathione,and the treat-ment group was treated with sesquiterpene peptide based on the control *** and compare the differences in indicators after *** The comparison of serum total bilirubin,direct bilirubin,and serum alanine transferase after treatment was significantly different and lower in the treatment group than in the control group(P0.05).The comparison of CD4+,CD3+,CD4+/CD8+after treatment was significantly different and higher in the treatment group than in the control group,and the comparison was statist-ically significant(P0.05).The complication of the two groups showed that the rash,cough and sputum,elevated platelets,and gastrointestinal reactions in the treatment group were significantly lower than those in the control group,and the differences were statistically significant by test(P0.05).CONCLUSION The comparative study of IHS treated with arsphenamine combined with reduced glutathione is more effective.
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