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Association of interleukin-6 and C-reactive protein genetic polymorphisms levels with venous thromboembolism

Chinese medical Journal 2012年第22期125卷 3997-4002页

作者： Ailiman Mahemuti Kailibinuer Abudureheman Xiaimuxikamaier Aihemaiti HU Xue-mei XIA Yu-ning TANG Bao-peng Halmurat Upur xinjiang med univ Coll Tradit Chinese Med Urumqi 830011 Xinjiang Peoples R China xinjiang med univ Affiliated Hosp 1 Dept Cardiol Urumqi 830054 Xinjiang Peoples R China

Background Increased levels of interleukin-6 （IL-6） and C-reactive protein （CRP） have been reported in patients with venous thromboembolisms （VTE）. However, prospective studies did not confirm an association between IL-6, CRP and their polymorphism with the risk of VTE. Methods One hundred and forty patients （including 66 males and 74 females, mean age （55.55±17.11） years） and one hundred and sixty controls （including 74 males and 86 females, mean age （56.58±12.24） years） were involved. An enzyme linked immunosorbent assay （ELISA） method was used for detecting the serum levels of inflammatory factors IL-6 and CRP in both groups. Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was used for analyzing the distribution of polymorphisms at the -572C/G and -597G/A sites of the promoter of the IL-6 gene and at 1059G/C of the CRP gene. Results Serum levels of IL-6 and CRP were significantly higher in the VTE group than in the control group （P 〈0.05）. The frequencies of-572C/G promoter polymorphisms CC, CG, and GG in the IL-6 gene were found to be 34%, 48%, and 18%, respectively, and the derived allele frequencies for the C and G alleles were 58% and 42%. There was a significant difference in the -572C/G promoter polymorphisms between the VTE group and control group （P 〈0.05）. For the -597G/A polymorphism, individuals all carried the GG and GA type; AA genotypes were not detected. The frequency of the GG, GC, and CC genotypes at the CRP1059G/C promoter was 87.57%, 7.86% and 3.57% in V-rE group, while 86.25%, 10%, and 3.75% in control group, respectively. The frequency of G and C alleles at CRP 1059G/C was 91.43% and 8.57% in VTE group and 91.56% and 8.44% in the control group. The results showed that there was no statistically significant difference of 1059G/C genotype and mutation frequency of the allele between the VTE group and control group （P 〉0.05）. Multiple Logistic regression analysis showed CC homozygotes of the IL-6 -572G/C, body mass

关键词： venous thromboembolism interleukin-6 C-reactive protein gene polymorphism

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The correlation between human leukocyte antigen-DRBl alleles and anti-neutrophil cytoplasmatic antibodies in Han and Uygur ulcerative colitis patients in xinjiang region

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China medical Abstracts(Internal medicine) 2013年第1期30卷 44-45页

作者：卢加杰 Dept Digestol Xinjiang Med Univ

Objective To study the correlation between human leukocyte antigen(HLA)-DRBl alleles and anti-neutrophil cytoplasmatic antibodies(ANCA) in Han and Uygur ulcerative colitis(UC) patients in xinjiang region. Methods The ... 详细信息

关键词： neutrophil alleles ANCA leukocyte indirect confidence typing severity statistically involvement

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Prospective cohort study on the predictive value of serum uric acid levels to the incident nonalcoholic fatty liver disease

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China medical Abstracts (Internal medicine) 2017年第2期 114-115页

作者：蔡雯 Clin Nursing Faculty Nursing School Xinjiang Med Univ

Objective To assess the predictive value of serum uric acid levels to the incident nonalcoholic fatty liver disease(NAFLD)in a cohort of healthy *** A prospective cohort study of NAFLD incidence was conducted in xinjiang province,from 2012 to 2014.A cohort study was performed on 2 207 subjects with no evidence of fatty liver disease by liver ultrasound and with

关键词： NAFLD acid Prospective cohort study on the predictive value of serum uric acid levels to the incident nonalcoholic fatty liver disease of on

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Construction and validation of a Nomogram-based prediction model for the risk of gout in men

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China medical Abstracts(Internal medicine) 2023年第3期40卷 155-156页

作者：陈昱名 Coll Public Health Xinjiang Med UnivUrumqi 830000

Objective To investigate the risk factors of gout and establish a columnar graph model to predict the risk of gout *** A total of 1032 Han Chinese men attending the Affiliated Hospital of Traditional Chinese medicine of xinjiang medical university,People’s Hospital of xinjiang Uygur Autonomous Region,and the First Affiliated Hospital of xinjiang medical university from 2018 to 2020 were selected as study subjects and divided into training set(722 cases)and validation set(310 cases)by simple random sampling method in the ratio of 7:3.

关键词： medical medicine development

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Clinical study on prevention and treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage by Xifeng Jiejing decoction and Nimodipine

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China medical Abstracts (Internal medicine) 2020年第1期 10-11页

作者：向兴刚 Dept Neurosurg Affil TCM HospXinjiang Med Univ

Objective To observe the clinical efficacy of Xifeng Jiejing Decoction (XFJJD) combined Nimodipine for treating delayed cerebral vasospasm (CVS) after aneurysmal subarachnoid hemorrhage (aSAH).Methods Sixtyfour aSAH p... 详细信息

关键词： Clinical study on prevention and treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage by Xifeng Jiejing decoction and Nimodipine

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PD-1/PD-L1 expression and its implications in patients with chronic lymphocytic leukemia

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China medical Abstracts (Internal medicine) 2017年第2期 120-121页

作者：李金花 xinjiang med univ 1st Affil Hosp Blood Dis CenterXinjiang Uygur Autonom Reg Hematol

Objective The observe the expression levels of PD-1/PD-L1 costimulatory molecules and explore the clinical significance in patients with chronic lymphocytic leukemia(CLL).Methods The expression of PD-1/PD-L1 in peripheral blood CD8+T cells,CD4+T cells,CD19+B,and dendrites cells(DC)was detected by flow cytometry in 57 CLL patients and 20 healthy *** correla-

关键词： PD-1/PD-L1 expression and its implications in patients with chronic lymphocytic leukemia in ZAP with

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Proteomics analysis of rat liver fibrosis caused by sodium arsenite

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China medical Abstracts(Internal medicine) 2016年第2期33卷 13-14页

作者：吴顺华 Occupat & Environment Hyg Dept Public HealthXinjiang Med Univ

Objective To study the mechanism of liver fibrosis in rats caused by chronic exposure through drinking water containing sodium arsenite,and to identify the differential proteins via proteomics *** Totally 40healthy 8-week-old male Sprague Dawley(SD)rats of specific pathogen free(SPF)grade were randomly divided into 4 groups,which were control group(deionized water),0.68,1.36 and 2.73 mg/kg sodium

关键词： Proteomics proteomics drinking exposure pathogen metabolism serological confidence methionine decline

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Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese

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Chinese medical Journal 2012年第4期000卷 622-625页

作者： Zuo Peng-xiang Wu Han-rong Li Zeng-chun Cao Xu-dong Pang Li-juan Yang Lan Liu Fan Zhao Feng xinjiang Shihezi univ Coll Med Shihezi 832002 Xinjiang Peoples R China Huazhong univ Sci & Technol Dept Child & Adolescent Hlth Coll Publ Hlth Wuhan 430030 Hubei Peoples R China

Background Genetic association studies on populations of European origin have identified the DCDC2 gene as a susceptibility locus for developmental ***,we sought to investigate the association of DCDC2 polymorphisms with developmental dyslexia in children of Han Chinese *** We undertook a case-control genetic association study on 76 dyslexic children and 79 non-dyslexic matched *** isolated DNA from oral mucosal cell samples and genotyped two DCDC2 coding-sequence single nucleotide polymorphisms,rs2274305 and rs6456593,in each sample using SNaPshot single nucleotide *** compared the allele and genotype frequencies between the groups using the X2 test and analyzed the relationship between dyslexia and the polymorphism at both loci using unconditional logistic *** also predicted haplotypes and compared their frequencies between the two *** The differences in the genotype distribution and the allelic genes of the two single nucleotide luci of the DCDC2 gene,rs2274305 and rs6456593,between the two dyslexic and non-dyslexic groups were statistically meaningless （P 〉0.05）.The differences in the haplotype distributions of the DCDC2 gene between the dyslexic and normal group were statistically meaningless （P 〉0.05）.Conclusion The DCDC2 gene may not be a susceptibility factor for developmental dyslexia among the Han ***,methodological issues may have prevented the detection of oositive associations.

关键词： DCDC2 case-control genetic association study

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Effects of excessive fluoride on osteocalcin and glucose metabolism in mice

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China medical Abstracts(Internal medicine) 2019年第2期36卷 78-79页

作者： QIN Wen Dept Histol&Embryol Basic Med CollXinjiang Med UnivUrumqi 830011

Objective To observe the effects of excessive fluorideon osteocalcin and glucose metabolism in *** Thirty-two male C57 mice ( body mass: 18-24 g) were selected as study subjects which were randomizedinto four groups (8 mice in each group) accordingto their body mass by random number table method:0 mg /L group (control group),50 mg /L fluorine group,100 mg /L fluorine group and 150 mg /L fluorine *** fluoride in distilled water was freely taken bythese animals to replicate fluorosis animal model. After12 weeks,total osteocalcin,uncarboxylated osteocalcin,insulin and glucagon were measured by enzyme-linkedimmunosorbent assay,fasting blood glucose and glycatedhemoglobin were measured by chemiluminescence.

关键词： Effects excessive fluoride glucose metabolism

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Analysis of non-alcoholic fatty liver disease differences from metabolic dysfunction-associated fatty liver disease based on clinical features

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China medical Abstracts(Internal medicine) 2024年第3期41卷 175-176页

作者： LIU Yunxiao 4th Clin med Coll Xinjiang Med UnivUrumqi 830000China

Objective To explore the clinical features of fatty liver disease (FLD) from non-alcoholic fatty liver disease(NAFLD) to metabolic dysfunction-associated fatty liver disease (MASLD),so as to elucidate its clinical app... 详细信息

关键词： clinical liver NAFLD

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