Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese
Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese作者机构：Xinjiang Shihezi Univ Coll Med Shihezi 832002 Xinjiang Peoples R China Huazhong Univ Sci & Technol Dept Child & Adolescent Hlth Coll Publ Hlth Wuhan 430030 Hubei Peoples R China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2012年第000卷第4期
页 面：622-625页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 0713[理学-生态学]
主 题：DCDC2 case-control genetic association study
摘 要：Background Genetic association studies on populations of European origin have identified the DCDC2 gene as a susceptibility locus for developmental ***,we sought to investigate the association of DCDC2 polymorphisms with developmental dyslexia in children of Han Chinese *** We undertook a case-control genetic association study on 76 dyslexic children and 79 non-dyslexic matched *** isolated DNA from oral mucosal cell samples and genotyped two DCDC2 coding-sequence single nucleotide polymorphisms,rs2274305 and rs6456593,in each sample using SNaPshot single nucleotide *** compared the allele and genotype frequencies between the groups using the X2 test and analyzed the relationship between dyslexia and the polymorphism at both loci using unconditional logistic *** also predicted haplotypes and compared their frequencies between the two *** The differences in the genotype distribution and the allelic genes of the two single nucleotide luci of the DCDC2 gene,rs2274305 and rs6456593,between the two dyslexic and non-dyslexic groups were statistically meaningless （P 〉0.05）.The differences in the haplotype distributions of the DCDC2 gene between the dyslexic and normal group were statistically meaningless （P 〉0.05）.Conclusion The DCDC2 gene may not be a susceptibility factor for developmental dyslexia among the Han ***,methodological issues may have prevented the detection of oositive associations.
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