检索结果-南通市图书馆

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao xiang Zhou Fudan university Shanghai Cancer center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

引用

Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao xiang Cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology medical center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comprehensive Humoral and Cellular Immune Responses to SARS-CoV-2 Variants in Diverse Chinese Population

引用

Research 2022年第2期2022卷 61-69页

作者： Jiwei Li Jing Wu Qiuyue Long Yan'an Wu Xiaoyi Hu Yukun He Mingzheng Jiang Jia Li Lili Zhao Shuoqi Yang Xiaoyong Chen Minghui Wang Jianshi Zheng Fangfang Wu Ruiliang Wu Lihong Ren Liang Bu Houzhao Wang Ke Li Lijuan Fu Guojun Zhang Yali Zheng Zhancheng Gao Department of Respiratory Crilical Care and Sleep MedicineXiang'an Hospial of Xiamen UniersityXiamenFujianChina School of Medicine Xiamen University.XiamenFujianChina Department of Cimical Laboratory Xiang'an Hospial of Xiamen UniversityXiamenFuijianChina Department of Respiratory and Critical Care Medicine Peking University People's HospitalBejingChina Department of Thoracic Surgery xiang an hospital of xiamen university.xiamen FujianChina Department of Pediatrics Xiang'an Haspital of Xiamen UniversityXiamenFujianChina Department of Crical Care Medicine Xiang'an Hospial of Xiamen UriversityXiamenFujanChina Deparment of Infecious Diseases Xiang'an Hospital of Xiamen UniversiyXiamenFujianChina Cancer Research center and The Department of Breast Thyroid Surgery Xiang'an Hospital of Xiamen UntiversityXiamenFujianChina

The SARS-CoV-2 variants have been emerging and have made great challenges to current vaccine and pandemic control *** is urgent to understand the current immune status of various Chinese populations given that the preexisting immunity has been established by national vaccination or ex posure to past *** sera from 85 individuals(including 21 convalescents of natural infection,15 cases which suffered a breakthrough infection after being fully vaccinated,and 49 healthy vaccinees),we showed signifcantly enhanced neutralizing activities against SRAS-CoV-2 variants in convalescent sera,especially those who had been fully *** neut ralizing antibodies against Omicron were detectable in 75%of convalescents and 4.9%of healthy vaccinees(p=0.006),with a GMT of 289.5,180.9-463.3,and 42.6,31.3-59,***,the neutralizing activities were weaker in young convalescents(aged<18y),with a detectable rate of 50%and a GMT of 46.4 against *** also examined and found no *** neutralizing activities in vaccinated SARS-CoV-I survivors.A booster dose could further increase the breadth and magnitude of neutralization against WT and variants of concern(VOCs)to different *** addition,we showed that COVID-19-inactivated vaccines can elicit Omicron-specific T-cell *** positive rates of ELISpot reactions were 26.7%(4/15)and 43.8%(7/16)in the full vaccination group and the booster vaccination group,respectively,although without statistically significant *** neutralizing antibody titers declined while T-cell responses remain consistent over 6 *** findings will inform the optimization of public health vaccination and intervention strategies to protect diverse populations against SARS-CoV-2 *** infection significantly boosted neutralizing activities against SARS-CoV-2 variants a compared to booster immunization with inaclivated ***-induced vir us-specific T-cell imm

关键词： immunity vaccine protective

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular and functional imaging in cancer-targeted therapy:current applications and future directions

引用

Signal Transduction and Targeted Therapy 2023年第3期8卷 1112-1143页

作者： Jing-Wen Bai Si-Qi Qiu Guo-Jun Zhang Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen University361100 XiamenChina xiamen Key Laboratory of Endocrine-Related Cancer Precision Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen University361100 XiamenChina xiamen Research center of Clinical Medicine in Breast and Thyroid Cancers Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen University361100 XiamenChina Department of Breast-Thyroid-Surgery and Cancer center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen University361100 XiamenChina Department of medical Oncology Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen University361100 XiamenChina Cancer Research center of xiamen university School of MedicineXiamen University361100 XiamenChina Diagnosis and Treatment center of Breast Diseases Clinical Research CenterShantou Central Hospital515041 ShantouChina Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment Shantou University Medical College515041 ShantouChina

Targeted anticancer drugs block cancer cell growth by interfering with specific signaling pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing cells as in cytotoxic *** Response Evaluation Criteria in Solid Tumor(RECIST)system has been used to assess tumor response to therapy via changes in the size of target lesions as measured by calipers,conventional anatomically based imaging modalities such as computed tomography(CT),and magnetic resonance imaging(MRI),and other imaging ***,RECIST is sometimes inaccurate in assessing the efficacy of targeted therapy drugs because of the poor correlation between tumor size and treatment-induced tumor necrosis or *** approach might also result in delayed identification of response when the therapy does confer a reduction in tumor *** molecular imaging techniques have rapidly gained importance in the dawning era of targeted therapy as they can visualize,characterize,and quantify biological processes at the cellular,subcellular,or even molecular level rather than at the anatomical *** review summarizes different targeted cell signaling pathways,various molecular imaging techniques,and developed ***,the application of molecular imaging for evaluating treatment response and related clinical outcome is also systematically *** the future,more attention should be paid to promoting the clinical translation of molecular imaging in evaluating the sensitivity to targeted therapy with biocompatible *** particular,multimodal imaging technologies incorporating advanced artificial intelligence should be developed to comprehensively and accurately assess cancer-targeted therapy,in addition to RECIST-based methods.

关键词： targeted drugs directions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insights into the transition of ductal carcinoma in situ to invasive ductal carcinoma:morphology,molecular portraits,and the tumor microenvironment

引用

Cancer Biology & Medicine 2022年第10期19卷 1487-1495页

作者： Weiling Chen Guimei Wang Guojun Zhang Department of Breast-Thyroid-Surgery and Cancer center Xiang’An Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361101China Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer Xiang’An Hospital of Xiamen UniversityXiamen 361101China Key Laboratory for Endocrine-Related Cancer Precision Medicine of xiamen Xiang’An Hospital of Xiamen UniversityXiamen 361101China xiamen Research center of Clinical Medicine in Breast&Thyroid Cancers Xiang’An Hospital of Xiamen UniversityXiamen 361101China Department of Pathology Xiang’An Hospital of Xiamen UniversityXiamen 361101China

Breast cancer is posing an increasing burden and has become the cancer with the highest incidence among in women in *** most common histological subtype of breast cancer is invasive ductal carcinoma(IDC)1,*** carcinoma in situ(DCIS)is a pre-cancerous lesion that may give rise to *** is a highly heterogeneous group of lesions consisting of 5 main types,which differ in clinical presentation,histologic features,biomarker profiles,genetic abnormalities,progression potential,and clinical *** cancer cells invade through the basal membrane,they acquire the ability to *** process is usually accompanied by many genetic and epigenetic changes in tumor suppressors and oncogenes.

关键词： ductal clinical Breast

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation

引用

Signal Transduction and Targeted Therapy 2023年第10期8卷 4998-5009页

作者： Weijie Ouyang Shoubi Wang Dan Yan Jieli Wu Yunuo Zhang Wei Li Jiaoyue Hu Zuguo Liu xiamen university affiliated xiamen Eye center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenFujan 361005China Department of Ophthalmology Xiang'an Hospital of Xiamen UniversityXiamenFujian 361005China The First affiliated hospital of xiamen university School of MedicineXiamen UniversityXiamen 361005China Changsha Aier Eye hospital ChangshaHunan 410016China Department of Ophthalmology The First Affiliated Hospital of University of South ChinaHengyangHunan 421001China

The innate immune response is the main pathophysiological process of ocular surface diseases exposed to multiple environmental *** epithelium is central to the innate immune response,but whether and how innate immunity is initiated by ocular epithelial cells in response to various environmental stresses in ocular surface diseases,such as dry eye,is still unclear.

关键词： ocular immunity inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

引用

Oncology Research 2025年第1期33卷 67-81页

作者： xiang LI WENKE JIN LIFENG WU HUAN WANG XIN XIE WEI HUANG BO LIU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeted combination therapy for glioblastoma by co-delivery of doxorubicin,YAP-siRNA and gold nanorods

引用

Journal of Materials Science & Technology 2021年第4期63卷 81-90页

作者： Lihuang Li Qiuyan Guo Yanxiu Liu Mindan Lu Jun Yang Yunlong Ge Qiang Zhang Benqiang Sun Xiumin Wang Li Liang-cheng Lei Ren Key Laboratory of Biomedical Engineering of Fujian Province university/Research center of Biomedical Engineering of xiamen Department of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005China School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchXiamen UniversityXiamen 361102China Department of Neurosurgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China Stomatological hospital of xiamen medical College Xiamen 361105China State Key Lab of Physical Chemistry of Solid Surfaces Xiamen UniversityXiamen 361005China

The combination of brain targeting drug delivery systems and multi-modal intervention pose a promising therapeutic approach for glioblastoma *** this study,we developed an angiopep-2 peptide modified cationic liposome loaded with doxorubicin,YAP-siRNA and gold nanorods(D/R@Ang2-Lip+Au)simultaneously,which has high encapsulating efficiency for doxorubicin(95.4%)and effective binding of siRNA at N/P ratio of 20:*** fluorescence imaging and flow cytometry analysis revealed high cellular uptake of D/R@Ang2-Lip+***-time quantitative polymerase chain reaction and western blot analysis indicated that D/R@Ang2-Lip+Au could effectively inhibit the expression of YAP *** vitro and in vivo studies showed that D/R@Ang2-Lip+Au had the ability to target glioblastoma cells,and achieved better anti-proliferative effects compared with non-targeted D/R@Lip+***,in vivo experiment demonstrated that D/R@Ang2-Lip+Au was able to cross the blood-brain barrier,and combination therapy could significantly inhibit tumor ***,the multifunctional D/R@Ang2-Lip+Au might provide a novel approach for effectively delivery of DOX,YAP-siRNA and AuNRs into the glioblastoma cells simultaneously and exerting synergistic therapeutic effects.

关键词： doxorubicin glioblastoma simultaneous

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Revamping anti-cGAS-STING therapy via an injectable thermo-responsive supramolecular hydrogel for pathological retinal angiogenesis

引用

Asian Journal of Pharmaceutical Sciences 2024年第5期19卷 104-125页

作者： Dan Yan Yuqian Wang Weijie Ouyang Caihong Huang Qian Chen Jiaoyue Hu Zuguo Liu xiamen university affiliated xiamen Eye center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361100China Department of Ophthalmology The Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical UniversityGuizhou 550004China Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361102China Department of Ophthalmology The First Affiliated Hospital of University of South ChinaHengyang 421005China

Retinal neovascularization is a leading cause of *** current anti-VEGF drugs effectively inhibit pathological angiogenesis,some patients develop resistance or reduced responsiveness to treatments over time,leading to diminished *** this study,we identified high activation of the cGAS-STING signaling pathway,which exacerbated pathological neovascularization and vessel *** developed an injectable thermo-responsive supramolecular hydrogel loaded with an anti-STING *** hydrogel,made of Pluronic F127 demonstrated excellent transparency and ***,the thermo-sensitive property allowed for precise spatial release of the drug,extending the effective treatment duration of C-176,which suppressed STING activation in the retina,reduced inflammation and protected retinal ***^(C-176) effectively inhibited microglial cell infiltration and the release of inflammatory angiogenic factors,highlighting its enhanced *** demonstrating slightly lower effectiveness compared to traditional anti-VEGF therapy,Hydro^(C-176) exhibited more robust capabilities in regulating ocular microenvironmental *** approach may assist in enhancing the sensitivity and effectiveness of anti-VEGF therapy for reducing ocular inflammation,potentially improving patients’response to traditional *** results have suggested innovative and comprehensive strategies for the management of retinal neovascularization.

关键词： cGAS-STING Retinal angiogenesis Pluronic F127 C-176

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biallelic mutations in spermatogenesis and centriole-associated 1 like(SPATC1L)cause acephalic spermatozoa syndrome and male infertility

引用

Asian Journal of Andrology 2022年第1期24卷 67-72页

作者： You-Zhu Li Na Li Wen-Sheng Liu Yan-Wei Sha Rong-Feng Wu Ya-Ling Tang Xing-Shen Zhu Xiao-Li Wei Xiao-Ya Zhang Yi-Feng Wang Zhong-Xian Lu Fu-Xing Zhang Reproductive Medicine center The First Affiliated Hospital of Xiamen UniversityXiamen 361003China Intensive Care Unit Fujian Medical University Xiamen Humanity HospitalXiamen 361009China Obstetrics and Gynecology center Department of Obstetrics and GynecologyZhujiang HospitalSouthern Medical UniversityGuangzhou 510280China School of Pharmaceutical Sciences State Key Laboratory of Cellular Stress BiologyXiamen UniversityXiamen 361102China Department of Andrology United Diagnostic and Research Center for Clinical GeneticsWomen and Children’s Hospital and School of MedicineXiamen UniversityXiamen 361005China Department of Obstetrics and Gynecology First Affiliated Hospital of Xiamen UniversityXiamen 361003China Department of General Surgery First Affiliated Hospital of Xiamen UniversityXiamen 361003China

Acephalic spermatozoa syndrome is a rare type of teratozoospermia that severely impairs the reproductive ability of male patients,and genetic defects have been recognized as the main cause of acephalic spermatozoa *** and centrioleassociated 1 like(SPATC1L)is indispensable for maintaining the integrity of sperm head-to-tail connections in mice,but its roles in human sperm and early embryonic development remain largely ***,we conducted whole-exome sequencing(WES)of 22 infertile men with acephalic spermatozoa *** in silico analysis of the candidate variants was conducted,and WES data analysis was performed using another cohort consisting of 34 patients with acephalic spermatozoa syndrome and 25 control subjects with proven *** identified biallelic mutations in SPATC1L(c.910C>T:***304Cys and c.994G>T:***332X)from a patient whose sperm displayed complete *** SPATC1L variants are rare and ***1L is mainly expressed at the head–tail junction of elongating *** containing pathogenic variants decreased the level of SPATC1L in ***,none of the patient’s four attempts at intracytoplasmic sperm injection(ICSI)resulted in a transplantable embryo,which suggests that SPATC1L defects might affect early embryonic *** conclusion,this study provides the first identification of SPATC1L as a novel gene for human acephalic spermatozoa ***,WES might be applied for patients with acephalic spermatozoa syndrome who exhibit reiterative ICSI failures.

关键词： acephalic spermatozoa syndrome biallelic mutations spermatogenesis and centriole-associated 1 like whole-exome sequencing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：