Revamping anti-cGAS-STING therapy via an injectable thermo-responsive supramolecular hydrogel for pathological retinal angiogenesis

作     者：Dan Yan Yuqian Wang Weijie Ouyang Caihong Huang Qian Chen Jiaoyue Hu Zuguo Liu 

作者机构：Xiamen University affiliated Xiamen Eye CenterFujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361100China Department of OphthalmologyThe Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical UniversityGuizhou 550004China Department of OphthalmologyXiang’an Hospital of Xiamen UniversityXiamen 361102China Department of OphthalmologyThe First Affiliated Hospital of University of South ChinaHengyang 421005China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2024年第19卷第5期

页      面：104-125页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by grants from the National Natural Science Foundation of China(No.82271054 ZL No.U20A20363 JH) 

主　　题：cGAS-STING Retinal angiogenesis Pluronic F127 C-176 

摘      要：Retinal neovascularization is a leading cause of *** current anti-VEGF drugs effectively inhibit pathological angiogenesis,some patients develop resistance or reduced responsiveness to treatments over time,leading to diminished *** this study,we identified high activation of the cGAS-STING signaling pathway,which exacerbated pathological neovascularization and vessel *** developed an injectable thermo-responsive supramolecular hydrogel loaded with an anti-STING *** hydrogel,made of Pluronic F127 demonstrated excellent transparency and ***,the thermo-sensitive property allowed for precise spatial release of the drug,extending the effective treatment duration of C-176,which suppressed STING activation in the retina,reduced inflammation and protected retinal ***^(C-176) effectively inhibited microglial cell infiltration and the release of inflammatory angiogenic factors,highlighting its enhanced *** demonstrating slightly lower effectiveness compared to traditional anti-VEGF therapy,Hydro^(C-176) exhibited more robust capabilities in regulating ocular microenvironmental *** approach may assist in enhancing the sensitivity and effectiveness of anti-VEGF therapy for reducing ocular inflammation,potentially improving patients’response to traditional *** results have suggested innovative and comprehensive strategies for the management of retinal neovascularization.