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Application of magnetotactic bacteria as engineering microrobots:higher delivery efficiency of antitumor medicine

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Chinese Chemical Letters 2024年第10期35卷 139-146页

作者： Jing Zhang Charles Wang Yaoyao Zhang Haining Xia Yujuan Wang Kun Ma junfeng Wang high magnetic field Laboratory CAS Key Laboratory of High Magnetic Field and lon Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China University of California San DiegoLa JollaCA 92093United States International Magnetobiology Frontier Research center Hefei 230031China

For a significant duration,enhancing the efficacy of cancer therapy has remained a critical *** bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery ***,classified as anaerobic,aquatic,and gram-negative microorganisms,exhibit remarkable motility and precise control over their internal biomineralization *** unique ability results in the formation of magnetic nanoparticles arranged along filamentous structures in a catenary fashion,enclosed within a *** bacteria possess distinctive biochemical properties that facilitate their precise positioning within complex *** harnessing these biochemical attributes,MTB could potentially offer substantial advantages in the realm of cancer *** article reviews the drug delivery capabilities of MTB in tumor treatment and explores various applications based on their inherent *** objective is to provide a comprehensive understanding of MTB-driven drug delivery and stimulate innovative insights in this field.

关键词： Magnetotactic bacteria Engineering microrobot Tumor treatment Drug delivery Bioconjugation

Numerical investigation on thermomechanical behavior of alumina–calcium hexaluminate refractories for purging plug

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Journal of Iron and Steel Research International 2024年第2期31卷 389-400页

作者： Li-ping Pan Ya-wei Li Fang-guan Tan Yi-chen Chen Yang-fan Xu Zhu He Bao-kuan Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina national-Provincial Joint Engineering Research center of high Temperature Materials and Lining Technology Wuhan University of Science and TechnologyWuhan430081HubeiChina

Alumina–spinel refractories used in slit-type purging plugs are susceptible to cross-sectional damage,resulting in a serious mismatch between their service life and that of ***–calcium hexaluminate refractories have gradually become the new trend in purging plug materials with the development of refining *** thermomechanical damage of slit-type purging plugs with alumina–calcium hexaluminate refractory was investigated by the thermo-solid coupling *** with the polynomial fitting and design of experiments methods,the influence of thermophysical parameters on temperature and thermal stress of alumina–calcium hexaluminate refractories for purging plugs was systematically *** results show that the maximum thermal stress of the purging plugs appears during the stages of steel transporting and stirring,and the vulnerable parts are located above Y=0.323 *** thermal conductivity and the coefficient of thermal expansion of the material are the most sensitive parameters to the temperature and thermal stress inside the structure,*** addition of more calcium hexaluminate can relieve the stress concentration and large deformation around the ***,when the content of calcium hexaluminate is 47 wt.%and in the form of aggregate-binder,the temperature and thermal stress distribution inside the refractory are optimal,which can effectively improve the service life of the slit-type purging plug.

关键词： Purging plug Thermomechanical damage Refractory Design of experiments method Stress

Fluorinated [2]rotaxanes as sensitive ^(19)F MRI agents: Threading for higher sensitivity

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Chinese Chemical Letters 2024年第10期35卷 379-382页

作者： Lan Yang Yu Li Mou Jiang Rui Zhou Hengjiang Cong Minghui Yang Lei Zhang Shenhui Li Yunhuang Yang Maili Liu Xin Zhou Zhong-Xing Jjiang Shizhen Chen State Key Laboratory of magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory forOptoelectronicsWuhan430071China University of Chinese Academy of Sciences Beijing 100049China School of Pharmaceutical Sciences&College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430071China Optics Valley Laboratory Wuhan 430074China

As a promising imaging technology,the low sensitivity of fluorine-19 magnetic resonance imaging(^(19)F MRI)severely hinders its biomedical ***,we have developed an unprecedented rotaxanebased strategy to improve the sensitivity of^(19)F MRI *** threading the fluorinated macrocycle into2-blade pinwheel[2]rotaxanes,the^(19)F longitudinal relaxation rate R1was dramatically increased,resulting in a significant^(19)F MRI signal intensity enhancement of up to 79%.Through comparative molecular dynamics studies using a series of solution and solid-state^(1)H/^(19)F nuclear magnetic resonance(^(1)H/^(19)F NMR)and molecular dynamics simulations,it was found that the formation of mechanical bonds dramatically restricts the motion of the wheel fluorines and thus increasing the R1for higher^(19)F MRI *** a novel strategy for improving^(19)F MRI sensitivity,this study has established^(19)F NMR/MRI as a valuable technology for monitoring the molecular dynamics of rotaxanes,which may shed new light on high-performance^(19)F MRI agents and molecular devices.

关键词： Rotaxane ^(19)FMRI Imaging agent Mechanical bond Relaxation rate

Engineering Quantum Criticality for Quantum Dot Power Harvesting

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Chinese Physics Letters 2024年第2期41卷 14-25页

作者：王金义年磊磊吕京涛 School of Physics and Astronomy Yunnan UniversityKunming 650091China School of Physics Institute for Quantum Science and Engineeringand Wuhan National High Magnetic Field CenterHuazhong University of Science and TechnologyWuhan 430074China

Coupling of quantum-dot circuits to microwave photons enables us to investigate photon-assisted quantum ***,we revisit this typical circuit quantum electrodynamical setup by introducing the Kerr nonlinearity of *** exploiting quantum critical behavior,we propose a powerful scheme to control the power-harvesting efficiency in the microwave regime,where the driven-dissipative optical system acts as an energy *** drives electron transport against a load in the quantum-dot *** energy transfer and,consequently,the harvesting efficiency are enhanced near the critical *** the critical point moves towards to low input power,high efficiency within experimental parameters is *** results complement fundamental studies of photon-to-electron conversion at the nanoscale and provide practical guidance for designs of integrated photoelectric devices through quantum criticality.

关键词： quantum critical microwave

Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

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Zoological Research 2024年第3期45卷 478-490页

作者： Han-Xiao Chen Xin-Yu Wang Biao Yu Chuan-Lin Feng Guo-Feng Cheng Lei Zhang Jun-Jun Wang Ying Wang Ruo-Wen Guo Xin-Miao Ji Wen-Jing Xie Wei-Li Chen Chao Song Xin Zhang CAS Key Laboratory of high magnetic field and Ion Beam Physical Biology High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in *** predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late *** the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery *** the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte ***,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially ***,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP *** note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关键词： Acetaminophen Acute liver injury Static magnetic fields Oxidative stress DNA synthesis

Synthesis,disorder and Ising anisotropy in a new spin liquid candidate PrMgAl_(11)O_(19)

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Materials Futures 2024年第3期3卷 148-156页

作者： Yantao Cao Huanpeng Bu Zhendong Fu Jinkui Zhao Jason S Gardner Zhongwen Ouyang Zhaoming Tian Zhiwei Li Hanjie Guo Key Lab for Magnetism and magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000People’s Republic of China Songshan Lake Materials Laboratory DongguanGuangdong 523808People’s Republic of China Institute of Physics Chinese Academy of SciencesBeijing 100190People’s Republic of China Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831United States of America School of Physics and wuhan national high magnetic field center Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China

Here we report the successful synthesis of large single crystals of triangular frustrated PrMgAl_(11)O_(19)using the optical floating zone *** crystal x-ray diffraction(XRD)measurements unveiled the presence of quenched disorder within the mirror plane,specifically~7%of Pr ions deviating from the ideal 2d site towards the 6h *** susceptibility measurements revealed an Ising anisotropy with the c-axis being the easy *** a large spin–spin interaction that develops below~10 K and considerable site disorder,the spins do not order or freeze down to at least 50 *** availability of large single crystals offers a distinct opportunity to investigate the exotic magnetic state on a triangular lattice with an easy axis out of the plane.

关键词： spin liquid disorder frustration triangular lattice Ising anisotropy

40-meter-long REBCO tapes with critical current over 4,000 A/12 mm at 4.2 K and 13 T by advanced MOCVD

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Superconductivity 2024年第1期9卷 29-34页

作者： Mahesh Paidpilli Chirag Goel Bhabesh Sarangi Siwei Chen Eduard Galstyan Jan Jaroszynski Griffin Bradford Dmytro Abraimov Venkat Selvamanickam Department of Mechanical Engineering Advanced Manufacturing InstituteTexas Center for SuperconductivityUniversity of HoustonHoustonTexasUSA AMPeers LLC HoustonTexasUSA national high magnetic field Laboratory TallahasseeFloridaUSA

REBa_(2)Cu_(3)O_(7−δ)(REBCO,RE=rare earth)tapes doped with 5%and 15%Zr have been scaled up to lengths more than 40 m in a pilot‐scale advanced metal organic chemical vapor deposition(A‐MOCVD)*** precursor compositions used for the long tapes were guided by a study of the influence of(Ba+dopant)/Cu content on the critical current density(Jc)of 5 and 15 mol.%Hf‐and Zr‐added tapes at 4.2 K and 13 *** 40‐mlong tapes exhibited a critical current(Ic)over 4,000 A/12 mm at 4.2 K and 13 T as well as over 1,400 A/12 mm at 20 K and 20 *** critical current densities of a 40‐m‐long tape doped with 5%Zr at 4.2 K measured at the national high magnetic field Laboratory(NHMFL)were>10 MAcm^(−2)and>5 MAcm^(−2)at 14 T and 30 T,respectively,which are over three times those of commercial REBCO *** infield Jc of 5%Zradded 40‐m‐long tapes was similar to those of previously‐reported high‐performance short samples made with 15%Zr or *** results demonstrate the excellent potential of A‐MOCVD for manufacturing high Ic REBCO tapes for use in ultrahigh‐field magnet applications.

关键词： high‐temperature superconductors MOCVD REBCO Critical current

Transforming Adolescent Smiles:Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

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Current Medical Science 2024年第3期44卷 657-666页

作者： Wen-jie FAN Jia-qi ZHANG Jia-qi ZHAN Li HU Li-li CHEN Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China wuhan national high magnetic field center Wuhan430074China The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental *** traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial *** recent years,an invisible orthodontic technique,without brackets,has become increasingly ***,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect *** case report presents an adolescent patient with bimaxillary protrusion and mandibular *** on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular *** patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the *** case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction ***,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

Optimized the vanadium electrolyte with sulfate-phosphoric mixed acids to enhance the stable operation at high-temperature

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Frontiers of Chemical Science and Engineering 2024年第2期18卷 13-26页

作者： Ling Ge Tao Liu Yimin Zhang Hong Liu School of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China State Environmental Protection Key Laboratory of Mineral Metallurgical Resources Utilization and Pollution Control Wuhan University of Science and TechnologyWuhan 430081China Hubei Collaborative Innovation center for high Efficient Utilization of Vanadium Resources Wuhan University of Science and TechnologyWuhan 430081China Hubei Provincial Engineering Technology Research center of high Efficient Cleaning Utilization for Shale Vanadium Resource Wuhan University of Science and TechnologyWuhan 430081China School of Resource and Environmental Engineering Wuhan University of TechnologyWuhan 430070China

Herein, the influence of the concentration design and comprehensive performance of the sulfate-phosphoric mixed acid system electrolyte is investigated to realize an electrolyte that maintains high energy density and stable operation at high temperatures. Static stability tests have shown that VOPO4 precipitation occurs only with vanadium(V) electrolyte. The concentration of vanadium ion of 2.0–2.2 mol·L^(–1), phosphoric acid of 0.10–0.15 mol·L^(–1), and sulfuric acid of 2.5–3.0 mol·L^(–1) are suitable for a vanadium redox flow battery in the temperature range from –20 to 50 ℃. The equations for predicting the viscosity and conductivity of electrolytes are obtained by the response surface method. The optimized electrolyte overcomes precipitation generation. It has 2.8 times higher energy density than the non-phosphate electrolyte, and a coulomb efficiency of 94.0% at 50 ℃. The sulfate-phosphoric mixed acid system electrolyte promotes the electrode reaction process, increases the current density, and reduces the resistance. This work systematically optimizes the concentrations of composition of positive and negative vanadium electrolytes with mixed sulfate-phosphoric acid. It provides a basis for the different valence states and comprehensive properties of sulfate-phosphoric mixed acid system vanadium electrolytes under extreme environments, guiding engineering applications.

关键词： all vanadium redox flow battery mixed-acid vanadium electrolyte concentration optimization response surface methodology high-temperature stability