检索结果-南通市图书馆

Organoids: a novel modality in disease modeling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2021年第4期4卷 689-716页

作者： Zahra Heydari Farideh Moeinvaziri Tarun Agarwal Paria Pooyan Anastasia Shpichka Tapas KMaiti Peter Timashev Hossein Baharvand Massoud Vosough Department of Stem Cells and Developmental Biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyACECRTehran 14155-4364Iran Department of Developmental Biology University of Science and CultureTehran 14155-4364Iran Department of Biotechnology Indian Institute of TechnologyKharagpurWest Bengal 721302India world-class research center“digital biodesign and personalized healthcare” Sechenov First Moscow State Medical University19991 MoscowRussia Institute for Regenerative Medicine Sechenov University119991 MoscowRussia Chemistry Department Lomonosov Moscow State University119991 MoscowRussia Department of Polymers and Composites N.N.Semenov Federal Research Center for Chemical PhysicsRussian Academy of Sciences119991 MoscowRussia Department of Regenerative Medicine Cell Science Research CentreRoyan Institute for Stem Cell Biology and TechnologyACECRTehran 14155-4364Iran

Limitations of monolayer culture conditions have motivated scientists to explore new models that can recapitulate the architecture and function of human organs more *** advances in the improvement of protocols have resulted in establishing three-dimensional(3D)organ-like architectures called‘organoids’that can display the characteristics of their corresponding real organs,including morphological features,functional activities,and personalized responses to specific *** discuss different organoid-based 3D models herein,which are classified based on their original germinal *** of organoids simulating the complexity of real tissues could provide novel platforms and opportunities for generating practical knowledge along with preclinical studies,including drug screening,toxicology,and molecular pathophysiology of *** paper also outlines the key challenges,advantages,and prospects of current organoid systems.

关键词： Organoid Germ layer Disease modeling Drug screening

Multilayered organic semiconductors for high performance optoelectronic stimulation of cells

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano research 2023年第4期16卷 5809-5816页

作者： Aleksandr Markov Alexander Gerasimenko Annie-Kermen Boromangnaeva Sofia Shashova Elena Iusupovskaia Ulyana Kurilova Vita Nikitina Irina Suetina Marina Mezentseva Mikhail Savelyev Peter Timashev Dmitry Telyshev Xing-Jie Liang Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia Chemistry Department Lomonosov Moscow State UniversityLeninskie Gory1/3Moscow 119991Russia Ivanovsky Institute of Virology N.F.Gamaleya National Center of Epidemiology and MicrobiologyMoscow 123098Russia world-class research center“digital biodesign and personalized healthcare” I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Laboratory of Clinical Smart Nanotechnologies I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Institute for Regenerative Medicine I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The efficiency of devices for bioelectronic applications,including cell and tissue stimulation,is heavily dependent on the scale and the performance *** miniaturization of stimulation electrodes,achieving a sufficiently high current pulse to elicit action potentials becomes an *** we report on our approach of vertically stacking organic p-n junctions to create highlyefficient multilayered organic semiconductor(MOS)photostimulation device.A tandem arrangement substantially increases the photovoltage and charge density without sacrificing lateral area,while not exceeding 200-500 nm of *** devices generate 4 times higher voltages and at least double the charge densities over single p-n junction devices,which allow using lower light intensities for *** devices show an outstanding stability in the electrolyte that is extremely important for forthcoming in vivo ***,we have validated MOS devices performance by photostimulating fibroblasts and neuroblasts,and found that using tandem devices leads to more effective action potential *** a result,we obtained up to 4 times enhanced effect in cell growth density using 3 p-n layered *** results corroborate the conclusion that MOS technology not only can achieve parity with state-of-the-art silicon devices,but also can exceed them in miniaturization and performance for biomedical applications.

关键词： bioelectronics organic semiconductors wireless stimulation fibroblasts neuroblastoma cells

Identification of Proteins and Genes Associated with Hedgehog Signaling Pathway Involved in Neoplasm Formation Using Text-Mining Approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Big Data Mining and Analytics 2024年第1期7卷 107-130页

作者： Nadezhda Yu.Biziukova Sergey M.Ivanov Oga A.Tarasova Department of Bioinformatics Institute of Biomedical ChemistryMoscow 119121Russia Department of Bioinformatics Pirogov Russian National Research Medical UniversityMoscow 117997Russia

Analysis of molecular mechanisms that lead to the development of various types of tumors is essential for biology and medicine,because it may help to find new therapeutic opportunities for cancer treatment and cure including personalized treatment *** of the pathways known to be important for the development of neoplastic diseases and pathological processes is the Hedgehog signaling pathway that normally controls human embryonic *** accumulation of various types of biological data,including interactions between proteins,regulation of genes transcription,proteomics,and metabolomics experiments results,allows the application of computational analysis of these big data for identification of key molecular mechanisms of certain diseases and pathologies and promising therapeutic *** aim of this study is to develop a computational approach for revealing associations between human proteins and genes interacting with the Hedgehog pathway components,as well as for identifying their roles in the development of various types of *** automatically collect sets of abstract texts from the NCBI PubMed bibliographic *** recognition of the Hedgehog pathway proteins and genes and neoplastic diseases we use a dictionary-based named entity recognition approach,while for all other proteins and genes machine learning method is *** association extraction,we develop a set of semantic *** complete the results of the text analysis with the gene set enrichment *** identified key pathways that may influence the Hedgehog pathway and their roles in tumor development are then verified using the information in the literature.

关键词： text-mining data mining Hedgehog pathway neoplastic processes enrichment analysis pathology molecularmechanisms

IoMT-Based Smart healthcare of Elderly People Using Deep Extreme Learning Machine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2023年第7期76卷 19-33页

作者： Muath Jarrah Hussam Al Hamadi Ahmed Abu-Khadrah Taher M.Ghazal School of Information Technology Skyline University CollegeUniversity City Sharjah1797SharjahUAE College of Computing and Informatics Saudi Electronic UniversityRiyadh11673Saudi Arabia center for Cyber Security Faculty of Information Science and TechnologyUniversity Kebangsaan Malaysia(UKM)43600BangiSelangorMalaysia center for Cyber-Physical Systems Khalifa University127788Abu DhabiUAE

The Internet of Medical Things(IoMT)enables digital devices to gather,infer,and broadcast health data via the cloud *** phenomenal growth of the IoMT is fueled by many factors,including the widespread and growing availability of wearables and the ever-decreasing cost of sensor-based *** is a growing interest in providing solutions for elderly people living assistance in a world where the population is rising *** IoMT is a novel reality transforming our daily *** can renovate modern healthcare by delivering a more personalized,protective,and collaborative approach to ***,the current healthcare system for outdoor senior citizens faces new *** healthcare systems are inefficient and lack user-friendly technologies and interfaces appropriate for elderly people in an outdoor ***,in this research work,a IoMT based Smart healthcare of Elderly people using Deep Extreme Learning Machine(SH-EDELM)is proposed to monitor the senior citizens’*** performance of the proposed SH-EDELM technique gives better results in terms of 0.9301 accuracy and 0.0699 miss rate,respectively.

关键词： ICT ML FN DELM SH-EDELM

“digitalMe”in smart cities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Innovation 2024年第5期5卷 11-12页

作者： Seung-min Park Seunghun Hong Kyonghee Joo Soh Kim Michael D.Lepech School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637459Singapore Walmart Connect HobokenNJ 07030USA LG CNS Seoul 07795South Korea Department of Civil and Environmental Engineering Stanford UniversityStanfordCA 94305USA Stanford center at the Incheon Global Campus(SCIGC) IncheonSouth Korea

PRECISION HEALTH AND *** Continuous monitoring of high-value equipment,such as semiconductor production equipment and jet airplane engines,has become a standard practice across myriad commercial sectors.“digital twin”technologies enable such monitoring by providing sensor data for maintenance and other mission-critical operations in real *** continuous monitoring has become standard in some industry,its application to monitoring healthy adults globally remains underexplored,with many individuals seeking medical care only when *** gained from digital twin could be transferred to healthcare,revealing opportunities for more data-driven and personalized care.

关键词： gained seeking smart