Multilayered organic semiconductors for high performance optoelectronic stimulation of cells

作     者：Aleksandr Markov Alexander Gerasimenko Annie-Kermen Boromangnaeva Sofia Shashova Elena Iusupovskaia Ulyana Kurilova Vita Nikitina Irina Suetina Marina Mezentseva Mikhail Savelyev Peter Timashev Dmitry Telyshev Xing-Jie Liang Aleksandr Markov;Alexander Gerasimenko;Annie-Kermen Boromangnaeva;Sofia Shashova;Elena lusupovskaia;Ulyana Kurilova;Vita Nikitina;Irina Suetina;Marina Mezentseva;Mikhail Savelyev;Peter Timashev;Dmitry Telyshev;Xing-Jie Liang

作者机构：Institute for Bionic Technologies and EngineeringI.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Institute of Biomedical SystemsNational Research University of Electronic TechnologyZelenogradMoscow 124498Russia Chemistry DepartmentLomonosov Moscow State UniversityLeninskie Gory1/3Moscow 119991Russia Ivanovsky Institute of VirologyN.F.Gamaleya National Center of Epidemiology and MicrobiologyMoscow 123098Russia World-Class Research Center“Digital Biodesign and Personalized Healthcare”I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Laboratory of Clinical Smart NanotechnologiesI.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Institute for Regenerative MedicineI.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2023年第16卷第4期

页      面：5809-5816页

核心收录：

学科分类：080903[工学-微电子学与固体电子学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：funded by the Ministry of Science and Higher Education of the Russian Federation(No.075-15-2021-596) 

主　　题：bioelectronics organic semiconductors wireless stimulation fibroblasts neuroblastoma cells 

摘      要：The efficiency of devices for bioelectronic applications,including cell and tissue stimulation,is heavily dependent on the scale and the performance *** miniaturization of stimulation electrodes,achieving a sufficiently high current pulse to elicit action potentials becomes an *** we report on our approach of vertically stacking organic p-n junctions to create highlyefficient multilayered organic semiconductor(MOS)photostimulation device.A tandem arrangement substantially increases the photovoltage and charge density without sacrificing lateral area,while not exceeding 200-500 nm of *** devices generate 4 times higher voltages and at least double the charge densities over single p-n junction devices,which allow using lower light intensities for *** devices show an outstanding stability in the electrolyte that is extremely important for forthcoming in vivo ***,we have validated MOS devices performance by photostimulating fibroblasts and neuroblasts,and found that using tandem devices leads to more effective action potential *** a result,we obtained up to 4 times enhanced effect in cell growth density using 3 p-n layered *** results corroborate the conclusion that MOS technology not only can achieve parity with state-of-the-art silicon devices,but also can exceed them in miniaturization and performance for biomedical applications.