检索结果-南通市图书馆

Science China(Life Sciences) 2013年第11期56卷 1063-1065页

作者： ZHAO LiXi PAN Hong WANG Jing CHENG Zhi CHENG LongFei WANG BinBin MA Xu Graduate School of Peking Union Medical College National research Institute for Family Planning world health organization collaborating centre for research in human reproduction

Development dysplasia of the hip （DDH） is one of the most common hip defects in newborns. The main phenotypes of the disease are partial or whole femoral head extrusion from the acetahulum [1]. Because the frequency of DDH in mon- ozygotic twins was higher than that in dizygotic twins, and the affected individuals were often in the same family [2], we are focusing on the genetic factor in the present study.

关键词：发育不良单核苷酸多态性髋关节人口女性中国基因遗传因素

EFFECTS OF CHANGES IN PATTERN OF LHRH PULSE ON LH SECRETION BY PERFUSED ANTERIOR PITUITARY CELLS OF MALE RATS

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 1991年第2期34卷 161-170页

作者：屈智超喻晶华郭景郭建 Sichuan Family Planning research Institute WHO Collaborating Centre for Research in Human Reproduction

In the present study, a perfusion system of dispersed cells was used to investigate theeffects of LHRH pulse amplitude and frequency, and LHRH continuous stimulation on LHsecretion by anterior pituitary cells of adult male rats. The results have shown that, in therange of LHRH concentrations from 1×10^(-10) to 1 ×10^(-6) mol/L, the dose-response curve of LHsecretion was linear. LHRH pulse frequency generated a biphasic LH response: increasingLHRH pulse frequency increased the basal LH secretion and decreased LH/pulse. When1 ×10^(-9), mol/L or greater LHRH was given at frequencies of 3 pulses/h or higher, it wasobserved that a maximal LH peak was induced and then the LH release declined progres-sively to its LH basal level, i.e. LHRH self-priming effect and LH desensitization occurred.Enhancement of amplitude of LHRH pulses could reduce pulse frequency required for prim-ing. Increases in frequency of LHRH pulses with high amplitude would provoke the prim-ing effect more quickly. In addition, continuous perfusion of LHRH with different con-centrations could also elicit the LHRH self-priming effect and LH desensitization. LHRHwith low concentration (1×10^(-10) mol/L) would take much longer to evoke a self-primingeffect. These results indicate that the LH secretion pattern is dependent on LHRH pulsatileamplitude and frequency, and will help to clarify the kinetics mechanisms by which LHpulses fluctuate in vivo.

关键词： LHRH pulses pituitary cells LH secretion

An association study of HFEgene mutation with idiopathic male infertility in the Chinese Han population

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第4期14卷 599-603页

作者： Xiao-Ying Yu Bin-Bin Wang Zhong-Cheng Xin Tao Liu Ke Ma Jian Jiang Xiang Fang Li-Hua Yu Yi-Feng Peng Xu Ma Institute of Reproductive Medicine Yijishan HospitalWannan Medical CollegeWuhu 241001China National research Institute for Family Planning Beijing 100081China peking Union Medical College Beijing 100081China Andrology Center Peking University First HospitalBeijing 100034China world health organization collaborating centre for research in human reproduction Beijing 100081China

Mutations in the haemochromatosis gene （HFE） influence iron status in the general population of Northern Europe, and excess iron is associated with the impairment of spermatogenesis. The aim of this study is to investigate the association between three mutations （C282Y, H63D and S65C） in the HFEgene with idiopathic male infertility in the Chinese Han population. Two groups of Chinese men were recruited： 444 infertile men （including 169 with idiopathic azoospermia） and 423 controls with proven fertility. The HFEgene was detected using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） technique. The experimental results demonstrated that no C282Y or $65C mutations were detected. Idiopathic male infertility was not significantly associated with heterozygous H63D mutation （odds ratio=O.801, 95% confidence interval=0.452-1.421, X2=0.577, P=0.448）. The H63D mutation frequency did not correlate significantly with the serum luteinizing hormone （LH）, follicle-stimulating hormone （FSH） and testosterone （T） levels in infertile men （P=0.896, P=0.404 and P=O.05, respectively）. Our data suggest that the HFEH63D mutation is not associated with idiopathic male reproductive dysfunction.

关键词： gene mutation gonadotropic hormone HFE male infertility

health Emergency and Disaster Risk Management (health-EDRM):Developing the research Field within the Sendai Framework Paradigm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2017年第2期8卷 145-149页

作者： Sharon Tsoon Ting Lo Emily Ying Yang Chan Gloria Kwong Wai Chan Virginia Murray Jonathan Abrahams Ali Ardalan Ryoma Kayano Johnny Chung Wai Yau collaborating centre for Oxford University and CUHK for Disaster and Medical humanitarian Response (CCOUC) The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford Franois-Xavier Bagnoud Center for health & human Rights Harvard University Public health England The United Nations International Strategy for Disaster Reduction (UNISDR) Scientific and Technical Advisory Group Integrated research on Disaster Risk (IRDR) Scientific Committee world health organization Tehran University of Medical Sciences world health organization Kobe centre for health Development Faculty of Medicine The Chinese University of Hong Kong

The intersection of health and disaster risk reduction(DRR) has emerged in recent years as a field of critical *** is recognized as an outcome and a goal of DRR,and the integration of both fields is essential to ensure the implementation of the Sendai Framework for Disaster Risk Reduction 2015–*** Emergency and Disaster Risk Management(health-EDRM) has emerged as an umbrella field that encompasses emergency and disaster medicine,DRR,humanitarian response,community health resilience,and health systems *** September 2016,an international group of experts met in Hong Kong to assess the current status and potential of the health-EDRM research field,a research area that these scholars characterized as underdeveloped and *** challenges identified include research overlap,lack ofstrategic research agenda,absence of consensus regarding terminology,and limited coordination between *** Sendai Framework provides a useful paradigm within which to shape the research field's strategic *** WHO Thematic Platform for health-EDRM research Group was established to coordinate activities,promote information-sharing,develop partnerships,and provide technical advice to strengthen the health-EDRM research *** group will promote the generation of robust and scientific health research to support the meaningful implementation of the Sendai Framework.

关键词： health disaster risk reduction health emergency and disaster risk management health-EDRM Sendai Framework

A randomized, controlled, multicenter contraceptive efficacy clinical trial of the intravas device, a nonocclusive surgical male sterilization

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第3期16卷 432-436页

作者： Wen-Hong Lu Xiao-Wei Liang Yi-Qun Gu Wei-Xiong Wu Li-Wei Bo Tian-Gui Zheng Zhen-Wen Chen Key Laboratory of Male Reproductive health National Health and Family Planning Commission National Research Institute for Family Planning and WHO Collaborating Centre for Research in Human Reproduction Beijing Institute for Family Planning of Guangzhou city Guangzhou Institute for Family Planning of Henan Province Zhengzhou Institute for Family Planning of Putian City Putian China.

Because of unavoidable complications of vasectomy, this study was undertaken to assess the efficacy and safety of male sterilization with a nonobstructive intravas device （IVD） implanted into the vas lumen by a mini-surgical method compared with no-scalpel vasectomy （NSV）. IVDs were categorized into two types： IVD-B has a tail used for fixing to the vas deferens （fixed wing） whereas IVD-A does not. A multicenter prospective randomized controlled clinical trial was conducted in China. The study was comprised of 1459 male volunteers seeking vasectomy who were randomly assigned to the IVD-A （n = 487）, IVD-B （n = 485） or NSV （n = 487） groups and underwent operation. Follow-up included visits at the 3rd-6TM and 12~ postoperative months, The assessments of the subjects involved regular physical examinations （including general and andrological examinations） and semen analysis. The subjects＇ partners also underwent monitoring for pregnancy by monthly interviews regarding menstruation and if necessary, urine tests, There were no significant differences in pregnancy rates （0.65% for IVD-A, 0 for IVD-B and 0.21% for NSV） among the three groups （P 〉 0.05）. The cumulative rates of complications at the 12th postoperative month were zero, 0.9% and 1.7% in the three groups, respectively. In conclusion, IVD male sterilization exhibits a low risk of long-term adverse events and was found to be effective as a male sterilization method, similar to the NSV technique. IVD male sterilization is expected to be a novel contraceptive method.

关键词： complication male sterilization nonobstructive intravas device no-scalpel vasectomy

Intracellular calcium ions facilitate dengue virus entry into endothelial cells and compromise endothelial barrier integrity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2021年第11期14卷 505-516页

作者： Meng-Hooi Shu Pooi-Fong Wong Sing-Sin Sam Shih-Keng Loong Boon-Teong Teoh Sazaly AbuBakar Tropical Infectious Diseases research and Education centre(TIDREC) Universiti Malaya50603 Kuala LumpurMalaysia Department of Pharmacology Faculty of MedicineUniversiti Malaya50603 Kuala LumpurMalaysia world health organization collaborating centre for Arbovirus Reference and research(Dengue and Severe Dengue)MAA-12 Universiti Malaya50603 Kuala LumpurMalaysia

Objective:To investigate the involvement of Ca^(2+)in dengue virus(DENV)-infected human umbilical vein endothelial cells(HUVECs)and the disruption of endothelial ***:HUVECs were infected with DENV-2 in the presence of intracellular Ca^(2+)or endoplasmic reticulum Ca^(2+)*** infectivity was measured by focus-forming assay and quantitative *** Ca^(2+)was measured using Fluo-4-AM ***-cadherin and focal adhesion kinase(FAK)expressions were investigated by immunofluorescence and immunoblotting assays,***:DENV infection increased intracellular cytosolic Ca^(2+)levels and caused disassembly of the adherens junction protein,VEcadherin as evidenced by decreased VE-cadherin expression at the periphery of DENV-2 infected *** of intracellular Ca^(2+)stores,particularly those of the endoplasmic reticulum Ca^(2+),significantly decreased DENV yield in *** virus yield following the depletion of intracellular Ca^(2+)was caused by the inhibition of viral entry into HUVECs and not the inhibition of viral binding or ***-2 infection also resulted in Ca^(2+)-dependent activation of ***:Intracellular Ca^(2+)is required for the early phases of DENV infection in endothelial *** cytosolic Ca^(2+)levels in endothelial cells during DENV infection activated FAK,disrupted adherens junctions and compromised barrier ***,Ca^(2+)plays an important role in DENV infection in endothelial cells.

关键词： Endothelial cells Calcium signalling Dengue virus Endothelium permeability Intracellular calcium

Prevalence of term low birth weight andits determinants in Shanghai, China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生殖医学杂志 2000年第S1期9卷 14-20页

作者：车焱郭友宁 lqbal Shah Shanghai Institute of Planned Parenthood research centre of Population Studies London School of Hygiene & TropicalMedicineUK Special Program of research Development and Research Training in Human ReproductionWorld Health Organization

Objective: To investigate the prevalence of term low birth weight (TLBW) and its risk factors. Methods: A follow-up study with 7, 872 couples was conducted from 1987 to 199o beginning from the time they got marriage licenses in two districts defined in Shanghai. They were interviewed in the third month and again in the fifteenth month and in the fifth to sixth year afterwards individually at home. The total follow up rate reached 98%. Couple’s background characteristics as well as the information on their general health. reproductivc history and contraceptive use etc.. were collected dynamically. All of the single live births with term delivery were Included for data analysis in this paper. Adjusted odd ratios and population attributable risk (PAR%) were computed. Results: The prevalence of TLBW in Shanghai single term live births was 2. 0% (134,/6.573), represents 54. 7% (134/245) of the total low birth weights in our sam pie. Significant social and behaviour risk factors relating with TI-BW were wife’s dissat- isfaction with marriage; low education level of husband; co-residence with parents during pregnancy; heavy housework done by the wife while being pregnant. Significant biomedical risky factors were menarche age greater than 16 years old; maternal age at delivery greater than 29 years old; maternal body mass index less than 19. 8; wife suf- fered from serious disease prior to conceiving; having pregnancy complication; gestational weight gain less than 20 % of pre-pregnancy weight; having abortion, stillbirth and fetal death history. Conclusion: *** constituted over half of all low birth weights in Shanghai. Special attention should be paid to the determinants mentioned above in TLBW intervention program. Improving couples’ economic and living condition and husband ’s education at tainment, and caloric supplementation with women while being pregnant would all be particularly effective in reducing the occurrence of TLBW in Shnaghai.

关键词： Term low birth weight Logistic regression Population attributable risk Determinant

An association study of HFE gene mutation with idiopathic male infertility in Chinese Han population

在线全文

学校读者我要写书评

暂无评论

An association study of HFE gene mutation with idiopathic ma...

health and Risks:Integrating health into Disaster Risk Reduction,Risk Communication,and Building Resilient Communities

中华医学会第六次全国生殖医学学术会议

作者： Yu XY Wang BB Xin ZC Liu T Ma K Jiang J Fang X Yu LH Peng YF Ma X Institute of Reproductive Medicine Yijishan HospitalWannan Medical College National research Institute for Family Planning Peking Union Medical College Andrology Center Peking University First Hospital world health organization collaborating centre for research in human reproduction

Hemochromatosis(HFE) mutations influence the iron status of the general population in Northern Europe,and excess iron is related with impairment of *** aim of this study is to investigate the association between three...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2017年第2期8卷 107-108页

作者： Emily Ying Yang Chan Peijun Shi collaborating centre for Oxford University and CUHK for Disaster and Medical humanitarian Response (CCOUC) The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong Kong world health organization (WHO) Thematic Platform for health Emergency and Disaster Risk Reduction Management(health-EDRM) research Group The Chinese University of Hong Kong State Key Laboratory of Earth Surface Processes and Resource Ecology/Academy of Disaster Reduction and Emergency Management Faculty of Geographical ScienceBeijing Normal University

In recent years,‘‘health’’has been recognized explicitly as both a determinant and an outcome of the human dimension of disaster risk reduction(DRR).Every disaster creates significant public health needs that can ... 详细信息

关键词： In DRR health and Risks:Integrating health into Disaster Risk Reduction,Risk Communication,and Building Resilient Communities

Amino Acid Biosynthesis and Proteolysis in <i>Lactobacillus Bulgaricus</i>Revisited: A Genomic Comparison

在线全文

学校读者我要写书评

暂无评论

Computational Molecular Bioscience 2012年第3期2卷 61-77页

作者： Enuo Liu Pei Hao Tomonobu Konno Yao Yu Munehiro Oda Huajun Zheng Zai-Si Ji Chinese National human Genome Center at Shanghai Shanghai China Division of research and Development Meiji Co. Ltd Odawara Kanagawa Japan Graduate School of Bioresource Sciences Nihon University Fujisawa Kanagawa Japan Shanghai Institutes for Biological Science Chinese Academy of Sciences Shanghai China WHO collaborating centre for research in human reproduction Shanghai China

The amino acid biosynthesis and proteolytic system of Lactobacillus bulgaricus (*** ) is important for its growth in niche-specific environments, as well as for flavour formation in the food industry. Comparative analyses of 4 completed sequences of the *** strain genome on a genomic scale revealed that genes involved in amino acids synthesis were undergoing reductive evolution. However, the selected industrial strains, namely, *** 2038 and *** ND02, retained more complete genes in the amino acid synthesis and proteolytic system category than the laboratory strains, and have some unique genes and pathways for obtaining amino acids that enable these bacteria to adapt to their various environmental niches.

关键词： Amino Acid Biosynthesis Proteolysis L.Bulgaricus