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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Ph.siological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： h.eonseok Kim Bruno Rigo Gabriella Wong Yoon Jae Lee Woon‑h.ng Yeo IEN Center for Wearable Intelligent Systems and h.alth.are Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff Sch.ol of Mech.nical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Sch.ol of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace h.coulter department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker h.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

Th.s review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous ph.siological signal monitoring,focusing on advancing h.man h.alth.*** considerations,such.as biological constraints,energy sourcing,and wireless communication,are discussed in ach.eving th. desired performance of th. devices and enh.nced interface with.h.man *** addition,we review th. recent ach.evements in materials used for developing implantable systems,emph.sizing th.ir importance in ach.eving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to th. body,enabling portable h.alth.monitoring and advanced disease ***,we summarize th. most recent practical applications of advanced implantable devices for h.man h.alth.care,h.gh.igh.ing th.ir potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Ph.siological signal monitoring

Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine

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Nano-Micro Letters 2024年第10期16卷 576-617页

作者： Leyan Xuan Yingying h.u Lu Liang Jialin Wu Kai Fan Liming Lian Jianh.a Qiu Yingling Miao h.ssein Ravanbakh.h.Mingen Xu Guosh.ng Tang Guangzh.u Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Ph.rmacology the NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436People's Republic of China Sch.ol of Automation Hangzhou Dianzi UniversityHangzhou 310018People's Republic of China department of Biomedical Engineering The University of AkronAkronOH 44325USA Wallace h.coulter department of Biomedical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Microgels prepared from natural or synth.tic h.drogel materials h.ve aroused extensive attention as multifunctional cells or drug carriers,th.t are promising for tissue engineering and regenerative *** can also be aggregated into microporous scaffolds,promoting cell infiltration and proliferation for tissue *** review gives an overview of recent developments in th. fabrication tech.iques and applications of microgels.A series of conventional and novel strategies including emulsification,microfluidic,lith.graph.,electrospray,centrifugation,gas-sh.aring,th.ee-dimensional bioprinting,*** discussed in *** ch.racteristics and applications of microgels and microgel-based scaffolds for cell culture and delivery are elaborated with.an emph.sis on th. advantages of th.se carriers in cell ***,we expound on th. ongoing and foreseeable applications and current limitations of microgels and th.ir aggregate in th. field of biomedical *** stimulating innovative ideas,th. present review paves new avenues for expanding th. application of microgels in cell delivery tech.iques.

关键词： Microgels Cell delivery Scaffolds 3D bioprinting Single-cell microgels

Reinforcement Learning in Process Industries:Review and Perspective

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 283-300页

作者： Oguzh.n Dogru Junyao Xie Om Prakash.Ranjith.Ch.plunkar Jansen Soesanto h.ngtian Ch.n Kirubakaran Velswamy Fadi Ibrah.m Biao h.ang department of Ch.mical and Materials Engineering University of AlbertaEdmontonT6G 1H9Canada IEEE

Th.s survey paper provides a review and perspective on intermediate and advanced reinforcement learning(RL)tech.iques in process industries. It offers a h.listic approach.by covering all levels of th. process control h.erarch.. Th. survey paper presents a compreh.nsive overview of RL algorith.s,including fundamental concepts like Markov decision processes and different approach.s to RL, such.as value-based, policy-based, and actor-critic meth.ds, wh.le also discussing th. relationsh.p between classical control and RL. It furth.r reviews th. wide-ranging applications of RL in process industries, such.as soft sensors, low-level control, h.gh.level control, distributed process control, fault detection and fault tolerant control, optimization,planning, sch.duling, and supply ch.in. Th. survey paper discusses th. limitations and advantages, trends and new applications, and opportunities and future prospects for RL in process industries. Moreover, it h.gh.igh.s th. need for a h.listic approach.in complex systems due to th. growing importance of digitalization in th. process industries.

关键词： Process control process systems engineering reinforcement learning

Layered Potassium Titanium Niobate/Reduced Graph.ne Oxide Nanocomposite as a Potassium‑Ion Battery Anode

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Nano-Micro Letters 2024年第1期16卷 1-16页

作者： Ch.rlie A.F.Nason Ajay Piriya Vijaya Kumar Saroja Yi Lu Runzh. Wei Yupei h.n Yang Xu department of Ch.mistry University College London20 Gordon StreetLondon WC1H 0AJUK

With.graph.te currently leading as th. most viable anode for potassium-ion batteries(KIBs),oth.r materials h.ve been left relatively *** metal oxides are among th.se,with.many positive attributes such.as synth.tic maturity,longterm cycling stability and fast redox ***,to address th.s research.deficiency we report h.rein a layered potassium titanium niobate KTiNbO5(KTNO)and its rGO nanocomposite(KTNO/rGO)synth.sised via solvoth.rmal meth.ds as a h.gh.performance anode for *** effective distribution across th. electrically conductive rGO,th. electroch.mical performance of th. KTNO nanoparticles was *** potassium storage performance of th. KTNO/rGO was demonstrated by its first ch.rge capacity of 128.1 mAh.g^(−1) and reversible capacity of 97.5 mAh.g^(−1) after 500 cycles at 20 mA g^(−1),retaining 76.1%of th. initial capacity,with.an exceptional rate performance of 54.2 mAh.g^(−1)at 1 A g^(−1).Furth.rmore,to investigate th. attributes of KTNO in-situ XRD was performed,indicating a low-strain ***-situ X-ray ph.toelectron spectra furth.r investigated th. mech.nism of ch.rge storage,with.th. titanium sh.wing greater redox reversibility th.n th. *** work suggests th.s lowstrain nature is a h.gh.y advantageous property and well worth.regarding KTNO as a promising anode for future h.gh.performance KIBs.

关键词： Potassium-ion batteries Intercalation Transition metal oxides Anodes Nanocomposite

Ultrath.n Zincoph.lic Interph.se Regulated Electric Double Layer Enabling h.gh.y Stable Aqueous Zinc‑Ion Batteries

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Nano-Micro Letters 2024年第5期16卷 285-299页

作者： Yimei Ch.n Zh.ping Deng Yongxiang Sun Yue Li h.o Zh.ng Ge Li h.ngbo Zeng Xiaolei Wang department of Ch.mical and Materials Engineering University of Alberta9211‑116 Street NWEdmontonAB T6G 1H9Canada department of Mech.nical Engineering University of Alberta9211‑116 Street NWEdmontonAB T6G 1H9Canada

Th. practical application of aqueous zinc-ion batteries for large-grid scale systems is still h.ndered by uncontrolled zinc dendrite and side *** th. elec-trical double layer via th. electrode/electrolyte interface layer is an effective strategy to improve th. stability of Zn ***,we report an ultrath.n zincoph.lic ZnS layer as a model *** a given cycling current,th. cell with.Zn@ZnS electrode displays a lower potential drop over th. h.lmh.ltz layer(stern layer)and a suppressed diffuse layer,indicating th. regulated ch.rge distribution and decreased electric double layer repulsion *** zinc adsorption sites are also expected as proved by th. enh.nced electric double-layer ***,th. symmetric cell with.th. ZnS protection layer can stably cycle for around 3,000 h.at 1 mA cm^(-2) with.a lower overpotential of 25 *** coupled with.an I2/AC cath.de,th. cell demonstrates a h.gh.rate performance of 160 mAh.g^(-1) at 0.1 A g^(-1) and long cycling stability of over 10,000 cycles at 10 A g^(-1).Th. Zn||MnO_(2) also sustains both.h.gh.capacity and long cycling stability of 130 mAh.g^(-1) after 1,200 cycles at 0.5 A g^(-1).

关键词： Zinc anode Electric double-layer regulation Multifunction SEI layer Inh.bited side reactions and dendrite Rapid kinetics

Controlled deployment of a long teth.r to operate as a partial space elevator

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Astrodynamics 2024年第2期8卷 311-321页

作者： Jinbang h.ang Arun K.Misra department of Mech.nical Engineering McGill UniversityMontrealQCH3A 0C3Canada

Th. deployment of a long teth.r to operate as a partial space elevator,starting from a nucleus in geostationary orbit,is *** deployment is an inh.rently unstable process because th. center of orbit gradually decreases from th. geostationary altitude wh.n deployment *** is also observed th.t th. elasticity of th. teth.r h.s an important effect on deployment *** is sh.wn th.t th. application of a transverse force on th. main spacecraft,determined by using linear state feedback and appropriate gains,can stabilize th. *** LQR controller is *** of th. dynamics of th. system are carried out using th.s controller for various parametric values of teth.r elasticity,deployment rates,etc.,to evaluate th. efficacy of th. controller.

关键词： teth.r space elevator deployment stability control

C19MC miRNA-520G induces SP100 antiviral gene transcription and inh.bits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh.Marian T.Smallin Nino Mtch.dlidze Ish. Godwin Marco Napoli Nicole h.ckel Manali S.Ph.dke Avani A.Desh.ande Xiaobo Li Joh. h.Lockh.rt Jaden R.Baldwin Sueh.lay Acevedo-Acevedo Yifeng Gao Mich.lle A.Reiser Keiran S.M.Smalley Elsa R.Flores Andrew S.Broh. department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveeth. Medical College ChennaiTamil Nadu 602105India Tumor Biology department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sarcoma department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antiviral protein th.t restricts th. productive stage of h.man papillomavirus(h.V)and multiple oth.r viruses,and viruses in turn block sUMO-1-mediated stabilization of SP100 and promotes its degradation(Table S1).Interferon(IFN)signaling could still produce more SP100 th.ough.transcription to counteract viruses.1 Viruses also disable th. transcriptional up-regulation of SP100 to ach.eve persistent infection in h.sts.

关键词： SP100 melanoma stabilization

Artificial ground freezing of underground mines in cold regions using th.rmosyph.ns with.air insulation

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International Journal of Mining Science and Tech.ology 2024年第5期34卷 643-654页

作者： Ah.ad F.Zueter Moh.mmad Zolfagh.rrosh.n Navid Bah.ani Agus P.Sasmito department of Civil and Resource Engineering Dalhousie UniversityHalifax B3H4R2Canada department of Mining Engineering McGill UniversityMontreal H3A0E8Canada

Current practice of underground artificial ground freezing(AGF)typically involves h.ge refrigeration systems of large economic and environmental *** th.s study,a novel AGF tech.ique is proposed deploying available cold wind in cold *** is ach.eved by a static h.at transfer device called th.rmosyph.n equipped with.an air insulation layer.A refrigeration unit can be optionally integrated to meet additional cooling *** introduction of air insulation isolates th. th.rmosyph.n from ground zones wh.re freezing is not needed,resulting in:(1)steering th. cooling resources(cold wind or refrigeration)towards zones of interest;and(2)minimizing refrigeration *** design is demonstrated using well-validated math.matical models from our previous work based on two-ph.se enth.lpy meth.d of th. ground coupled with.a th.rmal resistance network for th. *** Canadian mines are considered:th. Cigar Lake Mine and th. Giant *** results sh.w th.t our proposed design can speed th. freezing time by 30%at th. Giant Mine and by two month. at th. Cigar Lake ***,a cooling load of 2.4 GWh.can be saved at th. Cigar Lake ***,th.s study provides mining practitioners with.sustainable solutions of underground AGF.

关键词： Artificial ground freezing Underground mining Sustainable mining Th.rmosyph.n Air insulation Cold regions

Ultra-h.gh.spatio-temporal resolution imaging with.parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Ligh.(Science & Applications) 2024年第6期13卷 1140-1158页

作者： Xinzh. Xu Wenyi Wang Liang Qiao Yunzh. Fu Xich.an Ge Kun Zh.o Karl Zh.ngh.o Meiling Guan Xin Ch.n Meiqi Li Dayong Jin Peng Xi department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace h.coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Tech.ologies Co. Ltd.Beijing100086China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China Sch.ol of Life Science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)h.s emerged as a promising super-resolution fluorescence imaging tech.ique,offering diverse configurations and computational strategies to mitigate ph.totoxicity during real-time imaging of biological *** efforts to enh.nce system frame rates h.ve concentrated on processing algorith.s,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with.accelerated row readout *** th.s article,we introduce an approach.to elevate SIM frame rates and region of interest(ROI)coverage at th. h.rdware level,with.ut necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)ach.eves th. h.gh.st imaging speed for fluorescence imaging at currently available detector *** using th. full frame-width.of th. detector th.ough.synch.onizing th. pattern generation and image exposure-readout process,we h.ve ach.eved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold th.t of th. latest tech.iques,with.th. lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-sh.rt exposure ***,mitoch.ndrial dynamic tubulation and ongoing membrane fusion processes h.ve been captured in live COS-7 cell,recorded with.PAR-SIM at an impressive 408 *** posit th.t th.s novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also h.lds th. potential to benefit oth.r complex imaging systems with.a strategic controlling approach.

关键词： h.rdware illumination resolution