On-chip physiological mimicry of neurovascular unit: challenges and perspectives

作     者：Song Ih Ahn YongTae Kim Song Ih Ahn;YongTae Kim

作者机构：School of Mechanical EngineeringPusan National UniversityBusanSouth Korea George W.Woodruff School of Mechanical EngineeringGeorgia Institute of TechnologyAtlantaGAUSA Parker H.Petit Institute for Bioengineering and BioscienceGeorgia Institute of TechnologyAtlantaGAUSA Wallace H.Coulter Department of Biomedical EngineeringGeorgia Institute of TechnologyAtlantaGAUSA Institute for Electronics and NanotechnologyGeorgia Institute of TechnologyAtlantaGAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第3期

页      面：499-500页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by a 2-Year Research Grant of Pusan National University(to SIA) 

主　　题：diseases death arteries 

摘      要：Neurological disorders including neurodegenerative diseases,brain tumors,and stroke are the second leading cause of death and the greatest cause of disability ***,it remains challenging to achieve effective drug delivery to the central nervous system for treatments of neurological diseases due to the blood-brain barrier(BBB).The function of the BBB is regulated by the physiological interactions between various types of cells in the neurovascular unit(NVU).In the NVU,the brain vasculature of the BBB is surrounded by brain pericytes,brain astrocytes,neurons,and microglia(Figure 1).Moreover,the NVU at the levels of arteries and veins includes contractile smooth muscle cells(Schaeffer and Iadecola,2021).