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Aptamer-functionalized nanoplatforms overcoming temozolomide resistance in synergistic chemo/photothermal therapy through alleviating tumor hypoxia

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Nano Research 2023年第7期16卷 9859-9872页

作者： Yun Zeng Linfei Zhao Ke Li Jingwen Ma Dan Chen Changhu Liu Wenhua Zhan Yonghua Zhan School of Life Science and Technology Xidian University and Engineering Research Center of Molecular and Neuro ImagingMinistry of EducationXi’an 710126China Department of Radiation Oncology General Hospital of Ningxia Medical UniversityYinchuan 750004China International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and treatment and Xi’an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life Information School of Life Science and TechnologyXidian UniversityXi’an 710126China Xi’an Key Laboratory for prevention and treatment of Common Aging Diseases Translational and Research Centre for Prevention and Therapy of Chronic DiseaseInstitute of Basic and Translational MedicineXi’an Medical UniversityXi’an 710021China Radiology Department CT and MRI RoomNinth Hospital of Xi’anXi’an 710054China

Tumor hypoxia is intimately associated with gliomas,which represents a significant threat to human health and are resistant to the first-line chemotherapeutic drug temozolomide(TMZ)due to *** this work,to overcome TMZ resistance in orthotopic gliomas,aptamer-functionalized liposomes are manufactured to encapsulate TMZ and photothermal agent IR780,and can cross the blood-brain barrier and actively target *** is possible to employ liposomes for both fluorescence and photoacoustic imaging simultaneously due to their stability and excellent photothermal conversion *** chemo/photothermal synergistic therapeutic effect of liposomes on gliomas is demonstrated by their abilities to target orthotopic gliomas,alleviate tumor hypoxia and consequently reverse resistance of glioma cells to TMZ,thereby extending the survival time of tumor-bearing mice,making the nanoplatforms and their synergistic chemo/photothermal therapy as a potential clinical treatment for gliomas.

关键词： aptamers blood-brain barrier gliomas liposomes photothermal therapy

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Highly active antiretroviral therapy per se decreased mortality and morbidity of advanced human immunodeficiency virus disease in Hong Kong

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Chinese Medical Journal 2005年第16期118卷 1338-1345页

作者： CHAN Chi-wai CHENG Lai-sim CHAN Wai-kit WONG Ka-hing Integrated treatment centre Department of Health Hong Kong China

Background Morbidity and mortality of advanced human immunodeficiency virus infection （HIV） have declined in Western industrialized countries since the availability of highly active antiretroviral therapy （HAART）. It is unclear if this has also happened in Hong Kong. Methods We studied a retrospective cohort of patients with advanced HIV disease in Hong Kong, China. First, the mortality of advanced HIV disease per year was calculated for the decade 1993 to 2002, both annually and according to patient observation before and after 1997. Second, the event rates were estimated for the clinical end points of acquired immune deficiency syndrome （AIDS） and death. Univariate and multivariate analyses were then performed to identify associated factors. Results The crude mortality of advanced HIV disease declined from 10. 8 - 30. 4 per 100 patients during 1993 - 1996, to 0. 8 - 6. 9 per 100 patients during 1997 - 2002. A rate ratio of 4. 04 （95% CI, 2. 52 - 6. 47） was evident for those observed in 1993 - 1996, compared to those in 1997 - 2002. In a multivariate analysis where calendar period was adjusted, use of＇highly active antiretroviral therapy was associated with rate ratios of 0. 13 （95% CI, 0. 05 -0. 33） for death after AIDS, 0. 08 （95% CI, 0. 04 -0. 19） for AIDS after a CD4 cell count 〈200/μ1, and 0.21 （95% CI, 0.07 -0.67） for death after CD4 cell count 〈200/μl. In the same analysis, calendar period ceased to be a significant factor after adjustment for use of HAART. Conclusions The mortality and morbidity of advanced human immunodeficiency virus disease have declined in Hong Kong. This improved prognosis was attributable to the use of highly active antiretroviral therapy.

关键词： highly active antiretroviral therapy mortality· morbidity acquired immunodeficiency syndrome

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The pathology,phylogeny,and epidemiology of Echinococcus ortleppi(G5 genotype):a new case report of echinococcosis in China

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Infectious Diseases of Poverty 2021年第6期10卷 108-108页

作者： Xu Wang Aiya Zhu Hongying Cai Baixue Liu Gang Xie Rui Jiang Ji Zhang Nanzi Xie Yayi Guan Robert Bergquist Zhenghuan Wang Yang Li Weiping Wu National Institute of Parasitic Diseases Chinese Center for Diseases Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Guizhou Center for Disease Control and prevention GuiyangGuizhouChina 不详

Background:Cystic echinococcosis(CE),caused by the larval stage of the complex Echinococcus granulosus sensu lato(s.l.),is a zoonotic parasitic disease with a high social burden in *** is a species(formerly genotype 5 of *** s.l.)with unique epidemic areas(tropical areas),transmission patterns(mainly cattle origin),and pathological characteristics(large and small hook lengths)compared to other species that cause CE.A 19-year-old female patient in an area with no history of echinococcosis in Guizhou Province,China,was diagnosed with *** infection in *** study is to understand the source of this human *** ***:We performed computer tomography(CT)scans,surgical operation,morphological sectioning,molecular diagnosis,phylogenetic analyses,and epidemiological investigation in Anshun City,Guizhou Province,China in ***:The patient presented with intermittent distension and pain in the upper abdomen without other abnormal *** blood examination results were ***,abdominal CT revealed a fertile cyst with a diameter of approximately 8 cm,uniform density,and a clear boundary,but without an evident cyst wall in the right lobe of the *** cyst was fertile,and phylogenetic analyses revealed that the isolates represented a new *** genus haplotype.A result of 10‒14 years incubation period with indigenous infection was considered available for the case through the epidemiological ***:CE due to *** infection can be confused with other diseases causing liver cysts,resulting in misdiagnosis.A transmission chain of *** may exist or existed in the past in the previously considered nonendemic areas of echinococcosis in southwestern China.

关键词： Cystic echinococcosis(CE) Echinococcus ortleppi human Non-endemic area China

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Pharmacological and immunological effects of praziquantel against Schistosoma japonicum:a scoping review of experimental studies

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Infectious Diseases of Poverty 2018年第1期7卷 98-112页

作者： Shu-Hua Xiao Jun Sun Ming-Gang Chen National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthWHO Collaborating Centre for Tropical DiseasesShanghai 200025People’s Republic of China Institute for Infectious Disease and Vaccine Development Tongji University School of MedicineShanghai 200092People’s Republic of China

Background:Chemotherapy for schistosomiasis has been around for 100 *** the past century,great efforts have been made to develop new antischistosomal drugs from antimonials to nonantimonials,and some of these have been used extensively in clinical *** the exception of a few drugs,such as oxamniquine and metrifonate,most of the antischistosomals developed in the pre-praziquantel period have variable limitations with respect to safety and *** oxamniquine and metrifonate have been used for schistosomiasis control,they are only effective against Schistosoma mansoni and ***,***,praziquantel is the only drug used for treatment of all five species of human *** this review,the pharmacological and immunological effects of praziquantel against *** are summarized and *** text:From the end of the 1970s until the 2000s,scientists have conducted a series of experimental studies on the effects of praziquantel against *** have included examining its unique pharmacological action on schistosomes,the characteristics in susceptibility of the different developmental stages of schistosomes to the drug,the relationship between plasma concentration of the drug and efficacy,the impact of host factors on cidal action of the drug,prevention and early treatment of schistosomal infection,as well as praziquantel-resistant ***:The effects of praziquantel against ***,as elucidated by the experimental studies that are reviewed in this paper,may have some reference significance for the development of new antischistosomals.

关键词： Praziquantel Pharmacological action Immunological action Schistosoma japonicum Experimental study Review

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Unmanned aerial vehicles:potential tools for use in zoonosis control

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Infectious Diseases of Poverty 2018年第1期7卷 480-485页

作者： Qing Yu Hui Liu Ning Xiao National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyNational Health Comission of China207 Ruijin Er RoadShanghai 200025China Jinan Center for Disease Control and prevention Jinan 250021ShandongChina

Unmanned aerial vehicles(UAVs)have become useful tools to extend human abilities and *** UAVs are being used for the surveillance of environmental factors related to the transmission of infectious *** have also been used for delivering therapeutic drugs and life-saving supplies to patients or isolated persons in extreme *** have been very few applications of UAVs for disease surveillance,control and prevention to ***,we foresee many uses for these machines in the fight against zoonotic *** control of zoonoses has been a big challenge as these diseases are naturally maintained in animal *** 868 reported zoonoses,echinococcosis(hydatid disease)is one of the most severe public health problems and listed as one of 17 neglected tropical diseases targeted for control by the World Health *** dogs(domestic or stray)play the most important role as definitive hosts in maintaining the transmission of ***,the actual contribution of wild canines to transmission has received little attention as yet,but should certainly not be *** paper summarizes the history of development and application of UAVs,with an emphasis on their potential use for zoonosis *** an example,we outline a pilot trial of echinococcosis control in the Qinghai-Tibet Plateau region,in which UAVs were used to deliver baits with praziquantel for wildlife *** data suggested that this is a cost-effective and efficient approach to the control of zoonotic diseases transmitted among wild animal populations.

关键词： Control echinococcosis Public health Unmanned aerial vehicles Wild animal Zoonosis

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Development of an educational cartoon to prevent worm infections in Chinese schoolchildren

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Infectious Diseases of Poverty 2013年第1期2卷 240-248页

作者： Franziska A Bieri Li-Ping Yuan Yue-Sheng Li Yong-Kang He Andrew Bedford Robert S Li Feng-Ying Guo Sheng-Ming Li Gail M Williams Donald P McManus Giovanna Raso Darren J Gray QIMR Berghofer Medical Research Institute HerstonBrisbaneQueenslandAustralia The School of Population Health The University of QueenslandBrisbaneQueenslandAustralia Hunan Institute of Parasitic Diseases WHO Collaborating Centre for Research and Control on Schistosomiasis in Lake RegionYueyangPeople’s Republic of China Andrew Bedford Creative Services BrisbaneAustralia Swiss Tropical and Public Health Institute BaselSwitzerland centre Suisse de Recherches Scientifiques en Côte d’Ivoire AbidjanCôte d’Ivoire

Background:With more than two billion people infected worldwide,soil-transmitted helminths(STH)are the most widespread *** date,STH control efforts rely predominantly on recurrent mass drug administration(MDA),which does not prevent *** public health measures including novel health educational tools are required for more sustained integrated control of *** describe the development of an educational cartoon video(The Magic Glasses)targeting STH infections in Chinese schoolchildren and its pilot testing in *** applied an extensive community-based mixed methods approach involving input from the target group of 9–10 year old schoolchildren and key informants,such as teachers,doctors and parents,in order to identify potential STH infection risks in the study area and to formulate key messages for the *** development of the educational cartoon included three major steps:formative research,production,and pilot testing and ***:We found that most adults and approximately 50%of the schoolchildren were aware of roundworm(Ascaris)infection,but knowledge of transmission,prevention and treatment of STH was *** in the study area showed that unhygienic food practices,such as eating raw and unwashed fruit or playing in vegetable gardens previously fertilised with human faeces,posed major STH infection ***:It was crucial to assess the intellectual,emotional,social and cultural background of the target population prior to video production in order to integrate the key messages of the cartoon into everyday ***,our strategy for the development of the cartoon and its incorporation into a health education package proved successful,and we provide a summary of recommendations for the development of future educational videos based on our experiences in China.

关键词： Soil-transmitted helminths Neglected tropical diseases Health promotion Video-based health education package Development of educational cartoon Integrated control Formative research Pilot testing Sustainable control of soil-transmitted helminths

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Development of novel-nanobody-based lateral-flow immunochromatographic strip test for rapid detection of recombinant human interferon a2b

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Journal of Pharmaceutical Analysis 2022年第2期12卷 308-316页

作者： Xi Qin Maoqin Duan Dening Pei Jian Lin Lan Wang Peng Zhou Wenrong Yao Ying Guo Xiang Li Lei Tao Youxue Ding Lan Liu Yong Zhou Chuncui Jia Chunming Rao Junzhi Wang National Institutes for Food and Drug Control Beijing100050China Synthetic and Functional Biomolecules Center Peking UniversityBeijing100871China who Collaboration centre for Biologicals Standardization and Evaluation Beijing100050China

Recombinant human interferon a2b(rhIFNa2b)is widely used as an antiviral therapy agent for the treatment of hepatitis B and hepatitis *** current identification test for rhIFNa2b is *** this study,an anti-rhIFNa2b nanobody was discovered and used for the development of a rapid lateral flow strip for the identification of ***2b was used to immunize an alpaca,which established a phage nanobody *** five steps of enrichment,the nanobody I22,which specifically bound rhIFNa2b,was isolated and inserted into the prokaryotic expression vector *** subsequent purification,the physicochemical properties of the nanobody were determined.A semiquantitative detection and rapid identification assay of rhIFNa2b was developed using this novel *** develop a rapid test,the nanobody I22 was coupled with a colloidal gold to produce lateral-flow test *** developed rhIFNa2b detection assay had a limit of detection of 1 mg/*** isolation of I22 and successful construction of a lateral-flow immunochromatographic test strip demonstrated the feasibility of performing ligand-binding assays on a lateral-flow test strip using recombinant protein *** principle of this novel assay is generally applicable for the rapid testing of other commercial products,with a great potential for routine use in detecting counterfeit recombinant protein products.

关键词： Recombinant human interferon a2b Nanobody Phage display Screening Rapid test

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Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania

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Infectious Diseases of Poverty 2018年第1期7卷 486-491页

作者： Qin Liu Xiao-Ling Chen Mu-Xin Chen Han-Guo Xie Qing Liu Zhu-Yun Chen Yao-Ying Lin Hua Zheng Jia-Xu Chen Yi Zhang Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025China Fujian Medical University Union Hospital FuzhouFujian 350001People’s Republic of China Fujian Provincial Center for Diseases Control and prevention FuzhouFujian 350000People’s Republic of China

Background:human African trypanosomiasis(HAT)is one of the most complex parasitic diseases known to *** usually occurs in endemic areas in Africa,but is occasionally detected in returning travelers and migrants in non-endemic *** presentation:In August 2017,a case of HAT was diagnosed in China in a traveler returning from the Masai Mara area in Kenya and the Serengeti area in *** traveler visited Africa from 23 July to 5 August,*** return to China,she developed a fever(on 8 August),and Trypanosoma brucei rhodesiense infection was confirmed by laboratory tests(on 14 August)including observation of parasites in blood films and by polymerase chain *** was treated with pentamidine followed by suramin,and recovered 1 month ***:This is the first imported rhodesiense HAT case reported in *** case alerts clinical and public health workers to be aware of HAT in travelers,and expatriates and migrants who have visited at-risk areas in Africa.

关键词： Trypanosoma brucei rhodesiense human African trypanosomiasis Imported infection China treatment Suramin Tanzania

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Presence and role of stem cells in ovarian cancer

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World Journal of Stem Cells 2019年第7期11卷 383-397页

作者： Natasa Kenda Suster Irma Virant-Klun Department of Gynecology Division of Obstetrics and GynecologyUniversity Medical Centre LjubljanaLjubljana 1000Slovenia Department of human Reproduction Division of Obstetrics and GynecologyUniversity Medical Centre LjubljanaLjubljana 1000Slovenia

Ovarian cancer is the deadliest gynecological *** is typically diagnosed at advanced stages of the disease,with metastatic sites disseminated widely within the abdominal *** cancer treatment is challenging due to high disease recurrence and further complicated pursuant to acquired *** stem cell(CSC)theory proposes that both tumor development and progression are driven by undifferentiated stem cells capable of self-renewal and *** most recent evidence revealed that CSCs in terms of ovarian cancer are not only responsible for primary tumor growth,metastasis and relapse of disease,but also for the development of *** the elimination of this cell population is critical for increasing treatment success,a deeper understanding of ovarian CSCs pathobiology,including epithelial-mesenchymal transition,signaling pathways and tumor microenvironment,is ***,before introducing new therapeutic agents for ovarian cancer,targeting CSCs,accurate identification of different ovarian stem cell subpopulations,including the very small embryoniclike stem cells suggested as progenitors,is *** these ends,reliable markers of ovarian CSCs should be *** this review,we present the current knowledge and a critical discussion concerning ovarian CSCs and their clinical role.

关键词： Ovarian cancer Cancer stem cells Very small embryonic-like stem cells Epithelial-mesenchymal transition

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Activation of Anti-tumor Immune Response by Ablation of HCC with Nanosecond Pulsed Electric Field

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Journal of Clinical and Translational Hepatology 2018年第1期6卷 85-88页

作者： Xiaobo Xu Yiling Chen Ruiqing Zhang Xudong Miao Xinhua Che Collaborative Innovation Center for Diagnosis treatment of Infectious Diseases Key Laboratory of Combined Multi-organ TransplantationMinistry of Public HealthDepartment of Hepatobiliary and Pancreatic SurgeryFirst Affiliated HospitalZhejiang UniversityHangzhouZhejiangChina Department of Anatomy Tianjin Medical UniversityTianjinChina Hepatobiliary&Hydatid Department Digestive and Vascular Surgery CentreXinjiang Key Laboratory of EchinococcosisFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Orthopedics Second Affiliated HospitalZhejiang UniversityHangzhouZhejiangChina

Locoregional therapy is playing an increasingly important role in the non-surgical management of hepatocellular carcinoma(HCC).The novel technique of non-thermal electric ablation by nanosecond pulsed electric field has been recognized as a potential locoregional methodology for indicated *** manuscript explores the most recent studies to indicate its unique anti-tumor immune *** possible immune mechanism,termed as nano-pulse stimulation,was also analyzed.

关键词： Locoregional therapy Hepatocellular carcinoma(HCC) Nanosecond pulsed electric field(nsPEF) Nano-pulse stimulation(NPS)

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