Aptamer-functionalized nanoplatforms overcoming temozolomide resistance in synergistic chemo/photothermal therapy through alleviating tumor hypoxia
作者机构：School of Life Science and TechnologyXidian University and Engineering Research Center of Molecular and Neuro ImagingMinistry of EducationXi’an 710126China Department of Radiation OncologyGeneral Hospital of Ningxia Medical UniversityYinchuan 750004China International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment and Xi’an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life InformationSchool of Life Science and TechnologyXidian UniversityXi’an 710126China Xi’an Key Laboratory for Prevention and Treatment of Common Aging DiseasesTranslational and Research Centre for Prevention and Therapy of Chronic DiseaseInstitute of Basic and Translational MedicineXi’an Medical UniversityXi’an 710021China Radiology DepartmentCT and MRI RoomNinth Hospital of Xi’anXi’an 710054China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第7期
页 面：9859-9872页
核心收录：
学科分类：1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学]
基 金：This work was supported,in part,by the National Natural Science Foundation of China(Nos.32171173,32001074,and 82260473) the Key Research and Development Program in Ningxia Province of China(No.2022BEG03080) the Natural Science Basic Research Plan in Ningxia Province of China(No.2022AAC03522) the Health Commission of Ningxia Hui Autonomous Region Science and Technology Support Project for Quality Development of Medical Institutions(No.2023-NWKYT-019) the State Key Laboratory Grant of Space Medicine Fundamentals and Application(No.SMFA20A02) the Natural Science Basic Research Key Program of Shaanxi Province(No.2023-JC-ZD-53) the Natural Science Basic Research Plan in Shaanxi Province of China(No.2022JQ-201) the Fundamental Research Funds for the Central Universities(Nos.ZYTS23190 and xzy012022134) the Beijing Xisike Clinical Oncology Research Foundation
主 题：aptamers blood-brain barrier gliomas liposomes photothermal therapy
摘 要：Tumor hypoxia is intimately associated with gliomas,which represents a significant threat to human health and are resistant to the first-line chemotherapeutic drug temozolomide(TMZ)due to *** this work,to overcome TMZ resistance in orthotopic gliomas,aptamer-functionalized liposomes are manufactured to encapsulate TMZ and photothermal agent IR780,and can cross the blood-brain barrier and actively target *** is possible to employ liposomes for both fluorescence and photoacoustic imaging simultaneously due to their stability and excellent photothermal conversion *** chemo/photothermal synergistic therapeutic effect of liposomes on gliomas is demonstrated by their abilities to target orthotopic gliomas,alleviate tumor hypoxia and consequently reverse resistance of glioma cells to TMZ,thereby extending the survival time of tumor-bearing mice,making the nanoplatforms and their synergistic chemo/photothermal therapy as a potential clinical treatment for gliomas.
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