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Evaluation of intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis

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World Journal of Gastroenterology 2020年第29期26卷 4302-4315页

作者： Tilmann Graeter Hai-Hua Bao Rong Shi Wen-Ya Liu Wei-Xia Li Yi Jiang Julian Schmidberger Eleonore Brumpt Eric Delabrousse Wolfgang Kratzer Department of Diagnostic and Interventional Radiology University Hospital UlmUlm 89081Germany Qinghai University Qinghai University First Affiliated HospitalXining 810001Qinghai ProvinceChina University First Affiliated HospitalWHO Collaborating Centre on Prevention and Care Management of EchinococcosisUrumqi 830054Xinjiang Uyghur Autonomous RegionChina Department of Internal Medicine I University Hospital UlmUlm 89081Germany who collaborating Centre on prevention and treatment of human echinococcosis/National French Reference Centre for echinococcosis University Bourgogne Franche-Comtéand Besançon University HospitalBesançon 25030France

BACKGROUND The main endemic areas of alveolar echinococcosis(AE)are in Central Europe and Western *** the infiltration of intrahepatic vascular and bile duct structures as well as extrahepatic disease can lead to further complications and may increase morbidity in patients with *** To evaluate vascular/biliary involvement in hepatic AE and its distant extrahepatic disease manifestations in an international collective was the *** Consecutively,five experienced examiners evaluated contrast-enhanced abdominal computed tomography(CT)scans for 200 patients with hepatic AE of each of four locations(n=50)in Germany,France and ***,we retrospectively included the 50 most recent abdominal contrast-enhanced CT examinations at each center,performed because of hepatic AE from September 21,2007 to March 21,*** liver lesions were classified according to the echinococcosis multilocularis Ulm classification for CT(EMUC-CT).Distant extrahepatic manifestations were documented either by whole body positron emission tomography–CT or with the addition of thoracic CT and cranial magnetic resonance ***/biliary involvement of the hepatic disease as well as the presence of distant extrahepatic manifestations were correlated with the EMUC-CT types of liver *** analysis was performed using SAS Version 9.4(SAS Institute Inc.,Cary,NC,United States).RESULTS Distant extrahepatic AE manifestations were significantly more frequent in China than in Europe(P=0.0091).A significant relationship was found between the presence of distant extrahepatic disease and AE liver lesion size(P=0.0075).Vascular/biliary structures were involved by the liver lesions significantly more frequently in China than in Europe(P<0.0001),and vascular/biliary involvement depended on lesion *** morphological types of AE liver lesions led to varying frequencies of vascular/biliary involvement and were associated with different frequencies of distant extrahe

关键词： Alveolar echinococcosis Echinococcus multilocularis Echinococcus multilocularis Ulm classification for computed tomography Vascular/biliary involvement Extrahepatic manifestation XUUB project

Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode

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World Journal of Gastroenterology 2009年第17期15卷 2116-2124页

作者： Ren-Yong Lin Jun-Hua Wang Xiao-Mei Lu Xiao-Tao Zhou Georges Mantion Hao Wen Dominique A Vuitton Lysiane Richert Xinjiang Key Laboratory on echinococcosis and Liver Surgery 1st Teaching Hospital of Xinjiang Medical University No. 1 Liyushan Road Urumqi 830054 China Ren-Yong Lin Lysiane Richert Laboratoire de Toxicologie Cellulaire EA 4267 Faculte de Medecine et Pharmacie University of Franche-Comte Place Saint-Jacques 25030 Besangon France Liver Surgery and Transplantation Unit EA 3921 Department of Digestive Surgery University Hospital Jean Minjoz Boulevard Fleming 25030 Besangon France who-collaborating Centre for the prevention and treatment of human echinococcosis University of Franche-Comte Place Saint Jacques 25030 Besancon France who-collaborating Centre for the prevention and treatment of human echinococcosis University of Franche-Comte Place Saint Jacques 25030 Besancon France

AIM: To explore the effect of Echinococcus multilocularis (E. multilocularis) on the activation of mitogen-activated protein kinase (MAPK) signaling pathways and on liver cell proliferation. METHODS: Changes in the phosphorylation of MAPKs and proliferating cell nuclear antigen (PCNA) expression were measured in the liver of patients with alveolar echinococcosis (AE). MAPKs, MEK1/2 [MAPK/ extracellular signal-regulated protein kinase (ERK) kinase] and ribosomal S6 kinase (RSK) phosphorylation were detected in primary cultures of rat hepatocytes in contact in vitro with (1) E. multilocularis vesicle fluid (EmF), (2) E. multilocularis-conditioned medium (EmCM). RESULTS: In the liver of AE patients, ERK 1/2 and p38 MAPK were activated and PCNA expression was increased, especially in the vicinity of the metacestode. Upon exposure to EmF, p38, c-Jun N-terminal kinase (JNK) and ERK1/2 were also activated in hepatocytes in vitro, as well as MEK1/2 and RSK, in the absence of any toxic effect. Upon exposure to EmCM, only JNK was up-regulated. CONCLUSION: Previous studies have demonstrated an influence of the host on the MAPK cascade in E. multilocularis. Our data suggest that the reverse, i.e. parasite-derived signals efficiently acting on MAPK signaling pathways in host liver cells, is actually operating.

关键词：丝裂原活化蛋白激酶多房棘球绦虫肝细胞激活细胞外信号调节蛋白激酶增殖细胞核抗原分裂原 p38激酶

A historical view of alveolar echinococcosis, 160 years after the discovery of the first case in humans： part 1. What have we learnt on the distribution of the disease and on its parasitic agent？

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Chinese Medical Journal 2011年第18期124卷 2943-2953页

作者： Dominique Angele Vuitton WANG Qian ZHOU Hong-xia Francis Raoul Jenny Knapp Solange Bresson-Hadni WEN Hao Patrick Giraudoux who collaborating center for prevention and treatment of human echinococcosis University Hospital and University of Francbe-Comte 25030 Besancon France Sichuan center for Disease Control and prevention Chengdu Sichuan 610031 China Guangxi Medical University Nanning Guangxi 530021 China Chrono-Environnement Joint Research Unit UMR 6249 University of Franche-Comte CNRS and INRA 25030 Besancon France Xinjiang Key Laboratory for echinococcosis Research 1st Teaching Hospital of Xinjiang Medical University Urumqi Xiniianz 830000. China

Since the first 2 cases observed in southern Germany and the correct identification of a parasite at the origin of the disease by the famous scientist Rudolf Virchow in 1855, the borders of the endemic area of alveolar echinococcosis （AE） have never stopped to expand. The parasite was successively recognized in Switzerland, then in Russia, Austria and France which were long considered as the only endemic areas for the disease. Cases were disclosed in Turkey in 1939; then much attention was paid to Alaska and to Hokkaido, in Japan. The situation totally changed in 1991 after the recognition of the Chinese endemic areas by the international community of scientists. The world map was completed in the beginning of the 21st century by the identification of AE in most of the countries of central/eastern Europe and Baltic States, and by the recognition of cases in central Asia. Up to now, the disease has however never been reported in the South hemisphere and in the United Kingdom. In the mid-1950s, demonstration by Rausch and Schiller in Alaska, and by Vogel in Germany, of the distinction between 2 parasite species responsible respectively for cystic echinococcosis （＂hydatid disease＂） and AE put an end to the long-lasting debate between the ＂dualists＂, who believed in that theory which eventually proved to be true, and the ＂unicists＂, who believed in a single species responsible for both diseases. At the end of the 20th century, molecular biology fully confirmed the ＂dualist＂ theory while adding several new species to the initially described E. granulosus; within the past decade, it also confirmed that little variation existed within Echinococcus （E.） multilocularis species, and that AE-Iooking infection in some intermediate animal hosts on the Tibetan plateau was indeed due to a new species, distinct from E. multilocularis, named E. shiquicus. Since the 1970s, the unique ecological interactions between the landscape, the hosts, and E. multilocularis have progressively be

关键词： alveolar echinococcosis Echinococcus species epidemiology history Rudolf Virchow western China

Investigation on the Management for Patients with echinococcosis Treated with Albendazole-Three PLADs,China,2019

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China CDC weekly 2023年第20期5卷 437-441页

作者： Min Qin Liying Wang Ying Wang Xu Wang Jiaxi Lei Xixi Cheng Yu Feng Yanyan Hou Qian Wang Chuizhao Xue Laurent Gavotte Roger Frutos National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Espace-Dev UMR 228Universitéde MontpellierMontpellierFrance Cirad UMR 17IntertrypCampus international de BaillarguetMontpellierFrance Gansu Provincial center for Disease Control and prevention Lanzhou CityGansu ProvinceChina Xinjiang Uygur Autonomous Region center for Disease Control and prevention Urumqi CityXinjiang Uygur Autonomous RegionChina Sichuan Provincial center for Disease Control and prevention Chengdu CitySichuan ProvinceChina

Summary What is already known about this topic?In China,patients with echinococcosis receive complimentary healthcare services,such as medical treatment,diagnostic examinations,and follow-up *** this,no studies have been conducted to assess the quality of patient management to *** is added by this report?This study reviewed the medical records of 899 patients who underwent albendazole treatment across 10 endemic *** of 634 evaluable patient files,the proportion of patients with a ratio of actual followup and reexamination times to theoretical follow-up and reexamination times≥0.8 were both low(21.92%and 23.19%,respectively).What are the implications for public health practices?This study identified weaknesses and specific issues in patient management and proposed feasible recommendations to enhance patient file documentation,follow-up,and reexamination.

关键词： treatment spite feasible

Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options

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Infectious Diseases of Poverty 2014年第1期3卷 18-25页

作者： Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu Sichuan Provincial center for Diseases Control and prevention ChengduSichuanChina Ganzi Prefecture center for Diseases Control and prevention KangdingSichuanChina Institute of Parasitic Diseases China Center for Diseases Control and PreventionShanghaiChina who collaborating center for prevention and treatment of human echinococcosis University Hospital and University of Franche-Comté25030 BesançonFrance Department of Chrono-Environment UMR UFC/CNRS 6249 aff.INRAUniversity of Franche-ComtéBesançonFrance Cestode Zoonoses Research Group Bioscience Research Institute and School of Environment and Life SciencesUniversity of SalfordGreat Manchester M54WTUK

Objective: echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were

关键词： Control options echinococcosis Qinghai-Tibet Plateau Risk factors

Impact factors of Blastocystis hominis infection in persons living with human immunodeficiency virus:a large-scale,multi-center observational study from China

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Infectious Diseases of Poverty 2023年第5期12卷 95-96页

作者： Shun-Xian Zhang Ji-Chun Wang Zhong-Wei Li Jin-Xin Zheng Wen-Ting Zhou Guo-Bing Yang Ying-Fang Yu Xiu-Ping Wu Shan Lv Qin Liu Mu-Xin Chen Yan Lu Zhi-Hui Dou Da-Wei Zhang Wen-Wen Lv Lei Wang Zhen-Hui Lu Ming Yang Pei-Yong Zheng Yue-Lai Chen Li-Guang Tian Xiao-Nong Zhou Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China Chinese center for Disease Control and prevention (Chinese center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research On Tropical Diseases National Institute of Parasitic Diseases Shanghai China School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of Medicine Shanghai China Department of Science and Technology Chinese Center for Disease Control and Prevention Beijing China Gansu Province People’s Hospital Gansu Provincial Hospital Lanzhou China National Health Commission (NHC) Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Gansu Provincial center for Disease Control and prevention Lanzhou China National center for AIDS/STD Control and prevention China Center for Disease Control and Prevention Beijing China The People’s Liberation Army 302 Hospital Beijing China Clinical Research Institute Shanghai Jiao Tong University School of Medicine Shanghai China

Background Blastocystis hominis(Bh)is zoonotic parasitic pathogen with a high prevalent globally,causing opportunistic infections and diarrhea *** immunodeficiency virus(HIV)infection disrupts the immune system by depleting CD4^(+)T lymphocyte(CD4^(+)T)cell counts,thereby increasing Bh infection risk among persons living with HIV(PLWH).However,the precise association between Bh infection risk and HIV-related biological markers and treatment processes remains poorly ***,the purpose of the study was to explore the association between Bh infection risk and CD4^(+)T cell counts,HIV viral load(VL),and duration of interruption in antiviral therapy among *** A large-scale multi-center cross-sectional study was conducted in China from June 2020 to December *** genetic presence of Bh in fecal samples was detected by real-time fluorescence quantitative polymerase chain reaction,the CD4^(+)T cell counts in venous blood was measured using flowcytometry,and the HIV VL in serum was quantified using fluorescence-based *** cubic spline(RCS)was applied to assess the non-linear association between Bh infection risk and CD4^(+)T cell counts,HIV VL,and duration of interruption in highly active antiretroviral therapy(HARRT).Results A total of 1245 PLWH were enrolled in the study,the average age of PLWH was 43 years[interquartile range(IQR):33,52],with 452(36.3%)being female,50.4%(n=628)had no immunosuppression(CD4^(+)T cell counts>500 cells/μl),and 78.1%(n=972)achieved full virological suppression(HIV VL<50 copies/ml).Approximately 10.5%(n=131)of PLWH had *** prevalence of Bh was found to be 4.9%[95%confidence interval(CI):3.8-6.4%]among *** nonlinear associations were observed between the Bh infection risk and CD4^(+)T cell counts(Pfor nonlinearity<0.001,L-shaped),HIV VL(Pfor nonlinearity<0.001,inverted U-shaped),and duration of interruption in HARRT(Pfor nonlinearity<0.001,inverted U-shaped).Conclusions

关键词： Blastocystis hominis human immunodeficiency virus Viral load Non-linear association Restricted cubic spline Propensity score China

Deworming of stray dogs and wild canines with praziquantel-laced baits delivered by an unmanned aerial vehicle in areas highly endemic for echinococcosis in China

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Infectious Diseases of Poverty 2017年第1期6卷 1054-1059页

作者： Qing Yu Ning Xiao Shi-jie Yang Shuai Han Department of echinococcosis National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention207 Rui Jin Er RoadShanghai 200025China Key Laboratory of Parasite and Vector Biology National health and Family Planning CommissionShanghaiChina who collaborating center for Tropical Diseases ShanghaiChina

Background:Canines,the definitive hosts for the parasites causing alveolar(AE)and cystic echinococcosis(CE),are the main source of this infections playing the key role in the *** ten-year mortality rate of AE is extremely high(94%)if the patients are not given sustained *** aim of this field study is to explore the possibility of delivery of praziquantel-laced baits using unmanned aerial vehicles(UAVs)aimed at deworming wild canines in the endemic ***:UAVs were compared to manual bait delivery in the 1-km^(2)test areas followed by testing of canine faeces using an Echinococcus coproantigen ELISA test in the ensuing *** outcomes of the two approaches were compared with respect to time of delivery and overall ***:Compared to manual bait delivery,delivery by UAVs saved up to 67%of the overall *** times more staff was needed for the former approach compared to the latter and,time wise,UAV bait delivery saved 350%compared to manual bait delivery on *** regard to investment needed,the use of UAVs showed an efficiency 2.5 times better than manual bait *** to the area served by UAVs,the average positive rate for the canine faecal samples was more than 38%higher in the area served ***:The technique of bait delivery with praziquantel using UAVs for canine deworming has a strong potential with regard to savings of manpower,time and overall cost in areas highly endemic for echinococcosis.

关键词： echinococcosis Wild canine definitive hosts Control:Unmanned aerial vehicle Delivery Baits Qinghai-Tibet Plateau China

Ending the“Neglect”to End Neglected Tropical Diseases

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China CDC weekly 2022年第8期4卷 153-156页

作者： Pin Yang Xiao-nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghaiChina School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina

January 30,2022 will mark the third World Neglected Tropical Diseases(NTD)*** slogan for this year World NTD Day is“A New Day in the fight against NTDs”(https://***/).While human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS),tuberculosis,and malaria were regarded as the three major infectious diseases and have received greater treatment and research funding,NTDs have almost disappeared in the global health policy agenda to gain recognition in 2015 with the Sustainable Development Goals(SDG target 3.3).

关键词： Diseases diseases tuberculosis

Compared efficacy of University of Wisconsin and histidine-tryptophan-ketoglutarate solutions in ex-situ liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis patients

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 430-438页

作者： Shadike Apaer Tuerhongjiang Tuxun Tao Li Tuerganaili Aji Jiangduosi Payiziwula Jin-Ming Zhao Ying-Mei Shao Hao Wen State Key Laboratory of Pathogenesis PreventionTreatment of High Incidence Diseases in Central AsiaXinjiang Medical UniversityUrumqi 830011China Department of Liver Transplantation and Laparoscopic Surgery Center of Digestive and Vascular Surgerythe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China Department of Hepatobiliary and Hydatid Surgery Center of Digestive and Vascular Surgerythe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China who collaborating center for prevention and Care Management of echinococcosis the First Affiliated Hospital of Xinjiang Medical University and Xinjiang Center for Disease ControlUrumqi 830054China

Background: The University of Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) solutions are the two most frequently used liver graft preservation fluids. The present study aimed to compare their efficacy in end-stage hepatic alveolar echinococcosis patients who underwent ex-situ liver resection and autotransplantation (ELRA). Methods: A total of 81 patients received ELRA from August 2010 to March 2018. They were allocated into UW ( n = 48) and HTK groups ( n = 33) based on the type of solutions used. Demographic and operational data were retrospectively analyzed. Primary outcomes included 90-day mortality, incidence of early graft loss, primary dysfunction, and postoperative complications. Results: Demographic and operational characteristics were similarly distributed in the two groups. No statistically significant differences were observed with regard to 90-day mortality (12.77% vs. 12.12%) and early graft loss rate (8.51% vs. 9.09%) between the two groups. Patients in the UW and HTK groups showed a primary dysfunction rate of 27.66% and 27.27%, respectively. The UW group exhibited a higher incidence tendency of biliary complications, albeit with no statistical significance. Conclusions: This is the largest cohort study comparing the efficacy of the UW and HTK organ-preserving solutions in end-stage hepatic alveolar echinococcosis patients in ELRA settings. UW and HTK solutions presented similar efficacy and safety. A randomized clinical trial with larger scale is needed for further investigation in future clinical applications.

关键词： University of Wisconsin Histidine-tryptophan-ketoglutarate Liver autotransplantation Alveolar echinococcosis Efficacy