Impact factors of Blastocystis hominis infection in persons living with human immunodeficiency virus:a large-scale,multi-center observational study from China
作者机构：Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research On Tropical Diseases National Institute of Parasitic Diseases Shanghai China School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of Medicine Shanghai China Department of Science and Technology Chinese Center for Disease Control and Prevention Beijing China Gansu Province People’s Hospital Gansu Provincial Hospital Lanzhou China National Health Commission (NHC) Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Gansu Provincial Center for Disease Control and Prevention Lanzhou China National Center for AIDS/STD Control and Prevention China Center for Disease Control and Prevention Beijing China The People’s Liberation Army 302 Hospital Beijing China Clinical Research Institute Shanghai Jiao Tong University School of Medicine Shanghai China
出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)
年 卷 期：2023年第12卷第5期
页 面：95-96页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：Medical Innovation Research Special Project of the Shanghai 2021"Science and Technology Innovation Action Plan", (21Y11922400, 21Y11922500) Three-year Action Plan for Promoting Clinical Skills and Innovation Ability of Municipal Hospitals, (SHDC2022CRS039) Natural Science Foundation of Shanghai Municipality, (22ZR1462100, 23ZR1463900, 23ZR1464000) Natural Science Foundation of Shanghai Municipality National Natural Science Foundation of China, NSFC, (81473022) National Natural Science Foundation of China, NSFC Shanghai Municipal Education Commission, (A1-U21-205-902) Shanghai Municipal Education Commission Natural Science Foundation of Gansu Province, (21JR11RA182, 21JR7RA631) Natural Science Foundation of Gansu Province Shanghai Municipal Hospital Development Center, SHDC, (SHDC2022CRW006) Shanghai Municipal Hospital Development Center, SHDC Shanghai University of Traditional Chinese Medicine, SHUTCM, (LH001.007) Shanghai University of Traditional Chinese Medicine, SHUTCM
主 题：Blastocystis hominis Human immunodeficiency virus Viral load Non-linear association Restricted cubic spline Propensity score China
摘 要：Background Blastocystis hominis(Bh)is zoonotic parasitic pathogen with a high prevalent globally,causing opportunistic infections and diarrhea *** immunodeficiency virus(HIV)infection disrupts the immune system by depleting CD4^(+)T lymphocyte(CD4^(+)T)cell counts,thereby increasing Bh infection risk among persons living with HIV(PLWH).However,the precise association between Bh infection risk and HIV-related biological markers and treatment processes remains poorly ***,the purpose of the study was to explore the association between Bh infection risk and CD4^(+)T cell counts,HIV viral load(VL),and duration of interruption in antiviral therapy among *** A large-scale multi-center cross-sectional study was conducted in China from June 2020 to December *** genetic presence of Bh in fecal samples was detected by real-time fluorescence quantitative polymerase chain reaction,the CD4^(+)T cell counts in venous blood was measured using flowcytometry,and the HIV VL in serum was quantified using fluorescence-based *** cubic spline(RCS)was applied to assess the non-linear association between Bh infection risk and CD4^(+)T cell counts,HIV VL,and duration of interruption in highly active antiretroviral therapy(HARRT).Results A total of 1245 PLWH were enrolled in the study,the average age of PLWH was 43 years[interquartile range(IQR):33,52],with 452(36.3%)being female,50.4%(n=628)had no immunosuppression(CD4^(+)T cell counts500 cells/μl),and 78.1%(n=972)achieved full virological suppression(HIV VL50 copies/ml).Approximately 10.5%(n=131)of PLWH had *** prevalence of Bh was found to be 4.9%[95%confidence interval(CI):3.8-6.4%]among *** nonlinear associations were observed between the Bh infection risk and CD4^(+)T cell counts(Pfor nonlinearity0.001,L-shaped),HIV VL(Pfor nonlinearity0.001,inverted U-shaped),and duration of interruption in HARRT(Pfor nonlinearity0.001,inverted U-shaped).Conclusions
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