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Optical Molecular imaging Frontiers in Oncology: The Pursuit of Accuracy and Sensitivity

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Engineering 2015年第3期1卷 309-323页

作者： Kun Wang Chongwei Chi Zhenhua Hu Muhan Liu Hui Hui Wenting Shang Dong Peng Shuang Zhang Jiezuo Ye Haixiao Liu Jie Tian Key laboratory of Molecular imaging Institute of Automation Chinese Academy of Sciences

Cutting-edge technologies in optical molecular imaging have ushered in new frontiers in cancer research, clinical translation, and medical practice, as evidenced by recent advances in optical multimodality imaging, Cerenkov luminescence imaging(CLI), and optical imageguided surgeries. New abilities allow in vivo cancer imaging with sensitivity and accuracy that are unprecedented in conventional imaging approaches. The visualization of cellular and molecular behaviors and events within tumors in living subjects is improving our deeper understanding of tumors at a systems level. These advances are being rapidly used to acquire tumor-to-tumor molecular heterogeneity, both dynamically and quantitatively, as well as to achieve more effective therapeutic interventions with the assistance of real-time imaging. In the era of molecular imaging, optical technologies hold great promise to facilitate the development of highly sensitive cancer diagnoses as well as personalized patient treatment—one of the ultimate goals of precision medicine.

关键词： optical molecular imaging multimodality molecular imaging optical multimodality tomography Cerenkov luminescence imaging intraoperative image-guided surgery

Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development

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National Science Review 2019年第3期6卷 480-493页

作者： Lei Shi Xin Luo Jin Jiang Yongchang Chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su State Key laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Primate research Center Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences Yunnan Key laboratory of Primate Biomedical research Institute of Primate Translation Medicine Kunming University of Science and Technology Department of Psychiatry University of North CarolinaChapel Hill Department of Computer Science University of North CarolinaChapel Hill Key laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of Zoology Chinese Academy of Sciences Department of Medical imaging the First Affiliated Hospital of Kunming Medical University Department of Minimally Invasive Neurosurgery the First Affiliated Hospital of Kunming Medical University

Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive. Here, we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation) carrying human copies of MCPH1, an important gene for brain development and brain evolution. Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation, resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys, similar to the known evolutionary change of developmental delay(neoteny) in humans. Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes, providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys. More importantly, the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task. The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits.

关键词： human evolution brain development MCPH1 transgenic monkey neoteny cognition

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano research 2025年第1期18卷 653-674页

作者： Qian Gao Lin Tang Jun Zhan Yiyuan Xue Feng Luo State Key laboratory of Oral Diseases&National Center for Stomatology&National Clinical research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

Centimeter-Deep NIR-II Fluorescence imaging with Nontoxic AIE Probes in Nonhuman Primates

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research 2020年第1期2020卷 652-665页

作者： Zonghai Sheng Yaxi Li Dehong Hu Tianliang Min Duyang Gao Jen-Shyang Ni Pengfei Zhang Yuenan Wang Xin Liu Kai Li Hairong Zheng Ben Zhong Tang Paul C.Lauterbur research Center for Biomedical imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Biomedical Engineering Southern University of Science and Technology(SUSTech)Shenzhen 518055China Department of Radiation Oncology National Cancer CenterNational Clinical Research Center for CancerCancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518055China Department of Chemistry The Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina

Fluorescence probes with aggregation-induced emission(AIE)characteristics are of great importance in biomedical imaging with superior spatial and temporal ***,the lack of toxicity studies and deep tissue imaging in nonhuman primates hinders their clinical ***,we report the blood chemistry and histological analysis in nonhuman primates treated with AIE probes over tenfold of an intravenous dose of clinically used indocyanine green(ICG)during a study period of 36 days to demonstrate AIE probes are ***,through bright and nontoxic AIE probes and fluorescence imaging in the second window(NIR-II,1,000-1,700 nm),we achieve an unprecedented 1.5-centimeter-deep vascular imaging in nonhuman primates,breaking the current limitation of millimeter-deep NIR-II fluorescence *** important findings,i.e.,nontoxic features of AIE probes and centimeter-deep NIR-II vascular imaging in nonhuman primates,may facilitate successful translation of AIE probes in clinical trials.

关键词： Fluorescence Probe breaking

Magneto-mechanical effect of magnetic microhydrogel for improvement of magnetic neuro-stimulation

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Nano research 2023年第5期16卷 7393-7404页

作者： Le Xue Qing Ye Linyuan Wu Dong Li Siyuan Bao Qingbo Lu Sha Liu Dongke Sun Zonghai Sheng Zhijun Zhang Ning Gu Jianfei Sun State Key laboratory of Bioelectronics Jiangsu Key Laboratory of Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China School of Mechanic Engineering Southeast UniversityNanjing 211189China Department of Neurology Affiliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjing 210009China Paul C.Lauterbur research Center for Biomedical imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Mental Health and Public Health Faculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Medicine Nanjing UniversityNanjing 210008China

Superparamagnetic iron oxide(SPIO)nanoparticles play an important role in mediating precise and effective magnetic neurostimulation and can help overcome limitations related to penetration depth and spatial ***,nanoparticles readily diffuse in vivo,decreasing the spatial resolution and activation *** this study,we employed a microfluidic means to fabricate injectable microhydrogels encapsulated with SPIO nanoparticles,which significantly improved the stability of nanoparticles,increased the magnetic properties,reinforced the stimulation *** fabricated magnetic microhydrogels were highly uniform in size and sphericity,enabling minimally invasive injection into brain *** long-term residency in the cortex up to 22 weeks and the safety of brain tissue were shown using a mouse *** addition,we quantitatively determined the magneto-mechanical force yielded by only one magnetic microhydrogel using a video-based *** force was found to be within 7–8 pN under 10 Hz magnetic stimulation by both theoretical simulation and experimental ***,electrophysiological measurement of brain slices showed that the magnetic microhydrogels offer significant advantages in terms of neural activation relative to dissociative SPIO nanoparticles.A universal strategy is thus offered for performing magnetic neuro-stimulation with an improved prospect for biomedical translation.

关键词： magnetic stimulation superparamagnetic iron oxide(SPIO)nanoparticles magnetic microhydrogel long-term residency magneto-mechanical effect

A multifunctional nanotheranostic agent potentiates erlotinib to EGFR wild-type non-small cell lung cancer

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Bioactive Materials 2022年第7期7卷 312-323页

作者： Duo Wang Jun Zhou Weimin Fang Cuiqing Huang Zerong Chen Meng Fan Ming-Rong Zhang Zeyu Xiao Kuan Hu Liangping Luo Medical imaging Center The First Affiliated Hospital of Jinan UniversityGuangzhou510632PR China The Guangzhou Key laboratory of Molecular and Functional imaging for Clinical translation Jinan UniversityGuangzhou510632PR China Department of Advanced Nuclear Medicine Sciences Institute of Quantum Medical ScienceNational Institutes for Quantum and Radiological Science and TechnologyChiba263-8555Japan Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA

Epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKI),such as Erlotinib,have demonstrated remarkable efficacy in the treatment of non-small cell lung cancer(NSCLC)patients with mutated ***,the efficacy of EGFR-TKIs in wild-type(wt)EGFR tumours has been shown to be *** that can sensitize Erlotinib to EGFR wild-type NSCLC remain ***,we developed a multifunctional superparamagnetic nanotheranostic agent as a novel strategy to potentiate Erlotinib to EGFR-wt *** results demonstrate that the nanoparticles can co-escort Erlotinib and a vascular epithermal growth factor(VEGF)inhibitor,Bevacizumab(Bev),to EGFR-wt *** nanotheranostic agent exhibits remarkable effects as an inhibitor of EGFR-wt tumour ***,Bev normalizes the tumour embedded vessels,further promoting the therapeutic efficacy of *** addition,the tumour engagement of the nanoparticles and the vascular normalization could be tracked by magnetic resonance imaging(MRI).Collectively,our study,for the first time,demonstrated that elaborated nanoparticles could be employed as a robust tool to potentiate Erlotinib to EGFR-wt NSCLC,paving the way for imaging-guided nanotheranostics for refractory NSCLCs expressing EGFR wild-type genes.

关键词： Non-small cell lung cancer EGFR wild-Type Superparamagnetic iron oxide Erlotinib Bevacizumab Tumour vascular normalization

Mineral iron based self-assembling: bridging the small molecular drugs and transformative application

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Science Bulletin 2019年第4期64卷 216-218页

作者： En Ren Chengchao Chu Xin Pang Peng Lv Zhao Lei Gang Liu State Key laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular imaging and translational Medicine School of Public Health Xiamen University

The nanoparticle-based treatment and diagnosis of cancer remain challenging in clinical translation, mainly due to the hurdles that can be associated with the development of targeted delivery, biological side effects,... 详细信息

关键词： nanoparticle-based translation poor drug

A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics

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Nano research 2018年第8期11卷 4149-4168页

作者： Luyan Zong Huixia Wu Han Lin Yu Chen The Key laboratory of Resource Chemistry of Ministry of Education Shanghai Key Laboratory of the Rare Earth Functional Materialsand Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors Shanghai NormalUniversity Shanghai 200234 China State Key laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics ChineseAcademy of Sciences Shanghai200050 China

As a new family of two-dimensional （2D） nanomaterials, MXenes have recently attracted much attention because of high performance in versatile applications including energy storage and electrochemistry, but their specific application to biomedicine has been rarely reported, especially for theranostic nanomedicine, i.e., concurrent diagnostic imaging and therapy. This study shows for the first time surface engineering and functionalization of 2D Ti3C2 MXene nanosheets by the integration of GdWl0-based polyoxometalates （POMs）. These multifunctional GdWlo@Ti3C2 composite nanosheets provide hypertherrnal treatment with magnetic resonance （MR） and/or computed tomography （CT） imaging guidance toward tumor cells or xenografts. A tumor was effectively eradicated without further reoccurrence during the observation period. GdW10 nanoclusters that were integrated onto the surface of Ti3C2 nanosheets were demonstrated to serve as a contrast agent for contrast-enhanced CT and MR imaging based on their unique composition, thus showing the potential for diagnostic-imaging guidance and monitoring for tumor hyperthermia nanotherapy. The high in vivo biocompatibility of GdW10@TiaC2 composite nanosheets was demonstrated to guarantee their subsequent translation into a medical treatment. This study provides a novel strategy for broadening the biomedical applications of MXenes by surface engineering and multifunctionalization, which is expected to promote further exploration of biomedical applications of MXenes in nanotheranostics.

关键词： titanium carbide MXene,polyoxometalate dual-mode imaging photothermal therapy

Cell membrane-encapsulated nanoparticles for vaccines and immunotherapy

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Particuology 2022年第5期20卷 35-42页

作者： Wei Xiang Xue Liu Lili Zhang Chao Liu Gang Liu State Key laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular imaging and translational Medicine School of Public Health.Xiamen UniversityXiamen 361102China State Key laboratory of Molecular Vaccinology and Molecular Diagnostics and National Institute of Diagnostics and Vaccine Development in Infectious Disease School of Public HealthXiamen UniversityXiamen 361102China ShenZhen research Institute of Xiamen University.Shenzhen 518057 China

Functionalized nanoparticles are widely used in drug targeted delivery and immune microenvironment *** a new type of biomaterial,cell-derived carriers are receiving considerable attention in clinical translation owing to their desirable biocompatibility and lower ***,cell membrane-encapsulated nanoparticles can achieve specific biological effects from the benefit of their parent cell *** this review,we introduce the cell membrane coating technologies that are under extensive investigation,we also summarize various applications that have been developed for immunotherapy,and discuss the prospects in this *** further understanding and integration with advanced biotechnology methods,it is believed that the continuing development of cell membrane-encapsulated nanoparticles will achieve promotion in clinical application.

关键词： Cell membrane Nanoparticle Vaccine Immunotherapy