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Serological investigation of vector-borne disease in dogs from rural areas of China

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 102-103页

作者： Shiwen Wang Jing He Lijuan Zhang National Institute of Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Department of Infectious diseases 302 Hospital of PLA

Objective:To evaluate the Anaplasma phagocytophilum(***),Ehrlichia canis(***,Dirofilaria immitis(***)(canine heartworm),Borrelia burgdorferi(***)infections in countryside dogs from Yunnan,Hainan and Anhui ***:Serum samples were collected from 26 dogs in *** and Anhui *** samples were tested using a commercial ELISA rapid diagnostic assay kit(SNAP^(?)4Dx^(?);IDEXX Laboratories,Inc.U.S.A.).Meaiiwliile,indirect immunofluorescence assay(IFA)recommended by WHO was conducted to delect IgG to *** methods were analyzed and ***:The number of serologically positive dogs for IgG to *** was only 2which was from Hainan province and none of the 26 dogs responded positive for ***(canine heartworm,and *** by ELISA rapid diagnostic *** number of serologically positive dogs for IgG to *** was 13(50%)by IFA *** of the two methods were analyzed by statistical software and the difference was statistically significant(P=0.002).Conclusions:It can be concluded that IFA method was more sensitive than ELISA rapid diagnostic ***,we need conduct further and intensive epidemiology survey on tick-born diseases pathogens ***,***,***(canine heartworm),and *** which have public health significance.

关键词： Anaplasma phagocytophilum Ehrlichia canis Borrelia burgdorferi Dirofilaria immitis Dogs China vector-borne disease Serological investigation ELISA rapid diagnostic assay

Plant virology in the 21st century in China:Recent advances and future directions

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Journal of Integrative Plant Biology 2024年第3期66卷 579-622页

作者： Jianguo Wu Yongliang Zhang Fangfang Li Xiaoming Zhang Jian Ye Taiyun Wei Zhenghe Li Xiaorong Tao Feng Cui Xianbing Wang Lili Zhang Fei Yan Shifang Li Yule Liu Dawei Li Xueping Zhou Yi Li State Key laboratory for Ecological Pest Control of Fujian and Taiwan Crops Vector-borne Virus Research CenterCollege of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002China State Key laboratory of Plant Environmental Resilience and Ministry of Agriculture Key laboratory of Soil Microbiology College of Biological SciencesChina Agricultural UniversityBeijing 100193China State Key laboratory for Biology of Plant diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China State Key laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China State Key laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Department of Plant Pathology The Key Laboratory of Plant ImmunityNanjing Agricultural UniversityNanjing 210095China State Key laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Plant VirologyNingbo UniversityNingbo 315211China MOE Key laboratory of Bioinformatics Center for Plant BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China State Key laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China

Plant viruses are a group of intracellular pathogens that persistently threaten global food *** advances in plant virology have been achieved by Chinese scientists over the last 20 years,including basic research and technologies for preventing and controlling plant viral ***,we review these milestones and advances,including the identification of new crop-infecting viruses,dissection of pathogenic mechanisms of multiple viruses,examination of multilayered interactions among viruses,their host plants,and virus-transmitting arthropod vectors,and in-depth interrogation of plantencoded resistance and susceptibility ***,various plant virus-based vectors have also been successfully developed for gene function studies and target gene expression in *** also recommend future plant virology studies in China.

关键词： China emerging plant viruses plant virology plant resistance/susceptibility to viral infection plant-virus transmission vector interactions plant virus-based vectors viral pathogenesis

A Bunyavirus-Inducible Ubiquitin Ligase Targets RNA Polymerase IV for Degradation during Viral Pathogenesis in Rice

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Molecular Plant 2020年第6期13卷 836-850页

作者： Chao Zhang Ying Wei Le Xu Kang-Cheng Wu Liang Yang Chao-Nan Shi Guo-Yi Yang Dong Chen Fei-Fei Yu Qi Xie Shou-Wei Ding Jian-Guo Wu vector-borne Virus Research Center Key Laboratory of Plant Virology of Fujian ProvinceInstitute of Plant VirologyCollege of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002China Center for Plant Biology Tsinghua-Peking Center for Life SciencesCollege of Life SciencesTsinghua UniversityBeijing 100084China State Key laboratory of Plant Genomics National Center for Plant Gene ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Department of Microbiology and Plant Pathology and Center for Plant Cell Biology Institute for Integrative Genome BiologyUniversity of CaliforniaRiversideCA92521USA

The ubiquitin-proteasome system(UPS)is an important post-translational regulatory mechanism that controls many cellular functions in ***,we show that stable expression of P3 protein encoded by Rice grassy stunt virus(RGSV),a negative-strand RNA virus in the Bunyavirales,causes developmental abnormities similar to the disease symptoms caused by RGSV,such as dwarfing and excess tillering,in transgenic rice *** found that both transgenic expression of P3 and RGSV infection induce ubiquitination and UPS-dependent degradation of rice NUCLEAR RNA POLYMERASE D1a(OsNRPD1a),one of two orthologs of the largest subunit of plant-specific RNA polymerase IV(Pol IV),which is required for RNA-directed DNA methylation(RdDM).Furthermore,we identified a P3-inducible U-box type E3 ubiquitin ligase,designated as P3-inducible protein 1(P3IP1),which interacts with OsNRPD1a and mediates its ubiquitination and UPS-dependent degradation in vitro and in ***,both knockdown of OsNRPD1 and overexpression of P3IP1 in rice plants induced developmental phenotypes similar to RGSV disease *** together,our findings reveal a novel virulence mechanism whereby plant pathogens target host RNA Pol IV for UPS-dependent degradation to induce disease *** study also identified an E3 ubiquitin ligase,which targets the RdDM compotent NRPD1 for UPS-mediated degradation in rice.

关键词： ubiquitin-proteasome system NRPD1 Rice grassy stunt virus E3 ligase

Seventy years’ achievements of international cooperation by the National Institute of Parasitic diseases at the Chinese Center for Disease Control and Prevention

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Infectious diseases of Poverty 2020年第6期9卷 1-4页

作者： Ru-Bo Wang Yi-Ting Hong Xiao-Nong Zhou National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention Chinese Center for Tropical diseases Research WHO Collaborating Centre for Tropical diseases National Center for International Research on Tropical diseases Ministry of Science and Technology Key laboratory of Parasite and vector Biology Ministry of HealthShanghaiChina

Background: With the promotion of national control programs on parasitic and tropical diseases in China,the National Institute of Parasitic diseases(NIPD),Chinese Center for Disease Control and Prevention has gained significant experience in the global health arena through international cooperation over the last seven decades allowing a multilateral impact in the elimination of major endemic ***:: The achievements of NIPD since 1950 has been analyzed with emphasis on the various stages that started with research and control of the endemic parasitic and other tropical diseases at the national level and progressed via international cooperation into a global ***: The major achievements contributed by NIPD consist of(i)improving technical capability;(ii)promoting control and elimination of parasitic and tropical diseases;(iii)participating in global health governance and cooperation;and(iv)developing a cooperation model for technical assistance and global public health *** is expected that NIPD’s experience of international cooperation will be essential for the dissemination of China's successful experience in global health governance,emergency response and development,with focus on malaria and neglected tropical diseases such as schistosomiasis,soil-borne and food-borne helminthiases and ***: NIPD’s new tasks will not only continue to promote national control of endemic parasitic infections and disease elimination programs in China,but also play a leading role in global health and disease elimination programs in the future.

关键词： Seventy years International cooperation The National Institute of Parasitic diseases

Variation of the Vaginal Microbiome During and After Pregnancy in Chinese Women

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 322-333页

作者： Xiaoai Zhang Qingzhi Zhai Jinfeng Wang Xiuling Ma Bo Xing Hang Fan Zhiying Gao Fangqing Zhao Wei Liu State Key laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Department of Obstetrics and Gynecology First Medical CenterThe General Hospital of the People’s Liberation ArmyBeijing 100853China Computational Genomics Lab Beijing Institutes of Life ScienceChinese Academy of SciencesBeijing 100101China Beijing Key laboratory of vector borne and Natural Focus Infectious Disease Beijing 100071China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Key laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China University of Chinese Academy of Sciences Beijing 100049China

A comprehensive profiling of the vaginal microbial communities and their variability enables an accurate description of the microbiome in ***,there is a lack of studies available on Chinese *** the present study,the composition of the vaginal microbiota during pregnancy and the 6-week postpartum period of 454 Chinese women was characterized by sequencing the V3-V4 region of the 16S ribosomal RNA(rRNA)*** vaginal microbiome showed variations during pregnancy and the postpartum period based on the abortion history,hypertensive disorders,delivery mode,and maternal ***-variation of 22 bacterial taxa,including the Lactobacillus genus and two of its species,may account for the common characteristics of the vaginal microbiome under scenarios of different medical histories and pregnancy *** contrast,discriminant bacterial species were significantly different between women who had preterm birth(PTB)with and without premature rupture of membranes(PROM),and the community state type(CST)IV-A without any predominant Lactobacillus species in the microbiota was more prevalent during pregnancy in the PROM-PTB cases,suggesting that specific bacterial species could be considered to distinguish between different types of *** providing data on Chinese women,this study will enrich the knowledge of the human microbiome and contribute to a better understanding of the association between the vaginal microbiome and reproductive health.

关键词： Chinese pregnant women Vaginal microbiota Postpartum Pregnancy complication Premature rupture of membranes Preterm birth

Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1546-1558页

作者： Hao Li Xia-Ming Jiang Ning Cui Chun Yuan Shao-Fei Zhang Qing-Bin Lu Zhen-Dong Yang Qin-Lin Xin Ya-Bin Song Xiao-Ai Zhang Hai-Zhou Liu Juan Du Xue-Juan Fan Lan Yuan Yi-Mei Yuan Zhen Wang Juan Wang Lan Zhang Dong-Na Zhang Zhi-Bo Wang Ke Dai Jie-Ying Bai Zhao-Nian Hao Hang Fan Li-Qun Fang Gengfu Xiao Yang Yang Ke Peng Hong-Quan Wang Jian-Xiong Li Lei-Ke Zhang Wei Liu Beijing Institute of Microbiology and Epidemiology State Key Laboratory of Pathogen and BiosecurityBeijingP.R.China State Key laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanHubeiP.R.China The 154 Hospital Peopled Liberation ArmyXinyangHenanP.R.China School of Public Health Peking UniversityBeijingP.R.China lnstitute of Molecular Medicine Peking UniversityBeijingP.R.China Rongji Medical College Huazhong University of Science and TechnologyWuhanP.R.China Department of Biostatistics and Emerging Pathogens Institute University of FloridaGainesvilleFLUSA Department of Cancer People's Liberation Army General HospitalBeijingP.R.China Beijing Key laboratory of vector borne and Natural Focus Infectious diseases BeijingP.R.China

Severe fever with thrombocytopenia syndrome(SFTS)virus(SFTSV)is an emerging tick-borne virus with high fatality and an expanding ***,effective anti-SFTSV intervention remains ***(T-705)was recently reported to show in vitro and in animal model antiviral efficacy against ***,we conducted a single-blind,randomized controlled trial to assess the efficacy and safety of T-705 in treating SFTS(Chinese Clinical Trial Registry website,number ChiCTR1900023350).From May to August 2018,laboratory-confirmed SFTS patients were recruited from a designated hospital and randomly assigned to receive oral T-705 in combination with supportive care or supportive care *** outcome occurred in 9.5%(7/74)of T-705 treated patients and 18.3%(13/71)of controls(odds ratio,0.466,95%Cl,0.174-1.247).Cox regression showed a significant reduction in case fatality rate(CFR)with an adjusted hazard ratio of 0.366(95%Cl,0.142-0.944).Among the low-viral load subgroup(RT-PCR cycle threshold>26),T-705 treatment significantly reduced CFR from 11.5 to 1.6%(P=0.029),while no between-arm difference was observed in the high-viral load subgroup(RT-PCR cycle thresholdlaboratory abnormities compared with the *** in vitro and animal experiments demonstrated that the antiviral efficacies of T-705 were proportionally induced by SFTSV mutation rates,particularly from two transition mutation *** mutation analyses on T-705-treated serum samples disclosed a partially consistent mutagenesis pattern as those of the in vitro or animal experiments in reducing the SFTSV viral loads,further supporting the anti-SFTSV effect of T-705,especially for the low-viral loads.

关键词： effect faster supporting

Spatio-Temporal Distribution of Malaria in Perak, Malaysia

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Advances in Infectious diseases 2015年第4期5卷 154-161页

作者： Norzawati Yoep Hazrin Hasim Ummi Nadiah Yusoff Mahani Yusoff Noor Rizawati Mahpot Institute for Public Health Ministry of Health Kuala Lumpur Malaysia vector borne Disease Control Unit Perak State Health Department Ministry of Health Ipoh Malaysia

Malaria incidence in Perak, Malaysia has generally declined, but there remain regions of high incidence. The spatio-temporal distribution pattern of malaria in Perak was studied using Geographical Information Systems (GIS) and spatial statistical tools. Malaria data cases at the subdistrict level in Perak from 2007 to 2011 were analysed to determine the spatial and temporal distribution patterns of malaria incidence. Geographical Information Systems (GIS) and spatial statistical tools were used to identify spatial correlation in the data and malaria hot-spots. Spatial correlation was tested by using an autocorrelation method called Moran’s I. Hot spot analysis was done using Getis-Ord G*?statistic technique. Malaria incidence rates were categorized into 3 classes to map the spatial distribution. Malaria cases in Perak were geo-spatially clustered. Most of the hot spots locations were in Kenering, Ulu Kinta, Gerik and Kampar sub-districts. The prevalence of malaria among foreigners was noticeably higher than Malaysians. Improved surveillance of foreign workers can prevent outbreaks and identify high risk areas. This study implies that geographic-based mapping and information system are needed for an effective malaria control.

关键词： Malaria Spatial GIS Geocoding

Differentiating snail intermediate hosts of Schistosoma *** molecular approaches:fundamental to successful integrated control mechanism in Africa

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Infectious diseases of Poverty 2018年第1期7卷 301-313页

作者： Eniola Michael Abe Wei Guan Yun-Hai Guo Kokouvi Kassegne Zhi-Qiang Qin Jing Xu Jun-Hu Chen Uwem Friday Ekpo Shi-Zhu Li Xiao-Nong Zhou National Institute of Parasitic diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMOHNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyWHO Collaborating Centre for Tropical DiseasesShanghai 200020China Department of Pure&Applied Zoology Federal University of Agriculture AbeokutaAbeokutaNigeria

Background:Snail intermediate hosts play active roles in the transmission of snail-borne trematode infections in Africa.A good knowledge of snail-borne diseases epidemiology particularly snail intermediate host populations would provide the necessary impetus to complementing existing control *** body:This review highlights the importance of molecular approaches in differentiating snail hosts population structure and the need to provide adequate information on snail host populations by updating snail hosts genome database for Africa,in order to equip different stakeholders with adequate information on the ecology of snail intermediate hosts and their roles in the transmission of different ***,we identify the gaps and areas where there is need for urgent intervention to facilitate effective integrated control of schistosomiasis and other snail-borne trematode ***:Prioritizing snail studies,especially snail differentiation using molecular tools will boost disease surveillance and also enhance efficient schistosomaisis control programme in Africa.

关键词： Schistosomiasis snail host schistosoma spp. genome database Africa

laboratory Growth of <i>Anopheles gambiae</i>(Diptera: Culicidae) and Morphological Determinism of Moulting

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Advances in Entomology 2021年第4期9卷 176-185页

作者： Henri Gabriel Tsila Patrick Akono Ntonga Alvine Larissa Meyabeme Elono Timoleon Tchuinkam Mpoame Mbida Biology and Applied Ecology Unit Researches Department of Animal Biology Faculty of Science University of Dschang Dschang Cameroon vector borne Infectious diseases laboratory Department of Animal Biology Faculty of Science University of Dschang Dschang Cameroon Biology and Physiology of Animal Organisms laboratory Department of Animal Organisms University of Douala Douala Cameroon Forestry Department Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon

Growth in arthropods in general and in insects in particular, is supposed to be discontinuous and occurs during moulting. In Culicidae in general and Anopheles in particular, the number of moults is five with the fourth which gives the pupae. It is known that moulting in insects is a genetic and physiological phenomenon. Most physiological reactions are triggered by chemical or physical stimuli. The pressure exerted by the growth of the larval body on the exocuticle is one of the triggers of moulting. The objective of this work was therefore to determine the exact timing of the first three moults that determine the growth of An. gambiae larvae from egg hatch to pupation to highlight the role of increased larval size in the stimulation of moulting. We therefore, undertook to rear larvae of this anopheline species in the laboratory under conditions close to their natural environment from hatching to pupation. The length and width of the head, thorax and abdomen were recorded daily. Data analysis showed that the size of the head and thorax remained constant for the first three days (D0 to D2) of development and abdomen’s length for the first two days and then increased daily until day seven (D7) when it stopped. These observations led us to say that the M1 moult occurs at end of the third day of development and the M3 moult at end of the eighth day;the M2 moult could not be determined. All these observations led to the conclusion that the larval growth of An. gambiae has a c

关键词： Anopheles gambiae Larva Growth Determinism Body Sizes Moulting