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World Journal of Stem Cells 2024年第2期16卷 89-101页

作者： Pier Luigi Surico Anna Scarabosio Giovanni Miotti Martina Grando Carlo Salati Pier Camillo Parodi Leopoldo Spadea Marco Zeppieri Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology Campus Bio-Medico UniversityRome 00128Italy Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

This review comprehensively explores the versatile potential of mesenchymal stem cells(MSCs)with a specific focus on adipose-derived *** and oculoplastic surgery,encompassing diverse procedures for ocular and periocular enhancement,demands advanced solutions for tissue restoration,functional and aesthetic refinement,and *** immunomodulatory,regenerative,and healing capacities of MSCs,this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside,addressing common unmet needs in the field of reconstructive and regenerative surgery.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative

Hepatitis B virus reactivation in patients treated with monoclonal antibodies

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World Journal of Virology 2024年第1期13卷 33-37页

作者： Silvia De Pauli Martina Grando Giovanni Miotti Marco Zeppieri Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al TagliamentoPordenone 33170Italy Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

Hepatitis B virus(HBV)reactivation poses a significant clinical challenge,espe-cially in patients undergoing immunosuppressive therapies,including mono-clonal antibody *** manuscript briefly explores the complex rela-tionship between monoclonal antibody therapy and HBV reactivation,drawing upon current literature and clinical case *** delves into the mechanisms underlying this phenomenon,highlighting the importance of risk assessment,monitoring,and prophylactic measures for patients at *** manuscript aims to enhance the understanding of HBV reactivation in the context of monoclonal antibody therapy,ultimately facilitating informed clinical decision-making and improved patient *** paper will also briefly review the definition of HBV activation,assess the risks of reactivation,especially in patients treated with monoclonal antibodies,and consider management for patients with regard to screening,prophylaxis,and treatment.A better understanding of patients at risk can help clinicians provide optimum management to ensure successful patient outcomes and prevent morbidity.

关键词： Hepatitis B virus Reactivation Acute infection Chronic infection Monoclonal antibodies

甘肃省土地利用碳排放时空演变特征及影响因素

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环境科学 2024年

作者：李梓赫周冬梅江晶马静朱小燕石鹏张军 DONG Qing-han FlemishInstituteforTechnologicalResearch(vito) 甘肃农业大学管理学院甘肃省节水农业工程技术研究中心甘肃农业大学资源与环境学院

陆地生态系统是世界上最大的碳汇，而土地利用变化是导致区域碳排放主要因素之一，通过对2000～2020年甘肃省土地利用碳排放时空演变特征和影响因素研究，为促进甘肃省土地低碳利用、低碳经济发展提供一定科学依据与参考。利用土地利用... 详细信息

陆地生态系统是世界上最大的碳汇，而土地利用变化是导致区域碳排放主要因素之一，通过对2000～2020年甘肃省土地利用碳排放时空演变特征和影响因素研究，为促进甘肃省土地低碳利用、低碳经济发展提供一定科学依据与参考。利用土地利用数据，结合温室气体排放系数法，研究甘肃省市域尺度土地利用碳排放增长趋势与省域尺度时空演变特征，并通过主成分分析研究其控制因素。结果表明：①2000～2020年甘肃省土地利用碳排放整体为增加趋势，由2428.93万t长至5773.96万t，其中2000～2014年第一阶段为显著增加阶段，2014～2020年第二阶段为稳定且略有降低阶段。建设用地为主要碳源，碳源强度仍呈增加态势。②空间上表现为“东高西低”的特征，河东碳排放量明显高于河西碳排放量。③根据排放特征将甘肃省划分为缓慢增长型、较慢增长型、中速增长型、较快增长型和迅猛增长型5类碳排放类型区。④经济发展水平、土地利用程度与能源消费是导致甘肃省土地利用碳排放不断增加的主要原因。

关键词：土地利用碳排放时空特征主成分分析甘肃省

Recent progress in the structure optimization and development of proton-conducting electrolyte materials for low-temperature solid oxide cells

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 848-869页

作者： Jia Song Yuvraj Y.Birdja Deepak Pant Zhiyuan Chen Jan Vaes Separation and Conversion Technology Flemish Institute for Technological Research(VITO)Mol 2400Belgium

This work reviews technologies that can be used to develop low-temperature solid oxide cells(LT-SOCs)and can be applied in fuel cells and electrolyzers operating at temperatures below 500℃,thus providing a more cost-effective alternative than conventional high-temperature *** routes showing potential to reduce the operating temperature of SOCs to below 500℃ are *** first route is the principal way to enhance cell performance,namely,structure *** technique includes the reduction of electrolyte thickness to the nanometer scale and the exploration of electrode structure with low polarization *** other route is the development of novel protonconducting electrolyte materials,which is in the frontier of SOCs *** fundamentals of proton conduction and the design principles of commonly used electrolyte materials are briefly *** most widely studied electrolyte materials for LT-SOCs,namely,perovskitetype BaCeO_(3) -and BaZrO_(3) -based oxides,and the effect of doping on the physical-chemical properties of these oxide materials are summarized.

关键词： low-temperature solid oxide cells perovskite doping thin-film

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Fat management in upper blepharoplasty:Addition or subtraction blepharoplasties,how and when

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World Journal of Clinical Cases 2024年第16期12卷 2796-2802页

作者： Giovanni Miotti Jacopo Di Filippo Martina Grando Carlo Salati Pier Camillo Parodi Leopoldo Spadea Caterina Gagliano Mutali Musa Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Optometry University of BeninBenin 3000283Nigeria Department of Ophthalmology Centre for Sight AfricaNkporOnitsha 434112Niger

BACKGROUND As one of the most common aesthetic surgical procedures carried out today,blepharoplasty should be in the repertoire of every plastic *** term blepharoplasty encompasses a wide range of techniques and options that must be tailored to the specific defect and patient one has to treat.A sound knowledge of the upper and lower eyelids’anatomy is essential for proper surgical *** have shifted towards more conservative methods(especially of the fat compartment)and sometimes in combination with augmentation techniques,helping to reach a rejuvenated *** To present an overview of the surgical techniques considered for upper lid blepharoplasty and fat pad management,in addition to information on how a surgeon may approach the best treatment for his patient based on current publications in *** We searched the literature published between 2013,to 2023 using Medline and Reference Citation *** database was searched using the keywords“upper blepharoplasty”AND“fat”.Papers without full text/abstracts and reviews were *** search strategy followed the *** American Society of Plastic Surgeons guidelines for Therapeutic Studies checklist was used to assess all *** authors individually reviewed each article and rated them for importance and relevance to the topic.A consensus was sought and the most relevant *** After the application of the selection criteria used in our review,13 publications were found to address upper lid blepharoplasty *** of these studies were reviews and three were retrospective *** publications were comparative studies and a further two were clinical *** The tendency of modern surgery is to be conservative,by removing adipose tissue only if strictly necessary and restoring the volume of the upper eyelid in a concept of beauty that espouses a"full"*** is no gold standard technique to achieve younger and enhanced eyelids

关键词： Blepharoplasty Fat pads Eye lid surgery Cosmetic aesthetic surgery Rejuvenation Plastic surgery

Immunotherapy for nonalcoholic fatty liver disease-related hepatocellular carcinoma:Lights and shadows

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1622-1636页

作者： Federico Costante Carlo Airola Francesco Santopaolo Antonio Gasbarrini Maurizio Pompili Francesca Romana Ponziani Internal Medicine and Gastroenterology-Hepatology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRoma 00168Italy Catholic University Largo Francesco Vito 100168 RomaItaly

About one-fourth of adults globally suffer from nonalcoholic fatty liver disease(NAFLD), which is becoming a leading cause of chronic liver disease worldwide. Its prevalence has rapidly increased in recent years, and is projected to increase even more. NAFLD is a leading cause of hepatocellular carcinoma(HCC), the sixth-most prevalent cancer worldwide and the fourth most common cause of cancer-related death. Although the molecular basis of HCC onset in NAFLD is not completely known, inflammation is a key player. The tumor microenvironment(TME) is heterogeneous in patients with HCC, and is characterized by complex interactions between immune system cells, tumor cells and other stromal and resident liver cells. The etiology of liver disease plays a role in controlling the TME and modulating the immune response. Markers of immune suppression in the TME are associated with a poor prognosis in several solid tumors. Immunotherapy with immune checkpoint inhibitors(ICIs) has become the main option for treating cancers, including HCC. However, meta-analyses have shown that patients with NAFLD-related HCC are less likely to benefit from therapy based on ICIs alone. Conversely, the addition of an angiogenesis inhibitor showed better results regarding the objective response rate and progression-free survival. Adjunctive diagnostic and therapeutic strategies, such as the application of novel biomarkers and the modulation of gut microbiota, should be considered in the future to guide personalized medicine and improve the response to ICIs in patients with NAFLD-related HCC.

关键词： Hepatocellular carcinoma Immunotherapy Liver cancer Nonalcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Obesity

Combining Market-Based Control with Distribution Grid Constraints when Coordinating Electric Vehicle Charging

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Engineering 2015年第4期1卷 453-465页

作者： Geert Deconinck Klaas De Craemer Bert Claessens KU Leuven-Energy Ville vito-Energy Ville

The charging of electric vehicles(EVs) impacts the distribution grid, and its cost depends on the price of electricity when charging. An aggregator that is responsible for a large fleet of EVs can use a market-based control algorithm to coordinate the charging of these vehicles, in order to minimize the costs. In such an optimization, the operational parameters of the distribution grid, to which the EVs are connected, are not considered. This can lead to violations of the technical constraints of the grid(e.g., undervoltage, phase unbalances); for example, because many vehicles start charging simultaneously when the price is low. An optimization that simultaneously takes the economic and technical aspects into account is complex, because it has to combine time-driven control at the market level with eventdriven control at the operational level. Diff erent case studies investigate under which circumstances the market-based control, which coordinates EV charging, conflicts with the operational constraints of the distribution grid. Especially in weak grids, phase unbalance and voltage issues arise with a high share of EVs. A low-level voltage droop controller at the charging point of the EV can be used to avoid many grid constraint violations, by reducing the charge power if the local voltage is too low. While this action implies a deviation from the cost-optimal operating point, it is shown that this has a very limited impact on the business case of an aggregator, and is able to comply with the technical distribution grid constraints, even in weak distribution grids with many EVs.

关键词：电动汽车充电电源控制算法配电网市场三相不平衡驱动控制违规行为

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Kinetics of solid-state reduction of chromite overburden

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International Journal of Minerals,Metallurgy and Materials 2023年第12期30卷 2347-2355页

作者： Saida Shaik Zhiyuan Chen Preeti Prakash Sahoo Chenna Rao Borra Metallurgical and Materials Engineering Department Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India vito-Flemish Institute for Technological Research Boeretang 200B-2400 MolBelgium Research and Development Division Tata Steel Ltd.Jamshedpur 831001India

The demand for alternative low-grade iron ores is on the rise due to the rapid depletion of high-grade natural iron ore resources and the increased need for steel usage in daily ***,the use of low-grade iron ores is a constant clinical task for industry *** smelting of low-grade ores consumes a substantial amount of energy due to the large volume of slag *** condition can be avoided by direct reduction followed by magnetic separation(to separate the high amount of gangue or refractory and metal parts)and *** overburden(COB)is a mine waste generated in chromite ore processing,and it mainly consists of iron,chromium,and nickel(<1wt%).In the present work,the isothermal and non-isothermal kinetics of the solid-state reduction of self-reduced pellets prepared using low-grade iron ore(COB)were thoroughly investigated via thermal *** results showed that the reduction of pellets followed a firstorder autocatalytic reaction control mechanism in the temperature range of 900-1100℃.The autocatalytic nature of the reduction reaction was due to the presence of nickel in the *** apparent activation energy obtained from the kinetics results showed that the solid-state reactions between COB and carbon were the rate-determining step in iron oxide reduction.

关键词： chromite overburden solid-state reduction kinetics autocatalytic reaction

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Clinical implications of endogenous testosterone density on prostate cancer progression in patients with very favorable low and intermediate risk treated with radical prostatectomy

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Asian Journal of Andrology 2023年第5期25卷 556-563页

作者： Antonio Benito Porcaro Alessandro Tafuri Andrea Panunzio Clara Cerrato Alberto Bianchi Sebastian Gallina Stefano Vidiri Damiano D'Aietti Emanuele Serafin Giovanni Mazzucato Alessandro Princiotta Davide Brusa Matteo Brunelli Vincenzo Pagliarulo Maria Angela Cerruto AlessandroAntonelli Department of Urology University of VeronaIntegrated University Hospital of VeronaVerona 37126Italy Department of Urology Vito Fazzi HospitalLecce 73100Italy Department of Pathology University of VeronaIntegrated University Hospital of VeronaVerona 37126Italy

We tested the association between endogenous testosterone density(ETD;the ratio between endogenous testosterone[ET]and prostate volume)and prostate cancer(PCa)aggressiveness in very favorable low-and intermediate-risk PCa patients who underwent radical prostatectomy(RP).Only patients with prostate-specific antigen(PSA)within 10 ng ml^(-1),clinical stage T1c,and International Society of Urological Pathology(IsUP)grade group 1 or 2 were *** ET levels up to 350 ng dl^(-1)were classified as *** quantitation density factors were evaluated as the ratio between percentage of biopsy-positive cores and prostate volume(biopsy-positive cores density,BPCD)and the ratio between percentage of cancer invasion at final pathology and prostate weight(tumor load density,TLD).Disease upgrading was coded as ISUP grade group>2,and progression as recurrence(biochemical and/or local and/or distant).Risk associations were evaluated by multivariable Cox and logistic regression *** 320 patients,151(47.2%)had intermediate-risk ***(median:402.3 ng dl^(-1))resulted abnormal in 111(34.7%)cases(median ETD:9.8 ng dl^(-1)ml^(-1)).Upgrading and progression occurred in 109(34.1%)and 32(10.6%)cases,*** was predicted by ISUP grade group 2(hazard ratio[HR]:2.290;P=0.029)and upgrading(HR:3.098;P=0.003),which was associated with ISUP grade group 2(odds ratio[OR]:1.785;P=0.017)and TLD above the median(OR:2.261;P=0.001).After adjustment for PSAdensity and bodymass index(BMI),ETDabovethemedianwas positivelyassociatedwithBPCD(OR:3.404;P<0.001)and TLD(OR:5.238;P<0.001).Notably,subjects with abnormal ET were more likely to have higher BPCD(OR:5.566;P=0.002),as well as TLD(OR:14.998;P=0.016).Independently by routinely evaluated factors,as ETD increased,BPCD and TLD increased,but increments were higher for abnormal ET *** very favorable cohorts,ETD may further stratify the risk of aggressive PCa.

关键词： endogenous testosterone density prostate cancer radical prostatectomy tumor progression

Fat or fillers:The dilemma in eyelid surgery

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World Journal of Clinical Cases 2024年第17期12卷 2951-2965页

作者： Giovanni Miotti Luca De Marco Davide Quaglia Martina Grando Carlo Salati Leopoldo Spadea Caterina Gagliano Mutali Musa Pier Luigi Surico Pier Camillo Parodi Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna“Kore”Enna 94100Italy Eye Clinic Catania University San Marco Hospital Viale Carlo Azeglio CiampiCatania 95121Italy Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser CentreKm 7Benin 300105Nigeria Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States

The aging of the periocular region has always aroused great interest.A fresh,young,and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this *** particular,the change in the concept of a young look,considered then“full”,led to the increasing use of surgical(fat grafting)or medical(hyaluronic acid)filling *** rejuvenation became increasingly popular in the field of cosmetic treatments,with a focus on achieving a youthful and refreshed *** the various techniques available,the choice between using fat grafting or fillers presented a clinical *** particular,what surgery considered of fundamental importance was a long-lasting result over *** the other hand,aesthetic medicine considered it fundamental not to have to resort to invasive *** what was the reality?Was there one path better than the other,and above all,was there a better path for patients?The minireview aims to explore the physiopathology,diagnosis,treatment options,prognosis,and future studies regarding this *** analyzed the literature produced in the last 20 years comparing the two *** literature reveals advancements in biomaterials,stem cell research and tissue engineering held promise for further enhancing the field of eyelid *** choice between fat grafting and fillers in eyelid cosmetic treatments presented a clinical *** physiopathology,accurately diagnosing eyelid aging,exploring treatment options,assessing prognosis,and conducting future studies were essential for providing optimal care to patients seeking eyelid rejuvenation.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative