检索结果-南通市图书馆

Physiological and molecular biochemical mechanisms of bile formation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第42期19卷 7341-7360页

作者： vasiliy Ivanovich Reshetnyak V.A. negovsky scientific research institute of general reanimatology Russian Academy of Medical Sciences107031 MoscowRussia

This review considers the physiological and molecular biochemical mechanisms of bile *** composition of bile and structure of a bile canaliculus,biosynthesis and conjugation of bile acids,bile phospholipids,formation of bile micellar structures,and enterohepatic circulation of bile acids are *** general,the review focuses on the molecular physiology of the transporting systems of the hepatocyte sinusoidal and apical *** of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes,associated with diseases of the liver and biliary tract.

关键词： Bile acids Bile phospholipids Bile micelle structures Bile salt transporters

Significance of dormant forms of Helicobacter pylori in ulcerogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第27期23卷 4867-4878页

作者： vasiliy Ivanovich Reshetnyak Tatiana Magomedalievna Reshetnyak va negovsky research institute of general reanimatology of Federal research and Clinical Center of Intensive Care Medicine and Rehabilitology Department of Systemic Connective Tissue Diseases VA Nasonova Research Institute of Rheumatology

Nearly half of the global population are carriers of Helicobacter pylori(H. pylori),a Gram-negative bacterium that persists in the healthy human stomach. H. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. It is well established that H. pylori infection is the main cause of chronic gastritis and peptic ulcer disease(PUD). Decontamination of the gastric mucosa with various antibiotics leads to H. pylori elimination and longer remission in this disease. However,the reasons for repeated detection of H. pylori in recurrent PUD after its successful eradication remain unclear. The reason for the redetection of H. pylori in recurrent PUD can be either reinfection or ineffective anti-Helicobacter therapy. The administration of antibacterial drugs can lead not only to the emergence of resistant strains of microorganisms,but also contribute to the conversion of H. pylori into the resting(dormant) state. The dormant forms of H. pylori have been shown to play a potential role in the development of relapses of PUD. The paper discusses morphological H. pylori forms,such as S-shaped,C-shaped,U-shaped,and coccoid ones. The authors proposes the classification of H. pylori according to its morphological forms and viability.

关键词： Helicobacter pylori Forms of H. pylori Dormant forms of H. pylori Viable forms of H. pylori Non-viable forms of H. pylori Physiological states of H. pylori Culturable forms of H. pylori Unculturable forms of H. pylor Resuscitation of dormant H. pylori Ulcerogenesis

Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第25期21卷 7683-7708页

作者： vasiliy Ivanovich Reshetnyak V.A. negovsky research institute of general reanimatology

Primary biliary cirrhosis(PBC) is a chronic progressive cholestatic granulomatous, and destructive inflammatory lesion of small intralobular and septal bile ducts, which is likely to be caused by an autoimmune mechanism with a the presence of serum antimitochondrial antibodies and a potential tendency to progress to cirrhosis. Despite the fact that the etiology of this disease has beenunknown so far, there has been a considerable body of scientific evidence that can reveal the clinical and laboratory signs of PBC and the individual components of its pathogenesis and elaborate diagnostic criteria for the disease and its symptomatic therapy. Deficiencies in autoimmune tolerance are critical factors for the initiation and perpetuation of the disease. The purpose of this review is to summarize the data available in the literature and the author's findings on clinical and laboratory criteria for the diagnosis of PBC. This review describes the major clinical manifestations of the disease and the mechanisms of its development. It presents the immunological, biochemical, and morphological signs of PBC and their significance for its diagnosis. A great deal of novel scientific evidence for the problem of PBC has been accumulated. However, the inadequate efficiency of therapy for the disease lends impetus to the quest for its etiological factors and to further investigations of its pathogenetic mechanisms and, on this basis, to searches for new methods for its early diagnosis.

关键词： Primary biliary cirrhosis Clinical criteria Laboratory criteria Immunological signs Biochemicalsigns Morphological signs

Liver transplantation in a patient with primary antiphospholipid syndrome and Budd-Chiari syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第19期7卷 2229-2236页

作者： Tatiana M Reshetnyak Natalia V Seredavkina Maria A Satybaldyeva Evgeniy L Nasonov vasiliy I Reshetnyak va Nasonova research institute of Rheumatology Kashirskoye Shosse Russian Medical Academy of Post-graduate Education va Negorovsky research institute of general reanimatology

The antiphospholipid syndrome(APS) is an acquired thrombophilic disorder in which autoantibodies are produced to a variety of phospholipids determinants of cell membranes or phospholipid binding proteins. There are few reports about association between antiphospholipid antibodies and development of BuddChiari syndrome(BCS). We report the case of BCS development in young Russian male with primary APS. The patient underwent orthotopic liver transplantation on August 26, 2012. At present time his state is good, the blood flow in the liver restored and its function is not impaired. We report about the first time the successful use of dabigatran etexilate for prolonged anticoagulation therapy in APS patient with BCS. In addition patient is managed with immunosuppressive drugs.

关键词： Budd-Chiari syndrome Antiphospholipid syndrome Inh