Concept of the pathogenesis and treatment of cholelithiasis

作     者：Vasiliy Ivanovich Reshetnyak 

作者机构：VA Negovsky Scientific Research Institute of General Reanimatology Russia Academy of Medical Sciences 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2012年第4卷第2期

页      面：18-34页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Gallstone disease:Epidemiology Pathogenesis of cholesterol stones Treatment 

摘      要：Gallstone disease(GD) is a chronic recurrent hepatobiliary disease,the basis for which is the impaired metabolism of cholesterol,bilirubin and bile acids,which is characterized by the formation of gallstones in the hepatic bile duct,common bile duct,or *** is one of the most prevalent gastrointestinal diseases with a substantial burden to health care *** can result in serious outcomes,such as acute gallstone pancreatitis and gallbladder *** epidemiology,pathogenesis and treatment of GD are discussed in this *** prevalence of GD varies widely by *** prevalence of gallstone disease has increased in recent *** is connected with a change in lifestyle:reduction of motor activity,reduction of the physical load and changes to *** of the important benefits of early screening for gallstone disease is that ultrasonography can detect asymptomatic cases,which results in early treatment and the prevention of serious *** pathogenesis of GD is suggested to be multifactorial and probably develops from complex interactions between many genetic and environmental *** suggests that corticosteroids and oral contraceptives,which contain hormones related to steroid hormones,may be regarded as a model system of cholelithiasis development in *** achievement in the study of the physiology of bile formation and the pathogenesis of GD has allowed expanding indications for therapeutic treatment of GD.