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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan Stone Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah university of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Internet of Cultural Things: Current Research, Challenges and Opportunities

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Computers, Materials & Continua 2023年第1期74卷 469-488页

作者： Xiaoting Liang Fang Liu Linqi Wang Baoying Zheng Yiyuan Sun Hunan university Changsha410082China university of the arts london LondonSW1P 4JUUK

Driven by the visions of the Internet of Things(IoT),Artificial Intelligence(AI),and 5G communications,the Internet of Cultural Things(IoCT)realize the comprehensive interconnection among cultural products,cultural services,cultural resources,and cultural platforms,bringing individuals with richer humanistic experience,increasing economic benefits for the cultural sector,and promoting the development of cultural heritage protection and *** present,IoCT has received widespread attention in both industry and *** explore new research opportunities and assist users in constructing suitable IoCT systems for specific applications,this survey provides a comprehensive overview of the IoCT components and key technologies.A comparison study of representative IoCT systems is presented according to their applicability.A general platform architecture of IoCT is proposed to link cultural objects with the internet and ***,open issues for research challenges and future opportunities of IoCT are also studied in this paper.

关键词： Internet of cultural things cultural applications IoCT technology platform architecture

Quantitative data graphics in 3D desktop-based virtual environments-an evaluation

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International Journal of Digital Earth 2015年第8期8卷 623-639页

作者： Susanne Bleisch Jason Dykes Geomatics Engineering FHNW University of Applied Sciences and Arts Northwestern SwitzerlandMuttenzSwitzerland giCentre City University LondonLondonUK

3D desktop-based virtual environments provide a means for displaying quantitative data in *** that are inherently spatial in three dimensions may benefit from visual exploration and analysis in relation to the environment in which they were collected and to which they *** empirically evaluate how effectively and efficiently such data can be visually analyzed in relation to location and landform in 3D versus 2D *** two experiments,participants performed visual analysis tasks in 2D and 3D visualizations and reported insights and their confidence in *** results showed only small differences between the 2D and 3D visualizations in the performance measures that we evaluated:task completion time,confidence,complexity,and insight ***,we found differences for different datasets and settings suggesting that 3D visualizations or 2D representations,respectively,may be more or less useful for particular datasets and contexts.

关键词： 3D geovisualization quantitative data graphics visual data analysis empirical evaluation

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

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Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen Yuan Zhang Jie Ma Zhiqun Lin Amor Abdelkader Maria‑Magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional Materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

Recent advances in glycerol valorization through electrocatalytic methods

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Tungsten 2024年第4期6卷 696-710页

作者： Hao-Hai Dong Yu-Xin Zhu Yi-Gu Li Jia-Yan Liang Ya Tan Xin-Yue Zhang Hao-Min Jiang Liu Lin Ze-Min Sun Center for Advanced Materials Research&College of arts and Sciences Beijing Normal UniversityZhuhai519087China Department of Chemistry University College LondonLondonWC1H0AJUK

The recent tremendous growth of biodiesel production from vegetable oils or waste fats has led to increased glycerol accumulation as a by-product of this *** sparked attention towards glycerol use and valorization of this largely available and cheap *** several methods for glycerol valorization,electrochemical glycerol oxidation reaction(EGOR)is an attractive alternative anodic reaction to oxygen evolution reaction for a variety of electrolytic synthesis,due to the low thermodynamic ***,the EGOR at the anode can be coupled with a cathodic hydrogen evolution reaction to achieve efficient energy conversion in an aqueous electrolytic *** review provides a comprehensive summary and critical analysis of glycerol electrochemical oxidation research during the last 5 *** review focuses on the recent development and prospects of electrochemical pathways(indirect or direct routes)for application in the *** particular,the recent development and prospects of using noble and non-noble group metal catalysts for glycerol electro-oxidation are ***,reaction product selectivity analysis and conversion efficiency are also highlighted.

关键词： Glycerol Electrocatalytic methods Active oxygen species Noble metal catalysts Non-noble metal catalysts

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal Michele L Barbeau Charys M Martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

Conformal Ricci Collineations of Static Spherically Symmetric Spacetimes

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Communications in Theoretical Physics 2008年第6期49卷 1527-1532页

作者： Ugur Camci Asghar Qadir K.Saifullah Department of Physics Faculty of Arts and Sciencesanakkale Onsekiz Mart University17100 anakkaleTurkey Center for Advanced Mathematics and Physics National University of Sciences and TechnologyRawalpindiPakistan School of Mathematical Sciences Queen MaryUniversity of LondonLondonUK

Conformal Ricei collineations of static spherically symmetric spacetimes are studied. The general form of the vector fields generating eonformal Rieei eollineations is found when the Rieei tensor is non-degenerate, in which ease the number of independent eonformal Rieei eollineations is 15, the maximum number for four-dimensional manifolds. In the degenerate ease it is found that the static spherically symmetric spaeetimes always have an infinite number of eonformal Rieei eollineations. Some examples are provided which admit non-trivial eonformal Rieei eollineations, and perfect fluid source of the matter.

关键词： Ricci collineations conformal collineations static spherically symmetric spacetimes

The impacts of the COVID-19 pandemic on multimodal human mobility in london:A perspective of decarbonizing transport

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Geo-Spatial Information Science 2023年第4期26卷 703-715页

作者： Xianghui Zhang Tao Cheng SpaceTimeLab University College LondonLondonUK

Decarbonizing transport is one of the core tasks for achieving Net Zero targets,but the COVID-19 pandemic disrupts human mobility and the established transport development *** existing research has explored the relationship between virus transmission,human mobility,and restrictions policies,few have studied the responses of multimodal human mobility to the pandemic and their impacts on the achievement of decarbonizing *** paper employs 32 consecutive biweekly observations of mobile phone application data to understand the influences of the pandemics on multimodal human mobility from February 2020 to April 2021 in *** here illustrate that multimodal travel behavior and traffic flows significant changed after the pandemic and related lockdowns,but the decline or recovery varies across different travel modes and *** car mode has shown the most resilience throughout the pandemic,but the travel modes in the public transit sector were hit *** and walk modes remained high at the beginning of the pandemic,but the trend did not continue as the pandemic developed and the season *** findings suggest that the COVID-19 pandemic brought more challenges to travel mode shifting and the achievement of decarbonizing transport rather than *** analysis will assist transport authorities to optimize the established transport policies and to redistribute limited resources for accelerating the achievement of decarbonizing transport.

关键词： COVID-19 pandemic multimode human mobility decarbonizing transport