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Internet-based collaborative pseudo-dynamic testing of multi-span bridge structure

Progress in Natural Science:Materials International 2009年第5期19卷 623-633页

作者： Dapeng Wang a, Shizhu Tiana, Xinjiang Caia, Yunlei Fan b, Yan Xiaob,c a school of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China b school of Civil Engineering, Hunan university, Changsha 410082, China c Department of Civil Engineering, university of southern california, Los Angeles, CA 90089, usa [a]school of Civil Engineering Harbin Institute of Technology Harbin 150090 China [b]School of Civil Engineering Hunan University Changsha 410082 China [c]Department of Civil Engineering University of Southern California Los Angeles CA 90089 USA

In this paper, the first Internet-based collaborative pseudo-dynamic testing of a multi-span bridge system in China’s mainland is presented in detail, which has been carried out by the collaboration of Hunan university (HNU), Harbin Institute of Technology (HIT) and Tsinghua university (TU) in China’s mainland, and the university of southern california (USC) in the usa. The prototype system of Russion River Bridge at southern california in America is illustrated. Different testing specimens, testing equipments and substructure boundary conditions at HNU and HIT laboratories are described. A network protocol platform for collaborative pseudo-dynamic testing, called NetSLab, and some function modules developed on the use of its standardized interface are introduced. Aiming at the MTS system widely used in structural testing, two approaches are presented to implement the communication interface between NetSLab and testing equipment, respectively, studied by HNU and HIT. The integrated networked testing system and collaborative testing procedures are presented. The testing results manifest that the networked collaborative testing system with powerful capability provides a testing platform with good coordination for complex models or actual structures, and achieves remote sharing of testing equipments.

关键词： Internet-based collaborative pseudo-dynamic testing Multi-span bridge structure Network protocol platform Communication interface Remote sharing of testing equipment

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Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity:their action in Alzheimer's disease prevention

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Neural Regeneration Research 2023年第12期18卷 2675-2676页

作者： Rayudu Gopalakrishna Andrew Oh Narayan R.Bhat William J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neuroscience Medical University of South CarolinaCharlestonSCUSA

Recently,we have found that various intracellular cyclic adenosine monophosphate(cAMP)-e leva ting agents,both pharmacological(dibutyryl-cAMP,forskolin,and rolipram)and physiological(pituitary adenylate cyclase-activa... 详细信息

关键词： action prevention Cyclic

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Estimated Financing Amount Needed for Essential Medicines in China, 2014

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Chinese Medical Journal 2016年第6期129卷 716-722页

作者： Wei Xu Zheng-Yuan Xu Gong-Jie Cai Chiao-Yun Kuo Jing Li Yi-Syuan Huang school of International Pharmaceutical business China Pharmaceutical University Nanjing Jiangsu 211198 China International Center for Regulatory Science School of Pharmacy University of Southern'California Los-Angeles cA 90089 USA Titus Family Department of Clinical Pharmacy and Pharmaceutical Economics and Policy School of Pharmacy University of Southern California Los Angeles CA 90089 USA

Background： At the present time, the government is considering to establish the independent financing system for essential medicines （EMs）. However, it is still in the exploration phase. The objectives of this study were to calculate and estimate financing amount of EMs in China in 2014 and to provide data evidence for establishing financing mechanism of EMs. Methods： Two approaches were adopted in this study. First, we used a retrospective research to estimate the cost of EMs in China in 2014. We identified all the 520 drugs listed in the latest national EMs list （2012） and calculated the total sales amount of these drugs in 2014. The other approach included the steps that first selecting the 109 most common diseases in China, then identifying the EMs used to treat them, and finally estimating the total cost of these drugs. Results： The results of the two methods, which showed the estimated financing amounts of EMs in China in 2014, were 17,776.44 million USD and 19,094.09 million USD, respectively. Conclusions： Comparing these two results, we concluded that the annual budget needed to provide for the EMs in China would be about 20 billion USD. Our study also indicated that the irrational drug use continued to plague the health system with intravenous fluids and antibiotics being the typical examples, as observed in other studies.

关键词： China Essential Medicines Financing Amount Financing Mechanism Irrational Drug Use

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An accurate analytical I-V model for sub-90-nm MOSFETs and its application to read static noise margin modeling

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Journal of Zhejiang university-Science C(Computers and Electronics) 2012年第1期13卷 58-70页

作者： Behrouz AFZAL Behzad EBRAHIMI Ali AFZALI-KUSHA Massoud PEDRAM school of Electrical and Computer Engineering University of Tehran Department of Electrical Engineering University of Southern California

We propose an accurate model to describe the I-V characteristics of a sub-90-nm metal-oxide-semiconductor field-effect transistor(MOSFET) in the linear and saturation regions for fast analytical calculation of the *** model is based on the BSIM3v3 *** of using constant threshold voltage and early voltage,as is assumed in the BSIM3v3 model,we define these voltages as functions of the gate-source *** accuracy of the model is verified by comparison with HSPICE for the 90-,65-,45-,and 32-nm CMOS *** model shows better accuracy than the nth-power and BSIM3v3 ***,we use the proposed I-V model to calculate the read static noise margin(SNM) of nano-scale conventional 6T static random-access memory(SRAM) cells with high *** calculate the read SNM by approximating the inverter transfer voltage characteristic of the cell in the regions where vertices of the maximum square of the butterfly curves are *** results for the SNM are also in excellent agreement with those of the HSPICE simulation for 90-,65-,45-,and 32-nm *** in the presence of process variations and negative bias temperature instability(NBTI) shows that the model can accurately predict the minimum supply voltage required for a target yield.

关键词： Modeling Nano-scale Process variation Read static noise margin(SNM) SRAM

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Fecal incontinence - Challenges and solutions

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World Journal of Gastroenterology 2017年第1期23卷 11-24页

作者： Nallely Saldana Ruiz Andreas M Kaiser Department of Surgery Division of Colorectal SurgeryKeck School of MedicineUniversity of Southern California Department of Surgery Division of Colorectal SurgeryKeck School of MedicineUniversity of Southern California

Fecal incontinence is not a diagnosis but a frequent and debilitating common final pathway symptom resulting from numerous different causes. Incontinence not only impacts the patient’s self-esteem and quality of life but may result in significant secondary morbidity, disability, and cost. Treatment is difficult without any panacea and an individualized approach should be chosen that frequently combines different modalities. Several new technologies have been developed and their specific roles will have to be defined. The scope of this review is outline the evaluation and treatment of patients with fecal incontinence.

关键词： Fecal incontinence Sphincteroplasty Sacral nerve stimulation Endorectal ultrasound New technologies Quality of life

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Control of pain with topical plant medicines

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 268-273页

作者： James David Adams Jr. Xiaogang Wang university of southern california School of Pharmacy

Pain is normally treated with oral nonsteroidal anti-inflammatory agents and opioids. These drugs are dangerous and are responsible for many hospitalizations and deaths. It is much safer to use topical preparations made from plants to treat pain, even severe pain. Topical preparations must contain compounds that penetrate the skin, inhibit pain receptors such as transient receptor potential cation channels and cyclooxygenase-2, to relieve pain. Inhibition of pain in the skin disrupts the pain cycle and avoids exposure of internal organs to large amounts of toxic compounds. Use of topical pain relievers has the potential to save many lives, decrease medical costs and improve therapy.

关键词： Traditional healing Liniment Topical preparation Pain control

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Evolution and future of laparoscopic colorectal surgery

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World Journal of Gastroenterology 2014年第41期20卷 15119-15124页

作者： Andreas M Kaiser Department of Colorectal Surgery Keck School of MedicineUniversity of Southern California

The advances of laparoscopic surgery since the early 1990 s have caused one of the largest technical revolutions in medicine since the detection of antibiotics(1922,Flemming),the discovery of DNA structure(1953,Watson and Crick),and solid organ transplantation(1954,Murray).Perseverance through a rocky start and increased familiarity with the chop-stick surgery in conjunction with technical refinements has resulted in a rapid expansion of the indications for minimally invasive ***-related factors initially contributed to this success and included the improved postoperative recovery and cosmesis,fewer wound complications,lower risk for incisional hernias and for subsequent adhesionrelated small bowel obstructions; the major breakthrough however came with favorable long-term outcomes data on oncological *** future will have to determine the specific role of various technical approaches,define prognostic factors of success and true progress,and consider directing further innovation while potentially limiting approaches that do not add to patient outcomes.

关键词： Laparoscopic Laparoscopy Open surgery Colorectal surgery Colectomy Robot

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Fiscal Decentralization or Centralization:Diverging Paths of Chinese Cities

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China & World Economy 2019年第3期27卷 102-125页

作者： Shiming Yang university of southern california USA

If fiscal decentralization promotes growth,why do some regions decentralize more than others?This article identifies the growing divergence of fiscal centralization among Chinese cities and explains it in a public finance *** argues that fiscal decentralization and its economy-liberalizing effect entail significant short-term fiscal *** more a locality relies on uncompetitive business ownership for fiscal revenue,the less likely fiscal decentralization is to *** article compiles a dataset of 20 provincial capitals between 1999 and 2016 to test for the connection between a city's tax base and its fiscal centralization *** then pairs two"most similar"cities to trace how fiscal security concerns drove their fiscal and economic policies *** article adds a micro-level perspective to the literature on fiscal *** pointing out the fiscal constraints confronting local governments,it offers a new angle to understand the different growth paths of Chinese cities.

关键词： developing country economic growth fiscal decentralization state-owned enterprise

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Nogo-A receptor internalization by cyclic adenosine monophosphate in overcoming axonal growth inhibitors after stroke

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Neural Regeneration Research 2022年第1期17卷 91-92页

作者： Rayudu Gopalakrishna Charlotte Lin Mark S.Kindy William J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Pharmaceutical Sciences College of PharmacyUniversity of South FloridaTampaFLUSA

Currently,there are no clinically proven drugs for recovery from stroke and other neuronal injuries such as traumatic brain injury and spinal cord *** therapy requires axonal regeneration,which is inhibited by diverse axonal growth inhibitors,such as Nogo-A,myelin-associated glycoprotein(MAG),oligodendrocyte myelin glycoprotein(OMgp),and chondroitin sulfate proteoglycans(CSPGs)(Chaudhry and Filbin,2007;Carmichael,2010;Schwab and Strittmatter,2014).

关键词： axonal injuries inhibited

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Lesson Learned from COVID-19 Retrospective Study: An Entropy-Based Clinical-Interpretable Scorecard for Mortality Risk Control at ICU Admission

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Tsinghua Science and Technology 2024年第1期29卷 34-45页

作者： Chong Yao Chonghui Huangqi Anpeng Huang Laboratory of Network Information Security Beihang UniversityBeijing 100191China Andrew and Erna Viterbi school of Engineering University of Southern CaliforniaLos AnglesCA 90089USA Beijing Goodwill Information and Technology Co. Ltd.and Mobile Health LaboratoryPeking UniversityBeijing 100871China

With severe acute respiratory syndrome coronavirus 2 spreading globally and causing 2019 coronavirus disease(COVID-19),a challenge that we unprepared for was about how to optimally plan and distribute limited top-medical resources for patients in need of urgent *** address this challenge,physicians desperately needed a scientific tool to methodically differentiate between cases with varying *** this study,the unique data of COVID-19 intensive care unit(ICU)patients provided by the national medical team in Wuhan were classified into discrete and continuous variable *** continuous data were discretized using an entropy-based method and transformed into serial information margins,in which each information margin is related to a specific symptom or clinical ***,all these native and processed discrete data were used to configure a readable scorecard through logistic regression,which is the desired scientific tool aforementioned.A total of 322 ICU patients(age:[median:64,interquartile range:54-75],males:178[55.28%],and death:72[22.36%])were included in the *** of mortality in COVID-19 patients can be evaluated using a scorecard model(calibration slope:1.343,Brier:0.048,Dxy=0.972,and population stability index=0.071),with desired model performances(accuracy=0.948,area under curve=0.99,sensitivity=1,and specificity=0.939).This new model can interpret clinical meanings from complex data,and compare it with existing machine learning methods through a black-box *** new data-information model answers a critical question of how a computing algorithm produces clinically meaningful results that will help physicians logically allocate medical resources for COVID-19 ***,this tool has limitations,giving that this research is a retrospective ***,this tool will be tested further and optimized for adaptation to similar clinical cases in the future.

关键词： COVID-19 scorecard clinical-interpretable machine learning ICU admission control

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