Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity:their action in Alzheimer's disease prevention

作     者：Rayudu Gopalakrishna Andrew Oh Narayan R.Bhat William J.Mack Rayudu Gopalakrishna;Andrew Oh;Narayan R.Bhat;William J.Mack

作者机构：Department of Integrative Anatomical SciencesKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological SurgeryKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of NeuroscienceMedical University of South CarolinaCharlestonSCUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第12期

页      面：2675-2676页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：NIH grants,NINDS R21 NS116720 and NINDS/NIA RF1 NS130681(to RG and WJM) NIA R21 AG059422(to NRB) 

主　　题：action prevention Cyclic 

摘      要：Recently,we have found that various intracellular cyclic adenosine monophosphate(cAMP)-e leva ting agents,both pharmacological(dibutyryl-cAMP,forskolin,and rolipram)and physiological(pituitary adenylate cyclase-activating polypeptide),decrease cell-surface levels of 67-kDa laminin receptor(67LR)and cellular prion protein(PrP~C).