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Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi Srivastava Aparna Misra Snober S.Mir Department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India Department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

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Role of renin-angiotensin system/angiotensin converting enzyme-2 mechanism and enhanced COVID-19 susceptibility in type 2 diabetes mellitus

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World Journal of Diabetes 2024年第4期15卷 606-622页

作者： Ashwin Kumar Shukla Komal Awasthi Kauser Usman Monisha Banerjee Molecular and Human Genetics Laboratory Department of ZoologyUniversity of LucknowLucknow 226007Uttar PradeshIndia Department of Medicine King Georges’Medical UniversityLucknow 226003Uttar PradeshIndia Institute of Advanced Molecular Genetics and Infectious Diseases(IAMGID)University of LucknowLucknow 226007Uttar PradeshIndia

Coronavirus disease 2019(COVID-19)is a disease that caused a global pandemic and is caused by infection of severe acute respiratory syndrome coronavirus 2 *** has affected over 768 million people worldwide,resulting in approx-imately 6900000 ***-risk groups,identified by the Centers for Disease Control and Prevention,include individuals with conditions like type 2 diabetes mellitus(T2DM),obesity,chronic lung disease,serious heart conditions,and chronic kidney *** indicates that those with T2DM face a hei-ghtened susceptibility to COVID-19 and increased mortality compared to non-diabetic *** the renin-angiotensin system(RAS),a vital regulator of blood pressure and pulmonary stability,reveals the significance of the angiotensin-converting enzyme(ACE)and ACE2 *** converts angiotensin-I to the vasoconstrictor angiotensin-II,while ACE2 counters this by converting angiotensin-II to angiotensin 1-7,a *** ACE2 exp-ression,common in diabetes,intensifies RAS activity,contributing to conditions like inflammation and *** ACE inhibitors and angiotensin receptor blockers can be therapeutically beneficial by increasing ACE2 levels,concerns arise regarding the potential elevation of ACE2 receptors on cell membranes,potentially facilitating COVID-19 *** review explored the role of the RAS/ACE2 mechanism in amplifying severe acute respiratory syndrome cor-onavirus 2 infection and associated complications in *** treatment strategies,including recombinant human ACE2 therapy,broad-spectrum antiviral drugs,and epigenetic signature detection,are discussed as promising avenues in the battle against this pandemic.

关键词： Angiotensin-converting enzyme 2 Angiotensin-converting enzyme inhibitors Angiotensin-II receptor blockers Complex diseases COVID-19 Type 2 diabetes

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Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M Khan Zaw Ali Khan Mohsin Ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Transcranial direct current stimulation as early augmentation in adolescent obsessive compulsive disorder:A pilot proof-of-concept randomized control trial

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World Journal of Clinical Pediatrics 2024年第2期13卷 161-170页

作者： Aditya Agrawal Vivek Agarwal Sujita Kumar Kar Amit Arya Department of Psychiatry King George Medical UniversityUttar PradeshLucknow 226003India

BACKGROUND Transcranial direct current stimulation(tDCS)is proven to be safe in treating various neurological conditions in children and *** is also an effective method in the treatment of OCD in *** To assess the safety and efficacy of tDCS as an add-on therapy in drug-naive adolescents with *** We studied drug-naïve adolescents with OCD,using a Children’s Yale-Brown obsessive-compulsive scale(CY-BOCS)scale to assess their *** active and sham groups were given fluoxetine,and we applied cathode and anode over the supplementary motor area and deltoid for 20 min in 10 *** occurred at 2,6,and 12 wk using *** Eighteen adolescents completed the study(10-active,8-sham group).CY-BOCS scores from baseline to 12 wk reduced significantly in both groups but change at baseline to 2 wk was significant in the active group *** mean change at 2 wk was more in the active group(11.8±7.77 vs 5.25±2.22,P=0.056).Adverse effects between the groups were *** tDCS is safe and well tolerated for the treatment of OCD in ***,there is a need for further studies with a larger sample population to confirm the effectiveness of tDCS as early augmentation in OCD in this population.

关键词： Adolescents Early augmentation Obsessive compulsive disorder Safety Transcranial direct current stimulation

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HV Process Model of Software Development

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Journal of Software Engineering and Applications 2024年第7期17卷 553-570页

作者： Hemant Kumar Vipin Saxena Department of Computer Science Babasaheb Bhimrao Ambedkar University Lucknow India

Software Development Life Cycle (SDLC) is one of the major ingredients for the development of efficient software systems within a time frame and low-cost involvement. From the literature, it is evident that there are various kinds of process models that are used by the software industries for the development of small, medium and long-term software projects, but many of them do not cover risk management. It is quite obvious that the improper selection of the software development process model leads to failure of the software products as it is time bound activity. In the present work, a new software development process model is proposed which covers the risks at any stage of the development of the software product. The model is named a Hemant-Vipin (HV) process model and may be helpful for the software industries for development of the efficient software products and timely delivery at the end of the client. The efficiency of the HV process model is observed by considering various kinds of factors like requirement clarity, user feedback, change agility, predictability, risk identification, practical implementation, customer satisfaction, incremental development, use of ready-made components, quick design, resource organization and many more and found through a case study that the presented approach covers many of parameters in comparison of the existing process models. .

关键词： Software Process Model Software Development Software Engineering Software Risk Management and Software Quality

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Nested Levels of Hybrid Cryptographical Technique for Secure Information Exchange

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Journal of Computer and Communications 2024年第2期12卷 201-210页

作者： Pawan Kumar Vipin Saxena Department of Computer Science Babasaheb Bhimrao Ambedkar University Lucknow India

Data security is a very important part of data transmission over insecure channels connected through high-speed networks. Due to COVID-19, the use of data transmission over insecure channels has increased in an exponential manner. Hybrid cryptography provides a better solution than a single type of cryptographical technique. In this paper, nested levels of hybrid cryptographical techniques are investigated with the help of Deoxyribonucleic Acid (DNA) and Paillier cryptographical techniques. In the first level, information will be encrypted by DNA and at the second level, the ciphertext of DNA will be encrypted by Paillier cryptography. At the decryption time, firstly Paillier cryptography will be processed, and then DAN cryptography will be processed to get the original text. The proposed algorithm follows the concept of Last Encryption First Decryption (LEFD) at the time of decryption. The computed results are depicted in terms of tables and graphs.

关键词： Encryption Decryption DNA Paillier Cryptography Nested Levels Hybrid Cryptography

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Inflammatory bowel disease(ulcerative colitis type)severity shows inverse correlation with semen parameters and testosterone levels

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Asian Journal of Andrology 2024年第2期26卷 155-159页

作者： Darmadi Darmadi Cennikon Pakpahan Rajender Singh Ankur Saharan Wanly Syahrizal Pasaribu Hermansyah Hermansyah Andri Rezano Department of Internal Medicine Faculty of MedicineUniversitas Sumatera UtaraMedan 20155Indonesia Andrology Study Program Faculty of MedicineUniversitas AirlanggaSurabaya 60132Indonesia Department of Biomedical Sciences Faculty of MedicineUniversitas AirlanggaSurabaya 60132Indonesia Division of Endocrinology Central Drug Research InstituteLucknowUtar Pradesh 226031India Amity university LucknowUttar Pradesh 226010India Department of Biomedical Sciences Faculty of MedicineUniversitas PadjadjaranSumedang 45363Indonesia

Individuals with inflammatory bowel disease(IBD)have been reported to be at an increased risk of infertility and sexual *** the relationship between them remains unclear,IBD severity is suspected to affect hormone levels and *** analyze the impact of IBD severity on semen parameters and sex hormone levels in ulcerative colitis-type IBD(UC-IBD),we conducted a cross-sectional study involving 120 patients with UC-IBD in Adam Malik General Hospital,Medan,*** patients were classified into three groups based on the Mayo score for Uc,followed by a comparison of various semen and hormone parameters among these *** addition to the cross-sectional analysis,a simple correlation test was conducted irrespective of the patient *** concentration,motility,and morphology were found to decline significantly with an increase in IBD *** classifying patients with IBD into subgroups,the Mayo score showed negative correlations with sperm concentration(r=-0.375,P<0.0001),rapid progressive motility(r=-0.660,P<0.0001),free testosterone(r=-0.732,P<0.0001),and total testosterone(r=-0.721,P<0.0001),and positivecorrelations with immotile sperm(r=0.660,P<0.0001),abnormal morphology(r=0.657,P<0.0001),and sex hormone-binding globulin(SHBG;r=0.278,P=0.002).Sperm concentration,motility,and morphology declined significantly with the severity of *** study suggests a significant negative impact of IBD severityonsemenqualityand sexhormones.

关键词： inflammatory bowel disease reproductive health sexual health sperm parameter testosterone

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Software Defect Prediction Using Hybrid Machine Learning Techniques: A Comparative Study

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Journal of Software Engineering and Applications 2024年第4期17卷 155-171页

作者： Hemant Kumar Vipin Saxena Department of Computer Science Babasaheb Bhimrao Ambedkar University Lucknow India

When a customer uses the software, then it is possible to occur defects that can be removed in the updated versions of the software. Hence, in the present work, a robust examination of cross-project software defect prediction is elaborated through an innovative hybrid machine learning framework. The proposed technique combines an advanced deep neural network architecture with ensemble models such as Support Vector Machine (SVM), Random Forest (RF), and XGBoost. The study evaluates the performance by considering multiple software projects like CM1, JM1, KC1, and PC1 using datasets from the PROMISE Software Engineering Repository. The three hybrid models that are compared are Hybrid Model-1 (SVM, RandomForest, XGBoost, Neural Network), Hybrid Model-2 (GradientBoosting, DecisionTree, LogisticRegression, Neural Network), and Hybrid Model-3 (KNeighbors, GaussianNB, Support Vector Classification (SVC), Neural Network), and the Hybrid Model 3 surpasses the others in terms of recall, F1-score, accuracy, ROC AUC, and precision. The presented work offers valuable insights into the effectiveness of hybrid techniques for cross-project defect prediction, providing a comparative perspective on early defect identification and mitigation strategies. .

关键词： Defect Prediction Hybrid Techniques Ensemble Models Machine Learning Neural Network

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Protection of steel hooks embedded in glass-fiber-reinforced concrete against macrocell corrosion

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Petroleum Research 2024年第2期9卷 317-326页

作者： Husnu Gerengi Muhammed Maraşlı Marziya Rizvi Beni Kohen Ismail Taşkıran Corrosion Research Laboratory Department of Mechanical EngineeringDuzce University81620DuzceTurkey Department of Engineering and Applied Sciences University of BergamoBGItaly Fibrobeton Company R&D Center DuzceTurkey Department of Chemistry Babasaheb Bhimrao Ambedkar UniversityLucknow226003U.PIndia

This study evaluated the corrosion behavior of steel hooks embedded in GFRC,which were protected by a zinc-rich(96%Zn)galvanizing *** coating provided the hooks with active cathodic protection and a passive physical *** corrosion may form when the anode is smaller than the total steel ***,the steel hooks at the embedment juncture were additionally sealed against water ingress and air exchange using a construction *** study was conducted in three phases in a salt-spray ***,the electrogalvanized steel hooks embedded in GFRC were allowed to freely corrode for 7 *** the second phase,the electrogalvanized steel hooks were painted with the zinc-rich coating and observed over 7 *** the third phase,the steel hooks were protected by the zinc-rich coating together with a primer and construction sealant,and observed over 7 *** evaluate the electrogalvanized hooks and the corrosion products formed,the thickness of the material was *** on the metal surface was inferred by studying the surface morphology of the hooks at various points of contact and after different periods of time.

关键词： Steel rebars Concrete corrosion GFRC Galvanization Sealant

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Palaeodepositional environment,implications of Glossopteris flora,and organic matter characteristics from the Lower Permian,Karo Open Cast Mine,East Bokaro Coalfield,Damodar Basin,India

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Journal of Palaeogeography 2024年第3期13卷 528-546页

作者： Sankar Suresh Kumar Pillai Rose Ann Sebastian Runcie Paul Mathews Srikanta Murthy Anju Saxena Mrutyunjaya Sahoo Suraj Kumar Sahu Gulshan Kumar Dhingra Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow-226007UPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad-201002India Department of Geology School of Earth Science SystemsCentral University of KeralaKasaragod-671316KeralaIndia Department of Geology Ravenshaw UniversityCuttack-753003OdishaIndia Department of Botany Sri Dev Suman Uttarakhand UniversityUttarakhand-249145India

The present study deals with the Early Permian floral diversity,palaeoenvironment,palaeoclimate and depositional setting using a multiproxy approach that includes morphotaxonomy,palynology,and organic geochemistry of Karo OCM(Open Cast Mine),East Bokaro Coalfield,Damodar Gondwana Basin,*** Permian sediments of Peninsular India are widely regarded as fluvial,along with some marine *** macroplant fossil assemblage exhibits the presence of Glossopteridales,comprising Glossopteris,Gangamopteris,and Vertebraria,as well as Coniferales,which includes *** palynological assemblage encompasses the dominance of the striate bisaccate pollen Faunipollenites *** the subdominance of the non-striate bisaccate pollen Scheuringipollenites *** glossopterid *** megafloral and palynofloral assemblage confirms the biostratigraphical age to be Late Barakar palynoflora of Kungurian *** studied morphological characteristics,including small to large Glossopteris leaves exhibiting a lanceolate shape,acute apices,and acute cuneate or tapering bases,as well as entire margins with narrower lamina and narrow meshes,suggest the existence of a dense forest with the prevalence of a warm and humid climate during their *** organic geochemical characterization based on functional group and biomarker analyses reveals the diagenetic effects on organic *** symmetric(~2865-2855 cm^(-1))and asymmetric stretching(~2930-2910 cm^(-1))peaks are identifiable in coal samples,whereas they are absent in carbonaceous *** A-factor vs.C-factor plot suggests that the kerogen type is type Ⅲ,which can generate mainly gaseous *** vitrinite reflectance studies(R_(r) av.1.1%)show increased maturity of the samples,which is supported by the n-alkane distribution pattern and the absence of hopane *** Indian floral assemblages in contemporary of southern Gondwana continents reveal a stronger inclination/affinity with th

关键词： Glossopteris Palynomorph FTIR GCMS Gondwana Permian Palaeoclimate

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