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Classification of musical hallucinations and the characters along with neural-molecular mechanisms of musical hallucinations associated with psychiatric disorders

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World Journal of Psychiatry 2024年第9期14卷 1386-1396页

作者： Xin Lian Wei Song Tian-Mei Si Naomi Zheng Lian Department of Radiology and Biomedical Imaging Shanxi Bethune HospitalShanxi Academy of Medical SciencesTaiyuan 030032Shanxi ProvinceChina Department of Psychiatry and Behavioral Neurosciences McMaster UniversityHamilton L8S 4L8ONCanada Department of Psychopharmacology Peking University Sixth HospitalBeijing 100191China Department of Psychiatry Hartford HealthCareSt Vincent’s Medical CenterWestportCT 06088United States

BACKGROUND Musical hallucinations(MH)involve the false perception of music in the absence of external stimuli which links with different *** pathomechanisms of MH encompass various *** etiological classification of MH is of particular importance and offers valuable insights to understand MH,and further to develop the effective treatment of *** the recent decades,more MH cases have been reported,revealing newly identified medical and psychiatric causes of *** imaging studies reveal that MH activates a wide array of brain *** up-to-date analysis on MH,especially on MH comorbid psychiatric conditions is *** To propose a new classification of MH;to study the age and gender differences of MH in mental disorders;and neuropathology of *** Literatures searches were conducted using keywords such as“music hallucination,”“music hallucination and mental illness,”“music hallucination and gender difference,”and“music hallucination and psychiatric disease”in the databases of PubMed,Google Scholar,and Web of *** cases were collected and categorized based on their *** t-test and ANOVA were employed(P<0.05)to compare the age differences of MH different etiological *** neuroimaging studies of neural networks regulating MH and their possible molecular mechanisms were *** Among the 357 yielded publications,294 MH cases were *** average age of MH cases was 67.9 years,with a predominance of females(66.8%females vs 33.2%males).MH was classified into eight groups based on their etiological *** analysis of MH cases indicates varying associations with psychiatric *** We carried out a more comprehensive review of MH *** the first time according to our knowledge,we demonstrated the psychiatric conditions linked and/or associated with MH from statistical,biological and molecular point of view.

关键词： Pathomechanism Etiological factors Classification Gender difference Neuropathway Psychotic musical hallucination and non-psychotic musical hallucination Neuropathway Biological and molecular mechanism

Staged endovascular reconstruction of complex traumatic intracranial carotid artery dissection

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Stroke & Vascular Neurology 2020年第3期5卷 308-310页

作者： Karan K Topiwala Mohammed Hussain Janhavi Modak Inam Kureshi Amre Nouh Mubashir Pervez Brendan Killory Daniel Lee Neurology University of Connecticut School of MedicineFarmingtonConnecticutUSA Interventional Neuroradiology Hartford HospitalHartfordConnecticutUSA Neurosurgery Hartford HospitalHartfordConnecticutUSA Neurology Hartford HospitalHartfordConnecticutUSA

Case presenTaTion A 32-year old woman presented with traumatic facial injuries from a horseback riding *** was found to have a Glasgow Coma Score of 3T,left eyelid ptosis with a fixed-dilated pupil and a flaccid right upper *** angiogram of the head showed complex craniofacial injuries,including a transverse fracture transecting the clivus and the left petrous temporal bone,with SAH in the suprasellar *** was a bilateral engorgement of the superior ophthalmic veins,suggestive of bilateral CCF *** subtraction angiography(DSA)showed a left petrocavernous internal carotid artery dissection(ICAD).MRI of the brain demonstrated multiple embolic infarcts in the left middle cerebral artery(MCA)territory,despite therapeutic anticoagulation with heparin.

关键词： injuries dissection traumatic

Astrogenesis versus astrogliosis

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Neural Regeneration Research 2017年第2期12卷 203-204页

作者： Andrew O.Koob Biology Department and Neuroscience Program University of Hartford West Hartford CT USA

In the mammalian cortex,certain astrocyte subtypes can serve as local adult *** process of local astrogenesis has been linked to astrogliosis,a nebulous term to describe the astrocytic response to injury and *** current evidence indicates that astrogliosis occurs in a context-specific manneralong a graded continuum in response to injury：

关键词： Astrogenesis versus astrogliosis

Chimera RNA interference knockdown of γ-synuclein in human cortical astrocytes results in mitotic catastrophe

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Neural Regeneration Research 2020年第10期15卷 1894-1902页

作者： Timmy Le Cynthia L.Winham Fotis Andromidas Adam C.Silver Evan R.Jellison Aime A.Levesque Andrew O.Koob Graduate Program in Neuroscience Biology DepartmentUniversity of HartfordWest HartfordCTUSA Department of Immunology UCONN Health CenterFarmingtonCTUSA

Elevated levels of γ-synuclein(γ-syn)expression have been noted in the progression of glioblastomas,and also in the cerebrospinal fluid of patients diagnosed with neurodegenerative diseases.γ-Syn can be either internalized from the extracellular milieu or expressed endogenously by human cortical ***γ-syn results in increased cellular proliferation,brain derived neurotrophic factor release and ***,the function of endogenousγ-syn in primary astrocytes,and the relationship to these two opposing disease states are unknown.γ-Syn is expressed by astrocytes in the human cortex,and to gain a better understanding of the role of endogenous γ-syn,primary human cortical astrocytes were treated with chimera RNA interference(RNAi)targeting γ-syn after release from cell *** polymerase chain reaction analysis demonstrated an increase in endogenousγ-syn expression 48 hours after release from cell synchronization,while RNAi reduced γ-syn expression to control *** of Ki67 and 5-bromodeoxyuridine showed chimera RNAi γ-syn knockdown reduced cellular proliferation at 24 and 48 hours after release from cell *** further investigate the consequence of γ-syn knockdown on the astrocytic cell cycle,phosphorylated histone H3 pSer10(pHH3)and phosphorylated cyclin dependent kinase-2 pTyr15(pCDK2)levels were observed via western blot *** results revealed an elevated expression of pHH3,but not pCDK2,indicating γ-syn knockdown leads to disruption of the cell cycle and chromosomal compaction after 48 ***,flow cytometry with propidium iodide determined that increases in apoptosis coincided with γ-syn ***,γ-syn exerts its effect to allow normal astrocytic progression through the cell cycle,as evidenced by decreased proliferation marker expression,increased pHH3,and mitotic catastrophe after *** this study,we demonstrated that the knockdown of γ-syn with

关键词： apoptosis astrocyte cell cycle glioblastomas phospho-histone H3 proliferation synuclein

Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality

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World Journal of Transplantation 2024年第2期14卷 62-75页

作者： Faisal Inayat Pratik Patel Hassam Ali Arslan Afzal Hamza Tahir Ahtshamullah Chaudhry Rizwan Ishtiaq Attiq Ur Rehman Kishan Darji Muhammad Sohaib Afzal Gul Nawaz Alexa Giammarino Sanjaya K Satapathy Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Department of Internal Medicine Saint Francis Hospital and Medical CenterHartfordCT 06105United States Division of Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine Campbell University and Cape Fear Valley Medical CenterFayettevilleNC 28301United States Department of Internal Medicine North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States Division of Hepatology North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has posed a major public health concern *** with comorbid conditions are at risk of adverse outcomes following *** organ transplant recipients with concurrent immunosuppression and comorbidities are more susceptible to a severe COVID-19 *** could lead to higher rates of inpatient complications and mortality in this patient ***,studies on COVID-19 outcomes in liver transplant(LT)recipients have yielded inconsistent *** To evaluate the impact of the COVID-19 pandemic on hospital-related outcomes among LT recipients in the United *** We conducted a retrospective cohort study using the 2019–2020 National Inpatient Sample *** with primary LT hospitalizations and a secondary COVID-19 diagnosis were identified using the International Classi-fication of Diseases,Tenth Revision coding *** primary outcomes included trends in LT hospitalizations before and during the COVID-19 *** outcomes included comparative trends in inpatient mortality and transplant rejection in LT *** A total of 15720 hospitalized LT recipients were *** 0.8% of patients had a secondary diagnosis of COVID-19 *** both cohorts,the median admission age was 57 *** linear trends for LT hospitalizations did not differ significantly before and during the pandemic(P=0.84).The frequency of in-hospital mortality for LT recipients increased from 1.7% to 4.4% between January 2019 and December *** to the pre-pandemic period,a higher association was noted between LT recipients and in-hospital mortality during the pandemic,with an odds ratio(OR)of 1.69[95% confidence interval(CI):1.55-1.84),P<0.001].The frequency of transplant rejections among hospitalized LT recipients increased from 0.2%to 3.6% between January 2019 and December *** hospitalizations during the COVID-19 pandemic had a higher associ

关键词： Liver transplant recipients Solid organ transplantation COVID-19 Hospitalization Transplant rejection Mortality

Drug and herbal/dietary supplements-induced liver injury:A tertiary care center experience

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World Journal of Hepatology 2020年第5期12卷 207-219页

作者： Ayesha S Siddique Osama Siddique Michael Einstein Eva Urtasun-Sotil Saverio Ligato Department of Pathology and Laboratory Medicine Hartford HospitalHartfordCT 06102United States Department of Gastroenterology and Hepatology Hartford HospitalUniversity of ConnecticutHartfordCT 06102United States

BACKGROUND Drug-induced liver injury(DILI)and herbal/dietary supplements(HDS)related liver injury present unique diagnostic *** between the clinician and the pathologist is required for an accurate diagnosis and *** To report our experience on the clinical-pathological findings of hepatic injury caused by drugs/*** A retrospective review of clinically proven cases of DILI/HDS who presented to our institution from January 1,2013 to December 31,2017 was *** were reviewed for histopathological patterns of injury and correlated with the causative *** of 600 patients presenting with unexplained rise in liver enzymes undergoing biopsy,107 were suspected to have DILI/*** these,53 had a directly linked exposure to drug/herbal *** patients were excluded for concurrent known liver ***-eight patients with clinically proven DILI/HDS were finally *** Thirty-eight cases of DILI/HDS with a male:female of 1:1.5 and mean age of 51±3 years were *** was identified in 84.2%cases while HDS injury in 15.8%.Acute hepatitis(42.1%)was the most common pattern of injury while granulomatous hepatitis(2.6%)was the least *** found one case of acute-cholestasis due to rivaroxaban and two cases of cholestatic-hepatitis due to rizatriptan and trimethobenzamide-hydrochloride that,to the best of our knowledge,have not been previously *** case of steatohepatitis due to trimethoprim-sulfamethoxazole and three unusual cases of cholestatic-hepatitis with bile duct injury and steatosis due to dronedarone,C4-Extreme and hydroxycut,were also *** our cohort,81.6%of the patients fared well with discontinuation of drug and 18.4%underwent transplant;of which 42.9%were *** We describe the clinical findings,histopathological patterns of injury and clinical outcomes caused by *** particular,we report a few previously unreported/rarely observed clinical and histop

关键词： Drug-induced liver injury Herbals Dietary supplements Liver enzymes Biopsy Supplements

Interactions between invasive Eurasian watermilfoil and native water stargrass in Cayuga Lake, NY, USA

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Journal of Plant Ecology 2014年第6期7卷 499-508页

作者： Bin Zhu Samuel E.Georgian Department of Biology University of Hartford200 Bloomfield AvenueWest HartfordCT 06117USA Department of Biology Temple University1900 N 12 StreetPhiladelphiaPA 19122USA

Aims Eurasian watermilfoil(Myriophyllum spicatum L.)is a common invasive plant in American lakes and has many negative impacts on invaded *** decline of this plant at the north-ern end of Cayuga Lake in the New York State has occurred since the 1980s,with a much smaller magnitude of decline of Eurasian watermilfoil at the southern end(Johnson et al.2000)During the same period,increases in the abundance of native plants,partic-ularly water stargrass(Heteranthera dubia(Jacq.)MacMill.),have been observed(Johnson et al.(1998))We aimed to investigate the mechanisms responsible for the decline of Eurasian watermilfoil and evaluate the responses of co-occurring plants at the two ends of Cayuga Lake over *** hypothesized that plant interactions might have contributed to the drastic decline of Eurasian watermil-foil,particularly allelopathy by native water *** A lake survey was conducted to assess distribution and abundance of plant communities at the northern end and the southern end of Cayuga ***,two sets of greenhouse experiments were conducted to investigate the interactions between invasive Eurasian watermilfoil and native water stargrass.A competition experiment evaluated intra-versus inter-specific competition among plants grown together;an allelopathy experiment examined the responses of plants to each other’s *** Findings The lake survey showed that water stargrass was extremely abun-dant at the northern end,whereas Eurasian watermilfoil was sparse at the northern end but one of the most common species at the southern *** survey also revealed that water stargrass was more abundant than Eurasian watermilfoil at sites where the two species coexisted in the *** from greenhouse experi-ments revealed no effects of Eurasian watermilfoil on water star-grass ***,Eurasian watermilfoil biomass was reduced by 46%when treated with high concentration of water stargrass *** is likely d

关键词： allelopathy biological invasion plant interactions space competition submerged macrophytes

Biliary Mucinous Cystadenoma: A Review of the Literature

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Journal of Clinical and Translational Hepatology 2019年第2期7卷 149-153页

作者： Leon D.Averbukh David C.Wu Woo Cheal Cho George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Pathology Hartford HospitalHartfordCTUSA

Biliary mucinous cystadenomas are cystic neoplasms commonly mistaken for simple *** are rare and generally benign tumors,often incidentally found on imaging and during unrelated surgical *** tend to be slow growing though may reach symptomatic *** of biliary mucinous cystadenomas may have serious consequences secondary to their potential for malignant transformation into biliary mucinous ***,we review the epidemiology,etiology,pathology,diagnostic modalities,histology,and available treatment methods for mucinous cystadenomas reported in current literature.

关键词： Biliarymucinous cystadenoma Biliary mucinous cystadenocarcinoma Cystic neoplasm

Seminal biomarkers for the evaluation of male infertility

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Asian Journal of Andrology 2016年第3期18卷 426-433,I0009页

作者： Jared M Bieniek Andrei P Drabovich Kirk C Lo Department of Urology Hartford Hospital Hartford CT USA Department of Clinical Biochemistry University Health Network Toronto ON Canada Department ofLaboratory Medicine and Pathobiology University of Toronto Toronto ON Canada Department of Surgery Division of Urology Mount Sinai Hospital Toronto ONCanada.

For men struggling to conceive with their partners, diagnostic tools are limited and often consist of only a standard semen analysis. This baseline test serves as a crude estimation of male fertility, leaving patients and clinicians in need of additional diagnostic biomarkers. Seminal fluid contains the highest concentration of molecules from the male reproductive glands, therefore, this review focuses on current and novel seminal biomarkers in certain male infertility scenarios, including natural fertility, differentiating azoospermia etiologies, and predicting assisted reproductive technique success. Currently available tests include antisperm antibody assays, DNA fragmentation index, sperm fluorescence in situ hybridization, and other historical sperm functional tests. The poor diagnostic ability of current assays has led to continued efforts to find more predictive biomarkers. Emerging research in the fields of genomics, epigenetics, proteomics, transcriptomics, and metabolomics holds promise for the development of novel male infertility biomarkers. Seminal protein-based assays of TEXI01, ECM 1, and ACRV1 are already available or under final development for clinical use. Additional panels of DNA, RNA, proteins, or metabolites are being explored as we attempt to understand the pathophysiologic processes of male infertility. Future ventures will need to continue data integration and validation for the development of clinically useful infertility biomarkers to aid in male infertility diagnosis, treatment, and counseling.

关键词： assisted reproductive techniques diagnosis male infertility, semen