检索结果-南通市图书馆

Biological characteristics and clinical management of uveal and conjunctival melanoma

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第8期32卷 1265-1285页

作者： SNJEŽANA KAŠTELAN ANA DIDOVIĆPAVIČIĆ DARIA PAŠALIĆ TAMARA NIKUŠEVA-MARTIĆ SAMIRČANOVIĆ PETRA KOVAČEVIĆ SUZANA KONJEVODA School of Medicine University of ZagrebZagreb10000Croatia Department of Ophthalmology Clinical Hospital DubravaZagreb10000Croatia Department of Ophthalmology Zadar General HospitalZadar23000Croatia Department of Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Department of Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia Department of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of mortality for a large number of affected *** pathogenesis of melanoma at different sites is very similar,however,the prognosis for patients with ocular melanoma remains unfavourable,primarily due to its distinctive genetic proﬁle and tumor *** of considerable advances in understanding the genetic characteristics and biological behaviour,the treatment of uveal and conjunctival melanoma remains a formidable *** enhance the prospect of success,collaborative efforts involving medical professionals and researchers in theﬁelds of ocular biology and oncology are *** data show a lack of well-designed randomized clinical trials and limited beneﬁts in current forms of treatment for these *** advancements in the development of effective melanoma therapeutic strategies,all current treatments for uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisfactory,resulting in a poor long-term *** trials offer hope for positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of the genetic and molecular abnormalities involved in the development and progression of ocular melanomas opens the way for the development of personalized therapy,with various potential therapeutic targets currently under *** comprehension of the molecular pathogenesis of UM and CoM and their speciﬁcities may aid in the development of new and more effective systemic therapeutic agents,with the hope of improving the prognosis for patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic characteristics Immune checkpoint inhibitors Target molecular inhibitors

The role of aggression in range expansion and biological invasions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2014年第3期60卷 401-409页

作者： Sandra HUDINA Karlo HOCK Kresimir ZGANEC Faculty of Science University of Zagreb Rooseveltov trg 6 10000 Zagreb Croatia School of Biological Sciences University of Queensland Brisbane Australia Department of Teachers' Education in Gospie University of Zadar Croatia

Traits that aid in the invasion process should exhibit a gradient across the expansion range in response to changing selection pressures. Aggression has been repeatedly associated with invasion success in many taxa, as it may help invaders to wrestle the resources from other species which enhances their success in a novel environment. However, aggression primarily al lows individuals to overcome conspecific rivals, providing advantages in competition over resources. Agonistic prowess could therefore increase fitness at both ends of the expansion gradient. Here we review the role of aggression in range expansion of in vasive species, and its potential role as a driver of range expansion. We analyze how these different mechanisms could affect trait variation in expanding and invasive populations. Specifically, we look at how aggression could help dilate the edges of a popula tion through niche competition, as well as lead to exclusion from the center （Le. areas of high population density） by the conspe cities. Both of these processes will result in a characteristic spatial distribution of phenotypes related to aggression that could provide insights into the ecological pressures and dynamics of expanding populations, potentially providing clues to their success as niche competitors and invasive species

关键词： Aggression Trait variation Invasion success Invasive species

Temporal and Narrative Features of Ian McEwan＇s and Joe Wright＇s Atonement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sino-US English Teaching 2011年第8期8卷 532-543页

作者： Rajko Petkovie Petra Perkov university ofzadar Zadar Croatia

The paper deals with temporal and narrative properties of Ian McEwan＇s （2001） and Joe Wright＇s （2007） Atonement. In order to show continuity with his other works, four of McEwan＇s novels--The lnnocent （1990）, Amsterdam （1999）, Saturday （2006）, and On Chesil Beach （2008）, have been analyzed before elaborating the novel and film adaptation of Atonement （2007）. Apart from the narratological analysis, McEwan＇s layered works lend themselves to different kinds of readings, and the authors have used the theoretical notions of Immanuel Kant （1952） as well as concepts derived from the postmodem philosophical movement. The aim of the paper is to show how the chronotopical and intertextual nature of the literary original finds a worthy equivalent in the film version, proving the feasibility of a successful intermedial transfer of a complex narrative structure

关键词： chronotope narrative intertextuality fiction

Interlanguage Development in Early EFL Learning in Croatia：An Insight Into Individual Learner Profiles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sino-US English Teaching 2017年第7期14卷 436-445页

作者： Katica Balenovic university ofzadar Zadar Croatia

The goal of this paper is to gain insight into the individual lexical and syntactic development of learners＇interlanguage in early EFL （English as a Foreign Language） learning in Croatia. The total sample included 108Croatian L1 primary school learners （mean age 11-13）. In this research, we selected 12 focal learners from twoproject schools, whose interlanguage development was observed over a period of three years. The research wasbased on the recordings of individual oral production when the students were at the end of their second, third, andfourth year of EFL learning. The quantitative analysis of the collected data included the number of utterances andmorphemes count, mean length of utterances （MLU）, and type/token ratio （FREQ）. To gain better insight intostudent＇s individual development, learners＇ profiles were constructed consisting quantitative data analysis. Theinitial hypothesis is that students＇ oral production shows clear progress which supposes an increase in the meanlength of utterances and in type/token ratio as indicators of linguistic and lexical diversity. We also assume thatthere is a decrease in the use of L1 in learners＇ oral production throughout the years of EFL learning. The researchresults confirmed the initial hypothesis, i.e., due to the exposure to EFL learning, participants＇ overall languageproficiency gradually increased. The findings also showed expected interlanguage variations in early EFL learning.

关键词： interlanguage, learner, oral production

Structural Development of Oxford Advanced Learners＇ Dictionary

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Literature and Art Studies 2017年第5期7卷 588-607页

作者： Ivana Ivan i Ivo Fabijani university ofzadar Zadar Croatia

Oxford Advanced Learners＇ Dictionary （OALD） stands out, on the EFL market, as the only EFL dictionary which has been continuously republished for over 70 years. With each new edition upgraded, OALD conforms to the contemporary language teaching and learning processes worldwide. This article presents its structural development--an evolution from its very first, Japanese edition in 1942 towards the latest one in 2015. The analysis deals with the development and changes within the macrostructural （front matter, the body, appendices） and microstructural （headword, spelling, pronunciation, part of speech, senses, definitions, illustrations, usage） frames of the dictionary.

关键词： macrostructure microstructure verb-patterns OALD

The Effects of Ground Cover Mowing Height on the Fauna of Ground-dwelling Arthropods in Olive Grove

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Ecology 2020年第2期2卷 8-15页

作者： Kristijan Franin Nikolina Kapić Šime Marcelić ZoranŠikić university of zadar Department of EcologyAgronomy and AquacultureMIhovila Pavlinovića 123000 ZadarCroatia

Ground dwelling insects,spiders,and other arthropods play an important role in agroecosystems as predators and saprophytic *** presence on the soil surface helps the biological control of pests,enhances organic matter decomposition and promotes *** disturbance,particularly tilling and mowing has greatly affected the assemblage and abundance of epigeic *** study aimed to determine the effects of herbaceous vegetation cover mowing height on arthropods abundance and structure in olive *** experimental site was divided into three zones(Z1,Z2,and Z3)regarding mowing heights(0 cm,10 cm,and 15 cm).This research was done in 2019 from the beginning of May untill the end of *** this research,1490 individuals were recorded belonging to 6 classes,11 orders and 13 *** number of individuals was higher in the zones Z2 and Z3 comparing with *** highest number of individuals showed woodlices(Isopoda)comprising 67,5%of all individuals *** were significant differences in the number of Carabidae,Bleteliidae and Forficulidae between the zones of *** Forficulidae,higher heights of mown positively affected the population of Carabidae and Blateliidae.

关键词： Herbaceous vegetation cover Insects Mowing heights Spiders

Optimization of Gas Chromatography-electron Ionization-tandem Mass Spectrometry for Determining Toxic Non-ortho Polychlorinated Biphenyls in Breast Milk

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2020年第1期33卷 58-61页

作者： Iva Simic Gordana Jovanovic Snjezana Herceg Romanic Darija Klincic Marijana Matek Saric Aleksandar Popovic Institute for Medical Research and Occupational Health Ksaverska cesta 2PO Box 29110001 ZagrebCroatia Institute of Physics Belgrade National Institute of the Republic of SerbiaUniversity of BelgradePregrevica 11811080 BelgradeSerbia Department of Health Studies University of ZadarSplitska 123000 ZadarCroatia Faculty of Chemistry University of BelgradeStudentski trg 12-1611000 BelgradeSerbia

One of the most commonly used non-invasive methods for assessing human exposure to pollution is the analysis of human *** milk analyses help estimate the exposure of infants[1].This is why breast milk is receives scientific interest,and various methods for determining different pollutants from the environment are being developed[2,3].

关键词： Optimization Gas Chromatography-electron Ionization-tandem Mass Spectrometry Determining Toxic Non-ortho Polychlorinated Biphenyls Breast Milk

Effectiveness of Hypertension Therapy by Using Fixed Combinations and Monocomponent Drugs A Prospective Study from Croatia

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmacy and Pharmacology 2018年第4期6卷 333-339页

作者： Antonija Banic Vanesa Benkovi Aleksandar Knezevic Pharmacy of Split Dalmatia County Split 21000 Croatia Croatian Society for Pharmacoeconomics and Health Economics Drage Stipca 10 Zagreb 10090 Croatia General Hospital zadar Department of Cardiology Boze Perieica 5 Zadar 230000 Croatia university of zadar Department of Health Studies Mihovila Pavlinovica 1 Zadar 23000 Croatia

Arterial hypertension is the leading risk mortality factor in the world according to the report by the World Health Organization. The aim of this research was to compare fixed-dose combination with free-drug combination therapy and prove that fixed-dose combination improve patient compliance and persistence, measuring blood pressure among hypertensive patients in a Croatian Adriatic city. Methods： The study included 202 patients, 101 women and 101 men, mean age 66.8 4- 9.4 with previous diagnosis of hypertension. Results： Mean blood pressure was 152.8 4- 18.8/87.3 4- 10.3 mmHg. Blood pressure control 140/90 mmHg） was achieved in 24.8% of patients, 13.9% of women and 10.9% of men. Mean blood pressure in the group with fixed-dose combination was 149.2 4- 17.9/86.2 4- 8.5 mmHg, and 156.7 4- 18.9/88.4 4- 11.8 mmHg in the group with free-drug combination therapy. Conclusions： Results suggest that blood pressure control was better in patients with fixed-dose combinations than in patients with free-drug combinations. Fixed-drug combination improved compliance and adherence in patients with antihypertensive therapy. Results of the study indicate that fixed-drug combination should be considered in patients with hypertension according to the guidelines.

关键词： Hypertension fixed -dose combinations compliance adherence Croatia.

Effect of clonidine on the cutaneous silent period during spinal anesthesia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2018年第16期6卷 1136-1145页

作者： Sandra Graf Zupcic Miroslav Zupcic Viktor Duzel Tatjana imurina Milan Miloevi Silvio Basic Vladimira Vuletic Leonardo Kapural Clinic of Neurology Clinical Hospital Centre Rijeka Faculty of Medicine J.J.Strossmayer University Clinic of Anesthesiology and Intensive Care Medicine Clinical Hospital Centre Rijeka Faculty of Medicine University of Rijeka Department of Anaesthesia Barking Havering and Redbridge University Hospitals NHS Trust Department of Health Studies university of zadar Department of Anesthesiology and Intensive Care Medicine General Hospital Zadar university of Zagreb School of Medicine Andrija Stampar School of Public Health WHO Collaborative Centre for Occupational Health Department of Neurology Clinical Hospital Dubrava Center for Clinical Research Winston Salem

AIM To investigate the effect of clonidine on the cutaneous silent period(CSP) during spinal anesthesia. METHODS A total of 67 adult patients were included in this randomized, prospective, single-center, double-blind trial. They did not have neurological disorders and were scheduled for inguinal hernia repair surgery. This trial was registered on ***(NTC03121261). The patients were randomized into two groups with regards to the intrathecally administered solution:(1) 15 mg of 0.5% levobupivacaine with 50 μg of 0.015% clonidine, or(2) 15 mg of 0.5% levobupivacaine alone. There were 34 patients in the levobupivacaine-clonidine(LC) group and 33 patients in the levobupivacaine(L) group. CSP and its latency were measured four times: prior to the subarachnoid block(SAB), after motor block regression to the 0 level of the Bromage scale, with ongoing sensory blockade, and both 6 and 24 h after *** Only data from 30 patients in each group were analyzed. There were no significant differences between the groups investigated preoperatively and after 24 h. The CSP of the L group at the time point when the Bromage scale was 0 was 44.8 ± 8.1 ms, while in the LC group it measured 40.2 ± 3.8 ms(P = 0.007). The latency in the L group at the time point when the Bromage scale was 0 was 130.3 ± 10.2 ms, and in the LC group it was 144.7 ± 8.3 ms(P < 0.001). The CSP of the L group after 6 h was 59.6 ± 9.8 ms, while in the LC group it was 44.5 ± 5.0 ms(P < 0.001). The latency in the L group after 6 h was 110.4 ± 10.6 ms, while in LC group it was 132.3 ± 9.7 ms(P < 0.001).CONCLUSION Intrathecal addition of clonidine to levobupivacaine for SAB in comparison with levobupivacaine alone resultsin a diminished inhibitory tonus and shortened CSP.

关键词： Clonidine Local anesthetics Nerve fibers Spinal anesthesia Reflex