Effectiveness of Hypertension Therapy by Using Fixed Combinations and Monocomponent Drugs A Prospective Study from Croatia
Effectiveness of Hypertension Therapy by Using Fixed Combinations and Monocomponent Drugs A Prospective Study from Croatia作者机构：Pharmacy of Split Dalmatia County Split 21000 Croatia Croatian Society for Pharmacoeconomics and Health Economics Drage Stipca 10 Zagreb 10090 Croatia General Hospital Zadar Department of Cardiology Boze Perieica 5 Zadar 230000 Croatia University of Zadar Department of Health Studies Mihovila Pavlinovica 1 Zadar 23000 Croatia
出 版 物：《Journal of Pharmacy and Pharmacology》 (药剂与药理学（英文版）)
年 卷 期：2018年第6卷第4期
页 面：333-339页
学科分类：090603[农学-临床兽医学] 0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 09[农学] 0906[农学-兽医学] 083202[工学-粮食、油脂及植物蛋白工程]
主 题：Hypertension fixed -dose combinations compliance adherence Croatia.
摘 要：Arterial hypertension is the leading risk mortality factor in the world according to the report by the World Health Organization. The aim of this research was to compare fixed-dose combination with free-drug combination therapy and prove that fixed-dose combination improve patient compliance and persistence, measuring blood pressure among hypertensive patients in a Croatian Adriatic city. Methods： The study included 202 patients, 101 women and 101 men, mean age 66.8 4- 9.4 with previous diagnosis of hypertension. Results： Mean blood pressure was 152.8 4- 18.8/87.3 4- 10.3 mmHg. Blood pressure control 140/90 mmHg） was achieved in 24.8% of patients, 13.9% of women and 10.9% of men. Mean blood pressure in the group with fixed-dose combination was 149.2 4- 17.9/86.2 4- 8.5 mmHg, and 156.7 4- 18.9/88.4 4- 11.8 mmHg in the group with free-drug combination therapy. Conclusions： Results suggest that blood pressure control was better in patients with fixed-dose combinations than in patients with free-drug combinations. Fixed-drug combination improved compliance and adherence in patients with antihypertensive therapy. Results of the study indicate that fixed-drug combination should be considered in patients with hypertension according to the guidelines.
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