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Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture

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Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： Jean-Daniel Malcor Emma J.Hunter Natalia Davidenko Daniel V.Bax Ruth Cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUVECs),by inhibiting cell–collagen ***,we have improved crucial HUVEC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUVEC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

CoolVox:Advanced 3D convolutional neural network models for predicting solar radiation on building facades

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Building Simulation 2022年第5期15卷 755-768页

作者： Jung Min Han Eun Seuk Choi Ali Malkawi Harvard university Graduate School of Design CambridgeUSA Harvard Center for Green Buildings and Cities CambridgeUSA Harvard John A.Paulson School of Engineering and Applied Sciences CambridgeUSA

Data-driven models have become increasingly prominent in the building,architecture,and construction *** area ideally suited to exploit this powerful new technology is building performance ***-based models have traditionally been used to estimate the energy flow,air movement,and heat balance of ***,physics-based models require many assumptions,significant computational power,and a considerable amount of time to output *** neural networks(ANNs)with prefabricated or simulated data are likely to be a more feasible option for environmental analysis conducted by designers during the early design *** ANNs require fewer inputs and shorter computation times and offer superior performance and potential for data augmentation,they have received increased attention for predicting the surface solar radiation on ***,ANNs can provide innovative and quick design solutions,enabling designers to receive instantaneous feedback on the effects of a proposed change to a building's *** research introduces deep learning methods as a means of simulating the annual radiation intensities and exposure level of buildings without the need for physics-based *** propose the CoolVox model to demonstrate the feasibility of using 3D convolutional neural networks to predict the surface radiation on building *** CoolVox model accurately predicted the radiation intensities of building facades under different boundary conditions and performed better than ARINet(with average mean square errors of 0.01 and 0.036,respectively)in predicting the radiation intensity both with(validation error=0.0165)and without(validation error=0.0066)the presence of boundary buildings.

关键词： artificial neural networks 3D convolutional neural networks solar radiation simulation building performance simulation

A high-resolution optically addressed spatial light modulator based on ZnO nanoparticles

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Light(Science & Applications) 2015年第1期4卷 470-476页

作者： Pawan Kumar Shrestha Young Tea Chun Daping Chu university of cambridge Cambridge CB30FAUK

An optically addressed spatial light modulator(OASLM)can modulate the wavefront of a read light by displaying a phase pattern or a hologram configured by the intensity distribution of a write *** ZnO nanoparticles(NPs)as a novel photoconductor,a high-resolution OASLM was fabricated.A ZnO NP suspension was spin-coated on an indium tin oxide(ITO)-coated glass substrate and annealed to form a photosensitive *** device was characterized electrically and *** device was operated at low driving voltages in the transmission *** recording of a diffraction grating up to 825 lp mm^(-1) with a diffraction efficiency(DE)of 0.05%and binary holograms with pixel sizes from 2 mm down to 0.72 mm were demonstrated using a 405 nm wavelength write laser and a 635 nm wavelength read laser.

关键词： holography nanoparticles OASLM ZnO

Validation of a discrete element model using magnetic resonance measurements

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Particuology 2009年第4期7卷 297-306页

作者： Christoph R.Müller Stuart A.Scott Daniel J.Holland Belinda C.Clarke Andrew J.Sederman John S.Dennis Lynn F.Gladden Department of Chemical Engineering and Biotechnology University of CambridgePembroke StreetCambridge CB2 3RAUnited Kingdom

The discrete element model （DEM） is a very promising modelling strategy for two-phase granular systems. However, owing to a lack of experimental measurements, validation of numerical simulations of two-phase granular systems is still an important issue. In this study, a small two-dimensional gas- fluidized bed was simulated using a discrete element model. The dimensions of the simulated bed were 44mm × 10mm × 120 mm and the fluidized particles had a diameter dp = 1.2 mm and density ρp = 1000 kg/m^3. The comparison between DEM simulations and experiments are performed on the basis of time-averaged voidage maps. The drag-law of Beetstra et al. [Beetstra, R., van der Hoef, M.A., ＆ Kuipers,J. A. M. （2007b）. Drag force of intermediate Reynolds number flow past mono- and bidispersed arrays of spheres. AIChE Journal, 53,489-501 ] seems to give the best results. The simulations are fairly insensitive to the coefficient of restitution and the coefficient of friction as long as some route of energy dissipation during particle-particle and particle-wall contact is provided. Changing the boundary condition of the gas phase at the side-walls from zero-slip to full-slip does not affect the simulation results. Care is to be taken that the cell sizes are chosen so that a reasonable number of particles can be found in a fluid cell.

关键词： Discrete element modelling Magnetic resonance imaging Voidage Gas-fluidized beds

Functional changes after spinal lesions: implications for interventions

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Neural Regeneration Research 2018年第5期13卷 811-812页

作者： David Parker Department of Physiology Neuroscience and DevelopmentUniversity of Cambridge

We have known for many years that the spinal cord can generate some basic locomotor outputs under specific experimental conditions without any input from the brain or the periphery（Stuart and Hultborn,2008）.However,when inputs from the brain are lost following spinal cord injury（SCI）,the mammalian spinal cord is unable to generate normal,goal-directed locomotor outputs.

关键词： Functional changes after spinal lesions implications for interventions

HIGHLY OSCILLATORY DIFFUSION-TYPE EQUATIONS

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Journal of Computational Mathematics 2013年第6期31卷 549-572页

作者： Sevda Uskiiplii Altlnbasak Marissa Condon Alfredo Deano Arieh Iserles Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK School of Electronic Engineering Dublin City University Dublin Ireland Department of Mathematics University Carlos III de Madrid Madrid Spain Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK

We explore new asymptotic-numeric solvers for partial differential equations with highly oscillatory forcing terms. Such methods represent the solution as an asymptotic series, whose terms can be evaluated by solving non-oscillatory problems and they guarantee high accuracy at a low computational cost. We consider two forms of oscillatory forcing terms, namely when the oscillation is in time or in space： each lends itself to different treatment. Numerical examples highlight the salient features of the new approach.

关键词： Diffusion-type PDEs High oscillation Asymptotic expansions Modulated Fourier expansions.

Stress waves propagation in solids under high-speed liquid impact

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Science China(Physics,Mechanics & Astronomy) 2004年第6期47卷 752-766页

作者： J.E.Field Cavendish Laboratory Cambridge UniversityMadingly RoadCambridge CB3 0HEUK

An experiment of impact between 450 m/s water jets and polymethylme- thacrylate (PMMA) materials with complex surface geometry was conducted. The testing surfaces were a corner, step change, surface-breaking notch, inclined surface, etc. Stress waves propagation in the solid such as reflection, interference and diffraction was observed using polarized optics and an Imacon high speed camera (operating at both of 106 and 5×105 framing rates per second, fps). A damage test by the impact of the side jetting of an 850 m/s water jet was also carried out. It was found that stress waves propagation in solids depends not only on the surface geometry but also on the contact situation between liquid and solid. It was shown that the side jetting has sufficient damage potential although its head may consist of finer droplets. The results of this paper are useful to further analyze the dynamic stress state of solids under high-speed liquid impact.

关键词： high-speed liquid/solid impact, stress waves, mechanical property of solid, high-speed photography.

A Multi-physics Methodology for Four States of Matter

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Communications on Applied Mathematics and Computation 2020年第3期2卷 487-514页

作者： Louisa Michael Stephen T.Millmore Nikolaos Nikiforakis Laboratory for Scientifc Computing Cavendish LaboratoryDepartment of PhysicsUniversity of CambridgeCambridgeUK

We propose a numerical methodology for the simultaneous numerical simulation of four states of matter:gas,liquid,elastoplastic solids,and *** distinct,interacting physical processes are described by a combination of compressible,inert,and reactive forms of the Euler equations,multi-phase equations,elastoplastic equations,and resistive MHD *** of systems of equations are usually solved by coupling finite element for solid modelling and CFD models for fluid modelling or including material effects through boundary conditions rather than full material *** simultaneous solution methodology lies on the recasting of all the equations in the same,hyperbolic form allowing their solution on the same grid with the same finite volume numerical *** use a combination of sharp-and diffuse-interface methods to track or capture material interfaces,depending on the *** communication between the distinct systems of equations(i.e.,materials separated by sharp interfaces)is facilitated by means of mixed-material Riemann solvers at the boundaries of the systems,which represent physical material *** this end,we derive approximate mixed-material Riemann solvers for each pair of the above models based on characteristic *** demonstrate the applicability of the new methodology,we consider a case study,where we investigate the possibility of ignition of a combustible gas that lies over a liquid in a metal container that is struck by a plasma arc akin to a lightning *** study the effect of the metal container material and its conductivity on the ignition of the combustible gas,as well as the effects of an additional dielectric coating,the sensitivity of the gas,and differences between scenarios with sealed and pre-damaged metal surfaces.

关键词： Plasma modelling Four states of matter Lightning Ignition Combustible gas Elastoplastic solids

COMPUTING HARMONIC MAPS AND CONFORMAL MAPS ON POINT CLOUDS

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Journal of Computational Mathematics 2023年第5期41卷 879-908页

作者： Tianqi Wu Shing-Tung Yau Center of Mathematical Sciences and Applications Harvard UniversityCambridgeMA 02138USA Department of Mathematics Harvard UniversityCambridgeMA 02138USA

We use a narrow-band approach to compute harmonic maps and conformal maps for surfaces embedded in the Euclidean 3-space,using point cloud data *** a surface,or a point cloud approximation,we simply use the standard cubic lattice to approximate itsϵ-*** the harmonic map of the surface can be approximated by discrete harmonic maps on *** conformal map,or the surface uniformization,is achieved by minimizing the Dirichlet energy of the harmonic map while deforming the target surface of constant *** propose algorithms and numerical examples for closed surfaces and topological *** the best of the authors’knowledge,our approach provides the first meshless method for computing harmonic maps and uniformizations of higher genus surfaces.

关键词： harmonic maps conformal maps point clouds