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Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli Gu Kijung Sung Chengbiao Wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Cytochrome P450 endoplasmic reticulumassociated degradation(ERAD): therapeutic and pathophysiological implications

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Acta Pharmaceutica Sinica B 2020年第1期10卷 42-60页

作者： Doyoung Kwon Sung-Mi Kim Maria Almira Correia Department of Cellular and Molecular Pharmacology University of California San FranciscoSan FranciscoCA 94158-2517USA Pharmaceutical Chemistry University of California San FranciscoSan FranciscoCA 94158-2517USA Bioengineering and Therapeutic Sciences University of California San FranciscoSan FranciscoCA 94158-2517USA The Liver Center University of California San FranciscoSan FranciscoCA 94158-2517USA

The hepatic endoplasmic reticulum(ER)-anchored cytochromes P450(P450s)are mixedfunction oxidases engaged in the biotransformation of physiologically relevant endobiotics as well as of myriad xenobiotics of therapeutic and environmental relevance.P450 ER-content and hence function is regulated by their coordinated hemoprotein syntheses and proteolytic *** P450 proteolytic turnover occurs through a process known as ER-associated degradation(ERAD)that involves ubiquitindependent proteasomal degradation(UPD)and/or autophagic-lysosomal degradation(ALD).Herein,on the basis of available literature reports and our own recent findings of in vitro as well as in vivo experimental studies,we discuss the therapeutic and pathophysiological implications of altered P450 ERAD and its plausible clinical *** specifically(i)describe the P450 ERAD-machinery and how it may be repurposed for the generation of antigenic P450 peptides involved in P450 autoantibodypathogenesis in drug-induced acute hypersensitivity reactions and liver injury,or viral hepatitis;(ⅱ)discuss the relevance of accelerated or disrupted P450-ERAD to the pharmacological and/or toxicological effects of clinically relevant P450 drug substrates;and(ⅲ)detail the pathophysiological consequences of disrupted P450 ERAD,contributing to non-alcoholic fatty liver disease(NAFLD)/non-alcoholic steatohepatitis(NASH)under certain synergistic cellular conditions.

关键词： Cytochromes P450 Endoplasmic reticulumassociated degradation CHIP E3 ubiquitin ligase gp78/AMFR E3 ubiquitin ligase JNK1 AMPK1 Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis

Li,Na,and Cs-based metal-organic frameworks for room temperature phosphorescence applications

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Science China Chemistry 2025年

作者： Jiaqi Ma Rui Feng Yanyuan Jia Mingshi Zhang Shuo Guo College of Chemistry and Chemical Engineering Inner Mongolia University School of Materials Science and Engineering Smart Sensing Interdisciplinary Science Center Nankai University & TKL of Metal and Molecule Based Material Chemistry Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University Department of Chemistry and Biochemistry University of California San Diego

The conventional design of metal-organic frameworks (MOFs) with room-temperature phosphorescence (RTP) mostly relies on using heavy metals,as the heavy atom effect can effectively increase the efficiency of intersystem crossing (ISC) to get a better phosphorescence *** the first time,we reported the highly efficient RTP of a lithium-based MOF IMU-101 with a lifetime (τ) of 299 ms and a quantum yield (QY) of 4.91%.In addition,MOFs IMU-102 and IMU-103,with sodium and cesium as metal nodes,were successfully *** phosphorescence properties of this series of alkali metal MOFs were systematically studied and *** crystallography and computational calculation show that the mechanism for achieving RTP for this material lies in the ultrashort coordination bond of Li,which enables the reduction of non-radiative ***-101,as a cheap and environmentally friendly room-temperature phosphorescent material,has been further developed into composite polymer inks and bulk *** makes them promising for applications in anti-counterfeiting and information encryption.

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Measurement of copy number variation in single cancer cells using rapid-emulsification digital droplet MDA

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Microsystems & Nanoengineering 2017年第1期3卷 260-266页

作者： Samuel C.Kim Gayatri Premasekharan Iain C.Clark Hawi B.Gemeda Pamela L.Paris Adam R.Abate Department of Bioengineering and Therapeutic Sciences University of CaliforniaSan Francisco(UCSF)California Institute for Quantitative Biosciences(QB3)San FranciscoSan FranciscoCA 94158USA Department of Urology Division of Hematology&OncologyUniversity of CaliforniaSan Francisco(UCSF)San FranciscoCA 94158USA

Uniform amplification of low-input DNA is important for applications across biology,including single-cell genomics,forensic science,and microbial and viral ***,the requisite biochemical amplification methods are prone to bias,skewing sequence proportions and obscuring signals relating to copy *** droplet multiple displacement amplification enables uniform amplification but requires expert knowledge of microfluidics to generate monodisperse *** addition,existing microfluidic methods are tedious and labor intensive for preparing many ***,we introduce rapid-emulsification multiple displacement amplification,a method to generate monodisperse droplets with a hand-held syringe and hierarchical droplet *** conventional microfluidic devices require >10 min to emulsify a sample,our system requires tens of seconds and yields data of equivalent *** demonstrate the approach by using it to accurately measure copy number variation(CNV)in single cancer cells.

关键词： amplification bias copy number variation ddMDA droplet microfluidics multiple displacement amplification

Structure of human NCC:insights into the inhibition mechanism of thiazides

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3549-3550页

作者： Livia de Souza Goncalves Pattareeya Yottasan Onur Cil Department of Pediatrics University of CaliforniaSan FranciscoSan FranciscoCAUSA

A recent study published in Nature by Fan et al.1 identified the structure of human NCC alone and in complex with a thiazide diuretic using cryo-electron *** extensive clinical use of NCC inhibitor thiazide diuretics since 1950s,the structure and inhibition mechanisms of NCC have remained elusive,and Fan et *** is a major step toward better understanding the NCC biology and mechanism of action of thiazide ***-chloride cotransporter(NCC,also known as SLC12A3)is expressed in the kidney where it facilitates electroneutral NaCl absorption.

关键词： azide mechanism

Incidence of Acute Disseminated Encephalomyelitis in China: First National Survey

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Neuroscience Bulletin 2021年第6期37卷 761-762页

作者： Emmanuelle Waubant Department of Neurology University of California at San FranciscoSan FranciscoCAUSA

In this issue,the publication of Xiu et al.[1]provides novel and important information on the incidence and outcomes of acute disseminated encephalomyelitis(ADEM)nationwide in *** study analyzed information from 2,976 cases of ADEM that occurred over a 3-year period,and confirms ADEM is much less common than diseases such as multiple sclerosis(MS)and neuromyelitis optica spectrum disorders.

关键词： myelitis al. acute

A microscale optical implant for continuous in vivo monitoring of intraocular pressure

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Microsystems & Nanoengineering 2017年第1期3卷 11-19页

作者： Jeong Oen Lee Haeri Park Juan Du Ashwin Balakrishna Oliver Chen David Sretavan Hyuck Choo Department of Medical Engineering California Institute of TechnologyPasadenaCA 91106USA Department of Electrical Engineering California Institute of TechnologyPasadenaCA 91106USA Department of Ophthalmology University of California San FranciscoSan FranciscoCA 94143USA Department of Physiology University of California San FranciscoSan FranciscoCA 94143USA

Intraocular pressure(IOP)is a key clinical parameter in glaucoma ***,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lacking,and IOP is typically measured only a few times a *** we report on a microscale implantable sensor that could provide convenient,accurate,ondemand IOP monitoring in the home *** excited by broadband near-infrared(NIR)light from a tungsten bulb,the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to *** light is minimally absorbed by tissue and is not perceived *** sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm *** were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white *** sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.

关键词： glaucoma intraocular pressure(IOP) microscale sensor implant in vivo continuous monitoring remote optical readout near-infrared(NIR)broadband light minimally invasive

CD4^(+)Foxp3^(+)regulatory T cell therapy in transplantation

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Journal of Molecular Cell Biology 2012年第1期4卷 11-21页

作者： Qizhi Tang Jeffrey A.Bluestone sang-Mo Kang Division of Transplantation Department of SurgeryUniversity of California San Francisco513 Parnassus AveBox 0780San FranciscoCA 94143-0780USA UCSF Diabetes Center University of California San Francisco513 Parnassus AveSan FranciscoCA 94143USA

Regulatory T cells(Tregs)are long-lived cells that suppress immune responses in vivo in a dominant and antigen-specific ***,therapeutic application of Tregs to control unwanted immune responses is an active area of *** can confer long-term protection against auto-inflammatory diseases in mouse *** have also been shown to be effective in suppressing alloimmunity in models of graft-versus-host disease and organ *** on extensive research in Treg biology and preclinical testing of therapeutic efficacy over the past decade,we are now at the point of evaluating the safety and efficacy of Treg therapy in *** review focuses on developing therapy for transplantation using CD4^(+)Foxp3^(+) Tregs,with an emphasis on the studies that have informed clinical approaches that aim to maximize the benefits while overcoming the challenges and risks of Treg cell therapy.

关键词： regulatory T cells transplantation cell therapy immune tolerance