A microscale optical implant for continuous in vivo monitoring of intraocular pressure

作     者：Jeong Oen Lee Haeri Park Juan Du Ashwin Balakrishna Oliver Chen David Sretavan Hyuck Choo 

作者机构：Department of Medical EngineeringCalifornia Institute of TechnologyPasadenaCA 91106USA Department of Electrical EngineeringCalifornia Institute of TechnologyPasadenaCA 91106USA Department of OphthalmologyUniversity of California San FranciscoSan FranciscoCA 94143USA Department of PhysiologyUniversity of California San FranciscoSan FranciscoCA 94143USA 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2017年第3卷第1期

页      面：11-19页

核心收录：

学科分类：08[工学] 0802[工学-机械工程] 080201[工学-机械制造及其自动化] 

基　　金：The project was funded by the National Institute of Health(NIH)EY024582 the Basic Science Research Program through the National Research Foundation of Korea(NRF)under the Ministry of Education(NRF-2013R1A6A3A03026384) 

主　　题：glaucoma intraocular pressure(IOP) microscale sensor implant in vivo continuous monitoring remote optical readout near-infrared(NIR)broadband light minimally invasive 

摘      要：Intraocular pressure(IOP)is a key clinical parameter in glaucoma ***,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lacking,and IOP is typically measured only a few times a *** we report on a microscale implantable sensor that could provide convenient,accurate,ondemand IOP monitoring in the home *** excited by broadband near-infrared(NIR)light from a tungsten bulb,the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to *** light is minimally absorbed by tissue and is not perceived *** sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm *** were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white *** sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.