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Treatment options in stage I seminoma

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Oncology Research 2022年第3期30卷 117-128页

作者： UROS BUMBASIREVIC MARKO ZIVKOVIC MILOS PETROVIC VESNA CORIC NIKOLA LISICIC NEBOJSA BOJANIC Clinic of Urology University Clinical Center of SerbiaBelgrade11000Serbia Faculty of Medicine University of BelgradeBelgrade11000Serbia Institute of Medical and Clinical Biochemistry Faculty of MedicineUniversity of BelgradeBelgrade11000Serbia

Seminomas are most commonly diagnosed in clinical stage I(CSI).After orchiectomy,approximately 15%of patients in this stage have subclinical *** radiotherapy(ART)delivered to the retroperitoneum and ipsilateral pelvic lymph nodes has been the mainstay of treatment for many *** highly efﬁcient,with long-term cancer-speciﬁc survival(CSS)rates approaching almost 100%,ART is associated with considerable long-term consequences,particularly cardiovascular toxicity and increased risk of secondary malignancies(SMN).Therefore,active surveillance(AS)and adjuvant chemotherapy(ACT)were developed as alternative treatment *** AS prevents patient overtreatment,it is associated with strict follow-up regimens and increased radiation exposure due to repeated *** to equivalent CSS rates to ART,and lower toxicity,one course of adjuvant carboplatin presents the cornerstone of chemotherapy for CSI *** is almost 100%for patients with CSI seminoma,regardless of the chosen treatment ***,a personalized approach in treatment selection is ***,routine radiotherapy for CSI seminoma patients is no longer ***,it should be reserved for patients who are unﬁt or unwilling for AS or ***ﬁcation of prognostic factors for disease relapse allowed for the development of risk-adapted treatment strategy and stratiﬁcation of patients in low-risk and high-risk *** risk-adapted policy needs further validation,surveillance is currently recommended in low-risk patients,while ACT is reserved for patients with a higher risk of relapse.

关键词： Chemotherapy Radiotherapy Risk-adapted strategy Seminoma Surveillance

Study of TiO_2 thin films on Si substrate by the photoacoustic elastic bending method

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Science China(Physics,Mechanics & Astronomy) 2013年第7期56卷 1285-1293页

作者： TODOROVI Dragan M RABASOVI Mihailo D MARKUSHEV Dragan D FRANKO Mladen TANGAR Urka Lavreni Institute for Multidisciplinary Research University of Belgrade Institute of Physics University of Belgrade Laboratory for Environmental Research University of Nova Gorica

The quantitative photoacoustic investigation of different TiO2 thin films on Si substrates is presented using the elastic bending method. Photoacoustic signal amplitude and phase spectra versus modulation frequency were measured and analyzed using different sample thicknesses. Within the proposed method particular attention is given to the analysis of optical, thermal, elastic and structural sample parameters. Considerable focus is devoted to the fitting procedure of experimental results using the two-layer sample theoretical model. Characteristics of previously developed photoacoustic apparatus are discussed, attempting to search the ideal experimental conditions which can provide a good signal-to-noise ratio and sensitivity.

关键词： photoacoustic TiO2 thin films

Fast and scalable routing protocols for data center networks

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Digital Communications and Networks 2023年第6期9卷 1340-1350页

作者： Mihailo Vesovic Aleksandra Smiljanic Dusan Kostic School of Electrical Engineering University of Belgrade11120BelgradeSerbia Amazon Web Services(AWS) ZurichSwitzerland

Data center networks may comprise tens or hundreds of thousands of nodes,and,naturally,suffer from frequent software and hardware failures as well as link *** are routed along the shortest paths with sufficient resources to facilitate efficient network utilization and minimize *** such dynamic networks,links frequently fail or get congested,making the recalculation of the shortest paths a computationally intensive *** routing protocols were proposed to overcome this problem by focusing on network utilization rather than ***,the design of fast shortest-path algorithms for data centers was largely neglected,though they are universal components of routing ***,parallelization techniques were mostly deployed for random network topologies,and not for regular topologies that are often found in data *** aim of this paper is to improve scalability and reduce the time required for the shortest-path calculation in data center networks by parallelization on general-purpose *** propose a novel algorithm that parallelizes edge relaxations as a faster and more scalable solution for popular data center topologies.

关键词： Routing protocols Data center networks Parallel algorithms Distributed algorithms Algorithm design and analysis Shortest-path problem Scalability

Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential

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BIOCELL 2021年第6期45卷 1543-1550页

作者： MAJA MILOSEVIC MILOS LAZAREVIC BOSKO TOLJIC MILAN PETROVIC MIROSLAV VUKADINOVIC ZORAN JEZDIC BOBAN ANICIC DRAGO JELOVAC SVETLANA JOVANOVIC JELENA MILASIN Department of Human Genetics School of Dental MedicineUniversity of BelgradeBelgrade11000Serbia Clinic for Maxillofacial Surgery School of Dental MedicineUniversity of BelgradeBelgrade11000Serbia Department of Public Health School of Dental MedicineUniversity of BelgradeBelgrade11000Serbia

Specific cell subpopulations identified as cancer stem cells(CSCs)can be found in basal cell carcinoma(BCC).Generally,CSCs have a marked trans-differentiation potential that could potentially be used in differentiation ***,there are no studies regarding BCC CSCs *** aim of the study was to analyze the characteristic of CSCs of BCC with emphasis on their differentiation potential upon specific *** staining and cell morphology were used for differentiation confirmation,along with the expression analysis of osteogenic(ALP,BSP,Runx2,OCN,BMP2),chondrogenic(COL1 and COL2A1),adipogenic(PPAR-γ)and neurogenic(Nestin and MAP2)*** CSCs differentiated into osteogenic and chondrogenic lineages,as judged by staining and high expression of specific markers(from 2-to 92-fold higher upon induction).Concomitantly with differentiation,the levels of cancer stem cell markers decreased in the ***-differentiation and neuro-differentiation were *** conclusion,BCC CSCs exhibit the capacity to trans-differentiate,a characteristic that may potentially be useful in the development of new strategies for the treatment of aggressive BCCs.

关键词： Basal cell carcinoma Cancer stem cells Differentiation potential Osteo-differentiation Chondro-differentiation

Weighted Sum of Gray Gases Model Optimization for Numerical Investigations of Processes inside Pulverized Coal-Fired Furnaces

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Journal of Thermal Science 2017年第6期26卷 552-559页

作者： Nenad Crnomarkovic Srdjan Belosevic Ivan Tomanovic Aleksandar Milicevic university of belgrade Vinea Institute of Nuclear Sciences P. O. Box 522 11001 Belgrade Serbia

The effects of the number of significant figures （NSF） in the interpolation polynomial coefficients （IPCs） of the weighted sum of gray gases model （WSGM） on results of numerical investigations and WSGM optimization were investigated. The investigation was conducted using numerical simulations of the processes inside a pulverized coal-fired furnace. The radiative properties of the gas phase were determined using the simple gray gas model （SG）, two-term WSGM （W2）, and three-term WSGM （W3）. Ten sets of the IPCs with the same NSF were formcd for every weighting coefficient in both W2 and W3. The average and maximal relative difference values of the flame temperatures, wall temperatures, and wall heat fluxes were determined. The investigation showed that the results of numerical investigations were affected by the NSF unless it exceeded certain value. The increase in the NSF did not necessarily lead to WSGM optimization. The combination of the NSF （CNSF） was the necessary requirement for WSGM optimization.

关键词： Furnace Numerical simulation Significant figure Weighted sum of gray gases model Optimization

A non-isothermal Couette slip gas flow

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Science China(Physics,Mechanics & Astronomy) 2013年第9期56卷 1782-1797页

作者： MILICEV Snezana S. STEVANOVIC Nevena D. university of belgrade Faculty of Mechanical Engineering

A steady plane subsonic compressible non-isothermal Couette gas flow is analyzed for moderately high and low Reynolds *** flow channel is formed by two plates in relative *** cases are considered:(a) isothermal walls where the temperatures of the plates are equal and constant and(b) with constant but different plate *** Knudsen number is Kn 0.1,which corresponds to the slip and continuum *** flow is defined by continuity,Navier-Stokes and energy continuum equations,along with the velocity slip and the temperature jump first order boundary *** analytical solution for velocity and temperature is obtained by developing a perturbation *** first approximation corresponds to the continuum flow conditions,while the others represent the contribution of the rarefaction *** addition,a numerical solution of the problems is given to confirm the accuracy of the analytical *** exact analytical solution,for constant viscosity and conductivity is found for the isothermal walls case as *** is shown that it is entirely a substitution to the exact numerical solution for the isothermal walls case.

关键词： Couette gas flow non-isothermal slip flow analytical solution perturbation scheme

Sedimentation History of Neogene Lacustrine Sediments of Sueoka Bela Stena Based on Geochemical Parameters(Valjevo-Mionica Basin,Serbia)

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Acta Geologica Sinica(English Edition) 2008年第6期82卷 1201-1212页

作者： Aleksandra AJNOVI Vladimir SIMI Branimir JOVANIEVI Olga CVETKOVI Radovan DIMITRIJEVI Nenad GRUBIN Center of Chemistry IChTM11000 BelgradeSerbia Faculty of Mining and Geology University of Belgrade11000 BelgradeSerbia Faculty of Chemistry University of Belgrade11000 BelgradeSerbia Rio Tinto Exploration Bulevar A VNOJ-a 7111000 BelgradeSerbia

Sediments of the western part of the Valjevo-Mionica basin （Serbia） were examined both geochemically and mineralogically to explain, on the basis of their sedimentologicai characteristics, the causes of changes in their qualitative and quantitative composition. A total of 62 samples obtained from the drillhole at depths up to 400 m was investigated. Using correlation of the obtained data, six geochemical zones were defined, two of which being specially distinguished by their mineralogical, geochemical and sedimentological characteristics. The first one, upper zone A, consists of banded marlstones interbedded with clay and oil shales and is characterized by presence of analcite and searlesite. These minerals and very high contents of Na20 indicate sedimentation in alkaline conditions with increased salinity in arid climate. That provided pronounced water stratification, as well as higher bioproductivity in the basin and sedimentary organic matter preservation. Therefore, the zone A sediments are characterized by high organic matter contents of the type which provides good potential for production of liquid hydrocarbons. Another specific zone, zone F, contains sediments with very high MgO, K2O and Li concentrations. Their geochemical correlation, as well as almost complete absence of illite in this zone, indicates the presence of interstratified clay mineral type illite-saponite （lithium-bearing Mg-smectite）.

关键词： lacustrine sediments geochemistry searlesite statistical analysis

GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1514-1520页

作者： Miroslav Stamenkovic Vesna Lukic Sonja Suvakov Tatjana Simic Ivan Sencanic Marija Pljesa-Ercegovac Vesna Jaksic Sinisa Babovic Marija Matic Aleksandra Radosavljevic Ana Savic-Radojevic Tatjana Djukic university Eye Clinic Medical Center ZvezdaraBelgrade 11000Serbia Faculty of Special Education and Rehabilitation University of BelgradeBelgrade 11000Serbia Institute of Medical and Clinical Biochemistry Belgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia Hospital for Eye Diseases Clinical Center of SerbiaBelgrade 11000Serbia

AIM： To evaluate glutathione transferase theta 1 and mu 1（GSTT1 and GSTM1） polymorphisms as determinants of primary open angle glaucoma（POAG） risk, independently or in combination with cigarette smoking, hypertension and diabetes ***： A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or χ~2 test. Logistic regression analysis was used for assessing the risk for disease ***： The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma（P=0.044） which increased up to 4.36 when combined with GSTM1-null carriers（P=0.024）. When glutathione transferase（GST） genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively （OR=3.52, P=0.003; OR=10.02, P〈0.001; OR=4.53, P=0.002）. CONCLUSION： The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.

关键词： GSTM1 GSTT1 primary open angle glaucoma risk smoking hypertension diabetes mellitus

Light of the stars:calcium signals light up astrocytes in the presence of autoreactive CD4+T cells

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Neural Regeneration Research 2021年第12期16卷 2395-2396页

作者： Jelena BogdanovićPristov Ljiljana Nikolić Department of Life Sciences University of BelgradeInstitute for Multidisciplinary ResearchBelgradeSerbia Department of Neurophysiology University of BelgradeInstitute for Biological Research Siniša StankovićNational Institute of Republic of SerbiaBelgradeSerbia

Introduction:Astrocytes play important roles in the central nervous system(CNS)to support and regulate CNS *** are abundant type of glia that form a meshwork of interconnected cells almost completely tiling the *** astrocyte extends densely ramified processes that establish close contacts and interaction with other astrocytes,neurons and blood vessels,placing these cells in an ideal position to control extracellular milieu and to exert global effects on CNS physiology.

关键词： function. astrocytes cytes