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The protective effects of procyanidin C-1 on bisphenol A-induced testicular dysfunction in aged mice

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Food Science and Human Wellness 2022年第4期11卷 965-974页

作者： Mastura Abd Malek Razif Dasiman Nor-Ashikin Mohamed Noor Khan Sofee Mohamed-Akhlak Mohd-Hafi zi Mahmud Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam Campus42300 Puncak AlamSelangorMalaysia

The number and quality of sperm are decreased due to bisphenol A(BPA) exposure, an endocrine-disrupting chemical on the male reproductive system, especially in advanced paternal age(APA). Procyanidin C-1(PCY-1), an antioxidant from grape seed(Vitis vinifera L.), has demonstrated anti-viral, anti-melanogenic and immunostimulatory effects. Therefore, this study aims to determine the effects of PCY-1 intervention on sperm parameters, testis morphological changes, serum testosterone, oestradiol, and luteinizing hormone(LH) concentrations and the expression of apoptotic(Bax and Bcl-2) and mitochondria-related(Mfn1 and Opa1) genes in BPA-exposed aged mice. Results revealed that PCY-1 intervention improves aged male fertility in BPA-exposed conditions by decreasing abnormal sperms percentage and increasing spermatogenic cell diameter and epithelial height. PCY-1 also decreased oestradiol, and increased LH and testosterone levels. The gene expression of Bax was significantly down-regulated by PCY-1 intervention. In contrast, Bcl-2 was substantially up-regulated. Expression of Mfn1 and Opa1 genes were also significantly up-regulated in the PCY intervention group. Hence, it is demonstrated that PCY-1 was able to mitigate the adverse effects of BPA on reproductive parameters of aged mice. Collectively, we postulated that PCY-1 has a potential role in protecting the ageing male reproductive system against the damaging impacts of BPA.

关键词： Apoptosis Bisphenol A Procyanidin Mitochondrial dynamics Testis

Differential Expression of Gene of Streptococcus Mutans in Response to Treatment with Piper Betle Aqueous Extract-A Research Framework

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Differential Expression of Gene of Streptococcus Mutans in R...

The neuroprotective effects of(S)-3,5-dihydroxyphenylglycine preconditioning in middle cerebral artery occluded rats: a perspective as a contrivance for stroke

International Conference on Bioscience, Biochemistry and Bioinformatics（ICBBB 2011）

作者： Nurhayati Bt Mohd Zain Faculty of Dentistry Universiti Teknologi Mara(UiTM) Malaysia

This paper will provide the overview of the research framework to investigate gene expression in Streptococcus mutans,the major causative agents of dental caries in response to Piper betle aqueous extract which had reported to show anticaries *** culture will be treated with different concentrations of Piper betle extract(2,4 and 10 mg mL-1).Culture treatment with chlorhexidine(0.12%) will be used as comparison and positive *** Time PCR will be used to assess the expression of spaP,gbpB and gtfB after the *** findings from this study may provide gene expression profile of Streptococcus mutans after treatment with different concentration of Piper betle extract.

关键词： Streptococcus mutans,Piper betle,gene expression

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Neural Regeneration Research 2015年第8期10卷 1221-1222页

作者： Nik Nasihah Nik Ramli Rosfaiizah Siran Faculty of Medicine Universiti Teknologi MARA

Stroke is one of the fearsome causes of death that leads to high mortality and morbidity ***,the management of choice for ischemic stroke is either by thrombolysis or thrombectomy.

关键词： thrombolysis mortality morbidity challenge choice glutamate neuronal stimulation brief NMDA

Screening the synergy of sodium dodecylbenzenesulfonate and carboxymethyl cellulose for surfactant-polymer flooding

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Petroleum Research 2022年第3期7卷 308-317页

作者： Suriatie Mat Yusuf Radzuan Junin Mohd Akhmal Muhamad Sidek Augustine Agi Mohd Fazril Irfan Ahmad Fuad Nor Roslina Rosli Norazah Abd Rahman Effah Yahya Nor Adilah Muhamad Soffian Wong Muhammad Hazim Mustaza Department of Petroleum Engineering School of Chemical and Energy EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310Johor BahruMalaysia Institute for Oil and Gas Universiti Teknologi Malaysia81310Johor BahruMalaysia School of Chemical Engineering College of EngineeringUniversiti Teknologi MARA40450Shah AlamSelangorMalaysia

Carboxymethyl cellulose(CMC)has emerged in oil and gas industries as a superior substitution to the conventional HPAM and xanthan gum(XG)for high viscosity polymer flooding *** this study,the combined effect of conventional surfactant,sodium dodecylbenzenesulfonate(SDBS)and CMC for potential surfactant-polymer(SP)flooding in enhanced oil recovery(EOR)has been ***,SDBS–CMC interaction and the functional groups present in CMC were appropriately *** presence of various C–O bonds signifies the existence of carboxymethyl group which greatly influence the rheological properties of CMC *** behaviour of SDBS–CMC was characterized by their viscosity,shear rate,solubilization,wettability,and surface *** flooding utilizing SDBS-CMC was performed and compared to commercial SDBS-XG SP *** results indicate several SDBS-CMC combinations are favourable for EOR *** viscosity shows direct relationship with CMC ***,at any given SDBS concentrations,significant increment was observed at 0.3 wt%and ***,the trend displayed inconclusive relation to SDBS *** of the SDBS-CMC combinations generate Winsor III emulsions particularly at CMC of 0.2 and 0.3 wt%,while Type II were observed in few *** CMC concentrations increased the contact angle,while gradual reductions were observed with SDBS *** gradual reduction in surface tension was highly influenced by the addition of CMC rather than SDBS.A novel combination of 0.3 wt%SDBS and 0.4 wt%CMC possessed an encouraging criterion in term of viscosity,solubilization,and surface tension reduction for EOR *** experiment from several SDBS-CMC combinations proved to recover additional oil ranging 16.4–20.2%of oil initially in place(OIIP).The trend in incremental oil recovery is similar to that of when utilising SDBS-XG.

关键词： Carboxymethyl cellulose Sodium dodecylbenzenesulfonate Enhanced oil recovery Surfactant-polymer flooding

Behavioral Intrusion Prediction Model on Bayesian Network over Healthcare Infrastructure

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Computers, Materials & Continua 2022年第8期72卷 2445-2466页

作者： Mohammad Hafiz Mohd Yusof Abdullah Mohd Zin Nurhizam Safie Mohd Satar Faculty of Computer&Mathematical Sciences Universiti Teknologi MARA40450Shah AlamSelangorMalaysia Centre for Software Technology and Management(SOFTAM) Universiti Kebangsaan Malaysia43600BangiSelangor Malaysia

Due to polymorphic nature of malware attack,a signature-based analysis is no longer sufficient to solve polymorphic and stealth nature ofmalware *** the other hand,state-of-the-art methods like deep learning require labelled dataset as a target to train a supervised *** is unlikely to be the case in production network as the dataset is unstructured and has no *** an unsupervised learning is *** study is one of the techniques to elicit traffic ***,studies have shown that existing behavioral intrusion detection model had a few issues which had been parameterized into its common characteristics,namely lack of prior information(p(θ)),and reduced parameters(θ).Therefore,this study aims to utilize the previously built Feature Selection Model subsequently to design a Predictive Analytics Model based on Bayesian Network used to improve the analysis *** Selection Model is used to learn significant label as a target and Bayesian Network is a sophisticated probabilistic approach to predict ***,the results are extended to evaluate detection,accuracy and false alarm rate of the model against the subject matter expert model,Support Vector Machine(SVM),k nearest neighbor(k-NN)using simulated and ground-truth *** ground-truth dataset from the production traffic of one of the largest healthcare provider in Malaysia is used to promote realism on the real use case *** have shown that the proposed model consistently outperformed other models.

关键词： Intrusion detection prevention system behavioral malware analysis machine learning in cybersecurity deep learning in intrusion detection system(IDS)and intrusion prevention system(IPS)

Chromatic Uniqueness of Certain Complete Tripartite Graphs

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Acta Mathematica Sinica,English Series 2011年第5期27卷 919-926页

作者： G. C. LAU Y. H. PENG Faculty of Computer & Mathematical Sciences Universiti Teknologi MARA (Segamat Campus) 85100 Segamat Johor Malaysia Department of Mathematics and Institute for Mathematical Research Universiti Putra Malaysia 43400 UPM Serdang Malaysia

Let P（G,A） be the chromatic polynomial of a graph G. A graph G is chromatically unique if for any graph H, P（H, λ） = P（G, λ） implies H is isomorphic to G. Liu et al. [Liu, R. Y., Zhao, H. X., Ye, C. F.： A complete solution to a conjecture on chromatic uniqueness of complete tripartite graphs. Discrete Math., 289, 175 179 （2004）], and Lau and Peng [Lau, G. C., Peng, Y. H.： Chromatic uniqueness of certain complete t-partite graphs. Ars Comb., 92, 353-376 （2009）] show that K（p - k,p - i,p） for i = 0, 1 are chromatically unique if p ≥ k ＋ 2 ≥ 4. In this paper, we show that if 2 〈 i 〈 4, the complete tripartite graph K（p - k,p - i,p） is chromatically unique for integers k ≥ i and p 〉 k2/4 ＋ i ＋ 1.

关键词： Complete tripartit graphs chromatic polynomial chromatic uniqueness

Strength Performance and Microstructure Characteristic of Naturally-Bonded Fiberboard Composite from Malaysian Bamboo(Bambusa vulgaris)

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Journal of Renewable Materials 2022年第10期10卷 2581-2591页

作者： Shahril Anuar Bahari Mohd Nazarudin Zakaria Syaiful Osman Falah Abu Mohamad Jani Saad Reza Hosseinpourpia Eco-Technology Program Faculty of Applied SciencesUniversiti Teknologi MARA(UiTM)Shah Alam40450Malaysia Engineering Research Centre Malaysian Agricultural Research and Development Institute(MARDI)Serdang43400Malaysia Department of Forestry and Wood Technology Linnaeus UniversityVäxjö35195Sweden

This study investigated the mechanical properties and microstructural characteristics of fiberboard composite produced by naturally-bonded Malaysian bamboo fiber(Bambusa vulgaris).The components that obtained through soda pulping of bamboo culms such as fiber and black liquor,were used for the preparation of high-density fibreboard composite at two target densities of 850 and 950 kg/m^(3).The bamboo fiberboard composite(BFC)were then produced at 200°C and two pressing parameters of 125 and 175 s/*** mechanical properties,e.g.,flexural strength and internal bonding(IB)of BFC samples were evaluated according to BS EN 310:1993 and BS EN 319:1993,*** was found that the mechanical performance of the composite with 850 kg/m^(3)density was significantly higher than 950 kg/m^(3)ones,especially for the samples with 125 s/mm pressing *** characteristic of the BFC samples illustrated that the fiber linkages were cracked in the composites with higher density,e.g.,the composite with the density of 950 kg/m^(3)and also black liquor were slightly degraded at longer pressing time,which led to the reduction in mechanical properties,especially in IB strength.

关键词： Bamboo fiber naturally-bonded black liquor mechanical properties SEM composite

Syzygium aromaticum ethanol extract reduces AlCl_3-induced neurotoxicity in mice brain through regulation of amyloid precursor protein and oxidative stress gene expression

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Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 123-130页

作者： Sanila Amber Syed Adnan Ali Shah Touqeer Ahmed Saadia Zahid Neurobiology Research Laboratory Department of Healthcare BiotechnologyAtta-ur-Rahman School of Applied BiosciencesNational University of Sciences and Technology Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns)Universiti Teknologi MARA Puncak Alam Campus Faculty of Pharmacy Universiti Teknologi MARA Puncak Alam Campus

Objective: To investigate the neuroprotective effects of Syzygium aromaticum(***)extract(500 mg/kg) on AlCl_3(300 mg/kg)-induced mouse model of oxidative stress and ***: An ethanolic extract of *** seeds was prepared and the active compounds were identified using nuclear magnetic resonance ***/c mice were divided into five groups(negative control, AlCl_3-treated, self-recovery, AlCl_3 + ***, *** only; n=10) and treated with AlCl_3 and *** *** of oxidative markers [Superoxide dismutase 1(SOD1) and peroxiredoxin 6(Prdx6)] and amyloid precursor protein(APP) in the hippocampus and cortex was evaluated via *** assessment was performed to investigate the extent of ***: It was observed that AlCl_3 exposure increased the expression of APP770 while simultaneously down regulated the expression of ***_3 also induced a significant decrease(P<0.05) and an increase(P<0.05) in the expression level of SOD1 and Prdx6, respectively.A substantial decrease substantial(P<0.05) in the density of Nissl substance was also observed in cortex of the mice treated with AlCl_***, treatment with *** extract normalized the alterations in the expression level of SOD1, Prdx6 and APPisoforms and improved the neuronal structural ***: The results showed that *** is a promising antioxidant and a neuroprotective agent.

关键词： Amyloid precursor protein Oxidative stress Aluminum Neurodegeneration

The effect of nanosilica sizes in the presence of nonionic TX100 surfactant on CO_(2)foam flooding

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Petroleum Research 2022年第1期7卷 62-76页

作者： Suriatie Mat Yusuf Radzuan Junin Mohd Akhmal Muhamad Sidek Muhammad AManan Mohd Fazril Irfan Ahmad Fuad Mohd Zaidi Jaafar Effah Yahya Nor Roslina Rosli Department of Petroleum Engineering School of Chemical and Energy EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310Johor BahruMalaysia Institute for Oil and Gas Universiti Teknologi Malaysia81310Johor BahruMalaysia School of Chemical Engineering College of EngineeringUniversiti Teknologi MARA40450 Shah AlamSelangorMalaysia

The aim of this research is to study the effect of hydrophilic silica nanoparticles,sizes as CO_(2) foam stabilizer in the presence of nonionic TX100 *** nanosilica sizes,15 and 70 nm,have been examined *** of TX100 on silica nanoparticles(nanosilica)was characterized by adsorption isotherm and surface tension measurement,while CO_(2) foams stability was quantified based on their foamability,foam stability,particle partitioning in the foams,and bubble *** show that direct contact of TX100 with nanosilica does altered the wettability of hydrophilic nanosilica surface,enable them to lengthen CO_(2) foams life at certain surfactant and nanoparticles *** 15 nm nanosilica,CO_(2) foam stability shows excellent performance at 0.1 and 0.5 wt%TX100 *** for 70 nm nanosilica,CO_(2) foam demonstrates longer lifetime at much lower TX100 concentration,0.01 wt%.Without the presence of TX100,CO_(2) foams exhibit undesirable lifetime performances for both nanosilica *** partitioning in CO_(2) foams structures demonstrate consistent relation with contact angle *** bubble sizes shows insignificant effect on CO_(2) foams *** the assists of nanosilica and TX100,enhanced oil recovery via CO_(2) foam injection succeeds in increasing oil production by 13e22%of original oil-in-place(OOIP).

关键词： Nanoparticle sizes Adsorption Nonionic surfactant TX100 surfactant Foamability CO_(2)foam stability CO_(2)foam flooding EOR