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In vitro and in vivo proves of concept for the use of a chemically cross-linked poly(ester-urethaneurea)scaffold as an easy handling elastomeric biomaterial for bone regeneration

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Regenerative Biomaterials 2019年第6期6卷 311-323页

作者： Geraldine Rohman Sylvie Changotade Sophie Frasca Salah Ramtani Anne Consalus Credson Langueh Jean-Marc Collombet Didier Lutomski Universite Paris 13 Sorbonne Paris CiteTissue Engineering and Proteomics(TIP)TeamCSPBATUMR CNRS 724474 rue Marcel Cachin93000 BobignyFrance Departement Soutien Medico-Chirurgical des Forces(SMCF) BP73Institut de Recherche Biomedicale des Armees(IRBA)91223 Bretigny-sur-Orge CedexFrance universiteparis 13 Sorbonne Paris CiteLBPS TeamCSPBATUMR CNRS 724499 Avenue Jean-Baptiste Clement93430 VilletaneuseFrance

Bone loss can occur as a result of various pathologies,traumas and injuries and poor bone healing leads to functionally debilitating condition,loss of self-sufficiency and deterioration in life *** the increasing incidence of facial trauma and the emergence of new procedural techniques,advanced scaffolds are currently developed as substitutes for bone tissue *** this study,we investigated the capability of a chemically cross-linked e-caprolactone-based poly(esterurethane-urea)(PCLU)scaffold to support bone *** vitro assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold ***,PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3D spatial arrangement,and allowed osteogenic differentiation under appropriate *** vivo results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in *** histology and microtomography analysis,we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed ***,no sign of inflammation or rejection was *** envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.

关键词： bone regeneration scaffold elastomer PEUU PCLU

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Cellular automata modelling of austenite grain coarsening during reheating——I. Normal grain coarsening

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Journal of University of Science and Technology Beijing 2004年第6期11卷 517-523页

作者： WanhuaYU E.J.Palmiere S.P.Banks JingtaoHan MaterialsScienceandEngineeringSchool UniversityofScienceandTechnologyBeijingBeijing100083China DepartmentofEngineeringMaterials UniversityofSheffieldSheffieldS13JDUK DepartmentofAutomaticControlandSystemsEngineering UniversityofSheffieldSheffieldS13JDUK

A two-dimensional cellular automaton (CA) model has been developed for thedescription of the normal grain coarsening process. The probabilistic CA method incorporatingMoore's definition of the neighbourhood is used to simulate the normal grain coarsening process witha new transition rule. The model simulates the grain coarsening process in as much detail that ispossible, from the point of initial nucleation to subsequent coarsening with computational *** unique result is that the grain coarsening speed can be controlled by the specific method, thisresult is vital to model the grain coarsening quantitatively. In order to make this model valid,experimental work has been done to provide solid evidence for this model. Comparison of themodelling result and the experimental result has been carried out.

关键词： computer simulation grain growth microstructure reheating

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Computer-Aided Design of Some Advanced Steels and Cemented Carbides

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Journal of Iron and Steel Research International 2005年第6期12卷 42-48页

作者： LI Lin ZHANG Mei HE Yan-lin De Cooman Bruno Wollants Patrick Shanghai University Shanghai 200072 China Katholieke Universiteit Leuven Leuven 13-3001 Belgium Universiteit Gent Zwijnaarde 13-9052 Belgium

Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C （M= Ti, Ta, Nh） systems and Co-V-C system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.

关键词： computer-aided composition design TRIP steel cemented carbide prehardened mould steel concentration profile thermodynamic kinetic equilibrium composition

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Semen analysis with regard to and functional aspects sperm number, sperm morphology

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Asian Journal of Andrology 2010年第1期12卷 26-32页

作者： Rune Eliasson Bjornstigen 13 SE 165 71 HASSELBY Sweden

The new World Health Organization （WHO） Manual for Semen Analysis contains several improvements. One is that the 20 million spermatozoa per mL paradigm has been ousted in favour of proper calculations of lower reference limits for semen from men, whose partners had a time-to-pregnancy of 12 months or less. The recommendation to grade the progressive motility as described in the third and fourth editions of the WHO manual was not evidence-based, and WHO was therefore motivated to abandon it. However, the new recommendation is not evidence-based either, and it is difficult to understand the rational for the new assessment. It may have been a compromise to avoid returning to the rather robust system recommended in the first edition （1980）. The unconditional recommendation of the ＇Tygerberg strict criteria＇ is not evidence-based, and seems to be the result of an unfortunate bias in the composition of the Committee in favour of individuals known to support the ＇strict criteria＇ method. This recommendation will have negative effects on the develop- ment ofandrology as a scientific field. Given the importance of the WHO manual, it is unfortunate that the recommenda- tions for such important variables, as motility and morphology, lack evidence-based support.

关键词： evaluation report semen analysis spermatozoa sperm morphology sperm motility

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Cellular automata modelling of grain coarsening during reheating——Ⅱ. Abnormal grain growth

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Journal of University of Science and Technology Beijing 2005年第1期12卷 26-32页

作者： WanhuaYu E.J.Palmiere S.P.Banks JingtaoHan DepartmentofMaterialsEngineering UniversityofScienceandTechnologyBeijingBeijing100083China DepartmentofEngineeringMaterials UniversityofSheffieldS13JDSheffieldUK DepartmentofAutomaticControlandSystemsEngineering UniversityofSheffieldS13JDSheffieldUK

The 2-dimensional cellular automata (CA) simulation technique has been utilized to investigate the abnormal grain coarsening. The growth of abnormal grains is modelled under this assumption that different grains have different boundary energies and boundary mobilities. As temperature increases, some grains may first get rid of the particle pinning effect. Thus a high probability is obtained for atoms to jump over the boundary, so that they can consume other primary retained grains quickly. From the simulation, the characteristics of the abnormal grain coarsening under different conditions are demonstrated successfully. An experiment has also been carried out to reflect the abnormal grain coarsening on the microalloy steel. Simulation results are quite close to the experimental evidence.

关键词： computer simulation grain growth microstructure reheating

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Where Does ＂Axial Breakthrough＂ Take Place？ In the Past, or in Present Narratives of the Past？

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Fudan Journal of the Humanities and Social Sciences 2016年第4期9卷 565-576页

作者： Violaine Sebillotte Cuchel UMR 8210 ANHIMA (CNRS EHESS EPHE Padsl Paris7) UniversiteParis 1 Pantheon-Sorbonne 2 Rue Vivienne 75002 Pads France

This article focuses on Vernant＇s thesis, masterfully developed in Les origines de la pensde grecque （1962） and translated into English in 1982. Vernant explained that between the seventh- and the second-century BCE, one can note crucial modifications of the traditional and religious atmosphere, in civilizations as distant as China, India, Persia, Palestine and Greece. These turning points brought Confucianism, Buddhism, Zoroastrianism, Prophetism, and, in Greece, Search for Truth. For historians, who claim their expertise on the past, methodological issues are at stake in any inquiry about an ＂axial age＂ or an ＂axial breakthrough.＂ First, there is the epistemological question of historiography, a present narrative of the past that cannot, from a scientific point of view--that of the historians, erase varieties of past narratives （poetics, technical treatises, epigraphic decrees, vase paintings, etc.）. Then, there is the new understanding of the constant interaction of what we call the political sphere with what we call the religious sphere, insofar as the distinction between a strictly political sphere, separate from the religious sphere, is now fully challenged. Finally, the polis as we understand it nowadays includes women＇s acts, as feminist scholarship has demonstrated through the past 35 years. This new depiction makes the ＂citizens＂ different： They can no longer be thought of as all the same and interchangeable.

关键词： Vemant Ancient history Historiography Methodology Feminism

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Purification of Single-walled Carbon Nanotubes Grown by a Chemical Vapour Deposition(CVD) Method

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Chemical Research in Chinese Universities 2002年第2期18卷 130-132页

作者： Cigang Xu Emmanuel Flahaut Sam R.Bailey Gareth Brown Jeremy Sloan Karl S.Coleman VClifford Williams Malcolm L.H.Green Inorganic Chemistry Laboratory University of OxfordOxfordOX13QRUK Department of Materials University of OrfordOxfordOX13PHUK

A procedure for purification of single walled carbon nanotubes(SWNTs) grown by the chemical vapour deposition(CVD) of carbon monooxide has been developed. Based on the result from TGA/DTA of as prepared sample, the oxidation temperature was determined. The process included sonication, oxidation and acid washing steps. The purity and yield after purification were determined and estimated by TEM. Moreover, for the first time, a loop structure for CVD SWNTs has been observed.

关键词： Single walled carbon nanotubes(SWNTs) Purification Chemical vapour deposition(CVD)

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Expression and localization of c-Fos and NOS in the central nerve system following esophageal acid stimulation in rats

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World Journal of Gastroenterology 2004年第15期10卷 2287-2291页

作者： Xiao-Wei Peng-YanXie DepartmentofGastroenterology FirstHospitalofPekingUniversity13eijing100034China

AIM: To determine the distribution of neurons expressing c-Fos and nitric oxide synthase (NOS) in the central nerve system (CNS) following esophageal acid exposure, and to investigate the relationship between c-Fos and ***: Twelve Wistar rats were randomly divided into two equal groups. Hydrochloric add with pepsin was perfused in the lower part of the esophagus for 60 min. As a control,normal saline was used. Thirty minutes alter the perfusion, the rats were killed and brains were removed and processed for c-Fos immunohistochemist]y and NADPH-cl *** pressure (BP), heart rate (HR), and respiratory rate (RR) during the experimental procedures were recordedevery 10 ***: There were no significant differences in BP, HR and RR between the two groups, c-Fos immunoreactivitywas significantly increased in rats receiving acid plus pepsin perfusion in amygdala (AM), paraventricular nucleus (PVN),parabrachial nucleus (PBN), nucleus tractus solitarius and dorsal motor nucleus of vagus (NTS/DMV), nucleus ambiguous (NA), reticular nucleus of medulla (RNM) and area postrema (AP). NOS reactivity in this group was significantly increased in PVN, PBN, NTS/DMV, RNM andAP. c-Fos and NOS had significant correlation betweenPVN, PBN, NTS/DMV, RNM and ***: Acid plus pepsin perfusion of the esophagus results in neural activation in areas of CNS,and NO is likely one of the neurotransmitters in some of these areas,

关键词：基因表达地方化 c-Fos NOS 中枢神经系统食道酸刺激老鼠胃蛋白酶

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All-sky Data Assimilation of MWTS-2 and MWHS-2 in the Met Office Global NWP System.

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Advances in Atmospheric Sciences 2021年第10期38卷 1682-1694页

作者： Fabien CARMINATI Stefano MIGLIORINI Met Office Exeter EX13PBUK

Microwave radiances from passive polar-orbiting radiometers have been,until recently,assimilated in the Met Office global numerical weather prediction system after the scenes significantly affected by atmospheric scattering are *** system upgrades have seen the introduction of a scattering-permitting observation operator and the development of a variable observation error using both liquid and ice water paths as proxies of scattering-induced *** to the Fengyun 3 Microwave Temperature Sounder 2(MWTS-2)and the Microwave Humidity Sounder 2(MWHS-2),this methodology increases the data usage by up to 8%at 183 *** also allows for the investigation into the assimilation of MWHS-2118 GHz channels,sensitive to temperature and lower tropospheric humidity,but whose large sensitivity to ice cloud have prevented their use thus *** the impact on the forecast is mostly neutral with small but significant short-range improvements,0.3%in terms of root mean square error,for southern winds and low-level temperature,balanced by 0.2%degradations of short-range northern and tropical low-level temperature,benefits are observed in the background fit of independent instruments used in the *** lower tropospheric temperature sounding Infrared Atmospheric Sounding Interferometer(IASI)channels see a reduction of the standard deviation in the background departure of up to 1.2%.The Advanced Microwave Sounding Unit A(AMSU-A)stratospheric sounding channels improve by up to 0.5%and the Microwave Humidity Sounder(MHS)humidity sounding channels improve by up to 0.4%.

关键词： microwave remote sensing numerical weather prediction data assimilation Fengyun 3

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Comparison of near-infrared spectroscopy and DEM simulations for tracing spatial dispersion of water during mixing

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Particuology 2018年第3期16卷 94-102页

作者： Roland Hohl Nicolas Heigl Daniel Koller Charles A. Radeke Research Center Pharmaceutical Engineering GmbH lnffeldgasse 13 8010 Graz Austria

The aim of this work was to validate a wet mixing process, in which a liquid spray is used to impregnate particles during mixing. The experimental results obtained using a bladed-mixer with a near-infrared sensor were compared with the results obtained using a 1 ： 1 discrete element method simulation. The porous particles used in both cases absorbed the sprayed liquid for a process time of about 18 min. Mul- tiple sensors attached to the mixer wall continuously monitored the liquid contents of passing particles. The sensors were modeled in the simulation and the resulting signals were analyzed and compared with the experimental results. We show that the algorithms used for spray and liquid absorption can be used to predict the moisture distribution inside granular materials in chemical and pharmaceutical processes. Such simulations can help to save money, e.g., in resource-intensive experimental plans and equipment design studies, and by varying material parameters.

关键词： Mixing DEM Spray Near-infrared Particles

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