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Chinese Journal of Chemistry 2003年第10期21卷 1247-1251页

作者：姚小军范波涛 DOUCET J.P. PANAYE A. 刘满仓张瑞生胡之德 université paris 7-denis diderot Department of Chemistry

The quantitative relationship between relative electrophoretic mobility in capillary electrophoresis for a series of 31 closely related alkylpyridines and their molecular structures was studied by using CODESSA. According to the t test on the results, we found that the three most important descriptors affecting the mobility are the relative number of rings ( NR ), Min e n attraction for a C—N bond ( MEN ) and average complementary information index (ACIC) . With these structure descriptors a good three parameter linear model was developed to correlate the mobility of these compounds with their structures. This model can not only correctly predict the migration behavior of these compounds, but also find the structural factors which are responsible for the migration behavior of these compounds, thus can help to explain the separation mechanism of these compounds. The method used in this work can also be extended to the mobility structure relationship research of other compounds.

关键词： HPCE mobility QSPR alkylpyridine

Contribution to Structural Elucidation: Behaviours of Substructures Partially Defined from 2D NMR

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Chinese Journal of Chemistry 2003年第10期21卷 1268-1274页

作者： EPOUHE Celine 范波涛袁身刚 PANAYE A. DOUCET J.P. ITODYS université paris 7 denis diderot Shanghai Institute of Organic Chemistry

Structural elucidation (automatic determination of the structure of amolecule from its spectra) is frequently hampered by combinatorial explosion when trying to assemblethe identified substructures. We devised a new method which can avoid this pitfall by a systematicexamination of allowed ^(13)C chemical shifts ranges for all substructures chemically possible andcombined with a progressive pruning thanks to neighbouring relationships appearing from 2D NMR. Thismethod is explained by a detailed example.

关键词： structural elucidation ^(13)C NMR 2D NMR partially defined substructure

Role of endoscopy in predicting the disease course in inflammatory bowel disease

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World Journal of Gastroenterology 2010年第21期16卷 2626-2632页

作者： Matthieu Allez Marc Lémann Department of Gastroenterology and Equipe AVENIR INSERM Saint-Louis HospitalAPHPUniversité Denis Diderot Paris 775010 ParisFrance

Endoscopy provides a direct evaluation of mucosal lesions in inflammatory bowel disease(IBD),permitting the description of elementary lesions,their surface extent and *** severity of mucosal lesions directly reflects disease activity and may help to identify an aggressive behavior of the *** studies have recently pointed out the potential role of endoscopy in the prediction of IBD ***,severe endoscopic lesions in Crohn's disease(CD) patients,defined by deep and extensive ulcerations on at least one part of the colon,are associated with an increased risk of penetrating complication and *** endoscopic lesions during severe attacks of ulcerative colitis(UC) are associated with an increased risk of colectomy in the short and long *** of postoperative recurrence in CD may help to predict the risk of clinical relapse and need for further *** of mucosal healing,which can be obtained by administration of several types of drugs,is associated with a better outcome,less surgery and *** review focuses on the assessment of endoscopic severity in CD and UC and on the impact of endoscopic severity on disease *** specifically,we discuss how endoscopy can be used at different stages of IBD to predict the disease course and/or to adapt treatment strategies.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Colonoscopy Natural history Outcome Medical therapy Surgery

Liver transplantation for hepatocellular carcinoma： is zero recurrence theoretically possible？

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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 147-151页

作者： Sabine Irtan Louise Barbier Claire Francoz Federica Dondéro Francois Durand Jacques Belghiti Department of Hepato-Pancreato-Biliary Surgery Beaujon HospitalAssistance Publique Hopitaux de ParisUniversity Denis Diderot-ParisⅦClichyFrance Department of Hepatology Beaujon HospitalAssistance Publique Hopitaux de ParisUniversity Denis Diderot-ParisⅦClichyFrance

BACKGROUND： Hepatocellular carcinoma（HCC） recurrence remains a key issue after liver transplantation. This study aimed to determine a subgroup of HCC patients within the Milan criteria who could achieve a theoretical goal of zero recurrence rates after liver ***： Between 1999 and 2009, 179 patients who received liver transplantation for HCC within the Milan criteria were retrospectively included. Analysis of the factors associated with HCC recurrence was performed to determine the subgroup of patients at the lowest risk of ***： Seventy-two percent of the patients received a bridging therapy, including 54 liver resections. Eleven（6.1%） patients recurred within a delay of 19±22 months and ultimately died. Factors associated with recurrence were serum alpha-fetoprotein level 〉400 ng/m L, satellite nodules, poor differentiation, microvascular invasion and cholangiocarcinoma component. Recurrence rates decreased from 6.1% to 3.1% in patients without any of these ***： Among HCC patients within the Milan criteria, selecting patients with factors based on histology would allow tending towards zero recurrence, and prior histological assessment by liver biopsy or resection may be essential to rule out poorly differentiated tumors, microvascular invasion,and cholangiocarcinoma component.

关键词： hepatocellular carcinoma liver transplantation neoplasm recurrence survival rate

Evolution of the 128-cm^(-1) Raman phonon mode with temperature in Ba(Fe_(1-x)Co_x)_2As_2(x=0.065 and 0.2)

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Chinese Physics B 2015年第2期24卷 399-402页

作者：杨彦兴 Gallais Yann 方之颢石兢熊锐 School of Physics and Technology Wuhan University Laboratoire Matériaux et Phénomenes Quantiques(UMR 7162 CNRS) Université Paris Diderot-Paris 7

We report electronic Raman scattering measurements on Ba（Fei1-xCox）2As2（x = 0.065 and 0.2） single crystals with Raman shifts from 9 cm^-1 up to 600 cm^-1 in the symmetry of Blg with respect to 1 Fe unit *** the crystals are cooled down,the evident quasielastic peaks of Raman spectra occur only in the crystal with x = 0.065,which is due to the contribution of orbital ordering between xz and yz Fe 3d orbitals,as we reported in another ***,we analyze the Eg phonon at 128 cm^-1,which has the same function form of its Raman tensors as those of xz and yz Fe 3d orbitals in these two crystals *** their electronic continuums,no anomalies are found in the Eg phonons of these two samples,which simply follows the expressions corresponding to the anharmonic phonon decay into acoustic phonons with the same frequencies and opposite *** results indicate that the structural and magnetic phase transition might be completely suppressed by chemical doping and there is not any indication of coupling between charge nematicity and Eg phonon mode from our experimental results,which is consistent with the results in our previous work.

关键词： Raman scattering iron-based superconductor phonon mode

Update on imaging of Peutz-Jeghers syndrome

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World Journal of Gastroenterology 2014年第31期20卷 10864-10875页

作者： Catherine Tomas Philippe Soyer Anthony Dohan Xavier Dray Mourad Boudiaf Christine Hoeffel Department of Radiology H?pital Robert Debré51092 Reims Cedex France Department of Abdominal Imaging H?pital Lariboisière-AP-HP and Université Diderot Paris 775475 Paris Cedex 10 France Department of Digestive Diseases H?pital Lariboisière-AP-HP and Université Diderot-Paris 775475 Paris Cedex 10 France

Peutz-Jeghers syndrome(PJS) is a rare, autosomal dominant disease linked to a mutation of the STK 11 gene and is characterized by the development of benign hamartomatous polyps in the gastrointestinal tract in association with a hyperpigmentation on the lips and oral mucosa. Patients affected by PJS have an increased risk of developing gastrointestinal and extra-digestive cancer. Malignancy most commonly occurs in the smallbowel. Extra-intestinal malignancies are mostly breast cancer and gynecological tumors or, to a lesser extent, pancreatic cancer. These polyps are also at risk of acute gastrointestinal bleeding, intussusception and bowel obstruction. Recent guidelines recommend regular smallbowel surveillance to reduce these risks associated with PJS. Small-bowel surveillance allows for the detection of large polyps and the further referral of selected PJS patients for endoscopic enteroscopy or surgery. Video capsule endoscopy, double balloon pushed enteroscopy,multidetector computed tomography and magnetic resonance enteroclysis or enterography, all of which are relatively new techniques, have an important role in the management of patients suffering from PJS. This review illustrates the pathological, clinical and imaging features of small-bowel abnormalities as well as the role and performance of the most recent imaging modalities for the detection and follow-up of PJS patients.

关键词： Peutz-Jeghers syndrome Small-bowel disease Small bowel polyps Intussusception Double balloon enteroscopy Video capsule endoscopy Abdomen,Magnetic resonance Abdomen Computed tomography

Darwinian selection within an individual or somatic selection: facts and models

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Journal of Molecular Cell Biology 2019年第8期11卷 719-722页

作者： Reiner A.Veitia Institut Jacques Monod Universite Paris Diderot 75013 Paris France universite paris-diderot 75013 Paris France

There are known cases where a cell sub-population bearing a selective advantage tends to or eventually replaces another cell subpopulation within an organism. This process is supposed to underlie the purging of the most frequent mitochon-drial DNA pathogenic variant from leuko-cytes and other tissues. It is also likely to explain the normal increase of sex chromo-some aneuploidy in human leukocytes with age or under pathological conditions and the expansion of a cell subpopulation after the spontaneous in vivo reversion to normal of an inherited pathogenic variant.

关键词： Darwinian selection facts models

A survey of the Szeg? equation Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

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Science China Mathematics 2019年第6期62卷 1087-1100页

作者： Patrick Gérard Sandrine Grellier Laboratoire de Mathématiques d'Orsay Université Paris-Sud CNRSUniversité Paris-Saclay Institut denis Poisson-université d'Orléans/université de Tours CNRS UMR

We survey the main properties of the cubic Szeg? equation from the PDE viewpoint, emphasising global existence of smooth solutions, analytic regularity, growth of high Sobolev norms and the effects of weak damping.

关键词： cubic Szego equation integrable system Hankel operator spectral analysis analytic regularity wave turbulence

AFF3:a new player in maintaining XIST monoallelic expression

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Journal of Molecular Cell Biology 2019年第9期11卷 723-724页

作者： Reiner A.Veitia Institut Jacques Monod Universite Paris DiderotParisFrance universite paris-diderot ParisFrance

The existence of highly differentiated X and Y chromosomes in mammals raises the issue of X-linked gene dosage compensation between XX females and XY males to avoid what would be similar to a monosomy X in males(Veitia et al.,2015).Inactivation of one copy of the X chromosomes in females provides a dosage-compensation mechanism equalizing the expression of X-linked genes in males and females(Ohno et al.,1959;Lyon,1961).

关键词： dosage al. differentiated

HANDEL'S FIXED POINT THEOREM:A MORSE THEORETICAL POINT OF VIEW

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Acta Mathematica Scientia 2021年第6期41卷 2149-2172页

作者： Patrice LE CALVEZ Institut de Mathématiques de Jussieu-paris Rive Gauche IMJ-PRGSorbonne UniversitéUniversitéParis-DiderotCNRSF-75005ParisFrance Institut universitaire de France ParisFrance

Michael Handel has proved in [10] a fixed point theorem for an orientation preserving homeomorphism of the open unit disk, that turned out to be an efficient tool in the study of the dynamics of surface homeomorphisms. The present article fits into a series of articles by the author [13] and by Juliana Xavier [21, 22], where proofs were given, related to the classical Brouwer Theory, instead of the Homotopical Brouwer Theory used in the original article. Like in [13, 21] and [22], we will use “free brick decompositions” but will present a more conceptual Morse theoretical argument. It is based on a new preliminary lemma, that gives a nice “condition at infinity” for our problem.

关键词： brick decomposition Brouwer theory translation arc