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Saccharomyces cerevisiae I-3856 in irritable bowel syndrome with predominant constipation

World Journal of Gastroenterology 2022年第22期28卷 2509-2522页

作者： Florian Mourey Amélie decherf Jean-François Jeanne Mathieu Clément-Ziza Marie-Lise Grisoni François Machuron Sophie Legrain-Raspaud Arnaud Bourreille Pierre desreumaux Research and Applications department Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France Data Science and Bioinformatics Laboratory Research and Development DepartmentLesaffre InternationalLesaffre GroupMarcq-en-Baroeul 59700France Institut des Maladies de l'Appareil Digestif Centre Hospitalier Universitaire de NantesNantes 44093France Institute for Translational Research in Inflammation Centre Hospitalier Universitaire de LilleLille 59000France

BACKGROUND Probiotics are a promising solution for managing irritable bowel syndrome(IBS).Saccharomyces cerevisiae(***)I-3856 has already demonstrated beneficial effects in IBS subjects,particularly in IBS with predominant constipation(IBS-C).AIM To confirm the efficacy of *** I-3856 in the management of gastrointestinal symptoms in *** A randomized,double-blind,placebo-controlled clinical study was performed in a total of 456 *** a run-in period,subjects were randomly assigned to the group receiving *** I-3856(8×109 CFU daily)or the placebo for 8 wk,and they performed daily self-evaluations of gastrointestinal *** primary objective was to assess the effect of the probiotic on abdominal *** secondary objectives were the evaluation of other gastrointestinal symptoms,bowel movement frequency and consistency,and quality of life(QOL).RESULTS A significantly higher proportion of abdominal pain responders was reported in the Probiotic group(45.1%vs 33.9%,P=0.017).A nonsignificant difference in the area under the curve for abdominal pain over the second month of supplementation was observed in subjects receiving probiotic vs placebo[P=0.073,95%CI:-0.59(-1.23;0.05)].No statistically significant differences were reported in the evolution of bowel movement frequency and stool consistency between the *** 8 wk of supplementation,the overall QOL score was significantly higher in the Probiotic group than in the Placebo group[P=0.047,95%CI:3.86(0.52;7.20)].Furthermore,exploratory analyses showed statistically significant and clinically relevant improvements in QOL scores in abdominal pain responders vs *** The results of this clinical study confirmed the abdominal pain alleviation properties of *** I-3856 in *** pain relief was associated with improved *** identifier:NCT03150212.

关键词： Probiotic Yeast Saccharomyces cerevisiae Irritable bowel syndrome Abdominal pain Quality of life

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defensins couple dysbiosis to primary immunodeficiency in Crohn's disease

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World Journal of Gastroenterology 2011年第5期17卷 567-571页

作者： Mathias Chamaillard Rodrigue dessein Institut Pasteur de lille Center for Infection and Immunity of LilleF-59019 LilleFrance Mathias ChamaillardRodrigue DesseinCNRSUMR 8204F-59021 LilleFrance Institut National de la Santé et de la Recherche Médicale U1019Team 7Equipe FRMF-59019 LilleFrance Univ lille Nord de France F-59000 LilleFrance C.H.R.U.de lille F-59000 LilleFrance

Antimicrobial peptides,including defensins,are essential effectors in host defence and in the maintenance of immune *** studies have linked the defective expression of both α-and β-defensin to the reduced killing of certain microorganisms by the intestinal mucosa of patients suffering from ileal and colonic Crohn's disease(CD),*** recently have the events leading to defective expression of defensins in CD been further elucidated,and are discussed *** events may account for CD-associated alterations in the microbiome and may subsequently precipitate the development of granulomatous inflammatory lesions in genetically-predisposed *** also address how these discoveries may pave the way for the development of a molecular medicine aimed at restoring gut barrier function in CD.

关键词：免疫缺陷防御素 TiAl基宿主防御肠道黏膜分子医学屏障功能微生物

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Some recent studies on glass/glass-ceramics for use as sealants with special emphasis for high temperature applications

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Journal of Advanced Ceramics 2012年第2期1卷 110-129页

作者： G.P.Kothiyal Madhumita Goswami Babita Tiwari Kuldeep Sharma A.Ananthanarayanan Lionel Montagne Glass and Advanced Ceramics Division Bhabha Atomic Research CentreMumbai-400085India Technical Physics Division Bhabha Atomic Research CentreMumbai-400085India universitélille Nord de France UCCS-Unitéde Catalyse et Chimie du Solide-UMR CNRS 8181Ecole Nationale Supérieure de Chimie de LilleUniversitédes Sciences et Technologies de LilleBP 10859562 Villeneuve d’AscqCedexFrance

Glass-ceramics owing to a combination of useful properties such as tuneable thermal expansion coefficient(TEC),good mechanical durability and chemical inertness find widespread uses in a variety of applications including seals and ***-ceramic-to-metal seals have been fabricated with various silicate,phosphate and borate based oxide glasses depending upon the intended *** this article,we review our studies on various glass and glass-ceramics materials development with a view to understand bonding behaviour with metals/alloys at ambient and high temperatures through a comprehensive structure property correlation *** studies on BaO-CaO-Al2O3-B2O3-SiO2(BCABS),barium strontium alumino-silicate,and strontium alumino-silicate with different additives(like Nd2O3,La2O3,NiO,TiO2,V2O5,ZrO2,Cr2O3,and P2O5)and barium/strontiun zinc silicate(B/SZS)glass-ceramics for high temperature *** shall illustrate the role of various thermo-physical and structural characterization techniques that allowed optimum selection of materials and processing *** particularly highlight the complementary role of NMR and XRD in studying the material at the short range and long range length scales.

关键词： crystallization sintering glass-ceramics solid oxide fuel cells NMR

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Rainbow guiding of the lowest-order antisymmetric Lamb mode in phononic crystal plate

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Science China(Technological Sciences) 2019年第3期62卷 458-463页

作者： ZHAO JinFeng YUAN WeiTao BONELLO Bernard DJAFARI-ROUHANI Bahram PAN YongDong ZHONG Zheng School of Aerospace Engineering and Applied Mechanics Tongji University INSP UMR CNRS 7588 Sorbonne Université UPMC Université Paris 06 Institut d'Electronique de Microélectronique et de Nanotechnologie (IEMN-UMR CNRS 8520) Université de Lille Sciences et Technologies School of Science Harbin Institute of Technology

The modern acoustic circuits have experienced significant progress with the development of artificial structures, including phononic crystals, metamaterials or metasurfaces. Among the most intensive topics, the reconfigurable acoustic guides are achieved through several mechanisms. In this work, we report on the rainbow guiding for the lowest-order antisymmetric Lamb(A_0) mode in a phononic crystal plate, where the linear waveguides are constituted by erecting aligned pillars either solid or hollow. We show both numerically and experimentally that the whispering gallery modes(WGMs) in the hollow pillars can be generated by the defect mode that propagates in the waveguide. Then, the reemission of A_0 mode by the WGMs to the outer lateral areas can lead to spatial control of frequency selective wave guidance called "rainbow guiding". Our approach allows for an accurate control of the wave guiding and facilitates the integration of waveguides within other devices in the acoustic circuits.

关键词： whispering gallery mode rainbow guiding phononic crystal

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Keggin-type H_4PVMo_(11)O_(40)-based catalysts for the isobutane selective oxidation

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Science China Chemistry 2010年第9期53卷 2039-2046页

作者： PAUL Sébastien SULTAN Manzoor BORdeS-RICHARD Elisabeth université lille Nord de France ECLilleUnité de Catalyse et de Chimie du Solide(UMR CNRS 8181)Cité Scientifique université lille Nord de France ENSCLUnité de Catalyse et de Chimie du Solide(UMR CNRS 8181)Cité Scientifique

Cesium heteropolysalts Cs3PMo12O40 and HCs3PVMo11O40 were synthesized by modifying the preparation conditions in order to get materials with a much higher surface area than the original Keggin-type heteropolyacids(H3PMo12O40 and H4PVMo11O40).These solids were used as carriers for the dispersion of H4PVMo11O40 heteropolyacid by the incipient wetness impregnation *** textural and structural properties of supports and catalysts were examined by scanning electron microscopy,N2 adsorption-desorption isotherms and Raman *** supported catalysts were studied before and after red/ox pretreatments by X-ray photoelectron spectroscopy,which showed that both the surface composition and oxidized to reduced species ratio depend on the used *** catalytic performances of these novel supported catalysts in the selective oxidation of isobutane to methacrylic acid and methacrolein were *** best catalytic properties were obtained when H4PVMo11O40 was supported on *** isobutane conversion and yield of the desired oxygenates increased along the unsupported H4PVMo11O40

关键词： cesium heteropolysalts supports supported H4PVMo11O40 red/ox XPS isobutane selective oxidation Keggin-type heteropolycompounds

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An Enhanced Privacy Preserving, Secure and Efficient Authentication Protocol for VANET

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Computers, Materials & Continua 2022年第5期71卷 3703-3719页

作者： Safiullah Khan Ali Raza Seong Oun Hwang department of IT Convergence Engineering Gachon UniversitySeongnam13320Korea ENSAIT GEMTEX-Laboratoire de Genie et Materiaux TextilesUniversity of LilleLilleF59000France School of Computing&Institute of Cyber Security(ICSS) University of KentUnited Kingdom department of Computer Engineering Gachon UniversitySeongnam13320Korea

Vehicular ad hoc networks (VANETs) have attracted growing interest in both academia and industry because they can provide a viable solutionthat improves road safety and comfort for travelers on roads. However, wireless communications over open-access environments face many security andprivacy issues that may affect deployment of large-scale VANETs. Researchershave proposed different protocols to address security and privacy issues in aVANET, and in this study we cryptanalyze some of the privacy preservingprotocols to show that all existing protocols are vulnerable to the Sybilattack. The Sybil attack can be used by malicious actors to create fakeidentities that impair existing protocols, which allows them to imitate trafficcongestion or at worse cause an accident that may result in the loss of humanlife. This vulnerability exists because those protocols store vehicle identitiesin an encrypted form, and it is not possible to search over the encryptedidentities to find fake vehicles. This attack is serious in nature and veryprevalent for privacy-preserving protocols. To cope with this kind of attack,we propose a novel and practical protocol that uses Public key encryptionwith an equality test (PKEET) to search over the encrypted identities withoutleaking any information, and eventually eliminate the Sybil attack. Theproposed approach improves security and at the same time maintains privacyin VANET. Our performance analysis indicates that the proposed protocoloutperforms state-of-the-art protocols: The proposed beacon generation timeis constant compared to a linear increase in existing protocols, with beaconverification shown to be faster by 7.908%. Our communicational analysisshows that the proposed protocol with a beacon size of 322 bytes has the leastcommunicational overhead compared to other state-of-the-art protocols.

关键词： VANET authentication protocol cryptanalysis privacy preserving intelligent systems

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Relationships between mucinous gastric carcinoma, MUC2 expression and survival

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World Journal of Gastroenterology 2006年第21期12卷 3324-3331页

作者： Emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy Marie-Christine Copin Christophe Mariette Jean-Pierre Aubert Nicole Porchet Marie-Pierre Buisine INSERM U560 59045Lille cedexFrance Service d'Anatomie et Cytologie Pabologiques Pôle Biologie-Pathogie Pac Eurasanté.CHR-U de Lille59037 Lille cedexFrance Service de Biochimie et Biologie Moléculaire CHR-U de Lille59037 Lille cedexFrance Facultéde Médecine H.Warembourg 59045 Lille cedexFrance Service.de Chirurgie Digetive et Générale CAEB CHR-U de Lille59045 Lille cedexFrance

AIM:To investigate the expression of the four secreted gel-forming mucins(MUC2,MUCSAC,MUCSB and MUC6)in a series of gastric carcinomas,classified according Laurén's,Mulligan's,WHO and Goseki's classifications,with special attention to all the different components(major and minor)present in tumors and to follow up clinical ***:Expression of MUC2,MUC5AC,MUC5B and MUC6 was investigated using immunohistochemistry and in situ ***:Expression of secreted gel-forming mucins in gastric carcinoma was particularly complex,each mucin being not restricted to any histopathological type even considering all components(major and minor)present in a given *** was a worst survival in patients with a higher content of mucus(GosekiⅡorⅣ)and high positive MUC2 ***:Complexity of mucin gene expression patterns in gastric cancer may reflect a precise state of differentiation at the cell level not recognized in used morphologic classification *** expression of MUC2 was nevertheless associated with mucinous subtype of the WHO classification and with groupⅡof Goseki's classification identified by the major component of a particular *** quantity and quality of mucus were related to survival.

关键词： Gastric cancer Secreted gel-forming mucin MUC Immunohistochemistry in situ hybridization Survival

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Kinetics of remnant liver volume and function after a major hepatectomy

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 975-977页

作者： Stéphanie Truant Mehdi El Amrani François-RenéPruvot department of Digestive Surgery and Transplantation Hôpital HuriezCHU LilleUniv.LilleLilleFrance CANTHER Laboratory“Cancer Heterogeneity Plasticity and Resistance to Therapies”UMR-S1277Team“MucinsCancer and Drug Resistance”LilleFrance

Liver regeneration after a major hepatectomy(MH)is crucial for the patient postoperative recovery,with the first postoperative month(1M)being a critical period for the liver regeneration *** risk of post hepatectomy liver failure(PHLF),which is the leading cause of death,is usually anticipated in the preoperative period by the measurement of the future remnant liver volume(RLV)via computed tomography(CT)with volumetry.

关键词： Liver regeneration remnant liver volume(RLV) remnant liver function major hepatectomy(MH)

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Assessment of left-ventricular diastolic function in pediatric intensive-care patients:a review of parameters and indications compared with those for adults

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World Journal of Pediatrics 2021年第1期17卷 21-30页

作者： Morgan Recher Astrid Botte Jerome Soquet Jean-Benoit Baudelet François Godart Stephane Leteurtre ULR 2694-METRICS:évaluation des Technologies de santéet des Pratiques Médicales Univ.LilleCHU Lille59000 LilleFrance Réanimation et Surveillance Continue Pédiatriques Hopital Jeanne de FlandreCHU de Lille59037 Lille CedexFrance Pediatric and Neonatal Intensive Care Unit CHU Bordeaux33076 BordeauxFrance Cardiac Surgery Unit CHU Lille59000 LilleFrance Congenital and Pediatric Cardiology Unit CHU Lille59000 LilleFrance

Background The incidence of diastolic heart failure has increased over *** evaluation of left-ventricular diastolic func-tion is complex,ongoing,and remains poorly performed in pediatric intensive-care *** study aimed to review the literature and to provide an update on the evaluation of left-ventricular diastolic function in adults and children in intensive *** sources We searched data from PubMed/***-two studies were *** pragmatic questions were identified:(1)What is the physiopathology of diastolic dysfunction?(2)Which tools are required to evaluate diastolic func-tion?(3)What are the echocardiographic criteria needed to evaluate diastolic function?(4)When should diastolic function be evaluated in pediatric intensive care?Results Early diastole allows characterization of relaxation,whereas compliance assessments and filling pressures are evalu-ated during late *** evolution of diastolic function differs between adults and *** in adults,decreased compliance occurs at the same time as delayed relaxation in *** function can be evaluated by Doppler *** echocardiographic criteria for ventricular relaxation include the E wave,E/A wave ratio,and isovolumic relaxation *** compliance can be assessed by the E/e'wave ratio,atrial volume,and Ap wave duration during pulmonary vein *** adult intensive-care patients,the E/e'ratio can be used as an index of tolerance for volume expan-sion in septic patients and to adjust the inotropic *** Clinical studies would allow some of these parameters to be validated for use in children in intensive care.

关键词： Diastole Echocardiography Heart failure Intensive-care unit Pediatric

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Numerical Shock Viscosity for Impact Analysis Using ALE Formulation

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Computer Modeling in Engineering & Sciences 2018年第10期117卷 91-107页

作者： Souli Mhamed Paul Du Bois Essam Al-Bahkali universitéde lille1 Unitéde Mécanique de lille UMR CNRS 8107France Consulting Engineer Troy MichiganUSA Mechanical Engineering department King Saud UniversityP.O.Box 80011421 RiyadhSaudi Arabia

When the simulation takes account of dissipative mechanisms,*** conduction and viscosity,the shocks become smeared out to produce thin layers of rapidly and continuously varying energy,density,pressure and velocity rather than discrete surfaces of mathematical *** the mid twentieth century,Von Neumann and Richtmyer suggested the use of a viscous pressure term(bulk viscosity)in the equilibrium equations for ideal gases in order to examine the shock while avoiding numerical oscillations at the shock *** the bulk viscosity is included in the conservation equations,the comprehensive physics present a continuous solution satisfying the Rankine-Hugoniot ***,the published literature includes few engineering and research studies presenting the novel equilibrium equations in which the incorporation of bulk viscosity generates a continuous solution in keeping with conservation *** present work is aimed at demonstrating that the artificial bulk viscosity defined by Von Neumann and Richtmyer is also applicable to fluids described by a density-linear equation of state,that the novel equations present a continuous solution,and that a shock layer of the same order as the computational grid is *** the method has been employed and mathematically proven for onedimensional flow,it would seem to be just as relevant to the analysis of more complex flow dynamics and fluid structure interactions via an application of the Arbitrary Lagrangian Eulerian(ALE)formulation.

关键词： Shock wave fluid structure interaction ALE

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