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Nanoscale Stiffness Distribution in Bone Metastasis

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World Journal of Nano Science and Engineering 2015年第4期5卷 219-228页

作者： Ludovic Richert Laetitia Keller Quentin Wagner Fabien Bornert Catherine Gros Sophie Bahi Francois Clauss William Bacon Philippe Clézardin Nadia Benkirane-Jessel Florence Fioretti Centre National de la Recherche Scientifique(CNRS) UMRFacultéde Pharmacie de l’Universitéde Strasbourg(UdS)IllkirchFrance Institut National de la Santéet de la Recherche Médicale(INSERM) Osteoarticular and Dental Regenerative NanomedicineUMRFacultéde Médecine de l’Universitéde Strasbourg and FMTSStrasbourgFrance Facultéde Chirurgie dentaire de l’universitéde Strasbourg(UdS) StrasbourgFrance Hopitaux universitaires de Strasbourg StrasbourgFrance Institut National de la Santéet de la Recherche Médicale(INSERM) UMRFacultéde Médecine Laennec de l’UniversitéClaude Bernard Lyon 1LyonFrance

Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.

关键词： Bone Metastasis Stiffness Risedronate

高炉高热负荷区和炉缸区铜壁开发中有限元法应用

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高炉高热负荷区和炉缸区铜壁开发中有限元法应用

design of Fe(3–x)O4 raspberry decorated graphene nanocomposites with high performances in lithium-ion battery

2001中国钢铁年会

作者： R.THILL A.POENSGEN I.CARMICHAEL 高斌 PAUL WUTH S.A. LUXEMBOURG 32 rued’ Alsace + + ***/+ + *** PAUL WUTH S.A. LUXEMBOURG 32 rued’ Alsace + + ***/+ + *** PAUL WUTH S.A. LUXEMBOURG 32 rued’ Alsace + + ***/+ + ***

＜正＞1 前言高炉的任务是低成本、质量稳定地连续生产铁水。通过长寿和经济的快速大修,可以改善投资成本。而操作成本是高生产率、高效率、较少员工和最优原料成本的结果。采用灵活的炉料供应途径可以降低原料成本。例如,用粉煤代替...

＜正＞1 前言高炉的任务是低成本、质量稳定地连续生产铁水。通过长寿和经济的快速大修,可以改善投资成本。而操作成本是高生产率、高效率、较少员工和最优原料成本的结果。采用灵活的炉料供应途径可以降低原料成本。例如,用粉煤代替高成本的焦炭。冷却系统在追求成本效益中起一定作用。冷却系统,即冷却环路,冷却器和耐火材料的作用,是保持反应器工作状况良好和最大限度减少过程波动。

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Journal of Energy Chemistry 2016年第2期25卷 270-275页

作者： Olivier Gerber Sylvie Bégin-Colin Benoit P.Pichon Elodie Barraud Sébastien Lemonnier Cuong Pham-Huu Barbara Daffos Patrice Simon Jeremy Come Dominique Bégin Institut de Physique et Chimie des Materiaux de Strasbourg UMR 7504 - CNRS Universite de Strasbourg 23 rue du Loess 67034 Strasbourg Cedex 08France RS2E - FR CNRS n 3459 Universite Paul Sabatier Toulouse III CIRIMAT 118 route de Narbonne 31062 Toulouse Cedex 9 France French-German Research Institute of Saint-Louis 5 rue du General Cassagnou 68300 Saint-Louis France Institut de Chimie et Procedes pour l'Energie l'Environnement et la Sante UMR 7515-CNRS Universite de Strasbourg 25 rue Becquerel 67087 Strasbourg Cedex 02 France

Fe（3–x）O4 raspberry shaped nanostructures/graphene nanocomposites were synthesized by a one-step polyol-solvothermal method to be tested as electrode materials for Li-ion battery（LIB）. Indeed, Fe（3–x）O4 raspberry shaped nanostructures consist of original oriented aggregates of Fe（3–x）O4 magnetite nanocrystals, ensuring a low oxidation state of magnetite and a hollow and porous structure, which has been easily combined with graphene sheets. The resulting nanocomposite powder displays a very homogeneous spatial distribution of Fe（3–x）O4 nanostructures at the surface of the graphene sheets. These original nanostructures and their strong interaction with the graphene sheets resulted in very small capacity fading upon Li＋ion intercalation. Reversible capacity, as high as 660 m Ah/g, makes this material promising for anode in Li-ion batteries application.

关键词： Graphene Fe3–xO4 raspberry shaped nanostructures Fe3–xO4/graphene nanocomposites Lithium-ion battery Reversible capacity

Individual stages of bacterial dichloromethane degradation mapped by carbon and chlorine stable isotope analysis

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Journal of Environmental Sciences 2019年第4期31卷 147-160页

作者： Maria L.Torgonskaya Anatoly M.Zyakun Yuri A.Trotsenko Kestutis S.Laurinavichius Steffen Kümmel Stéphane Vuilleumier Hans H.Richnow Laboratory of Radioactive Isotopes G.K.Skryabin Institute of Biochemistry and Physiology of MicroorganismsFRC Pushchino Center for Biological ResearchRussian Academy of Sciences Laboratory of Mass Spectrometry G.K.Skryabin Institute of Biochemistry and Physiology of MicroorganismsFRC Pushchino Center for Biological ResearchRussian Academy of Sciences department of Isotope Biogeochemistry Helmholtz Centre for Environmental Research-UFZ université de Strasbourg CNRS

The fractionation of carbon and chlorine stable isotopes of dichloromethane(CH_2Cl_2,DCM)upon dechlorination by cells of the aerobic methylotroph Methylobacterium extorquens DM4 and by purified DCM dehalogenases of the glutathione S-transferase family was *** effects for individual steps of the multi-stage DCM degradation process,including transfer across the cell wall from the aqueous medium to the cell cytoplasm,dehalogenase binding,and catalytic reaction,were *** observed carbon and chlorine isotope fractionation accompanying DCM consumption by cell supensions and enzymes was mainly determined by the breaking of C\Cl bonds,and not by inflow of DCM into *** isotope effects of DCM dehalogenation were initially masked in high density cultures,presumably due to inverse isotope effects of non-specific DCM oxidation under conditions of oxygen *** cofactor supply remarkably affected the correlation of variations of DCM carbon and chlorine stable isotopes(Δδ^(13)C/Δδ^(37)Cl),increasing corresponding ratio from 7.2–8.6 to 9.6–10.5 under conditions of glutathione *** suggests that enzymatic reaction of DCM with glutathione thiolate may involve stepwise breaking and making of bonds with the carbon atom of DCM,unlike the uncatalyzed reaction,which is a one-stage process,as shown by quantum-chemical modeling.

关键词： Dichloromethane(DCM) Microbial degradation Aerobic methylotrophic bacteria Dichloromethane dehalogenase Carbon and chlorine isotopic fractionation

Mortality from liver cirrhosis and HCC in the DAA era:success in viral control is darkened by raise of metabolic disease

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 307-310页

作者： Antonio Saviano Thomas F.Baumert Inserm U1110 Institut de Recherche sur les Maladies Virales et HépatiquesUniversite de StrasbourgF-67000 StrasbourgFrance Pole Hépatodigestif Institut Hopitalo-UniversitaireHopitaux UniversitairesF-67000 StrasbourgFrance

Liver cirrhosis and primary liver cancers are leading causes of mortality worldwide with over than 1.7 million of deaths in 2010 representing about 3.4%of the overall deaths(1).Global liver cirrhosis deaths ceaselessly increased by 52.2%from 1980 to 2010(1).Similarly,primary liver cancers global deaths increased by 62.4%from 1990 to 2010(2).

关键词： cirrhosis liver mortality

Self-Organization of Urea-Based Oligomers from Structure to Function

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复旦学报（自然科学版） 2005年第5期44卷 684-685页

作者： G. Guichard Immunologie et Chimie Thérapeutiques (UPR 9021 CNRS) Institut de biologie Moléculaire et Cellulaire Strasbourg France

The remarkable and highly diverse biological activities exhibited by proteins rely on the unique capacity of these intrinsically flexible α-polypeptide chains to fold into well ordered and compact structures. The formation of protein tertiary and quaternary structures is attainable only with a small set of distinct secondary structural elements: i) sheets, ii) helices, and iii) *** fascinating structures have undoubtedly stimulated chemists to elaborate new synthetic oligomeric materials that could self-organize spontaneously but in a controlled fashion to form defined structural *** the field of biomimetic chemistry, seminal work by several research groups has demonstrated that properties such as folding and structural diversity are not restricted to natural linear α-polypeptides but are shared by a number of aliphatic (e. g. β- and γ-peptides)[1-3] and aromatic[4] oligo-amides. The predictability of folding in these oligomeric strands can be integrated to develop molecules with function (e. g. in biology).

关键词：自集合生物活性可折叠性分子大环多肽

FPGA Resources Reduction by a Multiplexing Technique Applied on ANN-Based Harmonics Extraction Algorithms

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Journal of Energy and Power Engineering 2012年第3期6卷 469-477页

作者： Serge Raoul Dzonde Naoussi Ngac-Ky Nguyen Charles-Hubert Kom Herve Berviller Jean-Philippe Blonde Martin Kom Francis Braun Solid Electronics and Systems Institute University of Strasbourg Strasbourg P.O. Box 6703 7 France Laboratory of Electronics Electrotechnics Automatic and Telecommunications University of Douala Douala P.O. Box 8698 Cameroon Modelling Inteligence Process and Systems Laboratory University of North Alsace Mulhouse P O. Box 68093 France National Advanced School of Engineering University of Yaounde L Yaounde P. O. Box 8390 Cameroon

In this paper, a multiplexing technique is applied on a neural harmonics extraction method, based on an efficient formulation of the instantaneous reactive power theory. This approach can be used in nonlinear loads compensation with APFs （Active Power Filters）. The architecture for reference current generation, synchronized by a neural phase lock-loop, is composed of three Adaline neural networks. This leads to an important consumption of field programmable gate array resources during implementation. The proposed technique uses only one Adaline and keeps the immunity of the approach under non-sinusoidal and unbalanced conditions of voltage. Simulation results of the neural harmonics detection system connected to a reference current controller show balanced and sinusoidal source currents under various conditions. Results with experimental measurement made on an APF test bench demonstrate its good performances on harmonics filtering. Moreover, the simplified structure from the new approach called mp-q method shows a significant resource reduction.

关键词： FPGA active power filters instantaneous reactive power theory power quality resource reduction.

Hepatitis C virus-mediated angiogenesis:Molecular mechanisms and therapeutic strategies

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World Journal of Gastroenterology 2014年第42期20卷 15467-15475页

作者： Mohamed Hassan denis Selimovic Abdelouahid El-Khattouti Martine Soell Hanan Ghozlan Youssef Haikel Ola Abdelkader Mosaad Megahed Cancer Institute University of Mississippi Medical Center Institut National de la Santé et de la Recherché Médicale S 1121 Hospitals of Hautepierre Dental Faculty University of Strasbourg department of Operative dentistry and Endodontics Hospitals of Hautepierre Dental Faculty University of Strasbourg department of Periodontology Hospitals of Hautepierre Dental Faculty University of Strasbourg department of Microbiology Faculty of Science Medical research Institute University of Alexandria department of Microbiology Medical research Institute University of Alexandria Clinic of dermatology University Hospital of Aachen

Angiogenesis is an essential process for organ growth and repair. Thus, an imbalance in this process can lead to several diseases including malignancy. Angiogenesis is a critical step in vascular remodeling, tissue damage and wound healing besides being required for invasive tumor growth and metastasis. Because angiogenesis sets an important point in the control of tumor progression, its inhibition is considered a valuable therapeutic approach for tumor treatment. Chronic liver disease including hepatitis C virus(HCV) infection is one of the main cause for the development of hepatic angiogenesis and thereby plays a critical role in the modulation of hepatic angiogenesis that finally leads to hepatocellular carcinoma progression and invasion. Thus, understanding of the molecular mechanisms of HCV-mediated hepatic angiogenesis will help design a therapeutic protocol for the intervention of HCV-mediated angiogenesis and subsequently its outcome. In this review, we will focus on the molecular mechanisms of HCV-mediated hepatic angiogenesis and the related signaling pathways that can be target for current and under development therapeutic approaches.

关键词： Hepatitis C virus Hepatocellular carcinoma Angiogenesis Signaling pathway Therapy

Conserved Cytochrome P450 Evolved in Seed Plants Regulates Flower Maturation

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Molecular Plant 2015年第12期8卷 1751-1765页

作者： Zhenhua Liu Benoit Boachon RaphaelLugan Raquel Tavares Mathieu Erhardt Jerome Mutterer Valerie demais Stephanie Pateyron Veronique Brunaud Toshiyuki Ohnishi Ales Pencik Patrick Achard Fan Gong Peter Hedden Daniele Werck-Reichhart Hugues Renault Institute of Plant Molecular Biology Centre National de la Recherche Scientifique (CNRS) University of Strasbourg 67084 Strasbourg France Laboratoire de Biometrie et Biologie Evolutive Universite Lyon 1 CNRS 69622 Villeurbanne France plateforme d'lmagerie In Vitro IFR 37 de Neurosciences 67084 Strasbourg France Transcriptomic Platform Unite de Recherche en Genomique Vegetale (URGV) INRA Universite d'Evry Val d'Essonne CNRS 91057 Evry France Bioinformatics for Predictive Genomics URGV INRA Universite d'Evry Val d'Essonne CNRS 91057 Evry France Graduate School of Agriculture Shizuoka University Shizuoka 422-8529 Japan Laboratory of Growth Regulators & department of Chemical Biology and Genetics Centre of the Region Hana for Biotechnological and Agricultural Research Faculty of Science Palacky University & Institute of Experimental Botany AS CR 771 47 Olomouc Czech Republic Rothamsted Research Harpenden Hertfordshire AL5 2JQ UK university of Strasbourg Institute for Advanced Study (USIAS) 67084 Strasbourg France Freiburg institute for Advanced Studies (FRIAS) University of Freiburg 79104 Freiburg Germany Present address: 158 Emerson Hall Section of Plant Biology School of Integrative Plant Science Cornell University Ithaca NY 14853 USA present address: Laboratoire Physiologie des Fruits et Legumes - EA 4279 Campus Agroparc Avignon France present address: Home Office Science - Centre for Applied Science and Technology Woodcock Hill Sandridge St Albans HeFts AL4 9HQ UK

Global inspection of plant genomes identifies genes maintained in low copies across taxa and under strong purifying selection, which are likely to have essential functions. Based on this rationale, we investigated the function of the low-duplicated CYP715 cytochrome P450 gene family that appeared early in seed plants and evolved under strong negative selection. Arabidopsis CYP715A 1 showed a restricted tissue-specific expres- sion in the tapetum of flower buds and in the anther filaments upon anthesis, cyp715a1 insertion lines showed a strong defect in petal development, and transient alteration of pollen intine deposition. Comparative expres- sion analysis revealed the downregulated expression of genes involved in pollen development, cell wall biogenesis, hormone homeostasis, and floral sesquiterpene biosynthesis, especially TPS21 and several key genes regulating floral development such as MYB21, MYB24, and MYC2. Accordingly, floral sesquiterpene emission was suppressed in the cyp715a1 mutants. Flower hormone profiling, in addition, indicated a modi- fication of gibberellin homeostasis and a strong disturbance of the turnover of jasmonic acid derivatives. Petal growth was partially restored by the active gibberellin GA3 or the functional analog of jasmonoyl-isoleucine, coronatine. CYP715 appears to function as a key regulator of flower maturation, synchronizing petal expan- sion and volatile emission. It is thus expected to be an important determinant of flower-insect interaction.

关键词： flower development phylogenomics negative selection jasmonate gibberellins volatile compounds