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Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes

World Journal of Gastroenterology 2012年第14期18卷 1579-1589页

作者： Sébastien AB Roy Marie-Josée Langlois Julie C Carrier Franois Boudreau Nathalie Rivard Nathalie Perreault Canadian Institutes of Health Research Team on digestive Epithelium Department of Anatomy and Cell BiologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada Canadian Institutes of Health Research Team on digestive Epithelium Service of GastroenterologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada

AIM:To investigate the impact of phosphatase and tensin homolog(Pten) in the specification of intestinal enteroendocrine ***:Using the Cre/loxP system,a mouse with conditional intestinal epithelial Pten deficiency was *** mutant mice and controls were sacrificed and small intestines collected for immunofluorescence and quantitative real-time polymerase chain *** was collected on 16 h fasted mice by cardiac ***-linked immunosorbent assay was used to measure blood circulating ghrelin,somatostatin(SST) and glucose-dependent insulinotropic peptide(GIP) ***:Results show an unexpected dual regulatory role for epithelial Pten signalling in the specification/differentiation of enteroendocrine cell subpopulations in the small *** data indicate that Pten positively regulates chromogranin A(CgA) expressing subpopulations,including cells expressing secretin,ghrelin,gastrin and cholecystokinin(CCK).In contrast,Pten negatively regulates the enteroendocrine subtype specification of non-expressing CgA cells such as GIP and SST expressing ***:The present results demonstrate that Pten signalling favours the enteroendocrine progenitor to specify into cells expressing CgA including those producing CCK,gastrin and ghrelin.

关键词： Phosphatase and tensin homolog Enteroendocrine cells Intestinal epithelial cell specification Chromogranin A

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Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study

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Neural Regeneration Research 2021年第5期16卷 805-812页

作者： Viviane Rostirola Elsner Lucieli Trevizol Isadora de Leon Marcos da Silva ThaynáWeiss Milena Braga Daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio Curso de Fisioterapia do Centro universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Biociências e Reabilitação do Centro universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil

A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of ***,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these *** exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different ***,little is reported on this in post-stroke *** purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FES)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke *** this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FES group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and *** intervention,higher Berg Balance Scale scores were obtained in the EXE+FES group than in the EXE alone *** was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FES *** intervention,a better cognitive performance was found in both groups compared with before the *** intervention,the Timed Up and Go test scores were higher in the EXE+FES group than in the EXE alone *** addition,the intervention induced lower levels of lipid *** intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FES group,compared with the

关键词： cognition epigenetic exercise functional electrical stimulation functional mobility oxidative stress stroke WalkAide

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X-ray Structure and Density Functional Theory Investigations of 4-((2R)-2-(3,4-dibromophenyl)-1-fluoro cyclopropyl)-N-(o-tolyl)benzamide Compound

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Chinese Journal of Structural Chemistry 2020年第9期39卷 1601-1614,1554页

作者： BENELHADJ-DJELLOUL Yamina BOUKABCHA Nourdine BENHALIMA Nadia YAHIAOUI Salem CHOUAIH Abdelkader ZANOUN Abdelouahab Laboratory of Technology and Solid Properties(LTPS) Abdelhamid Ibn Badis University of MostaganemMostaganem 27000Algeria Département de Génie des Procédés UniversitéAhmed Zabana de RelizaneRelizane 48000Algeria Département de Physique Facultédes SciencesUniversitéDr.Moulay Tahar de SaidaSaida 20000Algeria Ecole Normale Supérieure de Mostaganem Mostaganem 27000Algeria

In this work,the structure of 4-((2R)-2-(3,4-dibromophenyl)-1-fluorocyclopropyl)-N-(o-tolyl)benzamide(DBFB)has been determined at room temperature using single-crystal X-ray diffraction *** structure of the compound was solved using 1464 observed reflections with I≥2σ(I).It crystallizes in monoclinic space group P21 with a=20.0820(10),b=10.2770(10),c=4.860(2)?,β=95.9600(10)°,V=997.6(4)?3,Z=2,Dc=1.675 g/m3,F(000)=500,Μr=503.18,μ=4.09 mm-1 and the final R=*** molecular packing of the title compound exhibits C–H???O and C–H???F hydrogen bonds forming a supramolecular ***,conformational analysis has been performed in order to confirm the most stable conformer of the title *** parameters of the keto conformer in the ground state have been obtained using density functional theory(DFT)method with B3LYP/6-31G(d,p)level of *** general,a good agreement between the calculated and experimental results was *** normal modes of vibration,molecular boundary orbitals(HOMO and LUMO),reactivity descriptors,Mullikan atomic charges and molecular electrostatic potential for the title compound have been evaluated and discussed.

关键词： C23H18Br2FNO insecticide crystal structure DFT HOMO-LUMO

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Record of Leptometopa latipes(diptera:Milichiidae)from a human cadaver in the Mediterranean area

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Forensic Sciences Research 2019年第4期4卷 341-347页

作者： Giorgia Giordani Fabiola Tuccia Silvia Zoppis Carla Vecchiotti Stefano Vanin School of Applied Sciences University of HuddersfieldHuddersfieldUK dipartimento di Scienze Anatomiche Istologiche Medico Legali e dell’Apparato Locomotore Section of Legal MedicineLaboratory of Forensic GeneticsUniversity of Rome"Sapienza"RomeItaly

In forensic entomology,insects are used mainly to obtain information about the time since *** information is obtained studying the developmental rate of the first colonizers,principally species in the families Calliphoridae,Sarcophagidae,Muscidae,Stratiomyidae and ***,species belonging to other families can provide information about body transfer or the season of the *** them Milichiidae are flies rarely reported from human cases despite the larvae of some species are known as saprophagous feeding on plant and animal decomposing matter.A potential cause of the lack of records of these species from forensic cases can be related with the paucity of descriptions and illustrations of the immature *** this article,the entomological samples collected from a human body found inside an apartment in a Maghreb country,in Northern Africa,is reported and Leptometopa latipes(diptera:Milichiidae)is described in *** analysis is also reported to confirm the morphological analysis.

关键词： Forensic entomology postmortem interval decomposition Leptometopa latipes

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The Effects of Accelerated Photooxidation on Molecular Weight and Thermal and Mechanical Properties of PHBV/Cloisite 30B Bionanocomposites

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Journal of Renewable Materials 2018年第3期6卷 288-298页

作者： Kahina Iggui Mustapha Kaci Nicolas Le Moigne Anne Bergeret Centre des Matériaux des Mines d’Alès(C2MA) IMT Mines AlesUniversitéde Montpellier30100 AlèsFrance Laboratory of Advanced Polymer Materials University of BéjaïaBéjaïa Province06000Algeria Institut de Technologie UniversitéAkli Mohand OulhadjBouira 10000Algeria

The effects of accelerated photooxidation on the molecular weight and thermal and mechanical properties of Cast PHBV and PHBV/Cloisite 30B(3 wt%)bionanocomposites are investigated *** size exclusion chromatography(SEC)analysis,a significant decrease in both weight and number average molecular weights was observed for all irradiated samples over time,resulting from the chain scission *** scanning calorimetry(DSC)data indicated a decrease in degree of crystallinity and melting temperature after UV exposure,with the appearance of double melting peaks related to the changes in the crystal structure of *** stability,tensile and thermo-mechanical properties were also reduced consecutively in photooxidation,being more pronounced for Cast *** study shows that the incorporation of Cloisite 30B in PHBV provides a better resistance to photooxidation in comparison with the neat polymer.

关键词： Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) organo-modified montmorillonite bionanocomposites accelerated photooxidation and degradation

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Operando FT-IR study on basicity improvement of Ni(Mg, Al)O hydrotalcite-derived catalysts promoted by glow plasma discharge

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Plasma Science and Technology 2019年第4期21卷 127-140页

作者： R D?BEK D WIERZBICKI M MOTAK M E GALVEZ P DA COSTA F AZZOLINA-JURY Normandie Univ ENSICAEN UNICAEN CNRS Laboratoire Catalyse et Spectrochimie 2. AGH University of Science and Technology Faculty of Energy and Fuels Department of Fuels Technology Sorbonne université Institut Jean Le Rond d'Alembert

CO2adsorption on the surface of hydrotalcite-derived mixed oxide catalysts was investigated under low pressure glow discharge plasma in operando conditions via FT-IR *** catalysts were promoted with various transition metal species(Ce, Fe, La, Zr) to influence their physico-chemical *** and Zr species were successfully incorporated into hydrotalcite brucite *** calcination formed a single phase with Ni(Mg, Al)O mixed oxide, while La and Ce species formed separate *** had a consequence in the distribution of surface basic sites as well as in the affinity to CO produced upon CO2dissociation in *** treatment activated the surface of prepared materials and changed their properties via the generation of strong basic sites associated with low coordinated surface oxygen ***, the CO2adsorption capacity of prepared materials increased after plasma treatment.

关键词： plasma glow discharge basicity hydrotalcite carbon dioxide

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One Innovation of Mechanical Polishing Apparatus for Surface Treatment of 6 GHz TESLA Superconducting Cavity

One Innovation of Mechanical Polishing Apparatus for Surface...

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作者： YU Guo-long A.A.Rossi R.K.Thakur V.Palmieri Department of Nuclear Technology Application Laboratori Nazionali di Legnaro

6 GHz spinning seamless superconducting radio frequency(SRF)cavities are a very useful tool for testing alternative surface treatments in the fabrication of TESLA ***,the surface is damaged in internal part for the us...

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Insect immune resistance to parasitoids

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Insect Science 2008年第1期15卷 67-87页

作者： Yves Carton Marylène Poirié Anthony J. Nappi Laboratoire Evolution Génomes et Spéciation CNRS 91198 Gif/Yvette France and Université Paris-Sud 11 91405 Orsay CedexFrance Unité Mixte de Recherches 1112 'Réponse des Organismes aux Stress Environnementaux' Université Nice-Sophia AntipolisInstitut National de la Recherche Agronomique 400 route des Chappes 06903 Sophia-Antipofis France Department of Biology Loyola University of Chicago Chicago Illinois 60525 USA

Insect host-parasitoid interactions involve complex physiological, biochemical and genetic interactions. Against endoparasitoids, immune-competent hosts initiate a blood cell-mediated response that quickly destroys the intruders and envelops them in a multilayered melanotic capsule. During the past decade, considerable progress has been made in identifying some of the critical components of the host response, mainly because of the use of efficient molecular tools. This review examines some of the components of the innate immune response of Drosophila, an insect that has served as an exceptionally good experimental model for studying non-self recognition processes and immune cell signaling mechanisms. Topics considered in this review include hematopoiesis, proliferation and adhesion of hemocytes, melanogenesis and associated cytotoxic molecules, and the genetic aspects of the host-parasitoid interaction.

关键词： cytotoxic molecules hemocyte innate immunity melanogenesis parasitoid,resistance genes

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Preface to Focused Section on Efficient High-Order Time discretization Methods for Partial differential Equations

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Communications on Applied Mathematics and Computation 2021年第4期3卷 605-605页

作者： Sebastiano Boscarino Giuseppe Izzo Lorenzo Pareschi Giovanni Russo Chi-Wang Shu universita degli Studi di Catania 95131 CataniaItaly universita degli Studi di Napoli Federico II 80126 NaplesItaly universita degli Studi di Ferrara 44121 FerraraItaly Brown university ProvidenceRI02912USA

During May 8-10,2019,the International Workshop on Efficient High-Order Time discretization Methods for Partial differential Equations took place in Villa Orlandi,Anacapri,Italy,a Congress Center of the university of Naples Federico *** 40 senior researchers,young scholars,and *** attended this *** purpose of this event was to explore recent trends and directions in the area of time discretization for the numerical solution of evolutionary partial differential equations with particular application to high-order methods for hyperbolic systems with source and advection-diffusion-reaction equations,and with special emphasis on efficient time-stepping methods such as implicit-explicit(IMEX),semi-implicit and strong stability preserving(SSP)time *** present focused section entitled“Efficient High-Order Time discretization Methods for Partial differential Equations”in Communications on Applied Mathematics and Computation(CAMC)consists of five regularly reviewed manuscripts,which were selected from submissions of works presented during the *** thank all the authors of these contributions,and hope that the readers are interested in the topics,techniques and methods,and results of these *** also want to thank the CAMC journal editorial staff as well as all the referees for their contributions during the review and publication processes of this focused section.

关键词： thank hyperbolic preserving

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Rapid prototyping of a polymer MEMS dropletdispenser by laser-assisted 3D printing

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Microsystems & Nanoengineering 2023年第4期9卷 211-221页

作者： Rémi Courson Oleksii Bratash Ali Maziz CloéDesmet Ricardo Alvarado Meza Loïc Leroy Elodie Engel Arnaud Buhot Laurent Malaquin Thierry Leïchlé LAAS-CNRS Universitéde ToulouseCNRS31400 ToulouseFrance universitéGrenoble Alpes CNRSCEAIRIGSyMMES38000 GrenobleFrance Georgia Tech−CNRS International Research Laboratory AtlantaGA 30332USA

In this work, we introduce a polymer version of a previously developed silicon MEMS drop deposition tool for surfacefunctionalization that consists of a microcantilever integrating an open fluidic channel and a reservoir. The device isfabricated by laser stereolithography, which offers the advantages of low-cost and fast prototyping. Additionally,thanks to the ability to process multiple materials, a magnetic base is incorporated into the cantilever for convenienthandling and attachment to the holder of a robotized stage used for spotting. Droplets with diameters ranging from∼50 μm to ∼300 μm are printed upon direct contact of the cantilever tip with the surface to pattern. Liquid loading isachieved by fully immersing the cantilever into a reservoir drop, where a single load results in the deposition of morethan 200 droplets. The influences of the size and shape of the cantilever tip and the reservoir on the printing outcomeare studied. As a proof-of-concept of the biofunctionalization capability of this 3D printed droplet dispenser,microarrays of oligonucleotides and antibodies displaying high specificity and no cross-contamination are fabricated,and droplets are deposited at the tip of an optical fiber bundle.

关键词： cantilever reservoir printing

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