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The challenge of molecular selection in liver-limited metastatic colorectal cancer for surgical resection: a systematic review and meta-analysis in the context of current and future approaches

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Oncology Research 2024年第9期32卷 1407-1422页

作者： ROSSANA RONCATO JERRY POLESEL FEDERICA TOSI ELENA PERUZZI ERIKA BRUGUGNOLI CLAUdiA LAURIA PANTANO MARIA FURFARO FILIPPO di GIROLAMO ALESSANDRO NANI ARIANNA PANI NOEMI MILAN ELENA DE MATTIA ANDREA SARTORE-BIANCHI ERIKA CECCHIN Experimental and Clinical Pharmacology Unit Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy Department of Medicine(DMED) University of UdineUdine33100Italy Unit of Cancer Epidemiology Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy Department of Oncology and Hemato-Oncology Universitàdegli Studi di MilanoMilan20122Italy Department of Hematology Oncologyand Molecular MedicineGrande Ospedale Metropolitano NiguardaMilan20122Italy Oncology Pharmacy Unit IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino AmadoriMeldola47014Italy Pharmacy Unit Fondazione IRCCS Istituto Tumori di MilanoMilan20122Italy Department of Pharmacy Ca’Foncello Treviso Regional HospitalPiazzale Ospedale 1Treviso31100Italy Department of Medical Surgical and Health Sciences University of TriesteTrieste34127Italy Hospital Pharmacy Cattinara HospitalAzienda Sanitaria Universitaria Giuliano IsontinaTrieste34148Italy Department of Oncology and Onco-Hematology Postgraduate School of Clinical Pharmacology and ToxicologyUniversity of MilanMilan20122Italy

Objectives:Treatment of metastatic colorectal cancer(mCRC)includes resection of liver metastases(LM),however,no validated biomarker identifies patients most likely to benefit from this *** meta-analysis aimed to assess the impact of the most relevant molecular alterations in cancer-related genes of CRC(i.e.,RAS,BRAF,SMAD4,PIK3CA)as prognostic markers of survival and disease recurrence in patients with mCRC surgically treated by LM ***:A systematic literature review was performed to identify studies reporting data regarding survival and/or recurrence in patients that underwent complete liver resection for CRC LM,stratified according to RAS,BRAF,PIK3CA,and SMAD4 mutational *** ratios(HRs)from multivariate analyses were pooled in the meta-analysis and various adjustment strategies for confounding factors were *** search was conducted in numerous databases,including MEDLINE(PubMed),Embase,Cumulative Index to Nursing and Allied Health Literature(CINAHL)(EBSCO host),and WHO Global Index Medicus,through March 18th,***-analyses,editorials,letters to the editor,case reports,studies on other primary cancers,studies with primary metastatic sites other than the liver,studies lacking specific oncological outcome variables or genetic data,non-English language studies,and studies omitting residual disease data from liver metastasectomy were *** remaining 47 studies were summarized in a descriptive table which outlines the key characteristics of each study and final results were graphically ***:RAS mutation status was negatively associated with overall survival(OS)(HR,1.68;95%CI,1.54–1.84)and recurrence free survival(RFS)(HR,1.46;95%CI,1.33–1.61).A negative association was also found for BRAF regarding OS(HR,2.64;95%CI,2.15–3.24)and RFS(HR,1.89;95%CI,1.32–2.73)and SMAD4 regarding OS(HR,1.93;95%CI,1.56–2.38)and RFS(HR,1.95;95%CI,1.31–2.91).For PIK3CA only three studies were eligible and no significant associati

关键词： Metastasectomy Liver metastases RAS BRAF SMAD4 PIK3CA Colorectal

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An Integrated Approach for Optimal Design of Micro Gas Turbine Combustors

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Journal of Thermal Science 2009年第2期18卷 173-184页

作者： Luca Fuligno diego Micheli Carlo Poloni EnginSoft s.p.a. dipartimento di Ingegneria Meccanica Universita degli Studi di Trieste dipartimento

The present work presents an approach for the optimized design of small gas turbine combustors, that integrates a0-D code, CFD analyses and an advanced game theory multi-objective optimization algorithm. The output of the0-D code is a baseline design of the combustor, given the required fuel characteristics, the basic geometry (tubularor annular) and the combustion concept (i.e. lean premixed primary zone or diffusive processes). For the optimizationof the baseline design a simplified parametric CAD/mesher model is then defined and submitted to a CFDcode. Free parameters of the optimization process are position and size of the liner hole arrays, their total area andthe shape of the exit duct, while different objectives are the minimization of NOx emissions, pressure losses andcombustor exit Pattern Factor. A 3D simulation of the optimized geometry completes the design procedure. As afirst demonstrative example, the integrated design process was applied to a tubular combustion chamber with alean premixed primary zone for a recuperative methane-fuelled small gas turbine of the 100 kW class.

关键词： micro gas turbine combustor optimized design

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Dual stimuli-responsive polyurethane-based hydrogels as smart drug delivery carriers for the advanced treatment of chronic skin wounds

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Bioactive Materials 2021年第9期6卷 3013-3024页

作者： Rossella Laurano Monica Boffito Michela Abrami Mario Grassi Alice Zoso Valeria Chiono Gianluca Ciardelli Politecnico di Torino Mechanical and Aerospace Engineering DepartmentCorso Duca degli Abruzzi 2410129TorinoItaly universitàdegli studi di trieste Department of Engineering and ArchitectureVia Alfonso Valerio 6/134127TriesteItaly

The design of multi-stimuli-responsive vehicles for the controlled and localized release of drugs is a challenging issue increasingly catching the attention of many research groups working on the advanced treatment of hard-to-close *** this work,a thermo-and pH-responsive hydrogel(P-CHP407)was prepared from an ad hoc synthesized amphiphilic poly(ether urethane)(CHP407)exposing a significant amount of-COOH groups(8.8±0.9 nmol/g_(polymer)).The exposure of acid moieties in P-CHP407 hydrogel led to slightly lower initial gelation temperature(12.1◦C vs.14.6◦C,respectively)and gelation rate than CHP407 hydrogel,as rheologically *** hydrogel characterization by Low Field NMR(LF-NMR)spectroscopy suggested that the presence of carboxylic groups in P-CHP407 caused the formation of bigger micelles with a thicker hydrated shell than CHP407 hydrogels,as further proved by Dynamic Light Scattering *** addition,P-CHP407 hydrogel showed improved capability to change its internal pH compared to CHP407 one when incubated with an alkaline buffer(pH 8)(e.g.,pH_(change_5min)=3.76 and 1.32,respectively).Moreover,LF-NMR characterization suggested a stronger alkaline-pH-induced interaction of water molecules with micelles exposing-COOH ***,the hydrogels were found biocompatible according to ISO 10993 and able to load and release Ibuprofen:delivery kinetics of Ibuprofen was enhanced by P-CHP407 hydrogels at alkaline pH,suggesting their potential use as smart delivery systems in the treatment of chronic infected wounds.

关键词： Stimuli-responsive hydrogel Drug delivery system pH-triggered release Advanced wound treatment Polyurethane hydrogel LF-NMR characterization

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Extremotolerant fungi from alpine rock lichens and their phylogenetic relationships

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Fungal diversity 2016年第1期76卷 119-142页

作者： Lucia Muggia Antonia Fleischhacker Theodora Kopun Martin Grube Institute of Plant Sciences University of GrazHolteigasse 68010 GrazAustria Department of Life Sciences Universitàdegli Studi di TriesteVia Valerio 12/234128 TriesteItaly

Fungi other than the lichen mycobiont frequently co-occur within lichen thalli and on the same rock in harsh *** these situations dark-pigmented mycelial structures are commonly observed on lichen thalli,where they persist under the same stressful conditions as their *** we used a comprehensive sampling of lichen-associated fungi from an alpine habitat to assess their phylogenetic relationships with fungi previously known from other *** multilocus phylogenetic analyses suggest that most of the 248 isolates belong to the Chaetothyriomycetes and Dothideomycetes,while a minor fraction represents Sordariomycetes and *** many lichens also were infected by phenotypically distinct lichenicolous fungi of diverse lineages,it remains difficult to assess whether the culture isolates represent these fungi or are from additional cryptic,extremotolerant fungi within the *** of these strains represent yet undescribed lineages within Chaethothyriomycetes and Dothideomycetes,whereas other strains belong to genera of fungi,that are known as lichen colonizers,plant and human pathogens,rock-inhabiting fungi,parasites and *** symbiotic structures of the lichen thalli appear to be a shared habitat of phylogenetically diverse stress-tolerant fungi,which potentially benefit from the lichen niche in otherwise hostile habitats.

关键词： Black fungi Endolichenic Symbioses Lichenicolous.Life style Phylogeny

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Comparison between hepatocellular carcinoma prognostic scores:A 10-year single-center experience and brief review of the current literature

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World Journal of Hepatology 2020年第12期12卷 1239-1257页

作者： Michele Campigotto Mauro Giuffrè Anna Colombo Alessia Visintin Alessandro Aversano Martina Budel Flora Masutti Cristiana Abazia Lory Saveria Croce dipartimento universitario Clinico di Scienze Mediche Chirurgiche e Della SaluteUniversitàdegli Studi di TriesteTrieste 34149Italy Clinica Patologie del Fegato Azienda Sanitaria Universitaria Giuliano IsontinaTrieste 34149Italy

BACKGROUND Hepatocellular carcinoma(HCC)represents the most common primitive liver malignancy.A relevant concern involves the lack of agreement on staging systems,prognostic scores,and treatment allocation *** To compare the survival rates among already developed prognostic *** We retrospectively evaluated 140 patients with HCC diagnosed between February 2006 and November *** were categorized according to 15 prognostic scoring systems and estimated median survivals were compared with those available from the current medical *** The median overall survival of the cohort of patients was 35(17;67)mo,and it was statistically different in relation to treatment choice,ultrasound surveillance,and serum *** Italian Liver Cancer(***)tumor staging system performed best in predicting survival according to stage allocation among all 15 evaluated prognostic *** the *** prognostic system,28.6%,40.7%,22.1%,and 8.6%of patients fell within stages 0-1,2-3,4-5 and>5 *** median survival was 57.9 mo for stages 0-1,43 mo for stages 2-3,21.7 mo for stages 4-5,and 10.4 mo for stage>*** 1-,3-,and 5-year survival rates were respectively 95%,65%,and 20%,for stages 0-1;94.7%,43.9%and 26.3%for stages 2-3;71%,25.8%and 16.1%for stages 4-5;and 50%,16.7%and 8.3%for stage>*** the same time,although statistically significant in prognostic stratification,the most commonly used Barcelona Clinic Liver Cancer system showed one of the most relevant differences in median survival,especially for stages A and C,when compared to the medical *** fact,10.7%,59.3%,27.1%,1.4%,and 0%of patients were stratified into stages 0,A,B,C,and D *** median survival was>81.1 mo for stage 0,44.9 mo for stage A,21.3 mo for stage B,and 3.1 mo for stage *** 1-,3-,and 5-year survival rates were respectively 86.7%,60%,and 46.7%for stage 0;91.6%,50.6%,and 20.5%for stage A;73.7%,23.7%and 13.2%for stage B;and

关键词： Hepatocellular carcinoma Prognostic score system Prognostic factors Survival analysis Barcelona Clinic Liver Cancer score system Italian Liver Cancer score system

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Large earthquakes along slow converging plate margins:Calabrian Arc paleoseismicity based on the submarine turbidite record

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Geoscience Frontiers 2023年第5期14卷 241-266页

作者： A.Polonia R.Melis P.Galli E.Colizza D.D.Insinga L.Gasperini Istituto di Scienze Marine(ISMAR-CNR) Consiglio Nazionale delle RicercheArea della Ricerca di BolognaItaly dipartimento di Matematica e Geoscienze Universitàdegli Studi di TriesteItaly Presidenza del Consiglio dei Ministri Dipartimento della Protezione CivileServizio Rischio Sismico-RomaItaly

The Calabrian Arc subduction-rollback system hosts seismogenic faults capable of generating earthquakes exceeding magnitude *** earthquakes are the result of long-term geodynamic processes,documenting seismic activity during a sufficiently long time interval is of fundamental importance for hazard *** and historical data provide critical information on seismogenesis,but they cover time periods shorter than the recurrence times of large earthquakes,especially in areas with low deformation rates such as *** onshore paleoseismological studies are fundamental to compile earthquake catalogs,they are sometime affected by the relatively poor continuity of sedimentation in the subaerial *** this study we applied the paleoseismological approach to the submarine environment to reconstruct the record of high-energy sedimentary events triggered by seismic *** analyzed three gravity cores collected in disconnected sedimentary basins to reconstruct resedimentation processes during the Holocene,integrating inland information for a better assessment of tectonic activity and *** analyses of the sedimentary record constrained by radiometric dating allowed reconstructing event stratigraphy and linking resedimented deposits to specific *** and offshore data allow to identify large-magnitude earthquakes in the central Calabrian Arc subduction system during the Holocene,with inferred epicenters located either along normal faults onshore and/or related to the slab *** turbidite record reveals 20 major events during the last 10 ka,with sources including crustal faults in Calabria(***,Rossano and Cittanova faults).Analyses of sediment samples and high-resolution seismic reflection images allowed identification of different types of resedimented deposits during the last 30–50 *** basin-wide occurrence of three megaturbidites/homogenites suggests they are related to megatsunamis sourced by

关键词： Calabrian Arc Earthquakes Seismic shaking Sedimentation Seismo-turbidites

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Hydrodynamic finite-size scaling of the thermal conductivity in glasses

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npj Computational Materials 2023年第1期9卷 696-706页

作者： Alfredo Fiorentino Paolo Pegolo Stefano Baroni SISSA—Scuola Internazionale Superiore di studi Avanzati 34136 TriesteItaly CNR-IOM—Istituto Officina Materiali SISSA Unit34136 TriesteItaly

In the past few years,the theory of thermal transport in amorphous solids has been substantially extended beyond the Allen-Feldman *** resulting formulation,based on the Green-Kubo linear response or the Wigner-transport equation,bridges this model for glasses with the traditional Boltzmann kinetic approach for *** computational effort required by these methods usually scales as the cube of the number of atoms,thus severely limiting the size range of computationally affordable glass *** hydrodynamic arguments,we show how this issue can be overcome through a simple formula to extrapolate a reliable estimate of the bulk thermal conductivity of glasses from finite models of moderate *** showcase our findings for realistic models of paradigmatic glassy materials.

关键词： glasses conductivity thermal

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Embedding compact surfaces into the 3-dimensional Euclidean space with maximum symmetry

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Science China Mathematics 2017年第9期60卷 1599-1614页

作者： WANG Chao WANG ShiCheng ZHANG YiMu ZIMMERMANN Bruno Jonsvannsveien 87B H0201Trondheim 7050Noway School of Mathematical Sciences Peking UniversityBeijing 100871China Mathematics School Jilin UniversityChangehun 130012China dipartimento di Matematica e Geoseienze Universita degli Studi di TriesteTrieste 34100Italy

The symmetries of surfaces which can be embedded into the symmetries of the 3-dimensional Euclidean space R3 are easier to feel by human＇s intuition. We give the maximum order of finite group actions on （R3 E） among all possible embedded closed/bordered surfaces with given geometric/algebraic genus greater than 1 in R3. We also identify the topological types of the bordered surfaces realizing the maximum order, and findsimple representative embeddings for such surfaces.

关键词： finite group action extendable action symmetry of surface maximum order

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Evaluation of mercury biogeochemical cycling at the sediment–water interface in anthropogenically modified lagoon environments

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Journal of Environmental Sciences 2018年第6期30卷 5-23页

作者： Elisa Petranich Stefano Covelli Alessandro Acquavita Jadran Faganeli Milena Horvat Marco Contin dipartimento di Matematica e Geoscienze Universita degli Studi di Trieste Via Weiss 2 34128 Trieste Italy dipartimento di Scienze della Vita Universita degli Studi di Trieste Via Licio Giorgieri 5 34128 Trieste Italy CoN.I.S.Ma. Consorzio Nazionale Interuniversitario per le Scienze del Mare Piazzale Flaminio 9 00196 Rome Italy Agenzia Regionale per la Protezione Ambientale del Friuli Venezia Giulia ARPA FVC Via Cairoli 14 33057 Palmanoua (Udine) Italy Marine Biological Station Fornace 41 6330 Piran Slovenia Department of Environmental Sciences Joker Stefan Institute Jamova 39 1000 Ljubljana Slovenia dipartimento di Scienze Agro-Alimentari Ambientali e Animali Universita di Udine Via delle Scienze 206 33100 Udine Italy

The Marano and Grado Lagoon is well known for being contaminated by mercury（Hg） from the Idrija mine（Slovenia） and the decommissioned chlor-alkali plant of Torviscosa（Italy）.Experimental activities were conducted in a local fish farm to understand Hg cycling at the sediment–water interface. Both diffusive and benthic fluxes were estimated in terms of chemical and physical features. Mercury concentration in sediments（up to 6.81 μg/g）showed a slight variability with depth, whereas the highest methylmercury（MeHg） values（up to 10 ng/g） were detected in the first centimetres. MeHg seems to be produced and stored in the 2–3 cm below the sediment–water interface, where sulphate reducing bacteria activity occurs and hypoxic–anoxic conditions become persistent for days. DMeHg in porewaters varied seasonally（from 0.1 and 17% of dissolved Hg（DHg）） with the highest concentrations in summer. DHg diffusive effluxes higher（up to 444 ng/m^2/day） than those reported in the open lagoon（~ 95 ng/m^2/day）, whereas DMeHg showed influxes in the fish farm（up to-156 ng/m^2/day）. The diurnal DHg and DMeHg benthic fluxes were found to be higher than the highest summer values previously reported for the natural lagoon environment. Bottom sediments, especially in anoxic conditions, seem to be a significant source of MeHg in the water column where it eventually accumulates. However, net fluxes considering the daily trend of DHg and DMeHg, indicated possible DMeHg degradation processes. Enhancing water dynamics in the fish farm could mitigate environmental conditions suitable for Hg methylation.

关键词： Mercury Benthic fluxes Biogeochemistry lagoons Sediment–water interface

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Size contrast of Pt nanoparticles formed on neighboring domains within suspended and supported graphene

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Nano Research 2018年第3期11卷 1589-1598页

作者： Dario Roccella Matteo Amati Hikmet Sezen Rosaria Brescia Luca Gregoratti universita degli studi di Genova - Facolta di Scienze Matematiche Fisiche e Naturali Viale Benedetto XV Genova 3-16132 Italy Elettra - Sincrotrone trieste S.C.p.A. in Area Science Park SS 14-Km 163.5 Trieste 34149 Italy Electron Microscopy Facility Istituto Italiano di Tecnologia (liT) via Morego 30 Genova 16163 Italy

The relatively small size of thin （one or few layers） graphene flakes makes it extremely difficult to study the behavior of suspended graphene by characterization techniques other than the electron microscopies. Herein, we exploited the capability of spatially resolved photoemission in combination with high resolution transmission electron microscopy to investigate the interaction of thermally evaporated Pt atoms on suspended and supported graphene. Spectroscopic and microscopic analyses reveal that the nucleation of nanometer- sized Pt particles in these two regions exhibit different trends. While only small nanometer-sized islands are present on the supported graphene, relatively larger clusters of islands were also found on the suspended flakes. The X-ray photoemission C ls core levels acquired after the Pt deposition show an increase in the number of vacancies in the graphene sheets.

关键词： graphene X-ray photoemissionspectroscopy scanning photoelectron microscop nanoparticles platinum suspended films

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