检索结果-南通市图书馆

Milk exosomes:Nature’s abundant nanoplatform for theranostic applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第8期6卷 2479-2490页

作者： Benilde Adriano Nycol M.Cotto Neeraj Chauhan Meena Jaggi Subhash C.Chauhan Murali M.Yallapu Department of Immunology and Microbiology School of MedicineThe University of Texas Rio Grande ValleyMcAllenTX78504USA South Texas Center of Excellence in Cancer Research School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX78504USA

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle *** have proven to be excellent nanocarriers for carrying lipids,proteins,mRNAs,non-coding RNAs,and DNAs,and disseminating long-distance intercellular communications in various biological *** various cell-line or biological fluid derived exosomes,milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic *** be an effective delivery carrier for their clinical translation,exosomes must inbuilt loading,release,targeting,and imaging/tracking *** the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging *** review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery *** is emphasized on possible modifications of exosomes towards increasing the stability and delivery of *** article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle.

关键词： Milk exosomes Extracellular vesicles Drug delivery Imaging agents Theranostic applications

Melatonin prevents oxidative stress,inflammatory activity,and DNA damage in cirrhotic rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第3期28卷 348-364页

作者： Josieli R Colares Renata M Hartmann Elizângela G Schemitt Sandielly R B Fonseca Marilda S Brasil Jaqueline N Picada Alexandre S Dias Aline F Bueno Cláudio A Marroni Norma P Marroni medical Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Brazil Marilda S BrasilNorma Biological Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Brazil Cellular and Molecular Biology Program Lutheran University of Brazil(ULBRA)Canoas 92425-900Brazil Pneumological Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Brazil Posgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil

BACKGROUND Cirrhosis is an important health problem characterized by a significant change in liver *** animals,this can be reproduced by an experimental model of bile duct ligation(BDL).Melatonin(MLT)is a physiological hormone synthesized from serotonin that has been studied for its beneficial properties,including its antioxidant *** To evaluate MLT’s effects on oxidative stress,the inflammatory process,and DNA damage in an experimental model of secondary biliary *** Male Wistar rats were divided into 4 groups:Control(CO),CO+MLT,BDL,and BDL+*** was administered(20 mg/kg)daily beginning on day 15 after biliary *** day 29 the animals were *** samples,liver tissue,and bone marrow were collected for further *** BDL caused changes in biochemical and histological parameters and markers of inflammatory *** acid(0.46±0.01)reactive substance levels,superoxide dismutase activity(2.30±0.07)and nitric oxide levels(2.48±0.36)were significantly lower(P<0.001)n the groups that received *** damage was also lower(P<0.001)in MLT-treated groups(171.6±32.9)than the BDL-only group(295.5±34.8).Tissue damage and the expression of nuclear factor kappa B,interleukin-1β,Nrf2,NQO1 and Hsp70 were significantly lower in animals treated with MLT(P<0.001).CONCLUSION When administered to rats with BDL-induced secondary biliary cirrhosis,MLT effectively restored the evaluated parameters.

关键词： Antioxidants Secondary biliary cirrhosis Oxidative stress Melatonin Bile duct ligation

Proto-Adamastor ocean crust(920 Ma)described in Brasiliano Orogen from coetaneous zircon and tourmaline

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2019年第4期10卷 1623-1633页

作者： Léo A.Hartmann Mariana Werle Cassiana R.L. Michelin Cristiano Lana Gláucia N. Queiroga Marco P. Castro Karine R. Arena Instituto de Geociências Universidade Federal do Rio Grande do SulAvenida Bento Goncalves950091501-970Porto AlegreRio Grande do SulBrazil Departamento de Geologia Escola de MinasUniversidade Federal de Ouro PretoMorro do Cruzeiro35400-000Ouro PretoMinas GeraisBrazil

Proto-Adamastor ocean bathed Rodinia and successor continental fragments from 1.0-0.9 Ga up to0.75 Ga,and evolved into world Adamastor Ocean at 0.75-0.60 *** oceanic crust is poorly preserved on continents,only indirect evidence registered in Brasiliano *** report first evidence of ophiolite originated in *** use multi-technique U-Pb-Hf zircon andδ^11B tourmaline isotopic and elemental *** host tourmalinite is enclosed in metaserpentinite,both belonging to the Bossoroca *** is 920 Ma-old,εHf(920 Ma)=+12,HfTDM=1.0 Ga and has’oceanic’composition(e.g.,U/Yb<0.1).Tourmaline is dravite withδ^11B=+1.8‰(Tur 1),0‰(Tur 2),-8.5‰(Tur 3).These characteristics are a novel contribution to Rodinia and associated world ocean,because a fragment of proto-Adamastor oceanic crust and mantle evolved at the beginning of the Brasiliano Orogen.

关键词： Coeval zircon and tourmaline Bossoroca ophiolite Early Brasiliano Orogen Zircon U-Pb-Hf isotopes Zircon trace elements Tourmaline boron isotopes

Environmental determinants of social wasp diversity and assemblage structure in an Amazonian archipelagic landscape

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Zoological Research(Diversity and Conservation) 2024年第2期1卷 121-129页

作者： Jose Victor Alves Ferreira Alexandre Somavilla Maíra Benchimol Ana Filipa Palmeirim Carlos A.Peres Danielle Storck-Tonon Laboratório de Ecologia Aplicada àConservação Universidade Estadual de Santa CruzIlhéus 45662-900Brazil Instituto Nacional de Pesquisas da Amazônia Coordenação de BiodiversidadeManaus 69067-001Brazil CIBIO Centro de Investigação em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoUniversidade do PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de VairãoVairão 4485-661Portugal school of Environmental Sciences University of East AngliaNorwich NR47TJUK Instituto Juruá Manaus69057-060Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda Serra 78300-970Brazil

Hydropower development has become an important driver of habitat loss and fragmentation across lowland tropical *** ample evidence on the detrimental effects of insular habitat fragmentation on biodiversity,invertebrate taxa,that may be critical to ecosystem functioning,have been *** assessed the assemblage-level responses of social wasps to forest insularization induced by the Balbina Hydroelectric Dam in Central Brazilian *** Malaise trapping,we captured wasps on 27 forest islands and three continuous *** constructed Generalized Linear Models and employed a model selection approach to examine the impact of local variables(fire severity(FIRE)and basal area of pioneer tree species(PIONEER))and landscape-scale variables(amount of habitat(COVER))on patterns of species richness,composition,and body size of wasps.A total of 374 individuals(29 species)were collected across all sampling *** was the main predictor of species richness,while PIONEER was the only variable that explained variation in community composition,with a negative effect on body *** results add evidence to the pervasive impacts of large hydroelectric dams on tropical forest biodiversity,and suggest that social wasps,among other invertebrates,can be used as bioindicators in infrastructure development projects.

关键词： Habitat amount hypothesis Habitat fragmentation Habitat loss Hydroelectric dams Invertebrates

Technological trajectory based on micro level technological capability:Evidence from the Brazilian rice industry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Innovation Studies 2022年第3期6卷 196-215页

作者： Monica Fitz-Oliveira Jorge Tello-Gamarra Institute of Economic Administrative and Accounting SciencesFederal University of Rio GrandeRio Grande96203-900Brazil school of Chemistry and Food Federal University of Rio GrandeSanto.Antonio da Patrulha95500-000Brazil school of Administration Federal University of Rio Grande do SulPorto Alegre90010-460Brazil

This study examines technological capability accumulation and the Brazilian rice industry's technological *** case design was chosen,with an analysis of seven firms involved in the Brazilian rice *** results indicate three factors:The first was the identification of technological landmarks for firms in this sector(peeling and polishing,electronic grain selection,electronic packaging,use of forklifts and palletizers,and Industry 4.0).The second is related to the fact that different firms implemented innovative activities and technologies at different speeds,originating from the sector's different technological *** third is associated with identifying activities within the Brazilian rice industry that can be generalized to other food *** results have implications for formulating public policies in the sector,such as creating producer support mechanisms(research and technology transfer institutions),qualification of professionals,and encouragement for economic efficiency and competition.

关键词： Technological capability Technological trajectory Firm Industry Innovation Rice

Glutamine prevents oxidative stress in a model of mesenteric ischemia and reperfusion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第32期20卷 11406-11414页

作者： Gilmara Pandolfo Zabot Gustavo Franco Carvalhal Norma Possa Marroni Renata Minuzzo Hartmann Vinícius Duval da Silva Henrique Sarubbi Fillmann Department of Surgery School of Medicine Pontifical Catholic University of Rio Grande do Sul Porto Alegre RS 90610-000 Brazil Department of Gastroenterology School of Medicine Federal University of Rio Grande do Sul Porto Alegre RS 90035-903 Brazil Department of Pathology School of Medicine Pontifical Catholic University of Rio Grande do SulPorto Alegre RS 90610-000 Brazil

AIM: To evaluate preventative effects of glutamine in an animal model of gut ischemia/reperfusion (I/R).

关键词： Ischemia-reperfusion Glutamine Lipid peroxidation Superoxide dismutase Nuclear factor-kappa beta Interleukin 6

Core-softened potentials, multiple liquid-liquid critical points, and density anomaly regions： An exact solution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of physics 2018年第1期13卷 85-94页

作者： Eduardo O. Rizzatti Marco Aurelio A. Barbosa Marcia C. Barbosa Instituto de Fisica Universidade Federal do Rio Grande do Sul Porto Alegre-RS Brazil Programa de Pos-Graduacao em Ciencia de Materiais Universidade de Brasilia Planaltina-DF Brazil

The pressure versus temperature phase diagram of a shoulder-like potential is exactly computed in one system of particles interacting through a multiscale dimension. The N-shoulder potential exhibits N density anomaly regions in the phase diagram if the length scales can be connected by a convex curve The result is analyzed in terms of the convexity of the Gibbs free energy.

关键词： density anomalies regions

Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2021年第12期13卷 2052-2070页

作者： Larisse Longo Pabulo Henrique Rampelotto Eduardo Filippi-Chiela Valessa Emanoele Gabriel de Souza Fernando Salvati Carlos Thadeu Cerski Themis Reverbel da Silveira Cláudia P Oliveira Carolina Uribe-Cruz Mário ReisÁlvares-da-Silva Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Graduate Program in Genetics and Molecular Biology Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 91501-970Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Rio Grande do SulBrazil Experimental Research Center Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil school of Medicine Instituto Meridional de Educação-IMEDPasso Fundo 99070-220Rio Grande do SulBrazil Unit of Surgical Pathology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil

BACKGROUND Cardiovascular disease is the main cause of death in metabolic-associated fatty liver disease,and gut microbiota dysbiosis is associated with both of *** To assess the relationship between gut dysbiosis and cardiovascular risk(CVR)in an experimental model of *** Adult male Sprague-Dawley rats were randomized to a control group(n=10)fed a standard diet and an intervention group(n=10)fed a high-fat choline-deficient diet for 16 ***,molecular,hepatic,and cardiac *** microbiota variables were *** The intervention group had a significantly higher atherogenic coefficient,Castelli’s risk index(CRI)-I and CRI-II,interleukin-1β,tissue inhibitor of metalloproteinase-1(all P<0.001),monocyte chemoattractant protein-1(P=0.005),and plasminogen activator inhibitor-1(P=0.037)than the control *** expression of miR-33a increased(P=0.001)and miR-126(P<0.001)decreased in the intervention *** with fibrosis was seen in the intervention group,and heart computerized histological imaging analysis showed a significant decrease in the percentage of cardiomyocytes with a normal morphometric appearance(P=0.007),reduction in the mean area of cardiomyocytes(P=0.037),and an increase of atrophic cardiomyocytes(P=0.007).There were significant correlations between the cardiomyocyte morphometry markers and those of progression and severity of liver disease and *** intervention group had a lower Shannon diversity index and fewer changes in the structural pattern of gut microbiota(both P<0.001)than *** microbial families that are involved in lipid metabolism were differentially abundant in intervention group and were significantly correlated with markers of liver injury and *** The study found a link between gut dysbiosis and significant cardiomyocyte abnormalities in animals with steatohepatitis.

关键词： Animal model Cardiovascular diseases Gut microbiota Metabolic-associated fatty liver disease Predicted lipid metabolism Risk cardiovascular Steatohepatitis

Enhancing visible-light-driven NO oxidation through molecular‐level insights of dye-loaded sea sands

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第2期43卷 543-554页

作者： Yu-Han Li Bang-Fu Chen Sónia A.C.Carabineiro You-Yu Duan Ping Tan Wing-Kei Ho Fan Dong Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and Business UniversityChongqing400067China Nanchang Institute of Technology Nanchang33044China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516CaparicaPortugal College of Physics and Center of Quantum Materials and Devices Chongqing UniversityChongqing401331China Department of Science and Environmental Studies The Education University of Hong KongHong Kong999077China

Natural minerals,abundant and easily obtained through simple physical processing,offer a cost-effective and environmentally friendly solution for dyeing wastewater disposal and air pollution *** study investigates the photocatalytic removal of NO using natural different types of dyes,loaded on natural sand,under visible light *** examining various coating concentrations of dyes and sand weights,we discovered that sand loaded with Rhodamine B(RhB)exhibits high activity for the photo-oxidation of NO.A combination results of X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectroscopy(FTIR)and thermogravimetric(TG)analyses confirm the presence of SiO_(2),CaCO_(3),Al_(2)O_(3)and iron oxides as the main components of the ***,studying RhB-loaded individual components reveals that CaCO_(3)plays a crucial role in enhancing the NO removal *** results and theoretical calculations demonstrate the establishment of a directional charge transfer channel from CaCO_(3)to RhB,facilitating the adsorption and activation of molecular NO and O_(2).This work not only promotes the utilization of natural mineral resources but also enriches the fields of environmental photochemistry and semiconductor photocatalysis.

关键词： Sand dyes Rhodamine B Photo-oxidation of NO Visible light illumination