Melatonin prevents oxidative stress,inflammatory activity,and DNA damage in cirrhotic rats

作     者：Josieli R Colares Renata M Hartmann Elizângela G Schemitt Sandielly R B Fonseca Marilda S Brasil Jaqueline N Picada Alexandre S Dias Aline F Bueno Cláudio A Marroni Norma P Marroni 

作者机构：Medical Sciences ProgramUniversidade Federal do Rio Grande do SulPorto Alegre 90050-170Brazil Marilda S BrasilNorma Biological Sciences ProgramUniversidade Federal do Rio Grande do SulPorto Alegre 90050-170Brazil Cellular and Molecular Biology ProgramLutheran University of Brazil(ULBRA)Canoas 92425-900Brazil Pneumological Sciences ProgramUniversidade Federal do Rio Grande do SulPorto Alegre 90050-170Brazil Posgraduate Program in HepatologyUniversidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第3期

页      面：348-364页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Fundo de IncentivoàPesquisa e Eventos(FIPE) 

主　　题：Antioxidants Secondary biliary cirrhosis Oxidative stress Melatonin Bile duct ligation 

摘      要：BACKGROUND Cirrhosis is an important health problem characterized by a significant change in liver *** animals,this can be reproduced by an experimental model of bile duct ligation(BDL).Melatonin(MLT)is a physiological hormone synthesized from serotonin that has been studied for its beneficial properties,including its antioxidant *** To evaluate MLT’s effects on oxidative stress,the inflammatory process,and DNA damage in an experimental model of secondary biliary *** Male Wistar rats were divided into 4 groups:Control(CO),CO+MLT,BDL,and BDL+*** was administered(20 mg/kg)daily beginning on day 15 after biliary *** day 29 the animals were *** samples,liver tissue,and bone marrow were collected for further *** BDL caused changes in biochemical and histological parameters and markers of inflammatory *** acid(0.46±0.01)reactive substance levels,superoxide dismutase activity(2.30±0.07)and nitric oxide levels(2.48±0.36)were significantly lower(P0.001)n the groups that received *** damage was also lower(P0.001)in MLT-treated groups(171.6±32.9)than the BDL-only group(295.5±34.8).Tissue damage and the expression of nuclear factor kappa B,interleukin-1β,Nrf2,NQO1 and Hsp70 were significantly lower in animals treated with MLT(P0.001).CONCLUSION When administered to rats with BDL-induced secondary biliary cirrhosis,MLT effectively restored the evaluated parameters.