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Epidemiological characteristics of live births with esophageal atresia in Sao Paulo State,Brazil,from 2005 to 2018

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World Journal of Pediatric Surgery 2023年第1期6卷 8-16页

作者： Freitas Silvestri Eduardo Jamil Farah Oliveira Marcela Chiedde Felipe Sousa Santos Giusti Calderon universidade nove de julho Curso de Medicina Sao Bernardo do CampoSao PauloBrazil Epidemiology department Universidade de Sao Paulo Faculdade de Saude PublicaSao PauloBrazil Pediatric Surgery department Hospital Beneficencia Portuguesa de Sao PauloSao PauloBrazil Pediatric Surgery department Hospital Santa CatarinaSao PauloBrazil

Background The estimated prevalence of esophageal atresia(EA)is 1 in 2500–4500 live births(LBs).Researchers have already identified risk factors,but the mechanisms are still *** aim of this study is to identify EA prevalence trends and its risk factors in the São Paulo State(SPS)population *** We conducted a population-based study using all EA cases identified by the Live Births Information System across 14 years(2005–2018)to estimate EA prevalence trends in recent years,stratified by maternal age and SPS geographical *** calculated the prevalence trends,regression coefficient(β),annual percent change(APC),and 95%confidence interval(CI).Results We found 820 EA cases among 8,536,101 LBs with a prevalence of 1.0/10,000 LBs in SPS,*** was no significant difference in distribution by *** all the cases,the majority(65%)were Caucasian;51.8%were born at term;43%had weight of≥2500 g;95.4%were singleton;and 73.4%of births were by cesarean *** 2005 to 2018,there was an increasing trend of EA prevalence(APC=6.5%)with the highest APC of 12.2%.The highest EA prevalence rate(1.7/10,000 LB)was found in the group with maternal age of≥35 *** significant seasonal variation was found based on the conception month(p=0.061).Conclusions EA had an increasing prevalence trend in SPS,Brazil,in recent years,with the highest prevalence rate in the group with maternal age of≥35 *** seasonality was *** population-based study is the first to summarize the current epidemiology of EA in SPS LB.

关键词： trend birth characteristics

Case Report: Successful Post-COVID Severe Peripheral Polyneuropathy Treatment Post AZD1222 ChAdOx1 SARS-CoV-2 Vaccination

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Case Reports in Clinical Medicine 2022年第5期11卷 146-151页

作者： Paulo Macio Porto de Melo Rute Alves Pereira e Costa universidade nove de julho Uninove S&#227 o Paulo Brazil Sociedade Brasileira de Valorizacao das Sociedades Medicas-Sobemed S&#227 o Paulo Brazil

Background: The condition known as polyneuropathy causes peripheral nerve disability, and is characterized by symmetrical distal numbness and paresthesia, often accompanied by pain and weakness. With the advancement of the pandemic in Brazil and in the world, the need for therapies as well as prophylaxis became the main focus in disease control as the viral vector platform vaccine AstraZeneca. Some effects were observed over the period of application. Case Summary: A male patient, 63 years old, previously vaccinated for COVID-19, developed active infection by the virus and in his convalescent period presented intense weakness, with prejudice to his daily activities, including personal hygiene ones. Conclusion: The patient made a complete recovery after combination therapy with testosterone derivates, ivermectin, corticosteroids, and vitamins, besides rehabilitation.

关键词： COVID-19 Vaccines Case Report Corticosteroids Testosterone Ivermectin

Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 330-335页

作者： Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa departamento de Gastroenterologia Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil Hospital das Clinicas HCFMUSP Departamento de GastroenterologiaLIM07Faculdade de MedicinaUniversidade de Sao PauloSao PauloSPBrazil Laboratório de Carboidratos e Radioimunensaio LIM18Hospital das Clinicas HCFMUSP(LIM07)Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Programa de Pos-Graduacao em Medicina Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in ***: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of ***: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P des(TGL)(TT vs XA; P degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P degrees of fibrosis in NAFLD patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic polymorphism Metabolic syndrome

Mechanisms involved in cancer stem cell resistance in head and neck squamous cell carcinoma

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Cancer Drug Resistance 2023年第1期6卷 116-137页

作者： Juliana Mota Siqueira Daniele Heguedusch Camila Oliveira Rodini Fabio Daumas Nunes Maria Fernanda Setúbal destro Rodrigues department of Stomatology Discipline of Oral and Maxillofacial PathologySchool of DentistryUniversity of São PauloSao Paulo 05508-000Brazil department of Biological Sciences Bauru School of DentistryUniversity of Sao PauloSão Paulo 17012-230Brazil Biophotonics Applied to Health Sciences Nove de Julho UniversityUNINOVESao Paulo 01504-001Brazil

despite scientific advances in the Oncology field,cancer remains a leading cause of death *** and cellular heterogeneity of head and neck squamous cell carcinoma(HNSCC)is a significant contributor to the unpredictability of the clinical response and failure in cancer *** stem cells(CSCs)are recognized as a subpopulation of tumor cells that can drive and maintain tumorigenesis and metastasis,leading to poor prognosis in different types of *** exhibit a high level of plasticity,quickly adapting to the tumor microenvironment changes,and are intrinsically resistant to current chemo and *** mechanisms of CSC-mediated therapy resistance are not fully ***,they include different strategies used by CSCs to overcome challenges imposed by treatment,such as activation of DNA repair system,anti-apoptotic mechanisms,acquisition of quiescent state and Epithelial-mesenchymal transition,increased drug efflux capacity,hypoxic environment,protection by the CSC niche,overexpression of stemness related genes,and immune *** elimination of CSCs seems to be the main target for achieving tumor control and improving overall survival for cancer *** review will focus on the multi-factorial mechanisms by which CSCs are resistant to radiotherapy and chemotherapy in HNSCC,supporting the use of possible strategies to overcome therapy failure.

关键词： Head and neck squamous cell carcinoma cancer stem cell chemotherapy radiotherapy therapy resistance

Artificial Neural Network for Websites Classification with Phishing Characteristics

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Social Networking 2018年第2期7卷 97-109页

作者： Ricardo Pinto Ferreira Andréa Martiniano Domingos Napolitano Marcio Romero Dacyr Dante de Oliveira Gatto Edquel Bueno Prado Farias Renato José Sassi Graduate Program in Informaticsand Knowledge Management Universidade Nove de Julho S&atilde o Paulo Brazil

Several threats are propagated by malicious websites largely classified as phishing. Its function is important information for users with the purpose of criminal practice. In summary, phishing is a technique used on the Internet by criminals for online fraud. The Artificial Neural Networks (ANN) are computational models inspired by the structure of the brain and aim to simu-late human behavior, such as learning, association, generalization and ab-straction when subjected to training. In this paper, an ANN Multilayer Per-ceptron (MLP) type was applied for websites classification with phishing cha-racteristics. The results obtained encourage the application of an ANN-MLP in the classification of websites with phishing characteristics.

关键词： Artificial Intelligence Artificial Neural Network Pattern Recognition Phishing Characteristics Social Engineering

Quality of care in patients with inflammatory bowel disease from a public health center in Brazil

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World Journal of Clinical Cases 2022年第33期10卷 12184-12199页

作者： debora Mayumi Takamune Giovana Signorelli Astolfi Cury Giulia Ferrás Giedre Soares Prates Herrerias Adriana Rivera Jaqueline Ribeiro Barros Julio Pinheiro Baima Rogerio Saad-Hossne Ligia Yukie Sassaki department of Internal Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618686São PauloBrazil Research Unit Virgen Macarena University HospitalSeville 41009Spain department of Medicine Nove de Julho UniversityBauru 17011-102São PauloBrazil department of Surgery São Paulo State University(Unesp)Medical SchoolBotucatu 18618686São PauloBrazil

BACKGROUND Inflammatory bowel diseases(IBDs)are chronic diseases that demand continuous interaction between patients and healthcare *** of care(QoC)is a factor that contributes to a patient’s adherence to treatment and its *** To evaluate QoC in patients from a single IBD reference *** This cross-sectional study included 133 patients from a single Brazilian IBD public health *** was evaluated through the QoC Through the Eyes of Patients with IBD(QUOTE-IBD)questionnaire(based on patient perspectives),which measures eight dimensions of *** compared QoC among patients with Crohn’s disease and ulcerative colitis and analyzed the clinical and psychological factors associated with QoC *** evaluations assessed disease characteristics,quality of life,anxiety,and depression *** Sixty-nine patients with Crohn’s disease and 64 with ulcerative colitis were *** mean age was 37.26 years±13.05 years,and 63.91%of the patients were *** mean duration of the disease was 8.44 years±7.59 years,where most patients were in remission(70.31%of patients with ulcerative colitis and 62.32%with Crohn’s disease).The total QoC score of the sample was 8.61 years±1.31 points,indicating that the QoC provided by the center was *** to univariate logistic regression,patients with Crohn’s disease had higher satisfaction rates than those with ulcerative colitis[odds ratio(OR):2.746;95%confidence interval(CI):1.360-5.541;P=0.0048]and patients on infliximab(OR:2.175;95%CI:1.037-4.562;P=0.0398).CONCLUSION Patients from the IBD public center reported good doctor-patient relationships,but had problems related to the healthcare *** of healthcare centers is of paramount to improve QoC for the patients involved.

关键词： QUOTE-IBD questionnaire Quality of care Crohn’s disease Ulcerative colitis Inflammatory bowel disease Doctor-patient relationship

Neuroplasticity in Spinal Trauma: A Current Narrative Review of Treatments

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World Journal of Neuroscience 2021年第2期11卷 91-107页

作者： Vinicius Benatti Freire Lucas Cressoni de Souza Mario Henrique de Lima Martinelli Leonardo Moysés Sacchi Thales Andolfo de Souza Antonio Eduardo Damin Medical Students of the nove de julho University (Campus Vergueiro) S&#227o Paulo Brazil department of Neurology of the nove de julho University Medical School Neurologist and Professor of Neurology at Nove de Julho University Medical School S&#227o Paulo Brazil

Neuroplasticity is a condition that is present from birth, being found in the central and peripheral nervous system, in both physiological and pathological terms. Based on the findings, therapeutic and non-therapeutic attempts were tested on spinal cord trauma to recover locomotor function below the level of the injury. The work defined and showed other forms of the term neuroplasticity, talk about some pathological and non-pathological conditions, and, finally, show neuroplasticity and some of its treatments in the spinal cord injury process. A narrative literature review from 2000 to 2020 of the PubMed platform was conducted and analysis of two books for the elaboration of this work. Animal/human studies were included that addressed pathologies, forms of treatment for spinal trauma, and qualis from B1 to A1. Pre-2000 articles, which addressed neuroplasticity only to understand the molecular mechanisms and articles that were not in English, were excluded. As a result, the main molecules and structures that inhibit neuroplasticity were found, and, based on their knowledge, forms of treatments were developed to inhibit these molecules and structures to assist in neuroplasticity and assist in possible functional recovery. It can be concluded that the physiological barriers are already being overcome by the most recent forms of treatment and that soon new studies may propose a form of treatment that is protocoled for all patients.

关键词： Neuroplasticity Spinal Cord Injury Regeneration Nanomaterials Stem Cell Pharmacology

Co-Creation in the Game Industry:A Case Study in a Brazilian developer

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Social Networking 2018年第1期7卷 63-78页

作者： Marcos Vinicius Cardoso Huoston Rodrigues Batista Ernani Marques da Silva Marcos Antonio Gaspar Ivanir Costa Fábio Luís Falchi de Magalhaes universidade Anhembi Morumbi Sao PauloBrazil Graduate Program in Informatics and Knowledge Management Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

The objective of this work is to understand how the process of co-creation occurs within the creative industry of video games. For this, concepts of the creative industry, co-creation, information and communication technologies (ICTs) and innovation were studied. Since this is an exploratory and qualitative research, a single case study was chosen as a method. The analysis was done in a Brazilian company that develops games for mobile devices. The results show that the consumer (gamer) participates in value creation in the company’s products, mainly in the initial production stages. In the later phases, after the launch and other steps of the life cycle, although there is a relationship with the users, the joint creation of value is little explored by the organization. Also, it was verified that the co-creation process is supported by different information and communication tools, which provide agility to the process.

关键词： Co-Creation Empirical Studies Gaming Communities Information and Communication Technologies Innovation

Evaluation of functional, autonomic and inflammatory outcomes in children with asthma

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World Journal of Clinical Cases 2015年第3期3卷 301-309页

作者： Evelim Leal de Freitas Dantas Gomes Dirceu Costa Rehabilitation Sciences Physical Therapy Course University Nove de Julho Postgraduate Program in Rehabilitation Sciences University Nove de Julho

Asthma is common in childhood. This respiratory disease is characterized by persistent inflammation of the airways even when the child is not in thethroes of an attack. Chronic inflammation is caused by an imbalance between pro-inflammatory and antiinflammatory mechanisms as well as autonomic dysfunction, which plays an important role in the pathogenesis and control of this condition. The impact of these physiopathological aspects leads to inactivity and a sedentary lifestyle, which exerts an influence on functional capacity and control of the disease. The main objective of non-pharmacological therapy is the clinical control of asthma and the minimization of airway obstruction and hyperinflation during an attack. These factors can be controlled with noninvasive ventilation. The aim or the present review was to describe important neural, inflammatory and functional mechanisms that affect children with asthma.

关键词： Asthma Child Continuous positive airway pressure Noninvasive ventilation Autonomic nervous system Functional capacity Inflammatory mechanisms Evaluation