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外源性肺泡表面活性剂(Calfactant)对小儿急性肺损伤的疗效:随机对照试验

世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 1-2页

作者： Willson D. F. Thomas N. J. Markovitz B. P. 李开 univ. virginia children’s med.ctr. PO Box 800-386 Charlottesville VA 22908 United States

Context: Despite evidence that patients with acute lung injury (ALI) have pulmonary surfactant dysfunction, trials of several surfactant preparations to treat adults with ALI have not been successful. Preliminary studies in children with ALI have shown that instillation of a natural lung surfactant (calfactant) containing high levels of surfactant-specific protein B may be beneficial. Objective: To determine if endotracheal instillation of calfactant in infants, children, and adolescents with ALI would shorten the course of respiratory failure. Design, setting, and Patients: A multicenter, randomized, blinded trial of calfactant compared with placebo in 153 infants, children, and adolescents with respiratory failure from ALI conducted from July 2000 to July 2003. Twenty-one tertiary care pediatric intensive care units participated. Entry criteria included age 1 week to 21 years, enrollment within 48 hours of endotracheal intubation, radiological evidence of bilateral lung disease, and an oxygenation index higher than 7. Premature infants and children with preexisting lung, cardiac, or central nervous system disease were excluded. Intervention: Treatment with intratracheal instillation of 2 doses of 80 mL/m2 calfactant or an equal volume of air placebo administered 12 hours apart. Main Outcome Measures: Ventilator-free days and mortality; secondary outcome measures were hospital course, adverse events, and failure of conventional mechanical ventilation. Results: The calfactant group experienced an acute mean (sD) decrease in oxygenation index from 20 (12.9) to 13.9 (9.6) after 12 hours compared with the placebo group’s decrease from 20.5 (14.7) to 15.1 (9.0) (P=.01). Mortality was significantly greater in the placebo group compared with the calfactant group (27/75 vs 15/77; odds ratio, 2.32; 95%confidence interval, 1.15-4.85), although ventilator-free days were not different. More patients in the placebo group did not respond to conventional mechanical ventilation. T

关键词：急性肺损伤 Calfactant 随机对照试验常规机械通气气管内滴注氧合指数呼吸衰竭出生后三级医疗安慰剂

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德系犹太裔克罗恩病少儿患者与成年患者的NOD2/CARD15基因突变以及基因型-表现型相关性对比研究

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世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 46-47页

作者： Weiss B. shamir R. Bujanover Y. 张振 Div.Pediat.Gastroenterol.Nutr.safra children's Hospital Chaim Sheba Med.Ctr.Tel-H.HaifaIsrael

目的:NOD2/CARD15基因位点上的等位基因G908R、R702W和1007fs,与克罗恩病(CD)易感性之间存在显著而独立的相关性。笔者选择犹太裔CD患儿(≤16岁)和成年患者作为研究对象,比较分析两组患者NOD2/CARD15基因位点的基因型以及基因型-表现型... 详细信息

目的:NOD2/CARD15基因位点上的等位基因G908R、R702W和1007fs,与克罗恩病(CD)易感性之间存在显著而独立的相关性。笔者选择犹太裔CD患儿(≤16岁)和成年患者作为研究对象,比较分析两组患者NOD2/CARD15基因位点的基因型以及基因型-表现型相关性。方法:分析67例CD患儿和成年患者基因序列,采用等位基因特异性聚合酶链反应和限制性内切酶酶切反应,检测上述3个等位基因的携带率。同时,检测患者的表现型征象。结果:上述3个NOD2/CARD15 相关性等位基因的携带率,儿童组为51.1%,成年组为37.5%,两组间差异具有统计学显著性,P=0.07。G908R是最常见的等位基因,患儿组携带率为18%,成年患者组为11%,两组间差异具有统计学显著性,P= 0.063。德系犹太裔患儿的G908R等位基因携带率最高,远高于德系成年患者,两组的携带率分别为25%和9%,组间差异具有统计学显著性,P:0.003。患儿多有炎症性肠道疾患家族史,多患炎症性疾病,但与其携带的等位基因改变没有相关性。结论:德系犹太裔少儿幼年期发生的CD,与患儿NOD2/CARD15基因位点上出现G908R等位基因突变型存在密切的关联。

关键词：克罗恩病犹太裔 NOD2/CARD15 携带率 CARD 表现型聚合酶链反应基因突变统计学显著性基因位点

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Pedicled greater omentum flap for preventing bile leak in liver transplantation patients with poor biliary tract conditions

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Hepatobiliary & Pancreatic Diseases International 2007年第5期6卷 470-473页

作者： Ye, Qi-Fa Niu, Ying she, Xing-Guo Ming, Ying-Zi Cheng, Ke Ma, Yin Ren, Zu-Hai Cent s univ Xiangya Hosp 3 Res Ctr Natl Hlth Minist Transplantat Med Engn & Technol Changsha 410013 Peoples R China

BACKGROUND: Bile leak remains a main complication in liver transplantation patients with poor biliary tract conditions, mainly caused by an insufficient blood supply or dysplasia of the biliary tract. Although Roux-en-Y modus operandi can be adopted, the risk of other complications of the biliary tract such as infection increases. Using pedicled greater omentum flaps to wrap the anastomotic stoma, which increases the biliary tract blood supply, may reduce the incidence of bile leak. METHODs: Fourteen patients undergoing piggy-back liver transplantation and having poor biliary tract conditions were treated with pedicled greater omentum flaps to wrap the anastomotic stoma of the biliary tract. Their clinical data were analyzed retrospectively. REsULTs: Of the 14 patients, only one (7.1%) had a mild bile leak on the 8th day post-operation and fully recovered after symptomatic treatment. The other patients had no biliary complications. CONCLUsIONs: Using pedicled greater omentum flaps to wrap the anastomotic stoma of the biliary tract is an effective way to prevent bile leak in liver transplantation patients, especially those with poor biliary tract conditions. However, experience with this surgical technique still needs to be further explored.

关键词： liver transplantation bile leak greater omentum flap

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GDNF cDNA-engineered NIH 3T3 cells protect primary dopaminergic neurons

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Chinese science Bulletin 1997年第22期42卷 1921-1925页

作者： Ma, DD Wang, XM Jing, XJ Wang, J Xiong, L song, H Wan, Y Xu, GH sun, QL Cai, D Wang, XH Han, Js Beijing med univ Neurosci Res Ctr Beijing 100083 Peoples R China

IN vitro and in vivo experiments show the protective effects of glial cell line-derived neu-rotrophic factor (GDNF) on dopaminergic (DA) neurons are potent and relatively specif-ic. However, GDNF protein is not small ... 详细信息

关键词： GDNF Parkinson’s disease engineering cells dopaminergic neurons.

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Liver transplant recipients with portal vein thrombosis:a single center retrospective study

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 34-39页

作者： Tao, Yi-Feng Teng, Fei Wang, Zheng-Xin Guo, Wen-Yuan shi, Xiao-Min Wang, Gui-Hua Ding, Guo-shan Fu, Zhi-Ren second Mil med univ Changzheng Hosp Organ Transplantat Ctr Shanghai 200003 Peoples R China

BACKGROUND: Portal vein thrombosis (PVT) used to be a contraindication for liver transplantation (LT). This obstacle has been delt with following the improvement of LT-related techniques and therapeutic approaches to thrombosis. But the effect of PVT on LT outcomes is still controversial. We reviewed retrospectively the outcome of LT patients with PVT as well as risk factors and surgical management according to PVT grades. METHODs: A total of 465 adult LTs were performed from December 2002 through December 2006. Operative findings and the result of preoperative ultrasonography and imaging were reviewed for PVT grading (Yerdel grading). Comparison of risk factors, variables associated with perioperative period and prognosis between recipients with and without PVT is based on the grades. REsULTs: In the 465 LTs, 42 were operatively confirmed to have PVT (9.0%) (19 recipients with grade I, 14 with grade 2, 7 with grade 3, and 2 with grade 4). Increased age and treatment of portal hypertension were associated with PVT. Grade 1 or 2 PVT was treated by direct anastomosis or single thrombectomy. In grade 3 PVT patients, the donor PV was directly anastomosed to the dilated branch of the recipient portal venous system or to the distal open superior mesenteric vein through an interposition vein graft if needed. Grade 4 PVT was managed by our modified cavoportal hemitransposition technique. The comparison between PVT patients and controls showed no significant difference in operative duration and blood transfusion (P > 0.05). The flow rate of the PV was lower in the PVT patients (48.881 +/- 12.788 cm/s) than in the controls (57.172 +/- 21.715 cm/s, P s had such postoperative complications as renal failure and PV rethrombosis (P survival rates in PVT and non-PVT patients were 78.6% and 76.4% respectively (P > 0.05); the 3-year survival rates were 58.8% and 56.4% respectively (P > 0.05). CONCLUsIONs: PVT is not contraindicated for LT i

关键词： portal vein thrombosis liver transplantation prognosis

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Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2010年第13期16卷 1649-1654页

作者： Lv, Jin Cao, Xiu-Feng Zhu, Bin Ji, Lv Tao, Lei Wang, Dong-Dong Nanjing med univ Affiliated Nanjing Hosp 1 Dept Surg Ctr Oncol Nanjing 210006 Jiangsu Peoples R China

AIM: To investigate the role of perioperative chemoradiotherapy (CRT) in the treatment of locally advanced thoracic esophageal squamous cell carcinoma (EsCC). METHODs: Using preoperative computed tomography (CT)-based staging criteria, 238 patients with EsCC (stage ⅡⅢ ) were enrolled in this prospective study between January 1997 and June 2004. With informed consent, patients were randomized into 3 groups: preoperative CRT (80 cases), postoperative CRT (78 cases) and surgery alone (s) (80 cases). The 1-, 3-, 5and 10-year survival were followed up. Progressionfree survival (PFs) was chosen as the primary endpoint by treatment arm measured from study entry until documented progression of disease or death from any cause. The secondary endpoint was overall survival (Os) determined as the time (in months) between the date of therapy and the date of death. Other objectives were surgical and adjuvant therapy ***: With median follow-up of 45 mo for all the enrolled patients, significant differences in the 1-, 3-, 5-, 10-year Os (91.3%, 63.5%, 43.5%, 24.5% vs 91%, 62.8%, 42.3%, 24.4% vs 87.5%, 51.3%, 33.8%, 12.5%, P = 0.0176) and PFs (89.3%, 61.3%, 37.5%, 18.1% vs 89.1%, 61.1%, 37.2%, 17.8% vs 84.5%, 49.3%, 25.9%, 6.2%, P = 0.0151) were detected among the 3 arms. There were no significant differences in Os and PFs between the preoperative CRT and postoperative CRT arm (P > 0.05). For the patients who had radical resection, significant differences in median PFs (48 mo vs 61 mo vs 39.5 mo, P = 0.0331) and median Os (56.5 mo vs 72 mo vs 41.5 mo, P = 0.0153) were detected among the 3 arms, but there were no significant differences in Os and PFs between the preoperative CRT and postoperative CRT arm (P > 0.05). The local recurrence rates in the preoperative CRT, postoperative CRT group and s group were 11.3%, 14.1% and 35%, respectively (P significant differences were detected among the 3 groups when comparing complications but tended to be in favor

关键词： Esophageal cancer surgery Esophagectomy Chemotherapy Radiation therapy

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Pancreaticoduodenal transplantation with portal venous and enteric drainage in rats

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World Journal of Gastroenterology 2000年第6期6卷 914-916页

作者： Gu YP Gu JY Li Js Nanjing univ Nanjing Gen Hosp Sch Med Transplantat Ctr Nanjing 210002 Jiangsu Provinc Peoples R China

INTRODUCTIONThe use of combined pancreatic and renaltransplantation in patients with diabetes and end-stage renal failure has gained widespreadrecognition as an acceptable treatment *** method used for transplantation... 详细信息

关键词： pancreaticoduodenal transplantation kidney transplantation portal venous drainage enteric drainage postoperative complications rats

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LOH analysis of genes around D4s2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第16期16卷 2046-2054页

作者： Huang, Guo-Liang Li, Bin-Kui Zhang, Mei-Yin Zhang, Hui-Zhong Wei, Rong-Rong Yuan, Yun-Fei shi, Ming Chen, Xiao-Qian Huang, Long Li, An-Hua Huang, Bi-Jun Li, Hong-Hua Wang, Hui-Yun sun Yat sen univ Ctr Canc State Key Lab Oncol S China Guangzhou 510060 Guangdong Peoples R China sun Yat sen univ Ctr Canc Dept Hepatobiliary Oncol Guangzhou 510060 Guangdong Peoples R China sun Yat sen univ Ctr Canc Dept Pathology Guangzhou 510060 Guangdong Peoples R China sun Yat sen univ Ctr Canc Dept Ultrasound & Electrocardiogram Guangzhou 510060 Guangdong Peoples R China UMDNJ Robert Wood Johnson Med Sch Canc Inst New Jersey Dept Microbiol Mol Genet & Immunol Piscataway NJ 08854 USA

AIM:To investigate genes around the locus D4s2964 affected by loss of heterozygosity(LOH) and their clinical ***:Four hundred and forty single nucleotide polymorphisms(sNPs) located at 49 genes around D4s2964 were selected from the National Center for Biotechnology Information website for the sNPs microarray *** of sNPs markers in 112 cases of hepatocellular carcinoma(HCC) tissues and paired adjacent liver tissues were investigated by the sNPs *** correlation between allelic losses with clinicopathological features and overall survival was ***:A f ine map of LOH of sNPs in genes around D4s2964 was *** average frequency of LOH in genes was 0.39.A correlation between cirrhosis and the FAL index(fractional allelic loss) was found(P = 0.0202).Larger tumor size was found to be signif icantly associated with LOH in genes ADP-ribosyltransferase 3(ART3),nucleoporin 54 kDa(NUP54),scavenger receptor class B,member 2(sCARB2) and coiled-coil domain containing 158(CCDC158)(P = 0.043,P = 0.019,P = 0.001,P = 0.037,respectively).Kaplan-Meier analysis showed that patients with LOH in ARD1 homolog B(ARD1B) and septin 11(sEPT11) had a significantly lower survival rate than those with retention(P = 0.021 and P = 0.004,respectively).A Cox regression model suggested that LOH in ARD1B and sEPT11,respectively,were predictors of the overall survival in HCC(P = 0.006 and P = 0.026,respectively).CONCLUsION:LOH in genes around D4s2964 may play an important role in HCC development and *** in ARD1B and sEPT11 could serve as novel prognostic predictors in HCC patients.

关键词： ARD1 homolog B Hepatocellular carcinoma Loss of heterozygosity septin 11 single nucleotide polymorphism

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Reevaluation of the effect of lamivudine therapy preoperative to prevent HBV recurrence after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 357-361页

作者： Lu, An-Wei Zheng, shu-sen Wu, Mei-Ping shen, Yi Yang, Rong-Wei Zhejiang univ Sch Med Affiliated Hosp 1 Hepatobiliary Pancreat Surg Ctr Hangzhou 310003 Zhejiang Peoples R China Zhejiang univ Sch Med Ctr Clin Lab Hangzhou 310003 Zhejiang Peoples R China Zhejiang univ Coll Publ Hlth Dept Epidemiol & Hlth Stat Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: Hepatitis B virus (HBV) recurrence may result in hepatic, insufficiency or dysfunction of liver grafts. This study was to reevaluate the preventive effect of lamivudine therapy pretransplant on HBV recurrence after liver transplantation with combined lamivudine and hepatitis B immunoglobulin (HBIG) as a prophylactic regimen. METHODs: This is a single-center, retrospective study of 122 liver transplant recipients operated on from January 2002 to september 2006 at our hospital. All subjects showed positive hepatitis B surface antigen (HBsAg) and HBV DNA in blood, without HEX mutation in YMDD at the time of liver transplantation. The protocol with combined larnivudine and HBIG for preventing HBV recurrence was used on the day of operation. The initial immunosuppression therapy was identical. After one year follow-up, the recipients were divided into 2 groups: patients without HBV recurrence (group]) and patients with HBV recurrence (group 11). Preoperafive larnivudine therapy and postoperative mycophenolate mofetil (MMF) and glucocorticoid therapy were analyzed using the Wilcoxon's test and stepwise logistic regression method. REsULTs: In the HBV recurrence group, the duration of pre-transplant lamivudine administration was significantly longer than that in the without HBV recurrence group (Z=-4.424, P=0.000). The HBV recurrence rate was significantly higher in patients with preoperative lamivudine therapy than in patients without lamivudine therapy (chi(2)= 13.11, P=0.000); the risk of HBV recurrence increased by a 10.909-fold in patients with pre-transplant lamivudine therapy compared with that in patients without larnivudine therapy (OR=10.909; 95% Cl for OR: 2.86-41.67). seven (63.6%) of 11 HBV recurrence recipients had YMIDD mutants. The duration of MMF or glucocorticoid was not different between the 2 groups (Z(MMF)=-1.453, P-MMF=0.146; Z(Prc)=-0.795, P-Prc=0.427). No significant difference was noted in the HBV recurrent rate in patients with MMF dura

关键词： liver transplantation HBV recurrence lamivudine HBV DNA

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Anxiety-like behavior in mice deficient in the phosphodiesterase 4B （PDE4B） enzyme

Anxiety-like behavior in mice deficient in the phosphodieste...

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第十五届国际药理学大会

作者： MAsOOD Anbrin sTOLINsKI Lisa R. JM s.-L.Catheriner DLABOGA Daniel CONTI Marco O’ DONNELL James M. Depts of Behav med ＆ Psychiat and Neurobiol ＆ Anatomy West Virginia Univ Hlth Sci CtrMorgantownWV 26505USA. Depts of Behav med ＆ Psychiat and Neurobiol ＆ Anatomy West Virginia Univ Hlth Sci CtrMorgantownWV 26505USA. Dept of Gyn and Ob Stanford Univ Schl of MedStanfordCA 94305USA. Depts of Behav med ＆ Psychiat and Neurobiol ＆ Anatomy West Virginia Univ Hlth Sci CtrMorgantownWV 26505USA. Dept of Gyn and Ob Stanford Univ Schl of MedStanfordCA 94305USA. Depts of Behav med ＆ Psychiat and Neurobiol ＆ Anatomy West Virginia Univ Hlth Sci CtrMorgantownWV 26505USA.

＜正＞ Cyclic AMP （cAMP） - specific phophodiesterase 4 （PDE4）. an enzyme catalyzing cAMP breakdown,plays a critical role in controlling intracellular cAMP. which is implicated in various CNs disorders. Using mice deficient in PDE4B （PDE4B-/- ） or PDE4D （PDE4D-/- ）,two important isoemzymes of PDE4, we examined the function of PDE4 in anxiety - like behavior. The PDE4 inhibitor rolipram （0.1 - 1 mg/kg） dose - dependently decreased head - dips and the head - dipping time in the mouse holeboard test （HBT）. It also decreased transitions and the time spent on the light side in the mouse light - dark transition test （LDT）. Interestingly,only PDE4B-/- mice displayed anxiety - like behavior,as evidenced by inhibited open - arm activity in the elevated - plus maze,decreased head - dips and the head - dipping time in the HBT. reduced transitions and the time on the light side in the LDT. and decreased ambulation and rears in the open-field test. Consistent with this. PDE4B-/- mice displayed increased levels of plasma corticosterone. These results suggest that PDE4. in particular the PDE4B subtype,is important for maintaining a normal mood status

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